|
RAB1A
Ras-related protein Rab-1A is a protein that in humans is encoded by the ''RAB1A'' gene. Interactions RAB1A has been shown to interact with: * CHML, * GOLGA2, * GOLGA5, * MICAL1 * RABAC1 ''RABAC1'' is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1. It is highly conserved in eukaryotes. The protein is localized to Golgi and late endosomes, where it plays a role in vesicular t ..., and * CHM. References Further reading * * * * * * * * * * * * * * * * * * {{PDB Gallery, geneid=5861 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CHML (gene)
Rab proteins geranylgeranyltransferase component A 2 is an enzyme that in humans is encoded by the ''CHML'' gene. The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. Interactions CHML (gene) has been shown to interact with RAB1A and RAB5A Ras-related protein Rab-5A is a protein that in humans is encoded by the ''RAB5A'' gene. Function RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to late endosomes. I .... References Further reading * * * * * * * * * * * External links * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GOLGA2
Golgin subfamily A member 2 is a protein that in humans is encoded by the ''GOLGA2'' gene. Function The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. A patient with a neuromuscular disorder has been identified that is homozygous for a deletion mutation in this gene, and morpholino knockdown in zebrafish ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GOLGA5
Golgin subfamily A member 5 is a protein that in humans is encoded by the ''GOLGA5'' gene. The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins, whose members localize to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. Interactions GOLGA5 has been shown to Protein-protein interaction, interact with RAB1A. References Further reading * * * * * * * * * * * {{gene-14-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MICAL1
NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the ''MICAL1'' gene. Interactions MICAL1 has been shown to interact with NEDD9 and RAB1A Ras-related protein Rab-1A is a protein that in humans is encoded by the ''RAB1A'' gene. Interactions RAB1A has been shown to interact with: * CHML, * GOLGA2, * GOLGA5, * MICAL1 * RABAC1 ''RABAC1'' is a gene that in humans encodes the pr .... References Further reading * * * * * * * * * * * * * * {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RABAC1
''RABAC1'' is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1. It is highly conserved in eukaryotes. The protein is localized to Golgi and late endosomes, where it plays a role in vesicular trafficking, lipid transport and cell migration. Interactions RABAC1 has been shown to interact with numerous prenylated members of the Rab GTPase family and VAMP2 Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the ''VAMP2'' gene. Function Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein .... References Further reading * * * * * * * * * * * * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
