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A1BG
Alpha-1-B glycoprotein is a 54.3 kDa protein in humans that is encoded by the A1BG gene. The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. Patients who have pancreatic ductal adenocarcinoma show an overexpression of A1BG in pancreatic juice. Gene Neighborhood A1BG is located on the negative DNA strand of chromosome 19 from 58,858,172 – 58,864,865. Additionally, A1BG is located directly adjacent to the ZSCAN22 gene (58,838,385-58,853,712)) on the positive DNA strand, as well as the ZNF837 (58,878,990 - 58,892,389, complement) and ZNF497 (58865723 - 58,874,214, complement) genes on the negative strand. Expression A1BG is expressed at high levels in the adult and fetal liver. Additionally, the mammary gland shows roughly half as much expression as the liver. Trace amounts of A1BG expression can be found in the blood ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome 19
Chromosome 19 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 19 spans more than 58.6 million base pairs, the building material of DNA. It is considered the most gene-rich chromosome containing roughly 1,500 genes, despite accounting for only 2 percent of the human genome. Genes Number of genes The following are some of the gene count estimates of human chromosome 19. Because researchers use different approaches to genome annotation, their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project ( CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. Gene list The following is a partial list of genes on human chromosome 19. For complete list, see the link in the infobox on the right ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZNF837
ZNF837 is a protein that in humans is encoded by the ZNF837 gene, is located at 19q13.431 with minus strand orientation. ZNF837 protein is characterized as a C2H2-type zinc finger protein. Homology and Evolution The human ZNF837 has homologs present in many mammals and seen more distantly. All homologs are chordates. All contain both COG5048 and Zf-C2H2_2 domains. The areas that these domains are found contain the highest conservation rates. In humans, 5 Zf-H2C2 double domains and 2 COG5048 domains are present. The protein sequence is fast evolving among these homologs. ZNF837 has numerous paralogs in humans, all of which are zinc finger proteins. Human ZNF837 In humans, there are no other aliases, and its neighboring genes are MIR4754, Alpha-1-B glycoprotein, A1BG, and 40S ribosomal protein S5, RPS5. ZNF837 mRNA that is made into function protein contains 1921 nucleotides, of which 222-1817 are translated to a protein containing 3 exons. The protein consists of 531 ami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumors
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potential ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wild Boar
The wild boar (''Sus scrofa''), also known as the wild swine, common wild pig, Eurasian wild pig, or simply wild pig, is a suid native to much of Eurasia and North Africa, and has been introduced to the Americas and Oceania. The species is now one of the widest-ranging mammals in the world, as well as the most widespread suiform. It has been assessed as least concern on the IUCN Red List due to its wide range, high numbers, and adaptability to a diversity of habitats. It has become an invasive species in part of its introduced range. Wild boars probably originated in Southeast Asia during the Early Pleistocene and outcompeted other suid species as they spread throughout the Old World. , up to 16 subspecies are recognized, which are divided into four regional groupings based on skull height and lacrimal bone length. The species lives in matriarchal societies consisting of interrelated females and their young (both male and female). Fully grown males are usually solitary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sheep
Sheep or domestic sheep (''Ovis aries'') are domesticated, ruminant mammals typically kept as livestock. Although the term ''sheep'' can apply to other species in the genus '' Ovis'', in everyday usage it almost always refers to domesticated sheep. Like all ruminants, sheep are members of the order Artiodactyla, the even-toed ungulates. Numbering a little over one billion, domestic sheep are also the most numerous species of sheep. An adult female is referred to as a ''ewe'' (), an intact male as a ''ram'', occasionally a ''tup'', a castrated male as a ''wether'', and a young sheep as a ''lamb''. Sheep are most likely descended from the wild mouflon of Europe and Asia, with Iran being a geographic envelope of the domestication center. One of the earliest animals to be domesticated for agricultural purposes, sheep are raised for fleeces, meat (lamb, hogget or mutton) and milk. A sheep's wool is the most widely used animal fiber, and is usually harvested by shearing. In Comm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bolivian Squirrel Monkey
The black-capped squirrel monkey (''Saimiri boliviensis'') is a species of New-World monkey native to the upper Amazon basin in Bolivia, western Brazil and eastern Peru. They weigh between 365 and 1135 grams and measure, from the head to the base of the tail, between 225 and 370mm. Black-capped squirrel monkeys are primarily tree-dwelling and are found in both native and plantation forests as well as some farmed areas near running water. Their diet is omnivorous and mostly consists of flowers, fruit, leaves, nuts, seeds, insects, arachnids, eggs and small vertebrates. They mostly live in female-dominated troops of around 40 to 75 monkeys, with males having been observed to disperse to live in all-male troops after reaching sexual maturation. Their current conservation status according to the IUCN is 'Least Concern'. The species belongs to the genus ''Saimiri'' and has two subspecies, ''S. b. boliviensis'' (the Bolivian squirrel monkey) and ''S. b. peruviensis'' (the Peruvian squ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Baboon
Baboons are primates comprising the genus ''Papio'', one of the 23 genera of Old World monkeys. There are six species of baboon: the hamadryas baboon, the Guinea baboon, the olive baboon, the yellow baboon, the Kinda baboon and the chacma baboon. Each species is native to one of six areas of Africa and the hamadryas baboon is also native to part of the Arabian Peninsula. Baboons are among the largest non- hominoid primates and have existed for at least two million years. Baboons vary in size and weight depending on the species. The smallest, the Kinda baboon, is in length and weighs only , while the largest, the chacma baboon, is up to in length and weighs . All baboons have long, dog-like muzzles, heavy, powerful jaws with sharp canine teeth, close-set eyes, thick fur except on their muzzles, short tails, and nerveless, hairless pads of skin on their protruding buttocks called ischial callosities that provide for sitting comfort. Male hamadryas baboons have large whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White-cheeked Crested Gibbon
The northern white-cheeked gibbon (''Nomascus leucogenys'') is a Critically Endangered species of gibbon native to South East Asia. It is closely related to the southern white-cheeked gibbon (''Nomascus siki''), with which it was previously considered conspecific. The females of the two species are virtually indistinguishable in appearance. The genome of ''N. leucogenys'' was sequenced and published in 2011. Description Northern white-cheeked gibbons are sexually dimorphic, with males and females having different colourations and the former also being slightly larger. Males have black hair over their entire bodies, except for distinct white patches on their cheeks, as well as a prominent tuft of hair on the crown of head, and a gular sac. Females are reddish-tan in colour, lack a cranial tuft, and have a crest of black or dark brown fur running from the crown to the nape of the neck. They are reported to have an average weight of , although this is based on only a small number ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyadenylation
Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature mRNA for translation. In many bacteria, the poly(A) tail promotes degradation of the mRNA. It, therefore, forms part of the larger process of gene expression. The process of polyadenylation begins as the transcription of a gene terminates. The 3′-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3′ end. In some genes these proteins add a poly(A) tail at one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing. The poly(A) tail is important for the nucl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exons
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term ''exon'' refers to both the DNA sequence within a gene and to the corresponding sequence in RNA transcripts. In RNA splicing, introns are removed and exons are covalently joined to one another as part of generating the mature RNA. Just as the entire set of genes for a species constitutes the genome, the entire set of exons constitutes the exome. History The term ''exon'' derives from the expressed region and was coined by American biochemist Walter Gilbert in 1978: "The notion of the cistron… must be replaced by that of a transcription unit containing regions which will be lost from the mature messengerwhich I suggest we call introns (for intragenic regions)alternating with regions which will be expressedexons." This definition was originally made for protein-coding transcripts that are spliced before being transla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Promoter (genetics)
In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are located near the transcription start sites of genes, upstream on the DNA (towards the 5' region of the sense strand). Promoters can be about 100–1000 base pairs long, the sequence of which is highly dependent on the gene and product of transcription, type or class of RNA polymerase recruited to the site, and species of organism. Promoters control gene expression in bacteria and eukaryotes. RNA polymerase must attach to DNA near a gene for transcription to occur. Promoter DNA sequences provide an enzyme binding site. The -10 sequence is TATAAT. -35 sequences are conserved on average, but not in most promoters. Artificial promoters with conserved -10 and -35 elements transcribe more slowly. Al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
