Zinc is a
chemical element
A chemical element is a species of atoms that have a given number of protons in their nuclei, including the pure substance consisting only of that species. Unlike chemical compounds, chemical elements cannot be broken down into simpler sub ...
with the
symbol Zn and atomic number 30. Zinc is a slightly brittle metal at
room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in
group 12 (IIB) of the
periodic table. In some respects, zinc is chemically similar to
magnesium
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a shiny gray metal having a low density, low melting point and high chemical reactivity. Like the other alkaline earth metals (group 2 of the periodic ta ...
: both elements exhibit only one normal oxidation state (+2), and the Zn
2+ and Mg
2+ ion
An ion () is an atom or molecule with a net electrical charge.
The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by conve ...
s are of similar size.
[The elements are from different metal groups. See periodic table.] Zinc is the 24th most abundant
element in Earth's crust and has five stable
isotope
Isotopes are two or more types of atoms that have the same atomic number (number of protons in their nuclei) and position in the periodic table (and hence belong to the same chemical element), and that differ in nucleon numbers (mass numb ...
s. The most common zinc
ore
Ore is natural rock or sediment that contains one or more valuable minerals, typically containing metals, that can be mined, treated and sold at a profit.Encyclopædia Britannica. "Ore". Encyclopædia Britannica Online. Retrieved 7 Apr ...
is
sphalerite (zinc blende), a
zinc sulfide
Zinc sulfide (or zinc sulphide) is an inorganic compound with the chemical formula of ZnS. This is the main form of zinc found in nature, where it mainly occurs as the mineral sphalerite. Although this mineral is usually black because of various ...
mineral. The largest workable
lode
In geology, a lode is a deposit of metalliferous ore that fills or is embedded in a fissure (or crack) in a rock formation or a vein of ore that is deposited or embedded between layers of rock.
The current meaning (ore vein) dates from the 1 ...
s are in Australia, Asia, and the United States. Zinc is refined by
froth flotation
Froth flotation is a process for selectively separating hydrophobic materials from hydrophilic. This is used in mineral processing, paper recycling and waste-water treatment industries. Historically this was first used in the mining industry, wher ...
of the ore,
roasting, and final
extraction using
electricity
Electricity is the set of physical phenomena associated with the presence and motion of matter that has a property of electric charge. Electricity is related to magnetism, both being part of the phenomenon of electromagnetism, as describ ...
(
electrowinning).
Zinc is an essential
trace element
__NOTOC__
A trace element, also called minor element, is a chemical element whose concentration (or other measure of amount) is very low (a "trace amount"). They are classified into two groups: essential and non-essential. Essential trace elements ...
for humans,
animals,
plants
and for
microorganism
A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in olde ...
s
and is necessary for prenatal and postnatal development.
It is the second most abundant trace metal in humans after iron and it is the only metal which appears in all
enzyme classes.
Zinc is also an essential nutrient element for coral growth as it is an important cofactor for many enzymes.
Zinc deficiency
Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal range. However, since a decrease in the serum concentration is only detectable after long-term or severe depletion, s ...
affects about two billion people in the developing world and is associated with many diseases.
In children, deficiency causes growth retardation, delayed sexual maturation, infection susceptibility, and
diarrhea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin w ...
.
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
s with a zinc atom in the
reactive center
A reactive center, also called a propagating center, in chemistry is a particular location, usually an atom, within a chemical compound that is the likely center of a reaction in which the chemical is involved. In chain-growth polymer chemistry thi ...
are widespread in biochemistry, such as
alcohol dehydrogenase
Alcohol dehydrogenases (ADH) () are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+) to NA ...
in humans. Consumption of excess zinc may cause
ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements. Ataxia is a clinical manifestation indicating dysfunction of ...
,
lethargy
Lethargy is a state of tiredness, sleepiness, weariness, fatigue, sluggishness or lack of energy. It can be accompanied by depression, decreased motivation, or apathy. Lethargy can be a normal response to inadequate sleep, overexertion, overwo ...
, and
copper deficiency
Copper deficiency, or hypocupremia, is defined either as insufficient copper to meet the needs of the body, or as a serum copper level below the normal range. Symptoms may include fatigue, decreased red blood cells, early greying of the hair, an ...
.
Brass
Brass is an alloy of copper (Cu) and zinc (Zn), in proportions which can be varied to achieve different mechanical, electrical, and chemical properties. It is a substitutional alloy: atoms of the two constituents may replace each other wit ...
, an
alloy
An alloy is a mixture of chemical elements of which at least one is a metal. Unlike chemical compounds with metallic bases, an alloy will retain all the properties of a metal in the resulting material, such as electrical conductivity, ductilit ...
of
copper
Copper is a chemical element with the symbol Cu (from la, cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pinkis ...
and zinc in various proportions, was used as early as the third millennium BC in the
Aegean area and the region which currently includes
Iraq
Iraq,; ku, عێراق, translit=Êraq officially the Republic of Iraq, '; ku, کۆماری عێراق, translit=Komarî Êraq is a country in Western Asia. It is bordered by Turkey to the north, Iran to the east, the Persian Gulf and K ...
, the
United Arab Emirates
The United Arab Emirates (UAE; ar, اَلْإِمَارَات الْعَرَبِيَة الْمُتَحِدَة ), or simply the Emirates ( ar, الِْإمَارَات ), is a country in Western Asia ( The Middle East). It is located at t ...
,
Kalmykia,
Turkmenistan
Turkmenistan ( or ; tk, Türkmenistan / Түркменистан, ) is a country located in Central Asia, bordered by Kazakhstan to the northwest, Uzbekistan to the north, east and northeast, Afghanistan to the southeast, Iran to the sout ...
and
Georgia
Georgia most commonly refers to:
* Georgia (country), a country in the Caucasus region of Eurasia
* Georgia (U.S. state), a state in the Southeast United States
Georgia may also refer to:
Places
Historical states and entities
* Related to the ...
. In the second millennium BC it was used in the regions currently including
West India
Western India is a loosely defined region of India consisting of its western part. The Ministry of Home Affairs in its Western Zonal Council Administrative division includes the states of Goa, Gujarat, and Maharashtra along with the Unio ...
,
Uzbekistan
Uzbekistan (, ; uz, Ozbekiston, italic=yes / , ; russian: Узбекистан), officially the Republic of Uzbekistan ( uz, Ozbekiston Respublikasi, italic=yes / ; russian: Республика Узбекистан), is a doubly landlocked co ...
,
Iran
Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...
,
Syria, Iraq, and
Israel
Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated ...
.
Zinc
metal
A metal (from Greek μέταλλον ''métallon'', "mine, quarry, metal") is a material that, when freshly prepared, polished, or fractured, shows a lustrous appearance, and conducts electricity and heat relatively well. Metals are typicall ...
was not produced on a large scale until the 12th century in India, though it was known to the ancient Romans and Greeks. The mines of
Rajasthan
Rajasthan (; lit. 'Land of Kings') is a state in northern India. It covers or 10.4 per cent of India's total geographical area. It is the largest Indian state by area and the seventh largest by population. It is on India's northwestern s ...
have given definite evidence of zinc production going back to the 6th century BC. To date, the oldest evidence of pure zinc comes from Zawar, in Rajasthan, as early as the 9th century AD when a distillation process was employed to make pure zinc.
Alchemists
Alchemy (from Arabic: ''al-kīmiyā''; from Ancient Greek: χυμεία, ''khumeía'') is an ancient branch of natural philosophy, a philosophical and protoscientific tradition that was historically practiced in China, India, the Muslim world, ...
burned zinc in air to form what they called "
philosopher's wool" or "white snow".
The element was probably named by the alchemist
Paracelsus after the German word ''Zinke'' (prong, tooth). German chemist
Andreas Sigismund Marggraf
Andreas Sigismund Marggraf (; 3 March 1709 – 7 August 1782) was a German chemist from Berlin, then capital of the Margraviate of Brandenburg, and a pioneer of analytical chemistry. He isolated zinc in 1746 by heating Calamine (mineral), calamine ...
is credited with discovering pure metallic zinc in 1746. Work by
Luigi Galvani and
Alessandro Volta uncovered the electrochemical properties of zinc by 1800.
Corrosion
Corrosion is a natural process that converts a refined metal into a more chemically stable oxide. It is the gradual deterioration of materials (usually a metal) by chemical or electrochemical reaction with their environment. Corrosion engi ...
-resistant
zinc plating of iron (
hot-dip galvanizing) is the major application for zinc. Other applications are in electrical
batteries, small non-structural castings, and alloys such as brass. A variety of zinc compounds are commonly used, such as
zinc carbonate
Zinc carbonate is the inorganic compound with the formula ZnCO3. It is a white solid that is insoluble in water. It exists in nature as the mineral smithsonite. It is prepared by treating cold solutions of zinc sulfate with potassium bicarbonat ...
and
zinc gluconate
Zinc gluconate is the zinc salt of gluconic acid. It is an ionic compound consisting of two anions of gluconate for each zinc(II) cation. Zinc gluconate is a popular form for the delivery of zinc as a dietary supplement providing 14.35% eleme ...
(as dietary supplements),
zinc chloride
Zinc chloride is the name of inorganic chemical compounds with the formula ZnCl2 and its hydrates. Zinc chlorides, of which nine crystalline forms are known, are colorless or white, and are highly soluble in water. This salt is hygroscopic and e ...
(in deodorants),
zinc pyrithione
Zinc pyrithione (or pyrithione zinc) is a coordination complex of zinc. It has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic d ...
(anti-
dandruff
Dandruff is a skin condition that mainly affects the scalp. Symptoms include flaking and sometimes mild itchiness. It can result in social or self-esteem problems. A more severe form of the condition, which includes inflammation of the skin, ...
shampoos), zinc sulfide (in luminescent paints), and
dimethylzinc
Dimethylzinc, also known as Zinc methyl, DMZ, or DMZn is a colorless volatile liquid Zn(CH3)2, formed by the action of methyl iodide on zinc at elevated temperature or on zinc sodium alloy.
:2Zn + 2CH3I → Zn(CH3)2 + ZnI2
The sodium assists the ...
or
diethylzinc
Diethylzinc (C2H5)2Zn, or DEZ, is a highly pyrophoric and reactive organozinc compound consisting of a zinc center bound to two ethyl groups. This colourless liquid is an important reagent in organic chemistry. It is available commercially as a ...
in the organic laboratory.
Characteristics
Physical properties
Zinc is a bluish-white, lustrous,
diamagnetic
Diamagnetic materials are repelled by a magnetic field; an applied magnetic field creates an induced magnetic field in them in the opposite direction, causing a repulsive force. In contrast, paramagnetic and ferromagnetic materials are attracted ...
metal,
though most common commercial grades of the metal have a dull finish.
It is somewhat less dense than
iron
Iron () is a chemical element with Symbol (chemistry), symbol Fe (from la, Wikt:ferrum, ferrum) and atomic number 26. It is a metal that belongs to the first transition series and group 8 element, group 8 of the periodic table. It is, Abundanc ...
and has a hexagonal
crystal structure
In crystallography, crystal structure is a description of the ordered arrangement of atoms, ions or molecules in a crystalline material. Ordered structures occur from the intrinsic nature of the constituent particles to form symmetric patterns ...
, with a distorted form of
hexagonal close packing
In geometry, close-packing of equal spheres is a dense arrangement of congruent spheres in an infinite, regular arrangement (or lattice). Carl Friedrich Gauss proved that the highest average density – that is, the greatest fraction of space occu ...
, in which each atom has six nearest neighbors (at 265.9 pm) in its own plane and six others at a greater distance of 290.6 pm. The metal is hard and brittle at most temperatures but becomes malleable between 100 and 150 °C.
Above 210 °C, the metal becomes brittle again and can be pulverized by beating. Zinc is a fair
conductor of electricity.
For a metal, zinc has relatively low melting (419.5 °C) and boiling point (907 °C).
The melting point is the lowest of all the
d-block
A block of the periodic table is a set of elements unified by the atomic orbitals their valence electrons or vacancies lie in. The term appears to have been first used by Charles Janet. Each block is named after its characteristic orbital: s-blo ...
metals aside from
mercury and
cadmium
Cadmium is a chemical element with the symbol Cd and atomic number 48. This soft, silvery-white metal is chemically similar to the two other stable metals in group 12, zinc and mercury. Like zinc, it demonstrates oxidation state +2 in most of ...
; for this reason among others, zinc, cadmium, and mercury are often not considered to be
transition metal
In chemistry, a transition metal (or transition element) is a chemical element in the d-block of the periodic table (groups 3 to 12), though the elements of group 12 (and less often group 3) are sometimes excluded. They are the elements that ca ...
s like the rest of the d-block metals.
Many
alloy
An alloy is a mixture of chemical elements of which at least one is a metal. Unlike chemical compounds with metallic bases, an alloy will retain all the properties of a metal in the resulting material, such as electrical conductivity, ductilit ...
s contain zinc, including brass. Other metals long known to form binary alloys with zinc are
aluminium
Aluminium (aluminum in American and Canadian English) is a chemical element with the symbol Al and atomic number 13. Aluminium has a density lower than those of other common metals, at approximately one third that of steel. I ...
,
antimony
Antimony is a chemical element with the symbol Sb (from la, stibium) and atomic number 51. A lustrous gray metalloid, it is found in nature mainly as the sulfide mineral stibnite (Sb2S3). Antimony compounds have been known since ancient t ...
,
bismuth
Bismuth is a chemical element with the symbol Bi and atomic number 83. It is a post-transition metal and one of the pnictogens, with chemical properties resembling its lighter group 15 siblings arsenic and antimony. Elemental bismuth occurs ...
,
gold
Gold is a chemical element with the symbol Au (from la, aurum) and atomic number 79. This makes it one of the higher atomic number elements that occur naturally. It is a bright, slightly orange-yellow, dense, soft, malleable, and ductile me ...
, iron,
lead
Lead is a chemical element with the symbol Pb (from the Latin ) and atomic number 82. It is a heavy metal that is denser than most common materials. Lead is soft and malleable, and also has a relatively low melting point. When freshly cu ...
, mercury,
silver
Silver is a chemical element with the symbol Ag (from the Latin ', derived from the Proto-Indo-European ''h₂erǵ'': "shiny" or "white") and atomic number 47. A soft, white, lustrous transition metal, it exhibits the highest electrical ...
,
tin
Tin is a chemical element with the symbol Sn (from la, stannum) and atomic number 50. Tin is a silvery-coloured metal.
Tin is soft enough to be cut with little force and a bar of tin can be bent by hand with little effort. When bent, t ...
,
magnesium
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a shiny gray metal having a low density, low melting point and high chemical reactivity. Like the other alkaline earth metals (group 2 of the periodic ta ...
,
cobalt
Cobalt is a chemical element with the symbol Co and atomic number 27. As with nickel, cobalt is found in the Earth's crust only in a chemically combined form, save for small deposits found in alloys of natural meteoric iron. The free element, p ...
,
nickel
Nickel is a chemical element with symbol Ni and atomic number 28. It is a silvery-white lustrous metal with a slight golden tinge. Nickel is a hard and ductile transition metal. Pure nickel is chemically reactive but large pieces are slow ...
,
tellurium
Tellurium is a chemical element with the symbol Te and atomic number 52. It is a brittle, mildly toxic, rare, silver-white metalloid. Tellurium is chemically related to selenium and sulfur, all three of which are chalcogens. It is occasionall ...
, and
sodium
Sodium is a chemical element with the symbol Na (from Latin ''natrium'') and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 of the periodic table. Its only stable ...
. Although neither zinc nor
zirconium
Zirconium is a chemical element with the symbol Zr and atomic number 40. The name ''zirconium'' is taken from the name of the mineral zircon, the most important source of zirconium. The word is related to Persian '' zargun'' (zircon; ''zar-gun'' ...
is
ferromagnetic, their alloy, , exhibits ferromagnetism below 35
K.
Occurrence
Zinc makes up about 75
ppm (0.0075%) of
Earth's crust, making it the 24th most abundant element. Typical background concentrations of zinc do not exceed 1 μg/m
3 in the atmosphere; 300 mg/kg in soil; 100 mg/kg in vegetation; 20 μg/L in freshwater and 5 μg/L in seawater. The element is normally found in association with other
base metal
A base metal is a common and inexpensive metal, as opposed to a precious metal such as gold or silver. In numismatics, coins often derived their value from the precious metal content; however, base metals have also been used in coins in the past ...
s such as
copper
Copper is a chemical element with the symbol Cu (from la, cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pinkis ...
and
lead
Lead is a chemical element with the symbol Pb (from the Latin ) and atomic number 82. It is a heavy metal that is denser than most common materials. Lead is soft and malleable, and also has a relatively low melting point. When freshly cu ...
in
ore
Ore is natural rock or sediment that contains one or more valuable minerals, typically containing metals, that can be mined, treated and sold at a profit.Encyclopædia Britannica. "Ore". Encyclopædia Britannica Online. Retrieved 7 Apr ...
s.
Zinc is a
chalcophile
The Goldschmidt classification,
developed by Victor Goldschmidt (1888–1947), is a geochemical classification which groups the chemical elements within the Earth according to their preferred host phases into lithophile (Rock (geology), rock-lovi ...
, meaning the element is more likely to be found in minerals together with
sulfur and other heavy
chalcogen
The chalcogens (ore forming) ( ) are the chemical elements in group 16 of the periodic table. This group is also known as the oxygen family. Group 16 consists of the elements oxygen (O), sulfur (S), selenium (Se), tellurium (Te), and the radioac ...
s, rather than with the light chalcogen
oxygen
Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as ...
or with non-chalcogen electronegative elements such as the
halogens.
Sulfides formed as the crust solidified under the
reducing conditions of the early Earth's atmosphere.
Sphalerite, which is a form of zinc sulfide, is the most heavily mined zinc-containing ore because its concentrate contains 60–62% zinc.
Other source minerals for zinc include
smithsonite
Smithsonite, also known as zinc spar, is the mineral form of zinc carbonate ( Zn CO3). Historically, smithsonite was identified with hemimorphite before it was realized that they were two different minerals. The two minerals are very similar in a ...
(zinc
carbonate
A carbonate is a salt of carbonic acid (H2CO3), characterized by the presence of the carbonate ion, a polyatomic ion with the formula . The word ''carbonate'' may also refer to a carbonate ester, an organic compound containing the carbonate ...
),
hemimorphite
Hemimorphite is the chemical compound Zn4( Si2O7)( OH)2 ·H2O, a component of mineral calamine. It is a silicate mineral which, together with smithsonite (ZnCO3), has been historically mined from the upper parts of zinc and lead ores. Both ...
(zinc
silicate),
wurtzite
Wurtzite is a zinc and iron sulfide mineral with the chemical formula , a less frequently encountered structural polymorph form of sphalerite. The iron content is variable up to eight percent.Palache, Charles, Harry Berman & Clifford Frondel (19 ...
(another zinc sulfide), and sometimes
hydrozincite
Hydrozincite, also known as zinc bloom or marionite, is a white carbonate mineral consisting of Zn5( CO3)2( OH)6. It is usually found in massive rather than crystalline form.
It occurs as an oxidation product of zinc ores and as post mine incru ...
(basic
zinc carbonate
Zinc carbonate is the inorganic compound with the formula ZnCO3. It is a white solid that is insoluble in water. It exists in nature as the mineral smithsonite. It is prepared by treating cold solutions of zinc sulfate with potassium bicarbonat ...
).
With the exception of wurtzite, all these other minerals were formed by weathering of the primordial zinc sulfides.
Identified world zinc resources total about 1.9–2.8 billion
tonne
The tonne ( or ; symbol: t) is a unit of mass equal to 1000 kilograms. It is a non-SI unit accepted for use with SI. It is also referred to as a metric ton to distinguish it from the non-metric units of the short ton ( United State ...
s.
Large deposits are in Australia, Canada and the United States, with the largest reserves in
Iran
Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...
.
The most recent estimate of reserve base for zinc (meets specified minimum physical criteria related to current mining and production practices) was made in 2009 and calculated to be roughly 480 Mt.
Zinc reserves, on the other hand, are geologically identified ore bodies whose suitability for recovery is economically based (location, grade, quality, and quantity) at the time of determination. Since exploration and mine development is an ongoing process, the amount of zinc reserves is not a fixed number and sustainability of zinc ore supplies cannot be judged by simply extrapolating the combined mine life of today's zinc mines. This concept is well supported by data from the United States Geological Survey (USGS), which illustrates that although refined zinc production increased 80% between 1990 and 2010, the reserve lifetime for zinc has remained unchanged. About 346 million tonnes have been extracted throughout history to 2002, and scholars have estimated that about 109–305 million tonnes are in use.
Isotopes
Five stable
isotope
Isotopes are two or more types of atoms that have the same atomic number (number of protons in their nuclei) and position in the periodic table (and hence belong to the same chemical element), and that differ in nucleon numbers (mass numb ...
s of zinc occur in nature, with
64Zn being the most abundant isotope (49.17%
natural abundance
In physics, natural abundance (NA) refers to the abundance of isotopes of a chemical element as naturally found on a planet. The relative atomic mass (a weighted average, weighted by mole-fraction abundance figures) of these isotopes is the atomi ...
).
The other isotopes found in nature are (27.73%), (4.04%), (18.45%), and (0.61%).
Several dozen
radioisotope
A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess nuclear energy, making it unstable. This excess energy can be used in one of three ways: emitted from the nucleus as gamma radiation; transferr ...
s have been characterized. , which has a half-life of 243.66 days, is the least active radioisotope, followed by with a half-life of 46.5 hours.
Zinc has 10
nuclear isomer
A nuclear isomer is a metastable state of an atomic nucleus, in which one or more nucleons (protons or neutrons) occupy higher energy levels than in the ground state of the same nucleus. "Metastable" describes nuclei whose excited states have ...
s, of which
69mZn has the longest half-life, 13.76 h.
The superscript ''m'' indicates a
metastable
In chemistry and physics, metastability denotes an intermediate energetic state within a dynamical system other than the system's state of least energy.
A ball resting in a hollow on a slope is a simple example of metastability. If the ball i ...
isotope. The nucleus of a metastable isotope is in an
excited state and will return to the
ground state by emitting a
photon
A photon () is an elementary particle that is a quantum of the electromagnetic field, including electromagnetic radiation such as light and radio waves, and the force carrier for the electromagnetic force. Photons are massless, so they a ...
in the form of a
gamma ray
A gamma ray, also known as gamma radiation (symbol γ or \gamma), is a penetrating form of electromagnetic radiation arising from the radioactive decay of atomic nuclei. It consists of the shortest wavelength electromagnetic waves, typically ...
. has three excited metastable states and has two. The isotopes , , and each have only one excited metastable state.
The most common
decay mode of a
radioisotope
A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess nuclear energy, making it unstable. This excess energy can be used in one of three ways: emitted from the nucleus as gamma radiation; transferr ...
of zinc with a
mass number
The mass number (symbol ''A'', from the German word ''Atomgewicht'' tomic weight, also called atomic mass number or nucleon number, is the total number of protons and neutrons (together known as nucleons) in an atomic nucleus. It is approxima ...
lower than 66 is
electron capture
Electron capture (K-electron capture, also K-capture, or L-electron capture, L-capture) is a process in which the proton-rich nucleus of an electrically neutral atom absorbs an inner atomic electron, usually from the K or L electron shells. Thi ...
. The
decay product resulting from electron capture is an isotope of copper.
: + →
The most common decay mode of a radioisotope of zinc with mass number higher than 66 is
beta decay
In nuclear physics, beta decay (β-decay) is a type of radioactive decay in which a beta particle (fast energetic electron or positron) is emitted from an atomic nucleus, transforming the original nuclide to an isobar of that nuclide. For ...
(β
−), which produces an isotope of
gallium.
: → + +
Compounds and chemistry
Reactivity
Zinc has an
electron configuration of
rd
104s
2 and is a member of the
group 12 of the
periodic table. It is a moderately reactive
metal
A metal (from Greek μέταλλον ''métallon'', "mine, quarry, metal") is a material that, when freshly prepared, polished, or fractured, shows a lustrous appearance, and conducts electricity and heat relatively well. Metals are typicall ...
and strong
reducing agent
In chemistry, a reducing agent (also known as a reductant, reducer, or electron donor) is a chemical species that "donates" an electron to an (called the , , , or ).
Examples of substances that are commonly reducing agents include the Earth me ...
.
The surface of the pure metal
tarnish
Tarnish is a thin layer of corrosion that forms over copper, brass, aluminum, magnesium, neodymium and other similar metals as their outermost layer undergoes a chemical reaction. Tarnish does not always result from the sole effects of oxygen in ...
es quickly, eventually forming a protective
passivating layer of the basic
zinc carbonate
Zinc carbonate is the inorganic compound with the formula ZnCO3. It is a white solid that is insoluble in water. It exists in nature as the mineral smithsonite. It is prepared by treating cold solutions of zinc sulfate with potassium bicarbonat ...
, , by reaction with atmospheric
carbon dioxide
Carbon dioxide ( chemical formula ) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in the gas state at room temperature. In the air, carbon dioxide is trans ...
.
Zinc burns in air with a bright bluish-green flame, giving off fumes of
zinc oxide
Zinc oxide is an inorganic compound with the formula . It is a white powder that is insoluble in water. ZnO is used as an additive in numerous materials and products including cosmetics, food supplements, rubbers, plastics, ceramics, glass, cement ...
.
Zinc reacts readily with
acids,
alkalis and other non-metals. Extremely pure zinc reacts only slowly at
room temperature with acids.
Strong acids, such as
hydrochloric
Hydrochloric acid, also known as muriatic acid, is an aqueous solution of hydrogen chloride. It is a colorless solution with a distinctive pungent smell. It is classified as a strong acid. It is a component of the gastric acid in the digestiv ...
or
sulfuric acid, can remove the passivating layer and the subsequent reaction with the acid releases hydrogen gas.
The chemistry of zinc is dominated by the +2 oxidation state. When compounds in this oxidation state are formed, the outer
shell
Shell may refer to:
Architecture and design
* Shell (structure), a thin structure
** Concrete shell, a thin shell of concrete, usually with no interior columns or exterior buttresses
** Thin-shell structure
Science Biology
* Seashell, a hard o ...
''s'' electrons are lost, yielding a bare zinc ion with the electronic configuration
rd
10. In aqueous solution an octahedral complex, is the predominant species. The
volatilization of zinc in combination with zinc chloride at temperatures above 285 °C indicates the formation of , a zinc compound with a +1 oxidation state.
No compounds of zinc in positive oxidation states other than +1 or +2 are known. Calculations indicate that a zinc compound with the oxidation state of +4 is unlikely to exist. Zn(III) is predicted to exist in the presence of strongly electronegative trianions; however, there exists some doubt around this possibility. But in 2021 another compound was reported with more evidence that had the oxidation state of +3 with the formula ZnBeB
11(CN)
12.
Zinc chemistry is similar to the chemistry of the late first-row transition metals,
nickel
Nickel is a chemical element with symbol Ni and atomic number 28. It is a silvery-white lustrous metal with a slight golden tinge. Nickel is a hard and ductile transition metal. Pure nickel is chemically reactive but large pieces are slow ...
and copper, though it has a filled d-shell and compounds are
diamagnetic
Diamagnetic materials are repelled by a magnetic field; an applied magnetic field creates an induced magnetic field in them in the opposite direction, causing a repulsive force. In contrast, paramagnetic and ferromagnetic materials are attracted ...
and mostly colorless.
The
ionic radii
Ionic radius, ''r''ion, is the radius of a monatomic ion in an ionic crystal structure. Although neither atoms nor ions have sharp boundaries, they are treated as if they were hard spheres with radii such that the sum of ionic radii of the cation ...
of zinc and magnesium happen to be nearly identical. Because of this some of the equivalent salts have the same
crystal structure
In crystallography, crystal structure is a description of the ordered arrangement of atoms, ions or molecules in a crystalline material. Ordered structures occur from the intrinsic nature of the constituent particles to form symmetric patterns ...
, and in other circumstances where ionic radius is a determining factor, the chemistry of zinc has much in common with that of magnesium.
In other respects, there is little similarity with the late first-row transition metals. Zinc tends to form bonds with a greater degree of
covalency and much more stable
complexes with
N- and
S- donors.
Complexes of zinc are mostly 4- or 6-
coordinate
In geometry, a coordinate system is a system that uses one or more numbers, or coordinates, to uniquely determine the position of the points or other geometric elements on a manifold such as Euclidean space. The order of the coordinates is sign ...
, although 5-coordinate complexes are known.
Zinc(I) compounds
Zinc(I) compounds are very rare. The
2">n2sup>2+ ion is implicated by the formation of a yellow diamagnetic glass by dissolving metallic zinc in molten ZnCl
2. The
2">n2sup>2+ core would be analogous to the
2">g2sup>2+ cation present in
mercury(I) compounds. The
diamagnetic
Diamagnetic materials are repelled by a magnetic field; an applied magnetic field creates an induced magnetic field in them in the opposite direction, causing a repulsive force. In contrast, paramagnetic and ferromagnetic materials are attracted ...
nature of the ion confirms its dimeric structure. The first zinc(I) compound containing the Zn–Zn bond,
(η5-C5Me5)2Zn2.
Zinc(II) compounds
Binary compound
In materials chemistry, a binary phase or binary compound is a chemical compound containing two different elements. Some binary phase compounds are molecular, e.g. carbon tetrachloride (CCl4). More typically binary phase refers to extended soli ...
s of zinc are known for most of the
metalloids and all the
nonmetals except the
noble gas
The noble gases (historically also the inert gases; sometimes referred to as aerogens) make up a class of chemical elements with similar properties; under standard conditions, they are all odorless, colorless, monatomic gases with very low ch ...
es. The oxide
ZnO is a white powder that is nearly insoluble in neutral aqueous solutions, but is
amphoteric
In chemistry, an amphoteric compound () is a molecule or ion that can react both as an acid and as a base. What exactly this can mean depends on which definitions of acids and bases are being used.
One type of amphoteric species are amphipro ...
, dissolving in both strong basic and acidic solutions.
The other
chalcogen
The chalcogens (ore forming) ( ) are the chemical elements in group 16 of the periodic table. This group is also known as the oxygen family. Group 16 consists of the elements oxygen (O), sulfur (S), selenium (Se), tellurium (Te), and the radioac ...
ides (
ZnS ZNS or ZnS may refer to:
* Zinc sulfide or zinc sulphide (ZnS), a chemical compound
* ZNS-TV, a national radio and TV broadcaster operated by the state-owned Broadcasting Corporation of The Bahamas
** ZNS-1
ZNS-1 (branded as ''Radio Bahamas'') i ...
,
ZnSe, and
ZnTe
Zinc telluride is a binary chemical compound with the formula ZnTe. This solid is a semiconductor material with a direct band gap of 2.26 eV. It is usually a p-type semiconductor. Its crystal structure is cubic, like that for sphalerite and ...
) have varied applications in electronics and optics.
Pnictogenides (
,
,
and
), the peroxide (
), the hydride (
), and the carbide () are also known. Of the four
halides,
has the most ionic character, while the others (
,
, and
) have relatively low melting points and are considered to have more covalent character.
In weak basic solutions containing ions, the hydroxide
forms as a white
precipitate
In an aqueous solution, precipitation is the process of transforming a dissolved substance into an insoluble solid from a super-saturated solution. The solid formed is called the precipitate. In case of an inorganic chemical reaction leading ...
. In stronger alkaline solutions, this hydroxide is dissolved to form zincates (
).
The nitrate
, chlorate
, sulfate
, phosphate
, molybdate
, cyanide
, arsenite , arsenate and the chromate
(one of the few colored zinc compounds) are a few examples of other common inorganic compounds of zinc.
Organozinc compound
Organozinc compounds in organic chemistry contain carbon (C) to zinc (Zn) chemical bonds. Organozinc chemistry is the science of organozinc compounds describing their physical properties, synthesis and reactions.The Chemistry of Organozinc Compoun ...
s are those that contain zinc–carbon covalent bonds. Diethylzinc (
) is a reagent in synthetic chemistry. It was first reported in 1848 from the reaction of zinc and
ethyl iodide
Ethyl iodide (also iodoethane) is a colorless flammable chemical compound. It has the chemical formula C2H5I and is prepared by heating ethanol with iodine and phosphorus.''Merck Index of Chemicals and Drugs'', 9th ed., monograph 3753 On contact ...
, and was the first compound known to contain a metal–carbon
sigma bond
In chemistry, sigma bonds (σ bonds) are the strongest type of covalent chemical bond. They are formed by head-on overlapping between atomic orbitals. Sigma bonding is most simply defined for diatomic molecules using the language and tools of s ...
.
Test for zinc
Cobalticyanide paper (Rinnmann's test for Zn) can be used as a chemical indicator for zinc. 4 g of K
3Co(CN)
6 and 1 g of KClO
3 is dissolved on 100 ml of water. Paper is dipped in the solution and dried at 100 °C. One drop of the sample is dropped onto the dry paper and heated. A green disc indicates the presence of zinc.
History
Ancient use
The
Charaka Samhita, thought to have been written between 300 and 500 AD, mentions a metal which, when oxidized, produces ''pushpanjan'', thought to be zinc oxide. Zinc mines at Zawar, near
Udaipur
Udaipur () ( ISO 15919: ''Udayapura''), historically named as Udayapura, is a city and municipal corporation in Udaipur district of the state of Rajasthan, India. It is the administrative headquarter of Udaipur district. It is the historic cap ...
in India, have been active since the
Mauryan period ( and 187 BCE). The smelting of metallic zinc here, however, appears to have begun around the 12th century AD.
[p. 46, Ancient mining and metallurgy in Rajasthan, S. M. Gandhi, chapter 2 in ''Crustal Evolution and Metallogeny in the Northwestern Indian Shield: A Festschrift for Asoke Mookherjee'', M. Deb, ed., Alpha Science Int'l Ltd., 2000, .] One estimate is that this location produced an estimated million tonnes of metallic zinc and zinc oxide from the 12th to 16th centuries.
Another estimate gives a total production of 60,000 tonnes of metallic zinc over this period.
The
Rasaratna Samuccaya, written in approximately the 13th century AD, mentions two types of zinc-containing ores: one used for metal extraction and another used for medicinal purposes.
![Hemmoorer Eimer](https://upload.wikimedia.org/wikipedia/commons/6/66/Hemmoorer_Eimer.jpg)
Various isolated examples of the use of impure zinc in ancient times have been discovered. Zinc ores were used to make the zinc–copper alloy
brass
Brass is an alloy of copper (Cu) and zinc (Zn), in proportions which can be varied to achieve different mechanical, electrical, and chemical properties. It is a substitutional alloy: atoms of the two constituents may replace each other wit ...
thousands of years prior to the discovery of zinc as a separate element. Judean brass from the 14th to 10th centuries BC contains 23% zinc.
Knowledge of how to produce brass spread to
Ancient Greece
Ancient Greece ( el, Ἑλλάς, Hellás) was a northeastern Mediterranean Sea, Mediterranean civilization, existing from the Greek Dark Ages of the 12th–9th centuries BC to the end of Classical Antiquity, classical antiquity ( AD 600), th ...
by the 7th century BC, but few varieties were made.
Ornaments made of
alloy
An alloy is a mixture of chemical elements of which at least one is a metal. Unlike chemical compounds with metallic bases, an alloy will retain all the properties of a metal in the resulting material, such as electrical conductivity, ductilit ...
s containing 80–90% zinc, with lead, iron,
antimony
Antimony is a chemical element with the symbol Sb (from la, stibium) and atomic number 51. A lustrous gray metalloid, it is found in nature mainly as the sulfide mineral stibnite (Sb2S3). Antimony compounds have been known since ancient t ...
, and other metals making up the remainder, have been found that are 2,500 years old.
A possibly prehistoric statuette containing 87.5% zinc was found in a
Dacia
Dacia (, ; ) was the land inhabited by the Dacians, its core in Transylvania, stretching to the Danube in the south, the Black Sea in the east, and the Tisza in the west. The Carpathian Mountains were located in the middle of Dacia. It ...
n archaeological site.
The oldest known pills were made of the zinc carbonates hydrozincite and smithsonite. The pills were used for sore eyes and were found aboard the Roman ship
Relitto del Pozzino, wrecked in 140 BC.
The manufacture of brass was known to the
Romans
Roman or Romans most often refers to:
*Rome, the capital city of Italy
* Ancient Rome, Roman civilization from 8th century BC to 5th century AD
*Roman people, the people of ancient Rome
*''Epistle to the Romans'', shortened to ''Romans'', a lette ...
by about 30 BC.
They made brass by heating powdered
calamine
Calamine, also known as calamine lotion, is a medication used to treat mild itchiness. This includes from sunburn, insect bites, poison ivy, poison oak, and other mild skin conditions. It may also help dry out skin irritation. It is applie ...
(zinc
silicate or carbonate), charcoal and copper together in a crucible.
The resulting
calamine brass Calamine brass is brass produced by a particular alloying technique using the zinc ore calamine directly, rather than first refining it to metallic zinc. Direct zinc smelting appears to have been unknown in Europe until the mid-18th century, even th ...
was then either cast or hammered into shape for use in weaponry. Some coins struck by Romans in the Christian era are made of what is probably calamine brass.
Strabo writing in the 1st century BC (but quoting a now lost work of the 4th century BC historian
Theopompus
Theopompus ( grc-gre, Θεόπομπος, ''Theópompos''; c. 380 BCc. 315 BC) was an ancient Greek historian and rhetorician.
Biography
Theopompus was born on the Aegean island of Chios. In early youth, he seems to have spent some time at Athen ...
) mentions "drops of false silver" which when mixed with copper make brass. This may refer to small quantities of zinc that is a by-product of smelting
sulfide ores. Zinc in such remnants in smelting ovens was usually discarded as it was thought to be worthless.
The
Berne zinc tablet
The Bern zinc tablet or Gobannus tablet is a metal sheet found in 1984 in Bern, Switzerland. As it was only analysed after the death of the workman who had found and removed the tablet from its site, its original archaeological context can no l ...
is a votive plaque dating to
Roman Gaul
Roman Gaul refers to GaulThe territory of Gaul roughly corresponds to modern-day France, Belgium and Luxembourg, and adjacient parts of the Netherlands, Switzerland and Germany. under provincial rule in the Roman Empire from the 1st century ...
made of an alloy that is mostly zinc.
Early studies and naming
Zinc was distinctly recognized as a metal under the designation of ''Yasada'' or Jasada in the medical Lexicon ascribed to the Hindu king Madanapala (of Taka dynasty) and written about the year 1374.
[ (public domain text)] Smelting and extraction of impure zinc by reducing calamine with wool and other organic substances was accomplished in the 13th century in India.
The Chinese did not learn of the technique until the 17th century.
Alchemists
Alchemy (from Arabic: ''al-kīmiyā''; from Ancient Greek: χυμεία, ''khumeía'') is an ancient branch of natural philosophy, a philosophical and protoscientific tradition that was historically practiced in China, India, the Muslim world, ...
burned zinc metal in air and collected the resulting zinc oxide on a
condenser. Some alchemists called this zinc oxide ''lana philosophica'', Latin for "philosopher's wool", because it collected in wooly tufts, whereas others thought it looked like white snow and named it ''nix album''.
The name of the metal was probably first documented by
Paracelsus, a Swiss-born German alchemist, who referred to the metal as "zincum" or "zinken" in his book ''Liber Mineralium II'', in the 16th century.
The word is probably derived from the German , and supposedly meant "tooth-like, pointed or jagged" (metallic zinc crystals have a needle-like appearance). ''Zink'' could also imply "tin-like" because of its relation to German ''zinn'' meaning tin. Yet another possibility is that the word is derived from the
Persian
Persian may refer to:
* People and things from Iran, historically called ''Persia'' in the English language
** Persians, the majority ethnic group in Iran, not to be conflated with the Iranic peoples
** Persian language, an Iranian language of the ...
word ''seng'' meaning stone. The metal was also called Indian tin, tutanego, calamine, and spinter.
German metallurgist
Andreas Libavius
Andreas Libavius or Andrew Libavius was born in Halle, Germany c. 1550 and died in July 1616. Libavius was a renaissance man who spent time as a professor at the University of Jena teaching history and poetry. After which he became a physician a ...
received a quantity of what he called "calay" of Malabar from a cargo ship captured from the Portuguese in the year 1596. Libavius described the properties of the sample, which may have been zinc. Zinc was regularly imported to Europe from the Orient in the 17th and early 18th centuries,
but was at times very expensive.
[An ]East India Company
The East India Company (EIC) was an English, and later British, joint-stock company founded in 1600 and dissolved in 1874. It was formed to trade in the Indian Ocean region, initially with the East Indies (the Indian subcontinent and South ...
ship carrying a cargo of nearly pure zinc metal from the Orient sank off the coast Sweden in 1745.
Isolation
![Andreas Sigismund Marggraf-flip](https://upload.wikimedia.org/wikipedia/commons/8/85/Andreas_Sigismund_Marggraf-flip.jpg)
Metallic zinc was isolated in India by 1300 AD, much earlier than in the West. Before it was isolated in Europe, it was imported from India in about 1600 CE.
Postlewayt's ''Universal Dictionary'', a contemporary source giving technological information in Europe, did not mention zinc before 1751 but the element was studied before then.
Flemish
metallurgist
Metallurgy is a domain of materials science and engineering that studies the physical and chemical behavior of metallic elements, their inter-metallic compounds, and their mixtures, which are known as alloys.
Metallurgy encompasses both the sc ...
and
alchemist P. M. de Respour P. M. de Respour, a Flemish metallurgist and alchemist, was the first person to extract metallic zinc from zinc oxide
Zinc oxide is an inorganic compound with the formula . It is a white powder that is insoluble in water. ZnO is used as an additi ...
reported that he had extracted metallic zinc from zinc oxide in 1668.
By the start of the 18th century,
Étienne François Geoffroy
Étienne François Geoffroy (13 February 16726 January 1731) was a French physician and chemist, best known for his 1718 affinity tables. He first contemplated a career as an apothecary, but then decided to practice medicine. He is sometimes kn ...
described how zinc oxide condenses as yellow crystals on bars of iron placed above zinc ore that is being smelted.
In Britain,
John Lane is said to have carried out experiments to smelt zinc, probably at
Landore
Landore ( cy, Glandŵr) is a district and community in Swansea, Wales. The district falls in the Landore council ward. A mainly residential area, it is located about 2.5 miles north of Swansea city centre. The north-easterly part of Landore i ...
, prior to his bankruptcy in 1726.
In 1738 in Great Britain,
William Champion patented a process to extract zinc from calamine in a vertical
retort
In a chemistry laboratory, a retort is a device used for distillation or dry distillation of substances. It consists of a spherical vessel with a long downward-pointing neck. The liquid to be distilled is placed in the vessel and heated. The ...
-style smelter. His technique resembled that used at Zawar zinc mines in
Rajasthan
Rajasthan (; lit. 'Land of Kings') is a state in northern India. It covers or 10.4 per cent of India's total geographical area. It is the largest Indian state by area and the seventh largest by population. It is on India's northwestern s ...
, but no evidence suggests he visited the Orient.
Champion's process was used through 1851.
German chemist
Andreas Marggraf normally gets credit for discovering pure metallic zinc, even though Swedish chemist Anton von Swab had distilled zinc from calamine four years previously.
In his 1746 experiment, Marggraf heated a mixture of calamine and charcoal in a closed vessel without copper to obtain a metal.
This procedure became commercially practical by 1752.
Later work
![Luigi Galvani, oil-painting](https://upload.wikimedia.org/wikipedia/commons/5/51/Luigi_Galvani%2C_oil-painting.jpg)
William Champion's brother, John, patented a process in 1758 for
calcining
Calcination refers to thermal treatment of a solid chemical compound (e.g. mixed carbonate ores) whereby the compound is raised to high temperature without melting under restricted supply of ambient oxygen (i.e. gaseous O2 fraction of air), gener ...
zinc sulfide into an oxide usable in the retort process.
Prior to this, only calamine could be used to produce zinc. In 1798,
Johann Christian Ruberg improved on the smelting process by building the first horizontal retort smelter.
Jean-Jacques Daniel Dony built a different kind of horizontal zinc smelter in Belgium that processed even more zinc.
Italian doctor
Luigi Galvani discovered in 1780 that connecting the
spinal cord
The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the sp ...
of a freshly dissected frog to an iron rail attached by a brass hook caused the frog's leg to twitch.
He incorrectly thought he had discovered an ability of nerves and muscles to create
electricity
Electricity is the set of physical phenomena associated with the presence and motion of matter that has a property of electric charge. Electricity is related to magnetism, both being part of the phenomenon of electromagnetism, as describ ...
and called the effect "
animal electricity".
The galvanic cell and the process of galvanization were both named for Luigi Galvani, and his discoveries paved the way for
electrical batteries, galvanization, and
cathodic protection
Cathodic protection (CP; ) is a technique used to control the corrosion of a metal surface by making it the cathode of an electrochemical cell. A simple method of protection connects the metal to be protected to a more easily corroded "sacrific ...
.
Galvani's friend,
Alessandro Volta, continued researching the effect and invented the
Voltaic pile
upright=1.2, Schematic diagram of a copper–zinc voltaic pile. The copper and zinc discs were separated by cardboard or felt spacers soaked in salt water (the electrolyte). Volta's original piles contained an additional zinc disk at the bottom, ...
in 1800.
Volta's pile consisted of a stack of simplified
galvanic cell
A galvanic cell or voltaic cell, named after the scientists Luigi Galvani and Alessandro Volta, respectively, is an electrochemical cell in which an electric current is generated from spontaneous Oxidation-Reduction reactions. A common apparatus ...
s, each being one plate of copper and one of zinc connected by an
electrolyte. By stacking these units in series, the Voltaic pile (or "battery") as a whole had a higher voltage, which could be used more easily than single cells. Electricity is produced because the
Volta potential
The Volta potential (also called Volta potential difference, contact potential difference, outer potential difference, Δψ, or "delta psi") in electrochemistry, is the electrostatic potential difference between two metals (or one metal and one ele ...
between the two metal plates makes
electron
The electron ( or ) is a subatomic particle with a negative one elementary electric charge. Electrons belong to the first generation of the lepton particle family,
and are generally thought to be elementary particles because they have no ...
s flow from the zinc to the copper and corrode the zinc.
The non-magnetic character of zinc and its lack of color in solution delayed discovery of its importance to biochemistry and nutrition.
This changed in 1940 when
carbonic anhydrase, an enzyme that scrubs carbon dioxide from blood, was shown to have zinc in its
active site.
The digestive enzyme
carboxypeptidase
A carboxypeptidase ( EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds ...
became the second known zinc-containing enzyme in 1955.
Production
Mining and processing
![Skorpion Zink Mine](https://upload.wikimedia.org/wikipedia/commons/1/10/Skorpion_Zink_Mine.jpg)
Zinc is the fourth most common metal in use, trailing only
iron
Iron () is a chemical element with Symbol (chemistry), symbol Fe (from la, Wikt:ferrum, ferrum) and atomic number 26. It is a metal that belongs to the first transition series and group 8 element, group 8 of the periodic table. It is, Abundanc ...
,
aluminium
Aluminium (aluminum in American and Canadian English) is a chemical element with the symbol Al and atomic number 13. Aluminium has a density lower than those of other common metals, at approximately one third that of steel. I ...
, and
copper
Copper is a chemical element with the symbol Cu (from la, cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pinkis ...
with an annual production of about 13 million tonnes.
The world's largest zinc producer is
Nyrstar
Nyrstar is a global multi-metals business, with a market leading position in zinc and lead and growing positions in other base and precious metals, such as copper, gold and silver. Nyrstar has mining and smelting operations located in Europe, North ...
, a merger of the Australian
OZ Minerals and the Belgian
Umicore
Umicore N.V.. formerly '' Union Minière'', is a multinational materials technology company headquartered in Brussels, Belgium.
Formed in 1989 by the merger of four companies in the mining and smelting industries, Umicore has since reshaped ...
. About 70% of the world's zinc originates from mining, while the remaining 30% comes from recycling secondary zinc.
Commercially pure zinc is known as Special High Grade, often abbreviated ''SHG'', and is 99.995% pure.
Worldwide, 95% of new zinc is mined from
sulfidic ore deposits, in which sphalerite (ZnS) is nearly always mixed with the sulfides of copper, lead and iron.
Zinc mines are scattered throughout the world, with the main areas being China, Australia, and Peru. China produced 38% of the global zinc output in 2014.
Zinc metal is produced using
extractive metallurgy
Extractive metallurgy is a branch of metallurgical engineering wherein process and methods of extraction of metals from their natural mineral deposits are studied. The field is a materials science, covering all aspects of the types of ore, was ...
.
The ore is finely ground, then put through
froth flotation
Froth flotation is a process for selectively separating hydrophobic materials from hydrophilic. This is used in mineral processing, paper recycling and waste-water treatment industries. Historically this was first used in the mining industry, wher ...
to separate minerals from
gangue
In mining, gangue () is the commercially worthless material that surrounds, or is closely mixed with, a wanted mineral in an ore deposit. It is thus distinct from overburden, which is the waste rock or materials overlying an ore or mineral body ...
(on the property of
hydrophobicity
In chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe). In contrast, hydrophiles are attracted to water.
Hydrophobic molecules tend to be nonpolar and, t ...
), to get a zinc sulfide ore concentrate
consisting of about 50% zinc, 32% sulfur, 13% iron, and 5% .
Roasting converts the zinc sulfide concentrate to zinc oxide:
:
2ZnS + 3O2 -> ^o 2ZnO + 2SO2
The sulfur dioxide is used for the production of sulfuric acid, which is necessary for the leaching process. If deposits of
zinc carbonate
Zinc carbonate is the inorganic compound with the formula ZnCO3. It is a white solid that is insoluble in water. It exists in nature as the mineral smithsonite. It is prepared by treating cold solutions of zinc sulfate with potassium bicarbonat ...
,
zinc silicate, or
zinc-spinel (like the
Skorpion Deposit in
Namibia
Namibia (, ), officially the Republic of Namibia, is a country in Southern Africa. Its western border is the Atlantic Ocean. It shares land borders with Zambia and Angola to the north, Botswana to the east and South Africa to the south and ea ...
) are used for zinc production, the roasting can be omitted.
For further processing two basic methods are used:
pyrometallurgy
Pyrometallurgy is a branch of extractive metallurgy. It consists of the thermal treatment of minerals and metallurgical ores and concentrates to bring about physical and chemical transformations in the materials to enable recovery of valuable ...
or
electrowinning. Pyrometallurgy reduces zinc oxide with
carbon
Carbon () is a chemical element with the symbol C and atomic number 6. It is nonmetallic and tetravalent—its atom making four electrons available to form covalent chemical bonds. It belongs to group 14 of the periodic table. Carbon mak ...
or
carbon monoxide
Carbon monoxide (chemical formula CO) is a colorless, poisonous, odorless, tasteless, flammable gas that is slightly less dense than air. Carbon monoxide consists of one carbon atom and one oxygen atom connected by a triple bond. It is the simple ...
at into the metal, which is distilled as zinc vapor to separate it from other metals, which are not volatile at those temperatures. The zinc vapor is collected in a condenser.
The equations below describe this process:
:
ZnO + C -> 50^oCZn + CO
:
ZnO + CO -> 50^oCZn + CO2
In
electrowinning, zinc is leached from the ore concentrate by
sulfuric acid and impurities are precipitated:
:
ZnO + H2SO4 -> ZnSO4 + H2O
Finally, the zinc is reduced by
electrolysis.
:
2ZnSO4 + 2H2O -> 2Zn + O2 + 2H2SO4
The sulfuric acid is regenerated and recycled to the leaching step.
When galvanised feedstock is fed to an
electric arc furnace
An electric arc furnace (EAF) is a furnace that heats material by means of an electric arc.
Industrial arc furnaces range in size from small units of approximately one-tonne capacity (used in foundries for producing cast iron products) up to ...
, the zinc is recovered from the dust by a number of processes, predominantly the
Waelz process The Waelz process is a method of recovering zinc and other relatively low boiling point metals from metallurgical waste (typically EAF flue dust) and other recycled materials using a rotary kiln (''waelz kiln'').
The zinc enriched product is referr ...
(90% as of 2014).
Environmental impact
Refinement of sulfidic zinc ores produces large volumes of sulfur dioxide and
cadmium
Cadmium is a chemical element with the symbol Cd and atomic number 48. This soft, silvery-white metal is chemically similar to the two other stable metals in group 12, zinc and mercury. Like zinc, it demonstrates oxidation state +2 in most of ...
vapor. Smelter
slag and other residues contain significant quantities of metals. About 1.1 million tonnes of metallic zinc and 130 thousand tonnes of lead were mined and smelted in the Belgian towns of
La Calamine and
Plombières
Plombières (; german: Bleyberg or ''Bleiberg'', nl, Blieberg; wa, So-on-Mont-d'-Plomb) is a municipality of Wallonia located in the province of Liège, Belgium.
On 1 January 2006, Plombières had a total population of 10,401. The total are ...
between 1806 and 1882.
The dumps of the past mining operations leach zinc and cadmium, and the sediments of the
Geul River contain non-trivial amounts of metals.
About two thousand years ago, emissions of zinc from mining and smelting totaled 10 thousand tonnes a year. After increasing 10-fold from 1850, zinc emissions peaked at 3.4 million tonnes per year in the 1980s and declined to 2.7 million tonnes in the 1990s, although a 2005 study of the Arctic troposphere found that the concentrations there did not reflect the decline. Man-made and natural emissions occur at a ratio of 20 to 1.
Zinc in rivers flowing through industrial and mining areas can be as high as 20 ppm.
Effective
sewage treatment
Sewage treatment (or domestic wastewater treatment, municipal wastewater treatment) is a type of wastewater treatment which aims to remove contaminants from sewage to produce an effluent that is suitable for discharge to the surrounding e ...
greatly reduces this; treatment along the
Rhine
), Surselva, Graubünden, Switzerland
, source1_coordinates=
, source1_elevation =
, source2 = Rein Posteriur/Hinterrhein
, source2_location = Paradies Glacier, Graubünden, Switzerland
, source2_coordinates=
, so ...
, for example, has decreased zinc levels to 50 ppb.
Concentrations of zinc as low as 2 ppm adversely affects the amount of oxygen that fish can carry in their blood.
Soils contaminated with zinc from mining, refining, or fertilizing with zinc-bearing sludge can contain several grams of zinc per kilogram of dry soil. Levels of zinc in excess of 500 ppm in soil interfere with the ability of plants to absorb other
essential metals, such as iron and
manganese
Manganese is a chemical element with the symbol Mn and atomic number 25. It is a hard, brittle, silvery metal, often found in minerals in combination with iron. Manganese is a transition metal with a multifaceted array of industrial alloy use ...
. Zinc levels of 2000 ppm to 180,000 ppm (18%) have been recorded in some soil samples.
Applications
Major applications of zinc include (numbers are given for the US)
#
Galvanizing
Galvanization or galvanizing ( also spelled galvanisation or galvanising) is the process of applying a protective zinc coating to steel or iron, to prevent rusting. The most common method is hot-dip galvanizing, in which the parts are submerge ...
(55%)
#
Brass
Brass is an alloy of copper (Cu) and zinc (Zn), in proportions which can be varied to achieve different mechanical, electrical, and chemical properties. It is a substitutional alloy: atoms of the two constituents may replace each other wit ...
and
bronze (16%)
# Other alloys (21%)
# Miscellaneous (8%)
Anti-corrosion and batteries
![Feuerverzinkte Oberfläche](https://upload.wikimedia.org/wikipedia/commons/c/c4/Feuerverzinkte_Oberfl%C3%A4che.jpg)
Zinc is most commonly used as an anti-
corrosion
Corrosion is a natural process that converts a refined metal into a more chemically stable oxide. It is the gradual deterioration of materials (usually a metal) by chemical or electrochemical reaction with their environment. Corrosion engi ...
agent,
and galvanization (coating of
iron
Iron () is a chemical element with Symbol (chemistry), symbol Fe (from la, Wikt:ferrum, ferrum) and atomic number 26. It is a metal that belongs to the first transition series and group 8 element, group 8 of the periodic table. It is, Abundanc ...
or
steel) is the most familiar form. In 2009 in the United States, 55% or 893,000 tons of the zinc metal was used for galvanization.
Zinc is more reactive than iron or steel and thus will attract almost all local oxidation until it completely corrodes away.
A protective surface layer of oxide and carbonate ( forms as the zinc corrodes.
This protection lasts even after the zinc layer is scratched but degrades through time as the zinc corrodes away.
The zinc is applied electrochemically or as molten zinc by
hot-dip galvanizing or spraying. Galvanization is used on chain-link fencing, guard rails, suspension bridges, lightposts, metal roofs, heat exchangers, and car bodies.
The relative reactivity of zinc and its ability to attract oxidation to itself makes it an efficient
sacrificial anode in
cathodic protection
Cathodic protection (CP; ) is a technique used to control the corrosion of a metal surface by making it the cathode of an electrochemical cell. A simple method of protection connects the metal to be protected to a more easily corroded "sacrific ...
(CP). For example, cathodic protection of a buried pipeline can be achieved by connecting anodes made from zinc to the pipe.
Zinc acts as the
anode
An anode is an electrode of a polarized electrical device through which conventional current enters the device. This contrasts with a cathode, an electrode of the device through which conventional current leaves the device. A common mnemonic ...
(negative terminus) by slowly corroding away as it passes electric current to the steel pipeline.
[Electric current will naturally flow between zinc and steel but in some circumstances inert anodes are used with an external DC source.] Zinc is also used to cathodically protect metals that are exposed to sea water. A zinc disc attached to a ship's iron rudder will slowly corrode while the rudder stays intact.
Similarly, a zinc plug attached to a propeller or the metal protective guard for the keel of the ship provides temporary protection.
With a
standard electrode potential
In electrochemistry, standard electrode potential E^\ominus, or E^\ominus_, is a measure of the reducing power of any element or compound. The IUPAC "Gold Book" defines it as: ''"the value of the standard emf (electromotive force) of a cell in wh ...
(SEP) of −0.76
volt
The volt (symbol: V) is the unit of electric potential, electric potential difference (voltage), and electromotive force in the International System of Units (SI). It is named after the Italian physicist Alessandro Volta (1745–1827).
Defin ...
s, zinc is used as an anode material for batteries. (More reactive lithium (SEP −3.04 V) is used for anodes in
lithium batteries
Lithium battery may refer to:
* Lithium metal battery, a non-rechargeable battery with lithium as an anode
** Rechargeable lithium metal battery, a rechargeable counterpart to the lithium metal battery
* Lithium-ion battery, a rechargeable batte ...
). Powdered zinc is used in this way in
alkaline batteries
An alkaline battery (IEC code: L) is a type of primary battery where the electrolyte (most commonly potassium hydroxide) has a pH value above 7. Typically these batteries derive energy from the reaction between zinc metal and manganese dioxi ...
and the case (which also serves as the anode) of
zinc–carbon batteries is formed from sheet zinc. Zinc is used as the anode or fuel of the
zinc–air battery
Zinc–air batteries (non-rechargeable), and zinc–air fuel cells (mechanically rechargeable) are metal–air batteries powered by oxidizing zinc with oxygen from the air. These batteries have high energy densities and are relatively inex ...
/fuel cell. The
zinc-cerium redox flow battery
Redox (reduction–oxidation, , ) is a type of chemical reaction in which the oxidation states of substrate (chemistry), substrate change. Oxidation is the loss of Electron, electrons or an increase in the oxidation state, while reduction ...
also relies on a zinc-based negative half-cell.
Alloys
A widely used zinc alloy is brass, in which copper is alloyed with anywhere from 3% to 45% zinc, depending upon the type of brass.
Brass is generally more
ductile
Ductility is a mechanical property commonly described as a material's amenability to drawing (e.g. into wire). In materials science, ductility is defined by the degree to which a material can sustain plastic deformation under tensile stres ...
and stronger than copper, and has superior
corrosion resistance
Corrosion is a natural process that converts a refined metal into a more chemically stable oxide. It is the gradual deterioration of materials (usually a metal) by chemical or electrochemical reaction with their environment. Corrosion engin ...
.
These properties make it useful in communication equipment, hardware, musical instruments, and water valves.
![Microstructure of rolled and annealed brass; magnification 400X](https://upload.wikimedia.org/wikipedia/commons/6/69/Microstructure_of_rolled_and_annealed_brass%3B_magnification_400X.jpg)
Other widely used zinc alloys include
nickel silver
Nickel silver, Maillechort, German silver, Argentan, new silver, nickel brass, albata, alpacca, is a copper alloy with nickel and often zinc. The usual formulation is 60% copper, 20% nickel and 20% zinc. Nickel silver does not contain the eleme ...
, typewriter metal, soft and aluminium
solder
Solder (; NA: ) is a fusible metal alloy used to create a permanent bond between metal workpieces. Solder is melted in order to wet the parts of the joint, where it adheres to and connects the pieces after cooling. Metals or alloys suitable ...
, and commercial
bronze.
Zinc is also used in contemporary pipe organs as a substitute for the traditional lead/tin alloy in pipes. Alloys of 85–88% zinc, 4–10% copper, and 2–8% aluminium find limited use in certain types of machine bearings. Zinc has been the primary metal in
American one cent coins (pennies) since 1982.
The zinc core is coated with a thin layer of copper to give the appearance of a copper coin. In 1994, of zinc were used to produce 13.6 billion pennies in the United States.
Alloys of zinc with small amounts of copper, aluminium, and magnesium are useful in
die casting
Die casting is a metal casting process that is characterized by forcing molten metal under high pressure into a mold cavity. The mold cavity is created using two hardened tool steel dies which have been machined into shape and work similarly ...
as well as
spin casting
Spin casting, also known as centrifugal rubber mold casting (CRMC), is a method of utilizing inertia to produce castings from a rubber mold. Typically, a disc-shaped mold is spun along its central axis at a set speed. The casting material, us ...
, especially in the automotive, electrical, and hardware industries.
These alloys are marketed under the name
Zamak
ZAMAK (or Zamac, formerly trademarked as MAZAK) is a family of alloys with a base metal of zinc and alloying elements of aluminium, magnesium, and copper.
Zamak alloys are part of the zinc aluminium alloy family; they are distinguished from the ...
. An example of this is
zinc aluminium Zinc-aluminium (ZA) alloys are alloys whose main constituents are zinc and aluminium. Other alloying elements include magnesium and copper. This type of alloy was originally developed for gravity casting. Noranda, New Jersey Zinc Co. Ltd., St. Joe ...
. The low melting point together with the low
viscosity
The viscosity of a fluid is a measure of its resistance to deformation at a given rate. For liquids, it corresponds to the informal concept of "thickness": for example, syrup has a higher viscosity than water.
Viscosity quantifies the inte ...
of the alloy makes possible the production of small and intricate shapes. The low working temperature leads to rapid cooling of the cast products and fast production for assembly.
Another alloy, marketed under the brand name Prestal, contains 78% zinc and 22% aluminium, and is reported to be nearly as strong as steel but as malleable as plastic.
This
superplasticity
In materials science, superplasticity is a state in which solid crystalline material is deformed well beyond its usual breaking point, usually over about 600% during tensile deformation. Such a state is usually achieved at high homologous tempe ...
of the alloy allows it to be molded using die casts made of ceramics and cement.
Similar alloys with the addition of a small amount of lead can be cold-rolled into sheets. An alloy of 96% zinc and 4% aluminium is used to make stamping dies for low production run applications for which ferrous metal dies would be too expensive.
For building facades, roofing, and other applications for
sheet metal
Sheet metal is metal formed into thin, flat pieces, usually by an industrial process. Sheet metal is one of the fundamental forms used in metalworking, and it can be cut and bent into a variety of shapes.
Thicknesses can vary significantly; ex ...
formed by
deep drawing
Deep drawing is a sheet metal metal forming, forming process in which a sheet metal blank is radially drawn into a forming die by the mechanical action of a punch. It is thus a shape transformation process with material retention. The process is c ...
,
roll forming
Roll forming, also spelled roll-forming or rollforming, is a type of rolling involving the continuous bending of a long strip of sheet metal (typically coiled steel) into a desired cross-section. The strip passes through sets of rolls mounted on ...
, or
bending
In applied mechanics, bending (also known as flexure) characterizes the behavior of a slender structural element subjected to an external load applied perpendicularly to a longitudinal axis of the element.
The structural element is assumed to ...
, zinc alloys with
titanium
Titanium is a chemical element with the Symbol (chemistry), symbol Ti and atomic number 22. Found in nature only as an oxide, it can be reduced to produce a lustrous transition metal with a silver color, low density, and high strength, resista ...
and copper are used.
Unalloyed zinc is too brittle for these manufacturing processes.
As a dense, inexpensive, easily worked material, zinc is used as a
lead
Lead is a chemical element with the symbol Pb (from the Latin ) and atomic number 82. It is a heavy metal that is denser than most common materials. Lead is soft and malleable, and also has a relatively low melting point. When freshly cu ...
replacement. In the wake of
lead concerns, zinc appears in weights for various applications ranging from fishing to
tire balance
Tire balance, also called tire unbalance or tire imbalance, describes the distribution of mass within an automobile tire or the entire wheel (including the rim) on which it is mounted.
When the wheel rotates, asymmetries in its mass distribution ...
s and flywheels.
Cadmium zinc telluride Cadmium zinc telluride, (CdZnTe) or CZT, is a compound of cadmium, zinc and tellurium or, more strictly speaking, an alloy of cadmium telluride and zinc telluride. A direct bandgap semiconductor, it is used in a variety of applications, including ...
(CZT) is a
semiconductive
A semiconductor is a material which has an electrical conductivity value falling between that of a conductor, such as copper, and an insulator, such as glass. Its resistivity falls as its temperature rises; metals behave in the opposite way. ...
alloy that can be divided into an array of small sensing devices.
These devices are similar to an
integrated circuit and can detect the energy of incoming
gamma ray
A gamma ray, also known as gamma radiation (symbol γ or \gamma), is a penetrating form of electromagnetic radiation arising from the radioactive decay of atomic nuclei. It consists of the shortest wavelength electromagnetic waves, typically ...
photons.
When behind an absorbing mask, the CZT sensor array can determine the direction of the rays.
Other industrial uses
![Zinc oxide](https://upload.wikimedia.org/wikipedia/commons/1/13/Zinc_oxide.jpg)
Roughly one quarter of all zinc output in the United States in 2009 was consumed in zinc compounds;
a variety of which are used industrially. Zinc oxide is widely used as a white pigment in paints and as a
catalyst
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
in the manufacture of rubber to disperse heat. Zinc oxide is used to protect rubber polymers and plastics from
ultraviolet radiation
Ultraviolet (UV) is a form of electromagnetic radiation with wavelength from 10 nm (with a corresponding frequency around 30 PHz) to 400 nm (750 THz), shorter than that of visible light, but longer than X-rays. UV radiation i ...
(UV).
The
semiconductor
A semiconductor is a material which has an electrical conductivity value falling between that of a conductor, such as copper, and an insulator, such as glass. Its resistivity falls as its temperature rises; metals behave in the opposite way. ...
properties of zinc oxide make it useful in
varistor
A varistor is an electronic component with an electrical resistance that varies with the applied voltage. Also known as a voltage-dependent resistor (VDR), it has a nonlinear, non- ohmic current–voltage characteristic that is similar to that ...
s and photocopying products. The
zinc zinc-oxide cycle
Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodic ta ...
is a two step
thermochemical process based on zinc and zinc oxide for
hydrogen production
Hydrogen production is the family of industrial methods for generating hydrogen gas. As of 2020, the majority of hydrogen (∼95%) is produced from fossil fuels by steam reforming of natural gas and other light hydrocarbons, partial oxidation of ...
.
Zinc chloride
Zinc chloride is the name of inorganic chemical compounds with the formula ZnCl2 and its hydrates. Zinc chlorides, of which nine crystalline forms are known, are colorless or white, and are highly soluble in water. This salt is hygroscopic and e ...
is often added to lumber as a
fire retardant
A fire retardant is a substance that is used to slow down or stop the spread of fire or reduce its intensity. This is commonly accomplished by chemical reactions that reduce the flammability of fuels or delay their combustion. Fire retardants m ...
and sometimes as a wood
preservative
A preservative is a substance or a chemical that is added to products such as food products, beverages, pharmaceutical drugs, paints, biological samples, cosmetics, wood, and many other products to prevent decomposition by microbial growth or by ...
. It is used in the manufacture of other chemicals.
Zinc methyl () is used in a number of organic
syntheses.
Zinc sulfide
Zinc sulfide (or zinc sulphide) is an inorganic compound with the chemical formula of ZnS. This is the main form of zinc found in nature, where it mainly occurs as the mineral sphalerite. Although this mineral is usually black because of various ...
(ZnS) is used in
luminescent
Luminescence is spontaneous emission of light by a substance not resulting from heat; or "cold light".
It is thus a form of cold-body radiation. It can be caused by chemical reactions, electrical energy, subatomic motions or stress on a crystal ...
pigments such as on the hands of clocks,
X-ray
An X-ray, or, much less commonly, X-radiation, is a penetrating form of high-energy electromagnetic radiation. Most X-rays have a wavelength ranging from 10 picometers to 10 nanometers, corresponding to frequencies in the range 30&nb ...
and television screens, and
luminous paint
Luminous paint or luminescent paint is paint that exhibits luminescence. In other words, it gives off visible light through fluorescence, phosphorescence, or radioluminescence. There are three types of luminous paints: fluorescent paint, phosp ...
s.
Crystals of ZnS are used in
laser
A laser is a device that emits light through a process of optical amplification based on the stimulated emission of electromagnetic radiation. The word "laser" is an acronym for "light amplification by stimulated emission of radiation". The fi ...
s that operate in the mid-
infrared
Infrared (IR), sometimes called infrared light, is electromagnetic radiation (EMR) with wavelengths longer than those of visible light. It is therefore invisible to the human eye. IR is generally understood to encompass wavelengths from around ...
part of the spectrum.
Zinc sulfate
Zinc sulfate is an inorganic compound. It is used as a dietary supplement to treat zinc deficiency and to prevent the condition in those at high risk. Side effects of excess supplementation may include abdominal pain, vomiting, headache, and ti ...
is a chemical in
dyes and pigments.
Zinc pyrithione
Zinc pyrithione (or pyrithione zinc) is a coordination complex of zinc. It has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic d ...
is used in
antifouling
Biofouling or biological fouling is the accumulation of microorganisms, plants, algae, or small animals where it is not wanted on surfaces such as ship and submarine hulls, devices such as water inlets, pipework, grates, ponds, and rivers that ...
paints.
Zinc powder is sometimes used as a
propellant in
model rocket
A model rocket are small rockets designed to reach low altitudes (e.g., for model) and be recovered by a variety of means.
According to the United States National Association of Rocketry (NAR) Safety Code, model rockets are constructed of ...
s.
When a compressed mixture of 70% zinc and 30%
sulfur powder is ignited there is a violent chemical reaction.
This produces zinc sulfide, together with large amounts of hot gas, heat, and light.
Zinc sheet metal is used as a durable covering for roofs, walls, and countertops, the last often seen in
bistro
A bistro or bistrot , is, in its original Parisian incarnation, a small restaurant, serving moderately priced simple meals in a modest setting. Bistros are defined mostly by the foods they serve. French home-style cooking, and slow-cooked foods ...
s and
oyster bar
An oyster bar, also known as an oyster saloon, oyster house or a raw bar service, is a restaurant specializing in serving oysters, or a section of a restaurant which serves oysters buffet-style. Oysters have been consumed since ancient times and w ...
s, and is known for the rustic look imparted by its surface
oxidation
Redox (reduction–oxidation, , ) is a type of chemical reaction in which the oxidation states of substrate change. Oxidation is the loss of electrons or an increase in the oxidation state, while reduction is the gain of electrons or a ...
in use to a blue-gray
patina and susceptibility to scratching.
, the most abundant isotope of zinc, is very susceptible to
neutron activation
Neutron activation is the process in which neutron radiation induces radioactivity in materials, and occurs when atomic nuclei capture free neutrons, becoming heavier and entering excited states. The excited nucleus decays immediately by emit ...
, being
transmuted into the highly radioactive , which has a half-life of 244 days and produces intense
gamma radiation. Because of this, zinc oxide used in nuclear reactors as an anti-corrosion agent is depleted of before use, this is called
depleted zinc oxide Depleted zinc oxide (DZO) is a zinc oxide depleted in the zinc isotope with the atomic mass 64, and used as a corrosion inhibitor in nuclear pressurized water reactors.
The depletion of 64Zn is necessary, because this isotope is transformed into ...
. For the same reason, zinc has been proposed as a
salting material for
nuclear weapon
A nuclear weapon is an explosive device that derives its destructive force from nuclear reactions, either fission (fission bomb) or a combination of fission and fusion reactions ( thermonuclear bomb), producing a nuclear explosion. Both bom ...
s (
cobalt
Cobalt is a chemical element with the symbol Co and atomic number 27. As with nickel, cobalt is found in the Earth's crust only in a chemically combined form, save for small deposits found in alloys of natural meteoric iron. The free element, p ...
is another, better-known salting material).
A jacket of
isotopically enriched would be irradiated by the intense high-energy neutron flux from an exploding thermonuclear weapon, forming a large amount of significantly increasing the radioactivity of the weapon's
fallout
Nuclear fallout is the residual radioactive material propelled into the upper atmosphere following a nuclear blast, so called because it "falls out" of the sky after the explosion and the shock wave has passed. It commonly refers to the radioac ...
.
Such a weapon is not known to have ever been built, tested, or used.
is used as a
tracer to study how alloys that contain zinc wear out, or the path and the role of zinc in organisms.
Zinc dithiocarbamate complexes are used as agricultural
fungicides; these include
Zineb
Zineb is the chemical compound with the formula n. Structurally, it is classified as a coordination polymer and a dithiocarbamate complex. This pale yellow solid is used as fungicide.
Production and applications
It is produced by treating ethyle ...
, Metiram, Propineb and Ziram. Zinc naphthenate is used as wood preservative. Zinc in the form of
ZDDP, is used as an anti-wear additive for metal parts in engine oil.
Organic chemistry
Organozinc
Organozinc compounds in organic chemistry contain carbon (C) to zinc (Zn) chemical bonds. Organozinc chemistry is the science of organozinc compounds describing their physical properties, synthesis and reactions.The Chemistry of Organozinc Compoun ...
chemistry is the science of compounds that contain carbon-zinc bonds, describing the physical properties, synthesis, and chemical reactions. Many organozinc compounds are important. Among important applications are
* The Frankland-Duppa Reaction in which an
oxalate
Oxalate (IUPAC: ethanedioate) is an anion with the formula C2O42−. This dianion is colorless. It occurs naturally, including in some foods. It forms a variety of salts, for example sodium oxalate (Na2C2O4), and several esters such as dimethyl ...
ester
In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides a ...
(ROCOCOOR) reacts with an
alkyl halide
The haloalkanes (also known as halogenoalkanes or alkyl halides) are alkanes containing one or more halogen substituents. They are a subset of the general class of halocarbons, although the distinction is not often made. Haloalkanes are widely us ...
R'X, zinc and
hydrochloric acid
Hydrochloric acid, also known as muriatic acid, is an aqueous solution of hydrogen chloride. It is a colorless solution with a distinctive pungent smell. It is classified as a strong acid
Acid strength is the tendency of an acid, symbol ...
to form the α-hydroxycarboxylic esters RR'COHCOOR
* On the downside, organozincs are much less nucleophilic than Grignards, and they are expensive and difficult to handle. Commercially available diorganozinc compounds are
dimethylzinc
Dimethylzinc, also known as Zinc methyl, DMZ, or DMZn is a colorless volatile liquid Zn(CH3)2, formed by the action of methyl iodide on zinc at elevated temperature or on zinc sodium alloy.
:2Zn + 2CH3I → Zn(CH3)2 + ZnI2
The sodium assists the ...
,
diethylzinc
Diethylzinc (C2H5)2Zn, or DEZ, is a highly pyrophoric and reactive organozinc compound consisting of a zinc center bound to two ethyl groups. This colourless liquid is an important reagent in organic chemistry. It is available commercially as a ...
and diphenylzinc. In one study, the active organozinc compound is obtained from much cheaper
organobromine precursors.
Zinc has found many uses as a catalyst in organic synthesis including asymmetric synthesis, being cheap and easily available alternative to precious metal complexes. The results (yield and
enantiomeric excess
In stereochemistry, enantiomeric excess (ee) is a measurement of purity used for chiral substances. It reflects the degree to which a sample contains one enantiomer in greater amounts than the other. A racemic mixture has an ee of 0%, while a si ...
) obtained with chiral zinc catalysts are comparable to those achieved with palladium, ruthenium, iridium and others, and zinc becomes a metal catalyst of choice.
Dietary supplement
![Zinc 50 mg](https://upload.wikimedia.org/wikipedia/commons/7/7c/Zinc_50_mg.jpg)
In most single-tablet, over-the-counter, daily vitamin and
mineral
In geology and mineralogy, a mineral or mineral species is, broadly speaking, a solid chemical compound with a fairly well-defined chemical composition and a specific crystal structure that occurs naturally in pure form.John P. Rafferty, ed. (2 ...
supplements, zinc is included in such forms as
zinc oxide
Zinc oxide is an inorganic compound with the formula . It is a white powder that is insoluble in water. ZnO is used as an additive in numerous materials and products including cosmetics, food supplements, rubbers, plastics, ceramics, glass, cement ...
,
zinc acetate
Zinc acetate is a salt with the formula Zn(CH3CO2)2, which commonly occurs as the dihydrate Zn(CH3CO2)2·2H2O. Both the hydrate and the anhydrous forms are colorless solids that are used as dietary supplements. When used as a food additive, it ha ...
,
zinc gluconate
Zinc gluconate is the zinc salt of gluconic acid. It is an ionic compound consisting of two anions of gluconate for each zinc(II) cation. Zinc gluconate is a popular form for the delivery of zinc as a dietary supplement providing 14.35% eleme ...
, or zinc amino acid chelate.
Generally, zinc supplement is recommended where there is high risk of zinc deficiency (such as low and middle income countries) as a preventive measure. Although zinc sulfate is a commonly used zinc form, zinc citrate, gluconate and picolinate may be valid options as well. These forms are better absorbed than zinc oxide.
Gastroenteritis
Zinc is an inexpensive and effective part of treatment of
diarrhea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin w ...
among children in the developing world. Zinc becomes depleted in the body during diarrhea and replenishing zinc with a 10- to 14-day course of treatment can reduce the duration and severity of diarrheal episodes and may also prevent future episodes for as long as three months.
Gastroenteritis is strongly attenuated by ingestion of zinc, possibly by direct antimicrobial action of the ions in the
gastrointestinal tract, or by the absorption of the zinc and re-release from immune cells (all
granulocytes secrete zinc), or both.
Common cold
Weight gain
Zinc deficiency may lead to loss of appetite. The use of zinc in the treatment of anorexia has been advocated since 1979. At least 15 clinical trials have shown that zinc improved weight gain in anorexia. A 1994 trial showed that zinc doubled the rate of body mass increase in the treatment of anorexia nervosa. Deficiency of other nutrients such as tyrosine, tryptophan and thiamine could contribute to this phenomenon of "malnutrition-induced malnutrition".
A meta-analysis of 33 prospective intervention trials regarding zinc supplementation and its effects on the growth of children in many countries showed that zinc supplementation alone had a statistically significant effect on linear growth and body weight gain, indicating that other deficiencies that may have been present were not responsible for growth retardation.
Other
A Cochrane review stated that people taking zinc supplement may be less likely to progress to
age-related macular degeneration
Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Over time, however, som ...
. Zinc supplement is an effective treatment for
acrodermatitis enteropathica
Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc through the inner lining of the bowel, the mucous membrane. It is characterized by inflammation of the skin (dermatitis) around bodily openings ...
, a genetic disorder affecting zinc absorption that was previously fatal to affected infants.
Zinc deficiency has been associated with
major depressive disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Intro ...
(MDD), and zinc supplements may be an effective treatment.
Zinc may help individuals sleep more.
Topical use
Topical preparations of zinc include those used on the skin, often in the form of
zinc oxide
Zinc oxide is an inorganic compound with the formula . It is a white powder that is insoluble in water. ZnO is used as an additive in numerous materials and products including cosmetics, food supplements, rubbers, plastics, ceramics, glass, cement ...
. Zinc oxide is generally recognised by the FDA as safe and effective and is considered a very photo-stable. Zinc oxide is one of the most common active ingredients formulated into a sunscreen to mitigate
sunburn
Sunburn is a form of radiation burn that affects living tissue, such as skin, that results from an overexposure to ultraviolet (UV) radiation, usually from the Sun. Common symptoms in humans and animals include: red or reddish skin that is h ...
.
Applied thinly to a baby's diaper area (
perineum
The perineum in humans is the space between the anus and scrotum in the male, or between the anus and the vulva in the female. The perineum is the region of the body between the pubic symphysis (pubic arch) and the coccyx (tail bone), includi ...
) with each diaper change, it can protect against
diaper rash
Irritant diaper dermatitis (IDD, also called a diaper/nappy rash) is a generic term applied to skin rash in the diaper nappy area that are caused by various skin disorders and/or irritants.
Generic irritant diaper/nappy dermatitis is characteriz ...
.
Chelated zinc is used in toothpastes and mouthwashes to prevent
bad breath
Bad breath, also known as halitosis, is a symptom in which a noticeably unpleasant breath odour is present. It can result in anxiety among those affected. It is also associated with depression and symptoms of obsessive compulsive disorder.
Th ...
; zinc citrate helps reduce the build-up of
calculus
Calculus, originally called infinitesimal calculus or "the calculus of infinitesimals", is the mathematical study of continuous change, in the same way that geometry is the study of shape, and algebra is the study of generalizations of arithm ...
(tartar).
Zinc pyrithione
Zinc pyrithione (or pyrithione zinc) is a coordination complex of zinc. It has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic d ...
is widely included in shampoos to prevent dandruff.
Topical zinc has also been shown to effectively treat, as well as prolong remission in
genital herpes
Genital herpes is an infection by the herpes simplex virus (HSV) of the genitals. Most people either have no or mild symptoms and thus do not know they are infected. When symptoms do occur, they typically include small blisters that break open ...
.
Biological role
Zinc is an essential
trace element
__NOTOC__
A trace element, also called minor element, is a chemical element whose concentration (or other measure of amount) is very low (a "trace amount"). They are classified into two groups: essential and non-essential. Essential trace elements ...
for humans
and other animals,
for plants
and for
microorganism
A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in olde ...
s.
[Zinc's role in microorganisms is particularly reviewed in: ] Zinc is required for the function of over 300
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
s and 1000
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
s,
and is stored and transferred in
metallothionein
Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 500 to 14000 Da) proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological (such as zinc, copp ...
s.
It is the second most abundant trace metal in humans after iron and it is the only metal which appears in all
enzyme classes.
In proteins, zinc ions are often coordinated to the amino acid side chains of
aspartic acid,
glutamic acid,
cysteine and
histidine
Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH3+ form under biological conditions), a carboxylic acid group (which is in the d ...
. The theoretical and computational description of this zinc binding in proteins (as well as that of other transition metals) is difficult.
Roughly grams of zinc
are distributed throughout the human body. Most zinc is in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and parts of the eye.
Semen
Semen, also known as seminal fluid, is an organic bodily fluid created to contain spermatozoa. It is secreted by the gonads (sexual glands) and other sexual organs of male or hermaphroditic animals and can fertilize the female ovum. Sem ...
is particularly rich in zinc, a key factor in
prostate gland
The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation. It is found only in some mammals. It differs between species anatomically, chemically, and physio ...
function and
reproductive organ growth.
Zinc homeostasis of the body is mainly controlled by the intestine. Here,
ZIP4 and especially
TRPM7
Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.
Function
TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ...
were linked to intestinal zinc uptake essential for postnatal survival.
In humans, the biological roles of zinc are ubiquitous.
It interacts with "a wide range of organic
ligand
In coordination chemistry, a ligand is an ion or molecule ( functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's elec ...
s",
and has roles in the metabolism of RNA and DNA,
signal transduction, and
gene expression. It also regulates
apoptosis. A review from 2015 indicated that about 10% of human proteins (~3000) bind zinc,
in addition to hundreds more that transport and traffic zinc; a similar ''
in silico'' study in the plant ''
Arabidopsis thaliana'' found 2367 zinc-related proteins.
In the
brain
A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a ve ...
, zinc is stored in specific
synaptic vesicles
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse. The release is regulated by a voltage-dependent calcium channel. Vesicles are essential for propagating nerve impulse ...
by
glutamatergic
Glutamatergic means "related to glutamate". A glutamatergic agent (or drug) is a chemical that directly modulates the excitatory amino acid (glutamate/aspartate) system in the body or brain. Examples include excitatory amino acid receptor agonis ...
neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. ...
s and can modulate neuronal excitability.
It plays a key role in
synaptic plasticity
In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Since memories are postulated to be represented by vastly interconnected neural circuits ...
and so in learning.
Zinc
homeostasis
In biology, homeostasis (British also homoeostasis) (/hɒmɪə(ʊ)ˈsteɪsɪs/) is the state of steady internal, physical, and chemical conditions maintained by living systems. This is the condition of optimal functioning for the organism and ...
also plays a critical role in the functional regulation of the
central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...
.
Dysregulation of zinc homeostasis in the central nervous system that results in excessive synaptic zinc concentrations is believed to induce
neurotoxicity
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. It occurs when exposure to a substance – specificall ...
through mitochondrial oxidative stress (e.g., by disrupting certain enzymes involved in the
electron transport chain, including
complex I
Respiratory complex I, (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complex I) is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the ...
,
complex III
Complex commonly refers to:
* Complexity, the behaviour of a system whose components interact in multiple ways so possible interactions are difficult to describe
** Complex system, a system composed of many components which may interact with each ...
, and
α-ketoglutarate dehydrogenase), the dysregulation of calcium homeostasis, glutamatergic neuronal
excitotoxicity
In excitotoxicity, nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters such as glutamate become pathologically high, resulting in excessive stimulation of receptors. For example, when glutamate ...
, and interference with intraneuronal
signal transduction.
L- and D-histidine facilitate brain zinc uptake.
SLC30A3
Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the ''SLC30A3'' gene.
The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulat ...
is the primary
zinc transporter Zinc transporter proteins (Zrt), or simply zinc transporters, are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations. They include two ...
involved in cerebral zinc homeostasis.
Enzymes
![Carbonic anhydrase](https://upload.wikimedia.org/wikipedia/commons/4/40/Carbonic_anhydrase.png)
Zinc is an efficient
Lewis acid, making it a useful catalytic agent in
hydroxylation and other enzymatic reactions.
The metal also has a flexible
coordination geometry
The term coordination geometry is used in a number of related fields of chemistry and solid state chemistry/physics.
Molecules
The coordination geometry of an atom is the geometrical pattern formed by atoms around the central atom.
Inorganic coo ...
, which allows proteins using it to rapidly shift
conformations to perform biological reactions. Two examples of zinc-containing enzymes are
carbonic anhydrase and
carboxypeptidase
A carboxypeptidase ( EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds ...
, which are vital to the processes of
carbon dioxide
Carbon dioxide ( chemical formula ) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in the gas state at room temperature. In the air, carbon dioxide is trans ...
() regulation and digestion of proteins, respectively.
In vertebrate blood, carbonic anhydrase converts into bicarbonate and the same enzyme transforms the bicarbonate back into for exhalation through the lungs. Without this enzyme, this conversion would occur about one million times slower
at the normal blood
pH of 7 or would require a pH of 10 or more.
The non-related β-carbonic anhydrase is required in plants for leaf formation, the synthesis of
indole acetic acid
Indole-3-acetic acid (IAA, 3-IAA) is the most common naturally occurring plant hormone of the auxin class. It is the best known of the auxins, and has been the subject of extensive studies by plant physiologists. IAA is a derivative of indole, con ...
(auxin) and
alcoholic fermentation
Ethanol fermentation, also called alcoholic fermentation, is a biological process which converts sugars such as glucose, fructose, and sucrose into cellular energy, producing ethanol and carbon dioxide as by-products. Because yeasts perform this ...
.
Carboxypeptidase cleaves peptide linkages during digestion of proteins. A
coordinate covalent bond is formed between the terminal peptide and a C=O group attached to zinc, which gives the carbon a positive charge. This helps to create a
hydrophobic
In chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe). In contrast, hydrophiles are attracted to water.
Hydrophobic molecules tend to be nonpolar and, t ...
pocket on the enzyme near the zinc, which attracts the non-polar part of the protein being digested.
Signalling
Zinc has been recognized as a messenger, able to activate signalling pathways. Many of these pathways provide the driving force in aberrant cancer growth. They can be targeted through
ZIP transporters.
Other proteins
Zinc serves a purely structural role in
zinc finger
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized struct ...
s, twists and clusters.
Zinc fingers form parts of some
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
s, which are proteins that recognize
DNA base sequences during the replication and transcription of
DNA. Each of the nine or ten ions in a zinc finger helps maintain the finger's structure by coordinately binding to four
amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha a ...
s in the transcription factor.
In
blood plasma
Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but contains proteins and other constituents of whole blood in suspension. It makes up about 55% of the body's total blood volume. It is the intr ...
, zinc is bound to and transported by
albumin
Albumin is a family of globular proteins, the most common of which are the serum albumins. All the proteins of the albumin family are water-soluble, moderately soluble in concentrated salt solutions, and experience heat denaturation. Albumins ...
(60%, low-affinity) and
transferrin
Transferrins are glycoproteins found in vertebrates which bind to and consequently mediate the transport of iron (Fe) through blood plasma. They are produced in the liver and contain binding sites for two Fe3+ ions. Human transferrin is encode ...
(10%).
Because transferrin also transports iron, excessive iron reduces zinc absorption, and vice versa. A similar antagonism exists with copper.
The concentration of zinc in blood plasma stays relatively constant regardless of zinc intake.
Cells in the salivary gland, prostate, immune system, and intestine use
zinc signaling to communicate with other cells.
Zinc may be held in
metallothionein
Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 500 to 14000 Da) proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological (such as zinc, copp ...
reserves within microorganisms or in the intestines or liver of animals.
Metallothionein in intestinal cells is capable of adjusting absorption of zinc by 15–40%.
However, inadequate or excessive zinc intake can be harmful; excess zinc particularly impairs copper absorption because metallothionein absorbs both metals.
The human
dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dop ...
contains a
high affinity extracellular zinc
binding site
In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the macromolecule is often referred to as a ligand. Ligands may includ ...
which, upon zinc binding, inhibits dopamine
reuptake
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the Synapse, pre-synaptic neuron at a synapse) or glial cell after it has performed its function of ...
and amplifies
amphetamine-induced
dopamine efflux ''
in vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology ...
''.
The human
serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein tha ...
and
norepinephrine transporter
The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.
NET is a monoamine transporter and is responsible for the sodium- ...
do not contain zinc binding sites.
Some
EF-hand
The EF hand is a helix–loop–helix structural domain or ''motif'' found in a large family of calcium-binding proteins.
The EF-hand motif contains a helix–loop–helix topology, much like the spread thumb and forefinger of the human hand, in ...
calcium binding proteins such as
S100 or
NCS-1
Neuronal calcium sensor-1 (NCS-1) also known as frequenin homolog (Drosophila) (freq) is a protein that is encoded by the ''FREQ'' gene in humans. NCS-1 is a member of the neuronal calcium sensor family, a class of EF hand containing calcium-my ...
are also able to bind zinc ions.
Nutrition
Dietary recommendations
The
U.S. Institute of Medicine (IOM) updated Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for zinc in 2001. The current EARs for zinc for women and men ages 14 and up is 6.8 and 9.4 mg/day, respectively. The RDAs are 8 and 11 mg/day. RDAs are higher than EARs so as to identify amounts that will cover people with higher than average requirements. RDA for pregnancy is 11 mg/day. RDA for lactation is 12 mg/day. For infants up to 12 months the RDA is 3 mg/day. For children ages 1–13 years the RDA increases with age from 3 to 8 mg/day. As for safety, the IOM sets
Tolerable upper intake level
The Dietary Reference Intake (DRI) is a system of nutrition recommendations from the National Academy of Medicine (NAM) of the National Academies (United States). It was introduced in 1997 in order to broaden the existing guidelines known as Re ...
s (ULs) for vitamins and minerals when evidence is sufficient. In the case of zinc the adult UL is 40 mg/day (lower for children). Collectively the EARs, RDAs, AIs and ULs are referred to as
Dietary Reference Intake
The Dietary Reference Intake (DRI) is a system of nutrition recommendations from the National Academy of Medicine (NAM) of the National Academies (United States). It was introduced in 1997 in order to broaden the existing guidelines known as Re ...
s (DRIs).
The
European Food Safety Authority
The European Food Safety Authority (EFSA) is the agency of the European Union (EU) that provides independent scientific advice and communicates on existing and emerging risks associated with the food chain. EFSA was established in February 2002, ...
(EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined the same as in the United States. For people ages 18 and older the PRI calculations are complex, as the EFSA has set higher and higher values as the
phytate
Phytic acid is a six-fold dihydrogenphosphate ester of inositol (specifically, of the ''myo'' isomer), also called inositol hexakisphosphate (IP6) or inositol polyphosphate. At physiological pH, the phosphates are partially ionized, resulting in ...
content of the diet increases. For women, PRIs increase from 7.5 to 12.7 mg/day as phytate intake increases from 300 to 1200 mg/day; for men the range is 9.4 to 16.3 mg/day. These PRIs are higher than the U.S. RDAs.
The EFSA reviewed the same safety question and set its UL at 25 mg/day, which is much lower than the U.S. value.
For U.S. food and dietary supplement labeling purposes the amount in a serving is expressed as a percent of Daily Value (%DV). For zinc labeling purposes 100% of the Daily Value was 15 mg, but on May 27, 2016, it was revised to 11 mg.
A table of the old and new adult daily values is provided at
Reference Daily Intake
The Reference Daily Intake (RDI) used in nutrition labeling on food and dietary supplement products in the U.S. and Canada is the daily intake level of a nutrient that is considered to be sufficient to meet the requirements of 97–98% of healt ...
.
Dietary intake
![Foodstuff-containing-Zinc](https://upload.wikimedia.org/wikipedia/commons/1/19/Foodstuff-containing-Zinc.jpg)
Animal products such as meat, fish, shellfish, fowl, eggs, and dairy contain zinc. The concentration of zinc in plants varies with the level in the soil. With adequate zinc in the soil, the food plants that contain the most zinc are wheat (germ and bran) and various seeds, including
sesame,
poppy
A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae. Poppies are herbaceous plants, often grown for their colourful flowers. One species of poppy, '' Papaver somniferum'', is the source of the narcotic drug o ...
,
alfalfa,
celery
Celery (''Apium graveolens'') is a marshland plant in the family Apiaceae that has been cultivated as a vegetable since antiquity. Celery has a long fibrous stalk tapering into leaves. Depending on location and cultivar, either its stalks, ...
, and
mustard
Mustard may refer to:
Food and plants
* Mustard (condiment), a paste or sauce made from mustard seeds used as a condiment
* Mustard plant, one of several plants, having seeds that are used for the condiment
** Mustard seed, seeds of the mustard p ...
.
Zinc is also found in
beans,
nuts,
almonds,
whole grain
A whole grain is a grain of any cereal and pseudocereal that contains the endosperm, germ, and bran, in contrast to refined grains, which retain only the endosperm.
As part of a general healthy diet, consumption of whole grains is associated ...
s,
pumpkin seed
A pumpkin seed, also known in North America as a pepita (from the Mexican es, pepita de calabaza, "little seed of squash"), is the edible seed of a pumpkin or certain other cultivars of squash. The seeds are typically flat and asymmetrically ...
s,
sunflower seeds, and
blackcurrant.
Other sources include
fortified food
Food fortification or enrichment is the process of adding micronutrients (essential trace elements and vitamins) to food. It can be carried out by food manufacturers, or by governments as a public health policy which aims to reduce the number of p ...
and
dietary supplements in various forms. A 1998 review concluded that zinc oxide, one of the most common supplements in the United States, and zinc carbonate are nearly insoluble and poorly absorbed in the body.
This review cited studies that found lower plasma zinc concentrations in the subjects who consumed zinc oxide and zinc carbonate than in those who took zinc acetate and sulfate salts.
For fortification, however, a 2003 review recommended cereals (containing zinc oxide) as a cheap, stable source that is as easily absorbed as the more expensive forms. A 2005 study found that various compounds of zinc, including oxide and sulfate, did not show statistically significant differences in absorption when added as fortificants to maize tortillas.
Deficiency
Nearly two billion people in the developing world are deficient in zinc. Groups at risk include children in developing countries and elderly with chronic illnesses.
In children, it causes an increase in infection and diarrhea and contributes to the death of about 800,000 children worldwide per year.
The World Health Organization advocates zinc supplementation for severe malnutrition and diarrhea.
Zinc supplements help prevent disease and reduce mortality, especially among children with low birth weight or stunted growth.
However, zinc supplements should not be administered alone, because many in the developing world have several deficiencies, and zinc interacts with other micronutrients. While zinc deficiency is usually due to insufficient dietary intake, it can be associated with
malabsorption
Malabsorption is a state arising from abnormality in absorption of food nutrients across the gastrointestinal (GI) tract. Impairment can be of single or multiple nutrients depending on the abnormality. This may lead to malnutrition and a variety ...
,
acrodermatitis enteropathica
Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc through the inner lining of the bowel, the mucous membrane. It is characterized by inflammation of the skin (dermatitis) around bodily openings ...
, chronic liver disease, chronic renal disease,
sickle cell disease
Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red b ...
,
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...
,
malignancy
Malignancy () is the tendency of a medical condition to become progressively worse.
Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not s ...
, and other chronic illnesses.
In the United States, a federal survey of food consumption determined that for women and men over the age of 19, average consumption was 9.7 and 14.2 mg/day, respectively. For women, 17% consumed less than the EAR, for men 11%. The percentages below EAR increased with age. The most recent published update of the survey (NHANES 2013–2014) reported lower averages – 9.3 and 13.2 mg/day – again with intake decreasing with age.
Symptoms of mild zinc deficiency are diverse.
Clinical outcomes include depressed growth, diarrhea, impotence and delayed sexual maturation,
alopecia
Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body. Typically at least the head is involved. The severity of hair loss can vary from a small area to the entire body. Inflammation or scar ...
, eye and skin lesions, impaired appetite, altered cognition, impaired immune functions, defects in carbohydrate utilization, and reproductive
teratogenesis
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology. The related ...
.
Zinc deficiency depresses immunity, but excessive zinc does also.
Despite some concerns,
western vegetarians and vegans do not suffer any more from overt zinc deficiency than meat-eaters. Major plant sources of zinc include cooked dried beans, sea vegetables, fortified cereals, soy foods, nuts, peas, and seeds.
However,
phytates in many whole-grains and fibers may interfere with zinc absorption and marginal zinc intake has poorly understood effects. The zinc
chelator
Chelation is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom. These ligands are ...
phytate
Phytic acid is a six-fold dihydrogenphosphate ester of inositol (specifically, of the ''myo'' isomer), also called inositol hexakisphosphate (IP6) or inositol polyphosphate. At physiological pH, the phosphates are partially ionized, resulting in ...
, found in seeds and
cereal bran
Bran, also known as miller's bran, is the hard outer layers of cereal grain. It consists of the combined aleurone and pericarp. Corn (maize) bran also includes the pedicel (tip cap). Along with germ, it is an integral part of whole grains, ...
, can contribute to zinc malabsorption.
Some evidence suggests that more than the US RDA (8 mg/day for adult women; 11 mg/day for adult men) may be needed in those whose diet is high in phytates, such as some vegetarians.
The
European Food Safety Authority
The European Food Safety Authority (EFSA) is the agency of the European Union (EU) that provides independent scientific advice and communicates on existing and emerging risks associated with the food chain. EFSA was established in February 2002, ...
(EFSA) guidelines attempt to compensate for this by recommending higher zinc intake when dietary phytate intake is greater.
These considerations must be balanced against the paucity of adequate zinc
biomarker
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, p ...
s, and the most widely used indicator, plasma zinc, has poor
sensitivity and specificity
''Sensitivity'' and ''specificity'' mathematically describe the accuracy of a test which reports the presence or absence of a condition. Individuals for which the condition is satisfied are considered "positive" and those for which it is not are ...
.
Soil remediation
Species of ''
Calluna
''Calluna vulgaris'', common heather, ling, or simply heather, is the sole species in the genus ''Calluna'' in the flowering plant family Ericaceae. It is a low-growing evergreen shrub growing to tall, or rarely to and taller, and is found ...
'', ''
Erica
Erica or ERICA may refer to:
* Erica (given name)
* ''Erica'' (plant), a flowering plant genus
* Erica (chatbot), a service of Bank of America
* ''Erica'' (video game), a 2019 FMV video game
* ''Erica'' (spider), a jumping spider genus
* E ...
'' and ''
Vaccinium
''Vaccinium'' is a common and widespread genus of shrubs or dwarf shrubs in the heath family (Ericaceae). The fruits of many species are eaten by humans and some are of commercial importance, including the cranberry, blueberry, bilberry (whort ...
'' can grow in zinc-metalliferous soils, because translocation of toxic ions is prevented by the action of
ericoid mycorrhizal fungi.
Agriculture
Zinc deficiency appears to be the most common micronutrient deficiency in crop plants; it is particularly common in high-pH soils. Zinc-deficient
soil
Soil, also commonly referred to as earth or dirt
Dirt is an unclean matter, especially when in contact with a person's clothes, skin, or possessions. In such cases, they are said to become dirty.
Common types of dirt include:
* Debri ...
is
cultivated in the cropland of about half of Turkey and India, a third of China, and most of Western Australia. Substantial responses to zinc fertilization have been reported in these areas.
Plants that grow in soils that are zinc-deficient are more susceptible to disease. Zinc is added to the soil primarily through the weathering of rocks, but humans have added zinc through fossil fuel combustion, mine waste, phosphate fertilizers, pesticide (
zinc phosphide
Zinc phosphide ( Zn3 P2) is an inorganic chemical compound. It is a grey solid, although commercial samples are often dark or even black. It is used as a rodenticide. Zn3P2 is a II-V semiconductor with a direct band gap of 1.5 eV and may have a ...
), limestone, manure, sewage sludge, and particles from galvanized surfaces. Excess zinc is toxic to plants, although zinc toxicity is far less widespread.
Precautions
Toxicity
Although zinc is an essential requirement for good health, excess zinc can be harmful. Excessive absorption of zinc suppresses copper and iron absorption.
The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model is well-established in the literature, and shows that just
micromolar
Molar concentration (also called molarity, amount concentration or substance concentration) is a measure of the concentration of a chemical species, in particular of a solute in a solution, in terms of amount of substance per unit volume of sol ...
amounts of the free ion kills some organisms. A recent example showed 6 micromolar killing 93% of all ''
Daphnia
''Daphnia'' is a genus of small planktonic crustaceans, in length. ''Daphnia'' are members of the order Anomopoda, and are one of the several small aquatic crustaceans commonly called water fleas because their saltatory swimming style resembl ...
'' in water.
The free zinc ion is a powerful
Lewis acid up to the point of being
corrosive
A corrosive substance is one that will damage or destroy other substances with which it comes into contact by means of a chemical reaction.
Etymology
The word ''corrosive'' is derived from the Latin verb ''corrodere'', which means ''to gnaw'', ...
. Stomach acid contains
hydrochloric acid
Hydrochloric acid, also known as muriatic acid, is an aqueous solution of hydrogen chloride. It is a colorless solution with a distinctive pungent smell. It is classified as a strong acid
Acid strength is the tendency of an acid, symbol ...
, in which metallic zinc dissolves readily to give corrosive zinc chloride. Swallowing a post-1982 American one
cent piece (97.5% zinc) can cause damage to the stomach lining through the high solubility of the zinc ion in the acidic stomach.
Evidence shows that people taking 100–300 mg of zinc daily may suffer induced
copper deficiency
Copper deficiency, or hypocupremia, is defined either as insufficient copper to meet the needs of the body, or as a serum copper level below the normal range. Symptoms may include fatigue, decreased red blood cells, early greying of the hair, an ...
. A 2007 trial observed that elderly men taking 80 mg daily were hospitalized for urinary complications more often than those taking a placebo. Levels of 100–300 mg may interfere with the utilization of copper and iron or adversely affect cholesterol.
Zinc in excess of 500 ppm in soil interferes with the plant absorption of other essential metals, such as iron and manganese.
A condition called the
zinc shakes or "zinc chills" can be induced by inhalation of zinc fumes while
brazing
Brazing is a metal-joining process in which two or more metal items are joined together by melting and flowing a filler metal into the joint, with the filler metal having a lower melting point than the adjoining metal.
Brazing differs from we ...
or welding galvanized materials.
Zinc is a common ingredient of
denture
Dentures (also known as false teeth) are prosthetic devices constructed to replace missing teeth, and are supported by the surrounding soft and hard tissues of the oral cavity. Conventional dentures are removable ( removable partial denture or ...
cream which may contain between 17 and 38 mg of zinc per gram. Disability and even deaths from excessive use of these products have been claimed.
The U.S.
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respon ...
(FDA) states that zinc damages nerve receptors in the nose, causing
anosmia
Anosmia, also known as smell blindness, is the loss of the ability to detect one or more smells. Anosmia may be temporary or permanent. It differs from hyposmia, which is a decreased sensitivity to some or all smells.
Anosmia can be due to a nu ...
. Reports of anosmia were also observed in the 1930s when zinc preparations were used in a failed attempt to prevent
polio
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe s ...
infections. On June 16, 2009, the FDA ordered removal of zinc-based intranasal cold products from store shelves. The FDA said the loss of smell can be life-threatening because people with impaired smell cannot detect leaking gas or smoke, and cannot tell if food has spoiled before they eat it.
Recent research suggests that the topical antimicrobial zinc pyrithione is a potent
heat shock
The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused by stressors such as increased temperatures, oxidative stress, and heavy metals. In a normal ...
response inducer that may impair genomic integrity with induction of
PARP-dependent energy crisis in cultured human
keratinocyte
Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells.
Basal cells in the basal layer (''stratum basale'') of the skin are sometimes referre ...
s and
melanocytes.
Poisoning
In 1982, the
US Mint began minting
pennies
A penny is a coin ( pennies) or a unit of currency (pl. pence) in various countries. Borrowed from the Carolingian denarius (hence its former abbreviation d.), it is usually the smallest denomination within a currency system. Presently, it is t ...
coated in copper but containing primarily zinc. Zinc pennies pose a risk of zinc toxicosis, which can be fatal. One reported case of chronic ingestion of 425 pennies (over 1 kg of zinc) resulted in death due to gastrointestinal bacterial and fungal
sepsis
Sepsis, formerly known as septicemia (septicaemia in British English) or blood poisoning, is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage is follo ...
. Another patient who ingested 12 grams of zinc showed only
lethargy
Lethargy is a state of tiredness, sleepiness, weariness, fatigue, sluggishness or lack of energy. It can be accompanied by depression, decreased motivation, or apathy. Lethargy can be a normal response to inadequate sleep, overexertion, overwo ...
and
ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements. Ataxia is a clinical manifestation indicating dysfunction of ...
(gross lack of coordination of muscle movements). Several other cases have been reported of humans suffering zinc intoxication by the ingestion of zinc coins.
Pennies and other small coins are sometimes ingested by dogs, requiring veterinary removal of the foreign objects. The zinc content of some coins can cause zinc toxicity, commonly fatal in dogs through severe
hemolytic anemia
Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). This most commonly ...
and liver or kidney damage; vomiting and diarrhea are possible symptoms. Zinc is highly toxic in
parrots
Parrots, also known as psittacines (), are birds of the roughly 398 species in 92 genera comprising the order Psittaciformes (), found mostly in tropical and subtropical regions. The order is subdivided into three superfamilies: the Psittacoide ...
and poisoning can often be fatal.
The consumption of fruit juices stored in galvanized cans has resulted in mass parrot poisonings with zinc.
See also
*
List of countries by zinc production
This is a list of countries by zinc production in 2019 based on United States Geological Survey numbers.
References
{{Industry country lists
Zinc
Production
Production may refer to:
Economics and business
* Production (economics)
* Prod ...
*
Spelter
Spelter is a zinc–lead alloy that ages to resemble bronze, but is softer and has a lower melting point. The name can also refer to a copper–zinc alloy (a brass) used for brazing, or to pure zinc.
Etymology
In his etymology of the English ...
*
Wet storage stain
Wet storage stain, more commonly known as white rust or white corrosion, is a type of zinc corrosion. It is called wet storage stain because it occurs when a fresh zinc surface is stored in a wet environment with limited oxygen and carbon dioxide ...
*
Zinc alloy electroplating
Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodic ...
*
Metal fume fever
Metal fume fever, also known as brass founders' ague, brass shakes, zinc shakes, galvie flu, galvo poisoning, metal dust fever, welding shivers, or Monday morning fever, is an illness primarily caused by exposure to chemicals such as zinc oxide (Zn ...
*
Piotr Steinkeller
Notes
Citations
Bibliography
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External links
Zinc Fact Sheet
from the U.S. National Institutes of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...
History & Etymology of Zinc
Reducing Agents > Zinc
American Zinc Association
Information about the uses and properties of zinc.
ISZB
International Society for Zinc Biology, founded in 2008. An international, nonprofit organization bringing together scientists working on the biological actions of zinc.
Zinc-UK
Founded in 2010 to bring together scientists in the United Kingdom working on zinc.
at ''The Periodic Table of Videos
''Periodic Videos'' (also known as ''The Periodic Table of Videos'') is a video project and YouTube channel on chemistry. It consists of a series of videos about chemical elements and the periodic table, with additional videos on other topics i ...
'' (University of Nottingham)
ZincBind
– a database of biological zinc binding sites.
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Chemical elements
Dietary minerals
Transition metals
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Chemical elements with hexagonal close-packed structure
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