The Fibronectin type III domain is an evolutionarily conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of ...

that is widely found in animal proteins. The

fibronectin Fibronectin is a high- molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collage ...

protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha a ...

s long and possesses a

beta sandwich Beta-sandwich, β-sandwich domains consisting of 80 to 350 amino acids occur commonly in proteins. They are characterized by two opposing antiparallel beta sheets (β-sheets). The number of strands found in such domains may differ from one protei ...

structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.

Human proteins containing this domain

ABI3BP; ANKFN1; ASTN2; AXL; BOC; BZRAP1; C20orf75;

CDON Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the ''CDON'' gene. CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III ( FNIII) repeat family involved in my ...

; CHL1; CMYA5; CNTFR;

CNTN1 Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the ''CNTN1'' gene. Function The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuron ...

; CNTN2;

CNTN3 Contactin-3 is a protein that in humans is encoded by the ''CNTN3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ...

; CNTN4; CNTN5;

CNTN6 Contactin 6 is a protein in humans that is encoded by the CNTN6 gene. The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol Glycosylphosphatidylinositol (), or glycophosphatidylino ...

;

COL12A1 Collagen alpha-1(XII) chain is a protein that in humans is encoded by the ''COL12A1'' gene. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen famil ...

; COL14A1;

COL20A1 COL20A1 is a collagen Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up fro ...

;

COL7A1 Collagen alpha-1(VII) chain is a protein that in humans is encoded by the ''COL7A1'' gene. It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epide ...

; CRLF1; CRLF3;

CSF2RB CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors: * GM-CSF receptor * IL-3 receptor *IL-5 receptor The interleukin-5 receptor is a type I cytokine receptor. It is a heter ...

; CSF3R; DCC; DSCAM; DSCAML1;

EBI3 Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the ''EBI3'' gene. Function This gene was identified by the induction of its expression in B lymphocytes by Epst ...

;

EGFLAM Pikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is encoded by the ''EGFLAM'' gene. Pikachurin is a dystroglycan-interacting protein ...

;

EPHA1 EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the ''EPHA1'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated ...

; EPHA10;

EPHA2 EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the ''EPHA2'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein- tyrosine kinase family. EPH and EPH-related receptors have be ...

;

EPHA3 EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the ''EPHA3'' gene. Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been ...

;

EPHA4 EPH receptor A4 (ephrin type-A receptor 4) is a protein that in humans is encoded by the ''EPHA4'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated ...

;

EPHA5 EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the ''EPHA5'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicate ...

;

EPHA6 Ephrin type-A receptor 6 is a protein that in humans is encoded by the ''EPHA6'' gene. EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer Breast ...

;

EPHA7 Ephrin type-A receptor 7 is a protein that in humans is encoded by the ''EPHA7'' gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating devel ...

; EPHA8;

EPHB1 Ephrin type-B receptor 1 is a protein that in humans is encoded by the ''EPHB1'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their struct ...

;

EPHB2 Ephrin type-B receptor 2 is a protein that in humans is encoded by the ''EPHB2'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their stru ...

;

EPHB3 Ephrin type-B receptor 3 is a protein that in humans is encoded by the ''EPHB3'' gene. Function Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their struct ...

;

EPHB4 Ephrin type-B receptor 4 is a protein that in humans is encoded by the ''EPHB4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ...

;

EPHB6 Ephrin type-B receptor 6 is a protein that in humans is encoded by the ''EPHB6'' gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and s ...

; EPOR; FANK1; FLRT1; FLRT2;

FLRT3 Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the ''FLRT3'' gene. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhe ...

; FN1; FNDC1; FNDC3A; FNDC3B; FNDC4; FNDC5; FNDC7; FNDC8; FSD1; FSD1L; FSD2; GHR;

HCFC1 Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein, is a protein that in humans is encoded by the ''HCFC1'' gene. Structure HCF1 is a member of the highly conserved host cell factor family and encodes a protein wi ...

; HCFC2;

HUGO Hugo or HUGO may refer to: Arts and entertainment * ''Hugo'' (film), a 2011 film directed by Martin Scorsese * Hugo Award, a science fiction and fantasy award named after Hugo Gernsback * Hugo (franchise), a children's media franchise based on ...

; IFNGR2;

IGF1R The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 ( IGF-1) and by a related hormone called IGF-2. ...

; IGSF22; IGSF9; IGSF9B;

IL4R The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene. Function This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regu ...

; IL11RA;

IL12B Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein that in humans is encoded by the IL12B gene. IL-12B is a common ...

; IL12RB1; IL12RB2; IL20RB;

IL23R The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the ''IL23R'' gene. In complex with the interleukin-12 receptor β1 subunit ( IL-12Rβ1), it is activated by the cytokine interleukin 23 (IL-23). The ''IL23R'' mR ...

; IL27RA;

IL31RA Interleukin-31 receptor A is a protein that in humans is encoded by the ''IL31RA'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' ...

; IL6R; IL6ST; IL7R;

INSR The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose ho ...

; INSRR;

ITGB4 Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Function Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Di ...

;

KAL1 Anosmin-1 is a secreted, EM associated glycoprotein found in humans and other organisms responsible for normal development, which is expressed in the brain, spinal cord and kidney. Absence or damage to the protein results in Kallmann syndrome in ...

;

KALRN Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the ''KALRN'' gene. Kaliri ...

;

L1CAM L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, of 200-220 kDa, is a neuronal cell adhesion molecule with a strong implication in cell migration, adhesion, neurite outg ...

;

LEPR Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, a protein that in humans is encoded by the ''LEPR'' gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 ...

; LIFR; LRFN2; LRFN3; LRFN4; LRFN5; LRIT1; LRRN1; LRRN3;

MERTK Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the ''MERTK'' gene. Function This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin ...

; MID1; MID2; MPL;

MYBPC1 Myosin-binding protein C, slow-type is a protein that in humans is encoded by the ''MYBPC1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gene ...

;

MYBPC2 Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene. Function This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of ...

; MYBPC3; MYBPH; MYBPHL;

MYLK Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the ''MYLK'' gene. Function This gene, a muscle member of the immunoglobulin superfamily, encodes a myosi ...

;

MYOM1 Myomesin-1 is a protein that in humans is encoded by the ''MYOM1'' gene. Myomesin-1 is expressed in muscle cells and functions to stabilize the three-dimensional conformation of the thick filament. Embryonic forms of Myomesin-1 have been detected ...

;

MYOM2 Myomesin-2, also known as M-protein is a protein that in humans is encoded by the ''MYOM2'' gene. M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins com ...

; MYOM3;

NCAM1 Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discov ...

; NCAM2;

NEO1 Neogenin is a protein that in humans is encoded by the ''NEO1'' gene. Interactions NEO1 has been shown to interact with PTK2 PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is ...

; NFASC; NOPE; NPHS1; NRCAM;

OBSCN Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene. Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in ...

;

OBSL1 Obscurin-like protein 1 is a protein that in humans is encoded by the ''OBSL1'' gene. References Further reading * * * * * * * External links GeneReviews/NIH/NCBI/UW entry on 3-M syndrome OMIM entries on 3-M syndromePDBe-KB
provides an ...

; OSMR; PHYHIP; PHYHIPL; PRLR; PRODH2;

PTPRB Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the ''PTPRB'' gene. Function VE-PTP is a member of the classical protein tyrosine phosphatase (PTP ...

;

PTPRC Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the ''PTPRC'' gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocy ...

;

PTPRD Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the ''PTPRD'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signa ...

;

PTPRF Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the ''PTPRF'' gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that ...

; PTPRG; PTPRH;

PTPRJ Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the ''PTPRJ'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ...

;

PTPRK Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the ''PTPRK'' gene. PTPRK is also known as PTPkappa and PTPκ. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase ( ...

;

PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the ''PTPRM'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases a ...

;

PTPRO Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the ''PTPRO'' gene. This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic sign ...

;

PTPRS Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the ''PTPRS'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphata ...

;

PTPRT Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the ''PTPRT'' gene. PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome that ...

;

PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the ''PTPRU'' gene. Function The protein encoded by this gene is a member of the protein t ...

; PTPRZ1; PTPsigma; PUNC; RIMBP2;

ROBO1 Roundabout homolog 1 is a protein that in humans is encoded by the ''ROBO1'' gene. Function Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project t ...

; ROBO2; ROBO3; ROBO4;

ROS1 Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ''ROS1'' gene. Function This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase i ...

; SDK1; SDK2; SNED1;

SORL1 Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene. SORL1 (also known as SORLA, SORLA1, or LR11) is a neuronal apolipoprotein E receptor, the gene for which is predominantly expres ...

; SPEG; TEK;

TIE1 Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the ''TIE1'' gene. Function TIE1 is a cell surface protein expressed exclusively in endothelial cells, ...

; TNC; TNN; TNR; TNXB; TRIM36; TRIM42; TRIM46; TRIM67;

TRIM9 Tripartite motif-containing protein 9 is a protein that in humans is encoded by the ''TRIM9'' gene. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a ...

; TTN;

TYRO3 Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the ''TYRO3'' gene. Interactions TYRO3 has been shown to interact with: * GAS6, and * PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme ...

; UMODL1;

USH2A Usherin is a protein that in humans is encoded by the ''USH2A'' gene. This gene encodes the protein Usherin that contains laminin EGF motifs, a pentraxin domain, and many fibronectin type III motifs. The encoded basement membrane-associated p ...

; VASN; VWA1; dJ34F7.1; fmi;

References

* * * {{refend Protein domains Single-pass transmembrane proteins

Human proteins containing this domain

See also

References