molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

, housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular function, and are expressed in all cells of an organism under normal and patho-physiological conditions. Although some housekeeping genes are expressed at relatively constant rates in most non-pathological situations, the expression of other housekeeping genes may vary depending on experimental conditions. The origin of the term "housekeeping gene" remains obscure. Literature from 1976 used the term to describe specifically

tRNA Transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length (in eukaryotes), that serves as the physical link between the mRNA and the amino ...

and

rRNA Ribosomal ribonucleic acid (rRNA) is a type of non-coding RNA which is the primary component of ribosomes, essential to all cells. rRNA is a ribozyme which carries out protein synthesis in ribosomes. Ribosomal RNA is transcribed from ribosoma ...

. For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis of expression levels of other genes. The key criterion for the use of a housekeeping gene in this manner is that the chosen housekeeping gene is uniformly expressed with low variance under both control and experimental conditions. Validation of housekeeping genes should be performed before their use in gene expression experiments such as

RT-PCR Reverse transcription polymerase chain reaction (RT-PCR) is a laboratory technique combining reverse transcription of RNA into DNA (in this context called complementary DNA or cDNA) and amplification of specific DNA targets using polymerase ch ...

. Recently a web-based database o
human
an
mouse
housekeeping genes and reference genes/transcripts, name
Housekeeping and Reference Transcript Atlas
(HRT Atlas), was developed to offer updated list of housekeeping genes and reliable candidate reference genes/transcripts for RT-qPCR data normalization. This database can be accessed at http://www.housekeeping.unicamp.br.

Housekeeping gene regulation

Housekeeping genes account for majority of the active genes in the genome, and their expression is obviously vital to survival. The housekeeping gene expression levels are fine-tuned to meet the metabolic requirements in various tissues. Biochemical studies on

transcription Transcription refers to the process of converting sounds (voice, music etc.) into letters or musical notes, or producing a copy of something in another medium, including: Genetics * Transcription (biology), the copying of DNA into RNA, the fir ...

initiation of the housekeeping gene promoters have been difficult, partly due to the less-characterized promoter motifs and transcription initiation process. Human housekeeping gene promoters are generally depleted of TATA-box, have high GC content and high incidence of

CpG Islands The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG isl ...

. In Drosophila, where promoter specific CpG Islands are absent, housekeeping gene promoters contain DNA elements like DRE, E-box or DPE. Transcription start sites of housekeeping genes can span over a region of around 100 bp whereas transcription start sites of developmentally regulated genes are usually focused in a narrow region. Little is known about how the dispersed transcription initiation of housekeeping gene is established. There are

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...

s that are specifically enriched on and regulate housekeeping gene promoters. Furthermore, housekeeping promoters are regulated by housekeeping

enhancers In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins ( activators) to increase the likelihood that transcription of a particular gene will occur. These proteins are usually referred to as transcriptio ...

but not developmentally regulated enhancers.

Common housekeeping genes in humans

The following is a partial list of "housekeeping genes." For a more complete and updated list, se
HRT Atlas database
compiled by Bidossessi W. Hounkpe et al. The database was constructed by mining more than 12000 human and mouse RNA-seq datasets.

Gene expression

Transcription factors

ATF1 Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ''ATF1'' gene. This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. ...

NM_005171 *

ATF2 Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ''ATF2'' gene. Function This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This ...

NM_001880 * ATF4 Activating transcription factor 4 NM_001675 *

ATF6 Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ''ATF6'' gene and is involved in the unfolded protein response. Function ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembra ...

NM_007348 *

ATF7 Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ''ATF7'' gene. Homonym In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1. This ATF-7 is actu ...

NM_001206682 *

ATF7IP Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ''ATF7IP'' gene. Interactions ATF7IP has been shown to interact with MBD1 Methyl-CpG-binding domain protein 1 is a protein that in humans is en ...

NM_018179 *

BTF3 Transcription factor BTF3 is a protein that in humans is encoded by the ''BTF3'' gene. Function This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional ...

NM_001207 Homo sapiens basic transcription factor 3 *

E2F4 Transcription factor E2F4 is a protein that in humans is encoded by the ''E2F4'' gene. Function The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of c ...

Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4), mRNA * ERH (gene) Enhancer of rudimentary homolog of drosophila (which in turn is the first enzymatic step in pyrimidine synthesis. Regulated by MITF) *

HMGB1 High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the ''HMGB1'' gene. HMG-1 belongs to the high mobility group and contains a HMG-box domain. Functi ...

High mobility group box binds DNA *

ILF2 Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ''ILF2'' gene. Function Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT bin ...

Homo sapiens interleukin enhancer binding factor 2, 45kDa (ILF2), mRNA * IER2 formerly ETR101 Immediate Early Protein? *

JUND Under the early Caliphates, a ''jund'' ( ar, جند; plural ''ajnad'', اجناد) was a military division, which became applied to Arab military colonies in the conquered lands and, most notably, to the provinces into which Greater Syria (the Le ...

Homo sapiens jun D proto-oncogene (JUND), mRNA *

TCEB2 Elongin B is a protein that in humans is encoded by the ''ELOB'' gene. Function Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymer ...

Elongin Matheo er rar

=Repressors

= * PUF60 Homo sapiens fuse-binding protein-interacting repressor (SIAHBP1), transcript

RNA splicing

BAT1 Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the ''BAT1'' gene. This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is ...

aka DDX39B *

HNRPD Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the ''HNRNPD'' gene. Alternative splicing of this gene results in four transcript variants. ...

Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA *

HNRPK Heterogeneous nuclear ribonucleoprotein K (also protein K) is a protein that in humans is encoded by the ''HNRNPK'' gene. It is found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein par ...

Homo sapiens heterogeneous nuclear ribonucleoprotein K (HNRPK), transcript *

PABPN1 Polyadenylate-binding protein 2 (PABP-2) also known as polyadenylate-binding nuclear protein 1 (PABPN1) is a protein that in humans is encoded by the ''PABPN1'' gene. PABN1 is a member of a larger family of poly(A)-binding proteins in the human ge ...

poly(A) binding protein, nuclear 1 * SRSF3 splicing factor, arginine/serine-rich

Translation factors

* EIF1 aka SUI1 * EIF1AD * EIF1B *

EIF2A Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the ''EIF2A'' gene. The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a sepa ...

* EIF2AK1 *

EIF2AK3 Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the ''EIF2AK3'' gene. Function The protein encoded by this gene ...

EIF2AK4 Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the ''EIF2AK4'' gene. EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (E ...

* EIF2AK1 *

EIF2B2 Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the ''EIF2B2'' gene. Function Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha ( ...

EIF2B3 Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the ''EIF2B3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity.. ...

EIF2B4 Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the ''EIF2B4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity.. ...

EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the ''EIF2S2'' gene. Function Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by formin ...

EIF3A Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the ''EIF3A'' gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translatio ...

EIF3B Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the ''EIF3B'' gene. Interactions EIF3B has been shown to interact with P70-S6 Kinase 1 and EIF3A Eukaryotic translation initiation factor ...

EIF3D Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the ''EIF3D'' gene. Function Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed ...

formerly EIF3S4 *

EIF3G Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the ''EIF3G'' gene. Interactions EIF3G has been shown to interact with Band 4.1 Protein 4.1, also known as Beatty's Protein, is a protei ...

EIF3I Eukaryotic translation initiation factor 3 subunit I (eIF3i) is a protein that in humans is encoded by the ''EIF3I'' gene. Interactions eIF3i has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or int ...

EIF3H Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the ''EIF3H'' gene. Interactions eIF3h has been shown to interact with eIF3a Eukaryotic translation initiation factor 3 subunit A (eIF3a) ...

EIF3J Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the ''EIF3J'' gene. Interactions eIF3j has been shown to interact Advocates for Informed Choice, doing business as, dba interACT or inte ...

EIF3K Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the ''EIF3K'' gene. Function The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, inclu ...

* EIF3L * EIF3M * EIF3S5 * EIF3S8 *

EIF4A1 Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the ''EIF4A1'' gene, which is located on chromosome 17. It is the most prevalent member of the eIF4A family of ATP-depe ...

EIF4A2 Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the ''EIF4A2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gener ...

EIF4A3 Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the ''EIF4A3'' gene. Function This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEA ...

EIF4E2 Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the ''EIF4E2'' gene. It belongs to the eukaryotic translation initiation factor 4E family. Interactions EIF4E2 has been shown to Protein-protein inter ...

EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the ''EIF4G1'' gene. Function The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the ...

EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the ''EIF4G2'' gene. Function Translation initiation is mediated by specific recognition of the cap structure by euk ...

EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the ''EIF4G3'' gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Conf ...

EIF4H Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the ''EIF4H'' gene. This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of ...

EIF5 Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the ''EIF5'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ...

EIF5A Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the ''EIF5A'' gene. It is the only known protein to contain the unusual amino acid hypusine 'N''ε-(4-amino-2-hydroxybutyl)-lysine which is synthesized on eI ...

* EIF5AL1 *

EIF5B Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the ''EIF5B'' gene. Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The ...

EIF6 Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene. Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functio ...

TUFM Elongation factor Tu, mitochondrial is a protein that in humans is encoded by the ''TUFM'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gener ...

Tu translational elongation factor mitochondrial

=tRNA synthesis

= *

AARS Aars or Års, () is a Danish town with a population of 8,474 (1 January 2022)AARS2 NM_020745 alanyl-tRNA synthetase 2, mitochondrial * AARSD1 NM_001261434 alanyl-tRNA synthetase domain containing 1 *

CARS A car or automobile is a motor vehicle with wheels. Most definitions of ''cars'' say that they run primarily on roads, seat one to eight people, have four wheels, and mainly transport people instead of goods. The year 1886 is regarded as t ...

NM_001751 cysteinyl-tRNA synthetase *

CARS2 A car or automobile is a motor vehicle with wheels. Most definitions of ''cars'' say that they run primarily on roads, seat one to eight people, have four wheels, and mainly transport people instead of goods. The year 1886 is regarded as ...

NM_024537 cysteinyl-tRNA synthetase 2, mitochondrial (putative) *

DARS DARS may refer to: * DARS (gene), a human gene * DARS (radar) Deployable Air operations centre, Recognized air picture production centre, Sensor Fusion Post, a NATO mobile deployable Command & Control radar system * DoD Architecture Registry Syst ...

NM_001349 aspartyl-tRNA synthetase *

DARS2 DARS may refer to: * DARS (gene), a human gene * DARS (radar) Deployable Air operations centre, Recognized air picture production centre, Sensor Fusion Post, a NATO mobile deployable Command & Control radar system * DoD Architecture Registry Syst ...

NM_018122 aspartyl-tRNA synthetase 2, mitochondrial * EARS2 NM_001083614 glutamyl-tRNA synthetase 2, mitochondrial * FARS2 NM_006567 phenylalanyl-tRNA synthetase 2, mitochondrial *

FARSA Farsa (Italian, literally: ''farce'', plural: ''farse'') is a genre of opera, associated with Venice in the late 18th and early 19th centuries. It is also sometimes called ''farsetta''. Farse were normally one-act operas, sometimes performed to ...

NM_004461 phenylalanyl-tRNA synthetase, alpha subunit * FARSB NM_005687 phenylalanyl-tRNA synthetase, beta subunit * GARS NM_002047 glycyl-tRNA synthetase *

HARS Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the ''HARS'' gene. Function Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. ...

NM_002109 histidyl-tRNA synthetase *

HARS2 Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the ''HARS2'' gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gen ...

NM_012208 histidyl-tRNA synthetase 2, mitochondrial *

IARS Isoleucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the ''IARS1'' gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino a ...

NM_002161 isoleucyl-tRNA synthetase * IARS2 NM_018060 isoleucyl-tRNA synthetase 2, mitochondrial *

KARS Kars (; ku, Qers; ) is a city in northeast Turkey and the capital of Kars Province. Its population is 73,836 in 2011. Kars was in the ancient region known as ''Chorzene'', (in Greek Χορζηνή) in classical historiography ( Strabo), part of ...

NM_005548 Homo sapiens lysyl-tRNA synthetase (KARS), mRNA * LARS2 NM_015340 isoleucyl-tRNA synthetase 2, mitochondrial *

MARS Mars is the fourth planet from the Sun and the second-smallest planet in the Solar System, only being larger than Mercury (planet), Mercury. In the English language, Mars is named for the Mars (mythology), Roman god of war. Mars is a terr ...

NM_004990 methionyl-tRNA synthetase * MARS2 NM_138395 methionyl-tRNA synthetase 2, mitochondrial * NARS NM_004539 asparaginyl-tRNA synthetase *

NARS2 Nars or NARS may refer to: *Karl Nars (1874–1952), Finnish industrialist * Natural Area Reserves System such as the Natural Area Reserves System Hawaii * North Atlantic Radio System, a troposcatter communications system for the air defence of NATO ...

NM_024678 asparaginyl-tRNA synthetase 2, mitochondrial (putative) * QARS NM_005051 glutaminyl-tRNA synthetase * RARS NM_002884 arginyl-tRNA synthetase *

RARS2 RARS is an acronym for Robot Auto Racing Simulator. It is an open source 3D racing simulator Simulated racing or racing simulation, commonly known as simply sim racing, are the collective terms for racing game software that attempts to accu ...

NM_020320 arginyl-tRNA synthetase 2, mitochondrial *

SARS Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), the first identified strain of the SARS coronavirus species, ''sever ...

NM_006513 Homo sapiens seryl-tRNA synthetase (SARS), mRNA *

TARS Tars or TARS may refer to: Organisations * The Arthur Ransome Society, based on British children's author Arthur Ransome * Teen Age Republicans, a youth wing of the US Republican Party * TARS, an abbreviation for ''Transporturi Aeriene Româno-Sov ...

NM_152295 threonyl-tRNA synthetase * VARS2 NM_020442 valyl-tRNA synthetase 2, mitochondrial * WARS2 NM_015836 tryptophanyl tRNA synthetase 2, mitochondrial *

YARS Tyrosyl-tRNA synthetase, cytoplasmic, also known as Tyrosine-tRNA ligase, is an enzyme that in humans is encoded by the ''YARS'' gene. Living cells translate DNA sequences into RNA sequences and then into protein sequences. Proteins are chains ...

NM_003680 Homo sapiens tyrosyl-tRNA synthetase (YARS), mRNA * YARS2 NM_001040436 Homo sapiens tyrosyl-tRNA synthetase (YARS), mRNA mitochondrial

=RNA binding protein

= *

ELAVL1 ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ''ELAVL1'' gene. The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds ci ...

Ribosomal proteins

RPL5 60S ribosomal protein L5 is a protein that in humans is encoded by the ''RPL5'' gene. Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are compo ...

RPL8 60S ribosomal protein L8 is a protein that in humans is encoded by the ''RPL8'' gene. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of ...

RPL9 60S ribosomal protein L9 is a protein that in humans is encoded by the ''RPL9'' gene. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of ...

* RPL10A *

RPL11 60S ribosomal protein L11 is a protein that in humans is encoded by the ''RPL11'' gene. Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits a ...

RPL14 60S ribosomal protein L14 is a protein that in humans is encoded by the ''RPL14'' gene. Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits ar ...

* RPL25 *

RPL26L1 Ribosomal protein L26 like 1 is a protein that in humans is encoded by the RPL26L1 gene. Function This gene encodes a protein that shares high sequence similarity with RPL26 60S ribosomal protein L26 is a ...

* RPL27 * RPL30 * RPL32 * RPL34 * RPL35 * RPL35A * RPL36AL * RPS5 *

RPS6 Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, an ...

* RPS6KA3 *

RPS6KB1 Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the ''RPS6KB1'' gene. It is a serine/threonine kinase that acts downstream of PIP3 ...

* RPS6KB2 *

RPS13 40S ribosomal protein S13 is a protein that in humans is encoded by the ''RPS13'' gene. Function Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits ar ...

RPS19BP1 *

RPS20 40S ribosomal protein S20 is a protein that in humans is encoded by the ''RPS20'' gene. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 ...

* RPS23 * RPS24 * RPS27 transcribed with ubiquitin (see

FAU (gene) 40S ribosomal protein S30 is a protein that in humans is encoded by the ''FAU'' gene. Function This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein con ...

) *

RPN1 Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the ''RPN1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian ...

Ribophorin anchors the ribosome to rough endoplasmic reticulum

Mitochondrial ribosomal proteins

* MRPL9 * MRPL1 * MRPL10 * MRPL11 * MRPL12 * MRPL13 * MRPL14 * MRPL15 * MRPL16 * MRPL17 * MRPL18 * MRPL19 * MRPL2 * MRPL20 * MRPL21 * MRPL22 * MRPL23 * MRPL24 * MRPL27 * MRPL28 * MRPL3 * MRPL30 * MRPL32 * MRPL33 * MRPL35 * MRPL36 * MRPL37 * MRPL38 * MRPL4 *

MRPL40 39S ribosomal protein L40, mitochondrial is a protein that in humans is encoded by the ''MRPL40'' gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondri ...

MRPL41 39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the ''MRPL41'' gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondri ...

* MRPL42 * MRPL43 * MRPL44 * MRPL45 * MRPL46 * MRPL47 * MRPL48 * MRPL49 * MRPL50 * MRPL51 * MRPL52 * MRPL53 * MRPL54 * MRPL55 * MRPL9 * MRPS10 * MRPS11 * MRPS12 * MRPS14 * MRPS15 * MRPS16 * MRPS17 * MRPS18A * MRPS18B * MRPS18C * MRPS2 * MRPS21 * MRPS22 * MRPS23 * MRPS24 * MRPS25 * MRPS26 * MRPS27 * MRPS28 * MRPS30 * MRPS31 *

MRPS33 28S ribosomal protein S33, mitochondrial is a protein that in humans is encoded by the ''MRPS33'' gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondri ...

* MRPS34 * MRPS35 *

MRPS5 28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the ''MRPS5'' gene. Function Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis wit ...

MRPS6 28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the ''MRPS6'' gene. Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ...

* MRPS7 * MRPS9

RNA polymerase

POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 is a protein that in humans is encoded by the ''POLR1C'' gene. Interactions POLR1C has been shown to interact with CD3EAP, POLR1E and POLR1D DNA-directed RNA polymerases I and III subunit ...

POLR1D DNA-directed RNA polymerases I and III subunit RPAC2 is a protein that in humans is encoded by the ''POLR1D'' gene. Interactions POLR1D has been shown to Protein-protein_interaction, interact with POLR1C. References Further reading

...

* POLR1E *

POLR2A DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the ''POLR2A'' gene. Function This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing me ...

POLR2B DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the ''POLR2B'' gene. This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. ...

POLR2C DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the ''POLR2C'' gene. Function This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in ...

* POLR2D *

POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the ''POLR2E'' gene. This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA ...

POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the ''POLR2F'' gene. This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA i ...

POLR2G DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the ''POLR2G'' gene. This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. ...

POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the ''POLR2H'' gene. This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed ...

POLR2I DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the ''POLR2I'' gene. This gene encodes a subunit of RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA ...

POLR2J DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the ''POLR2J'' gene. Function This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. Th ...

POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the ''POLR2K'' gene. This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger R ...

*POLR2L *POLR3C *POLR3E *POLR3GL *POLR3K

Protein processing

*Peptidylprolyl isomerase D, PPID Peptidyl-prolyl cis-trans isomerase D *PPIE (gene), PPIE Peptidyl-prolyl cis-trans isomerase E *PPIF Peptidyl-prolyl cis-trans isomerase F *PPIG (gene), PPIG Peptidyl-prolyl cis-trans isomerase G *PPIH Cyclophilin H *CANX Calnexin. Folding of glycoproteins within endoplasmic reticulum *CAPN1 Calpain subunit *CAPN7 *CAPNS1 Calpain protease subunit *NACA (gene), NACA Nascent polypeptide associated complex alpha polypeptide *NACA2 *PFDN2 Prefoldin 2 *PFDN4 Prefoldin 4 *PFDN5 Prefoldin 5 *PFDN6 Prefoldin 6 *SNX2 Sorting nexin 2 *SNX3 Sorting nexin 3 *SNX4 Sorting nexin 4 *SNX5 Sorting nexin 5 *SNX6 Sorting nexin 6 *SNX9 Sorting nexin 9 *SNX12 Sorting nexin 12 *SNX13 Sorting nexin 13 *SNX17 Sorting nexin 17 *SNX18 Sorting nexin 18 *SNX19 Sorting nexin 19 *SNX25 Sorting nexin 25 *SSR1 Translocon-associated protein TRAPA. Protein translocation in ER *SSR2 Translocon-associated protein TRAPB. Protein translocation in ER *SSR3 Translocon-associated protein TRAPG. Protein translocation in ER *SUMO1 Protein targeting *SUMO3 Protein targeting

Heat shock proteins

*HSPA4 *HSPA5 *HSPA8 *HSPA9 *HSPA14 *HSBP1

Histone

*HIST1H2BC *H1FX *H2AFV *H2AFX *H2AFY Histone 2 Subfamily *H2AFZ essential for embryogenesis

Cell cycle

There is significant overlap in function with regards to some of these proteins. In particular, the Rho-related genes are important in nuclear trafficking (i.e.: mitosis) as well as with mobility along the cytoskeleton in general. These genes of particular interest in cancer research. *ARHGAP35 *ARHGAP5 *ARHGDIA *ARHGEF10L Rho guanine nucleotide exchange factor 10L *ARHGEF11 Rho guanine nucleotide exchange factor 11 *ARHGEF40 Rho guanine nucleotide exchange factor 40 *ARHGEF7 Rho guanine nucleotide exchange factor 7 *RAB10 NM_016131 The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes *RAB11A NM_004663 *RAB11B NM_004218 *RAB14 NM_016322 *RAB18 NM_021252 *RAB1A NM_004161 Homo sapiens RAB1A, member RAS oncogene family (RAB1A), mRNA *RAB1B NM_030981 *RAB21 NM_014999 *RAB22A NM_020673 *RAB2A NM_002858 *RAB2B NM_001163380 *RAB3GAP1 NM_012233 *RAB3GAP2 NM_012414 *RAB40C NM_021168 *RAB4A NM_004578 *RAB5A NM_004162 *RAB5B NM_002865 *RAB5C NM_004583 *RAB6A NM_002868 *RAB7A NM_004637 *RAB9A NM_004251 *RABEP1 NM_004703 *RABEPK NM_005833 *RABGEF1 NM_014504 *RABGGTA NM_004581 *RABGGTB NM_004582 *CENPB Centromere protein B *CTBP1 Centromere protein T *CCNB1IP1 NM_021178 E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase *CCNDBP1 NM_012142 May negatively regulate cell cycle progression *CCNG1 NM_004060 May play a role in growth regulation *CCNH NM_001239 Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle *CCNK NM_001099402 Regulatory subunit of cyclin-dependent kinases that mediates phosphorylation of the large subunit of RNA polymerase II *CCNL1 NM_020307 Transcriptional regulator which participates in regulating the pre-mRNA splicing process *CCNL2 NM_030937 Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates the expression of critical apoptotic factor, leading to cell apoptosis. *CCNY NM_145012 Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase *PPP1CA NM_002708 Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets *PPP1CC NM_002710 *PPP1R10 NM_002714 *PPP1R11 NM_021959 Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 11 (PPP1R11), *PPP1R15B NM_032833 *PPP1R37 NM_019121 *PPP1R7 NM_002712 *PPP1R8 NM_002713 *PPP2CA NM_002715 *PPP2CB NM_001009552 *PPP2R1A NM_014225 Negative regulator of growth and cell divisionHomo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), *PPP2R2A NM_002717 *PPP2R2D NM_018461 *PPP2R3C NM_017917 *PPP2R4 NM_021131 *PPP2R5A NM_006243 *PPP2R5B NM_006244 *PPP2R5C NM_002719 *PPP2R5D NM_006245 *PPP2R5E NM_006246 *PPP4C NM_002720 *PPP4R1 NM_005134 *PPP4R2 NM_174907 *PPP5C NM_006247 *PPP6C NM_002721 *PPP6R2 NM_014678 *PPP6R3 NM_018312 *RAD1 homolog, RAD1Homo sapiens ribonuclease/angiogenin inhibitor (RNH), mRNA *RAD17 NM_002869 Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage *RAD23B NM_002873 *RAD50 (gene), RAD50 NM_005732 *RAD51C NM_002874 *IST1 (locates to central dividing line of dividing cells)

Apoptosis

*DAD1 Defender against cell death *DAP3 Involved in mediating interferon-gamma-induced cell death. *DAXX Death Associated Protein 6

Oncogenes

*ARAF *MAZ (gene) *MYC ''also considered a transcription factor''

DNA repair/replication

*MCM3AP ''possibly a primase'' *XRCC5 NM_021141 Ku80 *XRCC6 NM_001469 Homo sapiens thyroid autoantigen: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation.

Metabolism

*PRKAG1 ''Senses energy level and inactivates HMGCoA reductase and Acetyl CoA Carboxylase'' *PRKAA1 NM_006251 Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism *PRKAB1 NM_006253 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism *PRKACA NM_002730 Phosphorylates a large number of substrates in the cytoplasm and the nucleus. *PRKAG1 NM_002733 Homo sapiens protein kinase, AMP-activated, gamma 1 non-catalytic subunit (PRKAG1), mRNA *PRKAR1A NM_002734 Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells *PRKRIP1 NM_024653 Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).

Carbohydrate metabolism

*Aldolase A, ALDOA *B3GALT6 NM_080605 *B4GALT3 NM_003779 Homo sapiens UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 *B4GALT5 NM_004776 *B4GALT7 NM_007255 *GSK3A *GSK3B *Triosephosphate isomerase, TPI1 *PGK1 Phosphoglycerate kinase *Phosphoglycerate mutase, PGAM5 *ENOPH1 Enolase phosphatase *LDHA Lactate dehydrogenase *TALDO1 Transaldolase in pentose shunt *TSTA3 Mannose metabolism

Citric Acid Cycle

*SDHA NM_004168 Succinate Dehydrogenase subunit A *SDHAF2 NM_017841 *SDHB NM_002973 Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) *SDHC (gene), SDHC NM_003000 Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). *SDHD NM_003001

Lipid metabolism

*HADHA Trifunctional protein subunit alpha

Amino acid metabolism

*COMT Catechol-O-methyl transferase)

NADH dehydrogenase

*NDUFA2NM_002488 *NDUFA3 NM_004542 *NDUFA4 NM_002489 *NDUFA5 NM_005000 *NDUFA6 NM_002490 *NDUFA7 NM_005001 Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa *NDUFA8 NM_014222 *NDUFA9 NM_005002 *NDUFA10 NM_004544 *NDUFA11 NM_175614 *NDUFA12 NM_018838 *NDUFA13 NM_015965 *NDUFAF2 NM_174889 *NDUFAF3 NM_199069 *NDUFAF4 NM_014165 *NDUFB2 NM_004546 *NDUFB3 NM_002491 *NDUFB4 NM_004547 *NDUFB5 NM_002492 *NDUFB6 NM_002493 *NDUFB7 NM_004146 Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa *NDUFB10 NM_004548 *NDUFB11 NM_019056 *NDUFB8 NM_005004 *NDUFB9 NM_005005 *NDUFC1 NM_002494Homo sapiens NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa *NDUFC2 NM_004549 *NDUFC2-KCTD14 NM_001203260 *NDUFS5 *NDUFV2 *NDUFS2 NM_004550 *NDUFS3 NM_004551 *NDUFS4 NM_002495 *NDUFS5 NM_004552 Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa *NDUFS6 NM_004553 *NDUFS7 NM_024407 *NDUFS8 NM_002496 *NDUFV1 NM_007103 Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa (NDUFV1), *NDUFV2 NM_021074 Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (NDUFV2),

Cytochrome C oxidase

(Note that COX1, COX2, and COX3 are mitochondrially encoded) *COX4I1 001861 *COX5B NM_001862 *COX6B1 NM_001863 *COX6C NM_004374 *COX7A2 NM_001865 Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver) (COX7A2), *COX7A2L NM_004718 *COX7C NM_001867 *COX8 *COX8A NM_004074 Homo sapiens cytochrome c oxidase subunit VIII (COX8), nuclear gene encoding *COX11 NM_004375 *COX14 NM_032901 *COX15 NM_004376 *COX16 NM_016468 *COX19 NM_001031617 *COX20 NM_198076 *CYC1 Homo sapiens cytochrome c-1 (CYC1) *UQCC NM_018244 Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex) *UQCR10 NM_013387 *UQCR11 NM_006830 Homo sapiens ubiquinol-cytochrome c reductase (6.4kD) subunit (UQCR), mRNA *UQCRB NM_006294 *UQCRC1 NM_003365 Homo sapiens ubiquinol-cytochrome c reductase core protein I (UQCRC1), mRNA *UQCRC2 NM_003366 *UQCRHL NM_001089591 *UQCRQ NM_014402 Homo sapiens low molecular mass ubiquinone-binding protein (9.5kD) (QP-C), mRNA

ATPase

*ATP2C1 NM_014382 *ATP5A1 NM_004046 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, alpha *ATP5B NM_001686 *ATP5C1 NM_005174 *ATP5D NM_001687 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta *ATP5F1 NM_001688 *ATP5G2 NM_005176 *ATP5G3 NM_001689 Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c *ATP5H NM_006356 Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d *ATP5J NM_001685 *ATP5J2 NM_004889 Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, *ATP5J2-PTCD1 NM_001198879 *ATP5L NM_006476 *ATP5O NM_001697 Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit *ATP5S NM_015684 *ATP5SL NM_018035 *ATP6AP1 NM_001183 Homo sapiens ATPase, H+ transporting, lysosomal interacting protein 1 (ATP6IP1), *ATP6V0A2 NM_012463 *ATP6V0B NM_004047 Homo sapiens ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c (ATP6V0B), *ATP6V0C NM_001694 Homo sapiens ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (ATP6V0C), *ATP6V0D1 NM_004691 *ATP6V0E1 NM_003945 *ATP6V1C1 NM_001695 *ATP6V1D NM_015994 *ATP6V1E1 NM_001696 Homo sapiens ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1 *ATP6V1F NM_004231 Homo sapiens ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (ATP6V1F), *ATP6V1G1 NM_004888 Homo sapiens ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1 *ATP6V1H NM_015941 *ATPAF2 NM_145691 *ATPIF1 NM_016311

Lysosome

*CTSD can degrade insulin in hepatocytes *Cystatin B, CSTB May protect cell from leaking lysosomes *LAMP1 *LAMP2 *Mannose 6-phosphate receptor, M6PR

Proteasome

*PSMA1 NM_002786 *PSMA2 NM_002787 *PSMA3 NM_002788 *PSMA4 NM_002789 *PSMA5 NM_002790 *PSMA6 NM_002791 *PSMA7 NM_002792 Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7), *PSMB1 NM_002793 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 1 (PSMB1), mRNA *PSMB2 NM_002794 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 2 (PSMB2), mRNA *PSMB3 NM_002795 *PSMB4 NM_002796 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 4 (PSMB4), mRNA *PSMB5 NM_002797 *PSMB6 NM_002798 *PSMB7 NM_002799 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 7 (PSMB7), mRNA *PSMC2 NM_002803 *PSMC3 NM_002804 *PSMC4 NM_006503 *PSMC5 NM_002805 *PSMC6 NM_002806 *PSMD1 NM_002807 *PSMD10 NM_002814 *PSMD11 NM_002815 Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 *PSMD12 NM_002816 *PSMD13 NM_002817 *PSMD14 NM_005805 *PSMD2 NM_002808 *PSMD3 NM_002809 *PSMD4 NM_002810 *PSMD5 NM_005047 *PSMD6 NM_014814 *PSMD7 NM_002811 *PSMD8 NM_002812 Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 (PSMD8), *PSMD9 NM_002813 *PSME2 NM_002818 Homo sapiens proteasome (prosome, macropain) activator subunit 2 (PA28 beta) *PSME3 NM_005789 *PSMF1 NM_006814 *PSMG2 NM_020232 *PSMG3 NM_032302 *PSMG4 NM_001128591 *UBA1 NM_003334 Homo sapiens ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature *UBA2 NM_005499 *UBA3 NM_003968 *UBA5 NM_024818 *UBA52 NM_003333 *UBAC2 NM_177967 *UBALD1 NM_145253 *UBAP1 NM_016525 *UBAP2L NM_014847 *Ubiquitin B, UBB NM_018955 Homo sapiens ubiquitin B (UBB), mRNA *UBC NM_021009 Homo sapiens ubiquitin C (UBC), mRNA *UBE2A NM_003336 *UBE2B NM_003337 *UBE2D2 NM_003339 Homo sapiens ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) *UBE2D3 NM_003340 *UBE2D4 NM_015983 *UBE2E1 NM_003341 *UBE2E2 NM_152653 *UBE2E3 NM_006357 *UBE2F NM_080678 *UBE2G2 NM_003343 *UBE2H NM_003344 *UBE2I NM_003345 Homo sapiens ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (UBE2I), *UBE2J1 NM_016021 *UBE2J2 NM_058167 *UBE2K NM_005339 *UBE2L3 NM_003347 *UBE2M NM_003969 Homo sapiens ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (UBE2M), *UBE2N NM_003348 *UBE2NL NM_001012989 *UBE2Q1 NM_017582 *UBE2R2 NM_017811 *UBE2V1 NM_021988 *UBE2V2 NM_003350 *UBE2W NM_018299 *UBE2Z NM_023079 *UBE3A NM_000462 *UBE3B NM_130466 *UBE3C NM_014671 *UBE4A NM_004788 *UBE4B NM_006048 *USP10 NM_005153 *USP14 NM_005151 *USP16 NM_006447 *USP19 NM_006677 *USP22 NM_015276 *USP25 NM_013396 *USP27X NM_001145073 *USP33 NM_015017 *USP38 NM_032557 *USP39 NM_006590 *USP4 NM_003363 *USP47 NM_017944 *USP5 NM_003481 *USP7 NM_003470 *USP8 NM_005154 *USP9X NM_001039590

Ribonuclease

*RNH Ribonuclease inhibitor

Thioreductase

*TXN2 NM_012473 *TXNDC11 NM_015914 *TXNDC12 NM_015913 *TXNDC15 NM_024715 *TXNDC17 NM_032731 *TXNDC9 NM_005783 *TXNL1 NM_004786 *TXNL4A NM_006701 *TXNL4B NM_017853 *TXNRD1 NM_003330

Structural

Cytoskeletal

*ANXA6 *ANXA7 *ARPC1A Actin-related peptide *ARPC2 *ARPC5L *CAPZA2 *CAPZB *RHOA ''also implicated in regulation of cell cycle'' *RHOB *RHOT1 mitochondrial trafficking *RHOT2 *TUBB Tubulin, beta polypeptide *WDR1 actin disassembly?

Organelle synthesis

''A specialized form of cell signaling'' *BLOC1S1 *BLOC1S2NM_173809 *BLOC1S3NM_212550 *BLOC1S4NM_018366 *BLOC1S6NM_012388 *AP1G1 NM_001128 *AP1M1 NM_032493 *AP2A1 NM_014203 *AP2A2 NM_012305 *AP2M1 *AP2S1 NM_004069 *AP3B1 NM_003664 *AP3D1 NM_003938 *AP3M1 NM_012095 *AP3S1 NM_001284 *AP3S2 NM_005829 *AP4B1 NM_006594 *AP5M1 NM_018229 *ANXA6 Annexin 6 *ANXA7 Annexin 7 *AP1B1 Coated vesicles *CLTA Clathrin A (vesicles) *CLTB Clathrin B (vesicles) *CLTC

Mitochondrion

*MTX2

Surface

*AP2S1 *CD81 *GPAA1 *LGALS9 *MGAT2 *MGAT4B *VAMP3

Cell adhesion

*CTNNA1 NM_001903 *Beta-catenin, CTNNB1 *CTNNBIP1 NM_020248 *CTNNBL1 NM_030877 *CTNND1 NM_001085458 delta catenin

Channels and transporters

*ABCB10 NM_012089 *ABCB7 NM_004299 *ABCD3 NM_002857 *ABCE1 NM_002939 *ABCF1 NM_001090 *ABCF2 NM_005692 *ABCF3 NM_018358 *CALM1 Calmodulin grasps calcium ions *MFSD11 NM_024311 similar to MSFD10 aka TETRAN or tetracycline transporter-like protein *MFSD12 NM_174983 *MFSD3 NM_138431 *MFSD5 NM_032889 *SLC15A4 NM_145648 *SLC20A1 NM_005415 *SLC25A11 mitochondrial oxoglutarate/malate carrier *SLC25A26 NM_173471 *SLC25A28 NM_031212 *SLC25A3 NM_002635 *SLC25A32 NM_030780 *SLC25A38 NM_017875 *SLC25A39 NM_016016 *SLC25A44 NM_014655 *SLC25A46 NM_138773 *SLC25A5 NM_001152 *SLC27A4 NM_005094 *SLC30A1 NM_021194 *SLC30A5 NM_022902 *SLC30A9 NM_006345 *SLC35A2 NM_005660 *SLC35A4 NM_080670 *SLC35B1 NM_005827 *SLC35B2 NM_178148 *SLC35C2 NM_015945 *SLC35E1 NM_024881 *SLC35E3 NM_018656 *SLC35F5 NM_025181 *SLC38A2 NM_018976 *SLC39A1 NM_014437 *SLC39A3 NM_144564 *SLC39A7 NM_006979 *SLC41A3 NM_017836 *SLC46A3 NM_181785 *SLC48A1 NM_017842

Receptors

*ACVR1 NM_001105 similar to ACVRL1 TGF Beta receptor family ''Rendu-Osler-Weber syndrome'' *ACVR1B NM_004302 *CD23 FCER2 low affinity IgE receptor (lectin)

HLA/immunoglobulin/cell recognition

aka DDX39B which is involved in RNA splicing *Basigin, BSG Basigin Immunoglobulin Superfamily, extracelluar metalloproteinase *MIF macrophage migration inhibitory factor *TAPBP

Kinases/signalling

*ADRBK1 can downregulate response to epinephrine *AGPAT1 acyl 3 phosphoglycerol acyl transferase *ARF1 *ARF3 *ARF4 *ARF5 *ARL2 RAS Superfamily *CSF1 Colony stimulating factor ''not highly expressed constitutively at 5-12'' *CSK C-src tyrosine kinase *DCT dopachrome tautomerase *EFNA3 *FKBP1A *GDI1 GDP Dissociation inhibitor (Rab family) *GNAS1 ubiquitously expressed, but differentially imprinted *GNAI2 *HAX1 associated with tyrosine kinases *ILK Integrin linked kinase *MAPKAPK2 *MAP2K2 *MAP3K11 *PITPNM Phosphatidylinositol transfer protein *RAC1 Ro GTPase involved with many signaling pathways *RAP1B GTPase involved with cell adhesion *RAGA Ras-related GTP Binding *STK19 *STK24 Serine/Threonine Kinase *STK25 *YWHAB Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide *YWHAH Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, h polypeptide *YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide *YWHAZ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Growth factors

*AIF1 *Hepatoma-derived growth factor, HDGF Hepatoma derived growth factor ''(translocates to nucleus)'' *HGS (gene), HGS *LTBP4 *VEGFB *ZFP36L1

Tissue necrosis factor

*CD40 formerly TNFRSF5

Casein kinase

*CSNK1E *CSNK2B

Miscellaneous

*ALAS1 Aminolevulinic Acid Synthase type 1 (type 2 is erythroid and associated with porphyria) *ARHGEF2 Rho guanine nucleotide exchange factor *ARMET Mesencephalic astrocyte-derived neurotrophic factor *AES (gene), AES amino terminal enhancer of split *BECN1 involved in autophagy and partners with PI3K *BUD31 formerly Maternal G10 transcript *Creatine kinase CKB (ATP reservoir) *Cytidine deaminase ''questionable: not present in very high levels at all'' *CPNE1 *ENSA (gene) *FTH1 Heavy chain of Ferritin *GDI2 rab/ras vesicular trafficking *GUK1 Guanylate kinase transfers phosphate from ATP to GMP *Hypoxanthine-guanine phosphoribosyltransferase, HPRT Hypoxanthine-guanine phosphoribosyltransferase *IFITM1 ''Induced by interferon, transmembrane protein'' *JTB (gene) Jumping translocation breakpoint *MMPL2 *NME2 (formerly NM23B) Nucleoside diphosphate kinase *NONO *P4HB *PRDX1 peroxiredoxin (reduces peroxides) *PTMA Prothymosin *RPA2 Binds DNA during replication to keep it straightened out *SULT1A3 Sulfate conjugation ''(note: SULT1C is cited in earlier literature as being ubiquitous but this may be an example of different tags being used to refer to a common area of 2 closely related genes. If the tag is too short, then it may not be specific enough to truly specify one member of a gene family from another)'' *SYNGR2 Synaptogyrin (may participate in vesicle translocation) *Tetratricopeptide, TTC1 ''small glutamine rich tetratricopeptide''

Open_reading_frame

*C11Orf13 *C14orf2 *C21orf33

Sperm/Testis

''Although this page is devoted to genes that should be ubiquitously expressed, this section is for genes whose current name reflects their relative upregulation in testes'' *SPAG7 *SRM (gene), SRM Spermidine synthase *TEGT ''Bax-1 inhibitor'' *DAZAP2 ''Deleted in azoospermia'' *MEA1 Male enhanced antigen

References

External links

* * * {{DEFAULTSORT:Housekeeping Gene Genes Gene expression