The immunoglobulin domain, also known as the immunoglobulin fold, is a type of

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...

that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two

β-sheets The beta sheet, (β-sheet) (also β-pleated sheet) is a common motif of the regular protein secondary structure. Beta sheets consist of beta strands (β-strands) connected laterally by at least two or three backbone hydrogen bonds, forming a gen ...

with a Greek key topology, consisting of about 125 amino acids. The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include

antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...

, the giant muscle kinase

titin Titin (contraction for Titan protein) (also called connectin) is a protein that in humans is encoded by the ''TTN'' gene. Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring that is responsible for t ...

, and

receptor tyrosine kinase Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase ...

s. Immunoglobulin-like domains may be involved in protein–protein and protein–

ligand In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electr ...

interactions.

Examples

Human genes encoding proteins containing the immunoglobulin domain include: *

A1BG Alpha-1-B glycoprotein is a 54.3 kDa protein in humans that is encoded by the A1BG gene. The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immun ...

* ACAM * ADAMTSL1 * ADAMTSL3 *

AGER Ager or AGER may refer to: * Ager (surname) * Ager (river), a river in Upper Austria *Àger, a municipality in Catalonia, Spain * Viscounty of Àger, a medieval Catalan jurisdiction that branched off the County of Urgell * Ager, California, uninc ...

ALCAM CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ''ALCAM'' gene. It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-G ...

* AMIGO1 * AMIGO2 * AXL * BCAM * BOC * BSG *

BTLA B- and T-lymphocyte attenuator or BTLA (also known as cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located on the 3rd human chromosome. BTLA was f ...

C10orf72 C1, C01, C.I or C-1 may refer to: Arts and media * C1, a note-octave in music * C1 Television, a Mongolian television channel * Schecter C-1 Hellraiser FR, a guitar model * A Yamaha grand piano model * "C1", a slang expression in the video game ...

C20orf102 C, or c, is the third letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''cee'' (pronounced ), plural ''cees''. History "C" ...

CADM1 Cell adhesion molecule 1 is a protein that, in humans, is encoded by the ''CADM1'' gene. Model organisms Model organisms have been used in the study of CADM1 function. A conditional knockout mouse line, called ''Cadm1tm1.2Brd'' was generated. Ma ...

CADM3 Cell adhesion molecule 3 is a protein that in humans is encoded by the ''CADM3'' gene. IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectin Nectins and Nectin-like molecules (Necl) a ...

CD200 OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the gene. The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belong ...

CD22 CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that ...

CD276 Cluster of Differentiation 276 (CD276) or B7 Homolog 3 (B7-H3) is a human protein encoded by the gene. Structure B7-H3 is a 316 amino acid-long type I transmembrane protein, existing in two isoforms determined by its extracellular domain. In m ...

CD33 CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. ...

* CD4 *

CDON Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the ''CDON'' gene. CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III ( FNIII) repeat family involved in my ...

CEACAM1 Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family. Function ...

* CEACAM16 * CEACAM20 * CEACAM21 *

CEACAM5 Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family. Functions In the literature, CEACAM5 is often used as a sy ...

* CEACAM6 *

CEACAM8 Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b), is a member of the carcinoembryonic antigen (CEA) gene family. Its main function is cell adhesion, cell migration, and pathog ...

* CHL1 * CILP * CNTFR *

CNTN1 Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the ''CNTN1'' gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuron ...

* CNTN2 *

CNTN3 Contactin-3 is a protein that in humans is encoded by the ''CNTN3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ...

* CNTN4 * CNTN5 *

CNTN6 Contactin 6 is a protein in humans that is encoded by the CNTN6 gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol Glycosylphosphatidylinositol (), or glycophosphatidylino ...

CSF1R Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human ''CSF1R'' gene (known also as c-FMS). CS ...

* DSCAM * DSCAML1 * EMB * F11R * FAIM3 *

FCAR Fc fragment of IgA receptor (''FCAR'') is a human gene that codes for the transmembrane receptor FcαRI, also known as CD89 (Cluster of Differentiation 89). FcαRI binds the heavy-chain constant region of Immunoglobulin A (IgA) antibodies. FcαRI ...

FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the ''FCER1A'' gene. Function The FcεRI, high affinity IgE receptor plays a central role in allergic diseas ...

FCGR1A High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the ''FCGR1A'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." ...

FCGR2A Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the ''FCGR2A'' gene. Interactions FCGR2A has been shown to interact with PIK3R1 and Syk. See also * CD32 CD32 (cluster of differentiation 3 ...

* FCGR2B * FCGR2C *

FCGR3A Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the ''FCGR3A'' gene. It is also known as CD16a as it is part of the cluster of differentiation The cluster of differentiation (also known as clus ...

FCGR3B FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene. Clinical relevance Mutations and copy-number variations in this gene have been associated to clinical cases of glomeru ...

* FCRH1 * FCRH3 * FCRH4 *

FCRL1 Fc receptor-like protein 1 is a protein that in humans is encoded by the ''FCRL1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' ...

FCRL2 Fc receptor-like protein 2 is a protein that in humans is encoded by the ''FCRL2'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' ...

FCRL3 Fc receptor-like protein 3 is a protein that in humans is encoded by the ''FCRL3'' gene. This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromo ...

* FCRL4 * FCRL5 * FCRL6 * FCRLA *

FGFR1 Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast ...

FGFR2 Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the ''FGFR2'' gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor. The protein ...

FGFR3 Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the ''FGFR3'' gene. FGFR3 has also been designated as CD333 (cluster of differentiation 333). The gene, which is located on chromosome 4, location q16.3, is expressed in ...

FGFR4 Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the ''FGFR4'' gene. FGFR4 has also been designated as CD334 (cluster of differentiation 334). The protein encoded by this gene is a member of the fibroblast growth fact ...

FGFRL1 Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the ''FGFRL1'' gene. The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conse ...

FLT1 Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the ''FLT1'' gene. Function ''FLT1'' is a member of VEGF receptor gene family. It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEGF-B, ...

FLT3 Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the ''FLT3'' gene. FLT3 is a cyto ...

FLT4 Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the ''FLT4'' gene. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involve ...

* FSTL4 * FSTL5 * GP6 *

GPA33 Cell surface A33 antigen is a protein that in humans is encoded by the ''GPA33'' gene. The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame In mo ...

GPR116 Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the ''GPR116'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ' ...

GPR125 Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the ''Adgra3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Me ...

HEPACAM Gene HEPACAM*, named based on its original site of identification - hepatocytes and the nature of its protein product - a cell adhesion molecule (CAM), was first discovered and characterised in human liver and reported by Shali Shen (MD, PhD) in ...

HLA-DMA HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the ''HLA-DMA'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredi ...

HLA-DMB HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the ''HLA-DMB'' gene. Function HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an ...

* HLA-DQB * HLA-DQB1 *

HMCN1 Hemicentin-1 is a protein that in humans is encoded by the ''HMCN1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' o ...

* HNT *

HSPG2 Perlecan (PLC) also known as basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) or heparan sulfate proteoglycan 2 (HSPG2), is a protein that in humans is encoded by the ''HSPG2'' gene. The HSPG2 gene codes for a 4,391 amin ...

* HYST2477 *

ICAM3 Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ''ICAM3'' gene. The protein is constitutively expressed on the surface of leukocytes, which are also called ...

ICAM5 Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ''ICAM5'' gene. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycopro ...

* IGHA1 *

IGHD Ig delta chain C region is a protein that in humans is encoded by the ''IGHD'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

IGHE Ig epsilon chain C region is a protein that in humans is encoded by the ''IGHE'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

IGSF10 Immunoglobulin superfamily, member 1 is a plasma membrane glycoprotein encoded by the ''IGSF1'' gene, which maps to the X chromosome in humans and other mammalian species. Function IGSF1's function in normal cells is unresolved. The protein i ...

* IGSF11 * IGSF2 * IGSF21 * IGSF3 * IGSF9 * IL11RA * IL1R1 * IL1R2 *

IL1RAPL1 X-linked interleukin-1 receptor accessory protein-like 1 is a protein that in humans is encoded by the ''IL1RAPL1'' gene. IL1RAPL1 is composed of 11 exons, about 1.37 Mb total. Function The protein encoded by this gene is a member of the inter ...

IL1RAPL2 X-linked interleukin-1 receptor accessory protein-like 2 is a protein that in humans is encoded by the ''IL1RAPL2'' gene. The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleuki ...

IL1RL1 Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the ''IL1RL1'' gene. Function IL1RL1 is a member of the Toll-like receptor superfamily based on the function of its intracellular TIR domain ...

* IL1RL2 * IL6R *

JAM2 Junctional adhesion molecule B is a protein that in humans is encoded by the ''JAM2'' gene. JAM2 has also been designated as CD322 (cluster of differentiation 322). Function Tight junctions represent one mode of cell-to-cell adhesion in endot ...

JAM3 Junctional adhesion molecule C is a protein that in humans is encoded by the ''JAM3'' gene. Gene This gene is located on the long arm of chromosome 11 (11q25) on the Watson strand. It is 83,077 bases in length. The encoded protein is 310 amino ...

* KIR-123FM *

KIR2DL1 Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the ''KIR2DL1'' gene. Function Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subs ...

KIR2DL2 KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

KIR2DL3 KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

KIR2DL4 Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the ''KIR2DL4'' gene. Function Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and sub ...

KIR2DL5A KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

KIR2DL5B KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

KIR2DLX KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

KIR2DS1 Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 is a protein that in humans is encoded by the KIR2DS1 gene. Function Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed b ...

KIR2DS2 KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

* KIR2DS3 * KIR2DS4 *

KIR2DS5 KIR, Kir or kir may refer to: Biology *Inward-rectifier potassium channel Kir *Killer-cell immunoglobulin-like receptor, a receptor protein expressed on the surface of natural killer cells and some T-cells Bodies of water *Kir (river), in northe ...

* KIR3DL1 *

KIR3DL2 Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the ''KIR3DL2'' gene. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cel ...

KIR3DL3 Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the ''KIR3DL3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." me ...

* KIR3DS1 * KIT *

L1CAM L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, of 200-220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neurite outg ...

LAG3 Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the ''LAG3'' gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differ ...

LILRA1 Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 is a protein that in humans is encoded by the ''LILRA1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the M ...

* LILRA2 *

LILRA3 Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in huma ...

* LILRA4 * LILRA5 * LILRA6 *

LILRB1 Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the ''LILRB1'' gene. Function This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene clu ...

LILRB2 Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the ''LILRB2'' gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chr ...

LILRB3 Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the ''LILRB3'' gene. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chrom ...

* LILRB4 *

LILRB5 Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the ''LILRB5'' gene. This gene is a member of the leukocyte immunoglobulin-like receptor The leukocyte immunoglobulin-like receptors (LILR) ar ...

* LILRP2 *

LRIG1 Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the ''LRIG1'' gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family and wi ...

* LRIG2 * LRIG3 * LRIT1 *

LRRC4 Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the ''LRRC4'' gene. This gene is significantly downregulated in primary brain tumor A brain tumor occurs when abnormal cells form within the brain. There are tw ...

* LSAMP *

MAG Mag, MAG or mags may refer to: Arts, entertainment and media * ''MAG'' (video game), 2010 * ''Mag'' (Slovenian magazine), 1995–2010 * '' The Mag'', a British music magazine Businesses and organisations * MacKenzie Art Gallery, in Regina, Sask ...

MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the ''MALT1'' gene. It's the human paracaspase. Function Genetic ablation of the paracaspase gene in mice and biochemical studies have ...

* MCAM * MDGA1 * MDGA2 *

MERTK Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the ''MERTK'' gene. Function This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin ...

* MFAP3 *

MIR ''Mir'' (russian: Мир, ; ) was a space station that operated in low Earth orbit from 1986 to 2001, operated by the Soviet Union and later by Russia. ''Mir'' was the first modular space station and was assembled in orbit from 1986 to&n ...

* MIR * MXRA5 *

MYBPC3 The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the ''MYBPC3'' gene. This isoform is expressed exclusively in heart muscle during human and mouse development, and is distinct from those expressed in slow skelet ...

MYOM1 Myomesin-1 is a protein that in humans is encoded by the ''MYOM1'' gene. Myomesin-1 is expressed in muscle cells and functions to stabilize the three-dimensional conformation of the thick filament. Embryonic forms of Myomesin-1 have been detected ...

* MYOM3 * NCA *

NCAM1 Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discov ...

* NCAM2 *

NEGR1 Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the ''NEGR1'' gene. Clinical significance Variants of the NEGR1 gene may be associated with obesity Obesity is a medical condition, sometimes ...

NEO1 Neogenin is a protein that in humans is encoded by the ''NEO1'' gene. Interactions NEO1 has been shown to interact with PTK2 PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is ...

* NFASC * NOPE * NPHS1 * NPTN * NRCAM *

NRG1 Neuregulin 1, or NRG1, is a gene of the epidermal growth factor family that in humans is encoded by the ''NRG1'' gene. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in num ...

* NT *

NTRK3 Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the ''NTRK3'' gene. TrkC is the high affinity catalyt ...

OBSCN Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene. Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in ...

OBSL1 Obscurin-like protein 1 is a protein that in humans is encoded by the ''OBSL1'' gene. References Further reading * * * * * * * External links GeneReviews/NIH/NCBI/UW entry on 3-M syndrome OMIM entries on 3-M syndromePDBe-KB
provides an ...

* OPCML *

PAPLN Papilin is a protein that in humans is encoded by the ''PAPLN'' gene. Papilin is an extracellular matrix In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular ...

PDGFRA PDGFRA, i.e. platelet-derived growth factor receptor A, also termed PDGFRα, i.e. platelet-derived growth factor receptor α, or CD140a i.e. Cluster of Differentiation 140a, is a receptor located on the surface of a wide range of cell types. This re ...

PDGFRB Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the ''PDGFRB'' gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies. Gene The ''PDGFRB'' gene is located on h ...

* PDGFRL *

PECAM1 Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the ''PECAM1'' gene found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutrop ...

PRODH2 Proline dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ''PRODH'' gene. The protein encoded by this gene is a mitochondrial proline dehydrogenase which catalyzes the first step in proline catabolism. Deletion of this gen ...

* PSG1 * PSG10 * PSG11 * PSG11s' *

PSG2 Function Human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large quantities by the placental trophoblast and released into the maternal circulation during pregnancy. Molecular cloning and analysis of ...

PSG3 Pregnancy-specific beta-1-glycoprotein 3 is a protein that in humans is encoded by the ''PSG3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning '' ...

PSG4 Pregnancy-specific beta-1-glycoprotein 4 is a protein that in humans is encoded by the ''PSG4'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning '' ...

* PSG5 *

PSG6 Pregnancy-specific beta-1-glycoprotein 6 is a protein that in humans is encoded by the ''PSG6'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning '' ...

* PSG7 * PSG8 * PSG9 *

PTGFRN Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the ''PTGFRN'' gene. PTGFRN has also been designated as CD315 (cluster of differentiation 315). Interactions PTGFRN has been shown to Protein-protein interact ...

PTK7 Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the ''PTK7'' gene. Function Receptor protein tyrosine kinases transduce extracellular signals across the cel ...

PTPRD Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the ''PTPRD'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signa ...

PTPRK Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the ''PTPRK'' gene. PTPRK is also known as PTPkappa and PTPκ. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase ( ...

PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the ''PTPRM'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases a ...

PTPRS Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the ''PTPRS'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphata ...

* PTPsigma * PUNC * PVR *

PVRL1 Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. It is a membrane protein ...

PVRL2 Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein. Function This gene encodes a single-pass type I membrane glycoprotein with two Ig- ...

* PVRL4 * RAGE *

SCN1B Sodium channel subunit beta-1 is a protein that in humans is encoded by the ''SCN1B'' gene. Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically ...

* SDK1 * SDK2 *

SEMA3A Semaphorin-3A is a protein that in humans is encoded by the ''SEMA3A'' gene. Function The ''SEMA3A'' gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sem ...

SEMA3B Semaphorin-3B is a protein that in humans is encoded by the ''SEMA3B'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' ...

* SEMA3E *

SEMA3F Semaphorin-3F is a protein that in humans is encoded by the ''SEMA3F'' gene. The semaphorin Semaphorins are a class of secreted and membrane proteins that were originally identified as axonal growth cone guidance molecules. They primarily act as ...

* SEMA3G *

SEMA4D Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the ''SEMA4D'' gene. Function Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secrete ...

* SIGLEC1 *

SIGLEC10 Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the ''SIGLEC10'' gene. Siglec-G is often referred to as the murine paralog of human Siglec-10 Structure and function Like most but not all other Siglecs, Siglec-10 ...

* SIGLEC11 * SIGLEC12 * SIGLEC14 * SIGLEC6 * SIGLEC7 *

SIGLEC8 Sialic acid-binding Ig-like lectin 8 is a protein that in humans is encoded by the ''SIGLEC8'' gene. This gene is located on chromosome 19q13.4, about 330 kb downstream of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Sig ...

SIRPG Signal-regulatory protein gamma is a protein that in humans is encoded by the ''SIRPG'' gene. SIRPG has also recently been designated CD172G (cluster of differentiation 172G). The protein encoded by this gene is a member of the signal-regulatory ...

THY1 Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 k Da heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte anti ...

TIE1 Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the ''TIE1'' gene. Function TIE1 is a cell surface protein expressed exclusively in endothelial cells, ...

TMIGD1 Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." ...

TMIGD2 Transmembrane and immunoglobulin domain containing 2 is a protein that in humans is encoded by the TMIGD2 gene. TMIGD2 was discovered by Nader Rahimi Nader Rahimi (born December 22, 1963) is a Molecular Biologist and is currently an Associate ...

* TTN *

TYRO3 Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the ''TYRO3'' gene. Interactions TYRO3 has been shown to interact with: * GAS6, and * PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme ...

* UNC5D *

VCAM1 Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the ''VCAM1'' gene. VCAM-1 functions as a cell adhesion molecule. Stru ...

* VSIG1 *

VSIG2 V-set and immunoglobulin domain containing 2 is a protein in humans that is encoded by the VSIG2 gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ...

* VSIG4 * hEMMPRIN * kir3d

References

External links

SCOP listing of immunoglobulin domains of known structure
{{Protein tertiary structure Protein domains Protein folds Single-pass transmembrane proteins