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CAPZA2
F-actin-capping protein subunit alpha-2 also known as CapZ-alpha2 is a protein that in humans is encoded by the ''CAPZA2'' gene. Structure CapZ-alpha2 is a 33.0 kDa protein composed of 286 amino acids. ''CAPZA2'' is located on human chromosome 7, position q31.2-q31.3. The primary sequence of CapZ-alpha2 contains three C-terminus, C-terminal, regularly spaced leucines at positions 258, 262 and 266 found in consensus sequence of KxxxLxxE/DLxxALxxK/R that are critical for actin binding; these residues are conserved within the CAPZB, CapZ-beta isoform. CapZ-alpha2 is 85% identical to CAPZA1, CapZ-alpha1, and differ by a small number of key amino acids; 21 amino acid differences perpetrate isoform specificity. CapZ-alpha2 is expressed in a variety of tissues, including cardiac muscle and skeletal muscle, where it caps sarcomere, sarcomeric actin at Z-discs; the ratio of CapZ-alpha2 to CAPZA1, CapZ-alpha1 varies significantly among different tissues. Function CapZ binds the barbe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid resid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
