ZNF837 is a protein that in humans is encoded by the ZNF837 gene, is located at 19q13.431 with minus strand orientation. ZNF837 protein is characterized as a C2H2-type zinc finger protein.

Homology and Evolution

The human ZNF837 has homologs present in many mammals and seen more distantly. All homologs are

chordate A chordate () is an animal of the phylum Chordata (). All chordates possess, at some point during their larval or adult stages, five synapomorphies, or primary physical characteristics, that distinguish them from all the other taxa. These fi ...

s. All contain both COG5048 and Zf-C2H2_2 domains. The areas that these domains are found contain the highest conservation rates. In humans, 5 Zf-H2C2 double domains and 2 COG5048 domains are present. The protein sequence is fast evolving among these homologs. ZNF837 has numerous paralogs in humans, all of which are zinc finger proteins.

Human ZNF837

In humans, there are no other aliases, and its neighboring genes are MIR4754,

A1BG Alpha-1-B glycoprotein is a 54.3 kDa protein in humans that is encoded by the A1BG gene. The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immun ...

, and RPS5. ZNF837 mRNA that is made into function protein contains 1921 nucleotides, of which 222-1817 are translated to a protein containing 3 exons. The protein consists of 531 amino acids with a weight of 58,078 Da with an

isoelectric point The isoelectric point (pI, pH(I), IEP), is the pH at which a molecule carries no net electrical charge or is electrically neutral in the statistical mean. The standard nomenclature to represent the isoelectric point is pH(I). However, pI is also u ...

at 9.525.

Gene Variants

There are 2 transcript variants. Transcript variant 1, 2050 base pairs in length, is non-coding due to a

nonsense-mediated mRNA decay Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons. Translation of these aberran ...

. Transcript variant 2 is made into the functional protein due to an alternate splice site

Post Translational

It is predicted via high conservation to have 4 phosphorylation sites at T386, T455, S460, Y503. The internal structure is includes combination of alpha helices, beta sheets and mainly random coils.

Expression

ZNF837 has observed in the pancreas, liver, uterus, and muscle cells. In all cases concentration is low. However, the expression of ZNF837 is seen to have the most impact is when looking at normal vs diseased state. There is a consistent change that is able to be seen.

References

{{reflist Human proteins