Iodine is a
chemical element
A chemical element is a species of atoms that have a given number of protons in their nuclei, including the pure substance consisting only of that species. Unlike chemical compounds, chemical elements cannot be broken down into simpler sub ...
with the
symbol I and
atomic number
The atomic number or nuclear charge number (symbol ''Z'') of a chemical element is the charge number of an atomic nucleus. For ordinary nuclei, this is equal to the proton number (''n''p) or the number of protons found in the nucleus of every ...
53. The heaviest of the stable
halogens, it exists as a semi-lustrous, non-metallic solid at
standard condition
Standard temperature and pressure (STP) are standard sets of conditions for experimental measurements to be established to allow comparisons to be made between different sets of data. The most used standards are those of the International Union ...
s that melts to form a deep violet liquid at , and boils to a violet gas at . The element was discovered by the French chemist
Bernard Courtois
Bernard Courtois, also spelled Barnard Courtois, (8 February 1777 – 27 September 1838) was a French chemist credited with first isolating iodine.
By 1811 the Napoleonic Wars had made the government-controlled saltpeter business taper off sinc ...
in 1811 and was named two years later by
Joseph Louis Gay-Lussac
Joseph Louis Gay-Lussac (, , ; 6 December 1778 – 9 May 1850) was a French chemist and physicist. He is known mostly for his discovery that water is made of two parts hydrogen and one part oxygen (with Alexander von Humboldt), for two laws ...
, after the
Ancient Greek
Ancient Greek includes the forms of the Greek language used in ancient Greece and the ancient world from around 1500 BC to 300 BC. It is often roughly divided into the following periods: Mycenaean Greek (), Dark Ages (), the Archaic p ...
'violet-coloured'.
Iodine occurs in many oxidation states, including
iodide
An iodide ion is the ion I−. Compounds with iodine in formal oxidation state −1 are called iodides. In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. Worldwide, iodine de ...
(I
−),
iodate
An iodate is the polyatomic anion with the formula . It is the most common form of iodine in nature, as it comprises the major iodine-containing ores. Iodate salts are often colorless. They are the salts of iodic acid.
Structure
Iodate is pyr ...
(), and the various
periodate
Periodate is an anion composed of iodine and oxygen. It is one of a number of oxyanions of iodine and is the highest in the series, with iodine existing in oxidation state +7. Unlike other perhalogenates, such as perchlorate, it can exist in two ...
anions. It is the least abundant of the stable
halogens, being the sixty-first most abundant element. As the heaviest essential
mineral nutrient
In the context of nutrition, a mineral is a chemical element required as an essential nutrient by organisms to perform functions necessary for life. However, the four major structural elements in the human body by weight (oxygen, hydrogen, carbon, ...
, iodine is required for the synthesis of
thyroid hormones.
Iodine deficiency
Iodine deficiency is a lack of the trace element iodine, an essential nutrient in the diet. It may result in metabolic problems such as goiter, sometimes as an endemic goiter as well as congenital iodine deficiency syndrome due to untreated cong ...
affects about two billion people and is the leading preventable cause of
intellectual disabilities
Intellectual disability (ID), also known as general learning disability in the United Kingdom and formerly mental retardation, Rosa's Law, Pub. L. 111-256124 Stat. 2643(2010). is a generalized neurodevelopmental disorder characterized by signif ...
.
The dominant producers of iodine today are
Chile
Chile, officially the Republic of Chile, is a country in the western part of South America. It is the southernmost country in the world, and the closest to Antarctica, occupying a long and narrow strip of land between the Andes to the east a ...
and
Japan. Due to its high atomic number and ease of attachment to
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. T ...
s, it has also found favour as a non-toxic
radiocontrast
Radiocontrast agents are substances used to enhance the visibility of internal structures in X-ray-based imaging techniques such as computed tomography ( contrast CT), projectional radiography, and fluoroscopy. Radiocontrast agents are typically i ...
material. Because of the specificity of its uptake by the human body, radioactive isotopes of iodine can also be used to treat
thyroid cancer
Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck. C ...
. Iodine is also used as a
catalyst
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
in the industrial production of
acetic acid and some
polymer
A polymer (; Greek '' poly-'', "many" + ''-mer'', "part")
is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic a ...
s.
It is on the
World Health Organization's List of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...
.
History
In 1811, iodine was discovered by French chemist
Bernard Courtois
Bernard Courtois, also spelled Barnard Courtois, (8 February 1777 – 27 September 1838) was a French chemist credited with first isolating iodine.
By 1811 the Napoleonic Wars had made the government-controlled saltpeter business taper off sinc ...
,
[ In French, seaweed that had been washed onto the shore was called "varec", "varech", or "vareck", whence the English word "wrack". Later, "varec" also referred to the ashes of such seaweed: the ashes were used as a source of iodine and salts of sodium and potassium.] who was born to a manufacturer of
saltpetre
Potassium nitrate is a chemical compound with the chemical formula . This alkali metal nitrate salt is also known as Indian saltpetre (large deposits of which were historically mined in India). It is an ionic salt of potassium ions K+ and nitra ...
(an essential component of
gunpowder
Gunpowder, also commonly known as black powder to distinguish it from modern smokeless powder, is the earliest known chemical explosive. It consists of a mixture of sulfur, carbon (in the form of charcoal) and potassium nitrate (saltpeter). Th ...
). At the time of the
Napoleonic Wars
The Napoleonic Wars (1803–1815) were a series of major global conflicts pitting the French Empire and its allies, led by Napoleon I, against a fluctuating array of European states formed into various coalitions. It produced a period of Fren ...
, saltpetre was in great demand in
France
France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of overseas regions and territories in the Americas and the Atlantic, Pacific and Indian Oceans. Its metropolitan area ...
. Saltpetre produced from French
nitre bed
Potassium nitrate is a chemical compound with the chemical formula . This alkali metal nitrate salt is also known as Indian saltpetre (large deposits of which were historically mined in India). It is an ionic salt of potassium ions K+ and ni ...
s required
sodium carbonate, which could be isolated from
seaweed collected on the coasts of
Normandy
Normandy (; french: link=no, Normandie ; nrf, Normaundie, Nouormandie ; from Old French , plural of ''Normant'', originally from the word for "northman" in several Scandinavian languages) is a geographical and cultural region in Northwestern ...
and
Brittany
Brittany (; french: link=no, Bretagne ; br, Breizh, or ; Gallo: ''Bertaèyn'' ) is a peninsula, historical country and cultural area in the west of modern France, covering the western part of what was known as Armorica during the period ...
. To isolate the sodium carbonate, seaweed was burned and the ash washed with water. The remaining waste was destroyed by adding
sulfuric acid. Courtois once added excessive sulfuric acid and a cloud of purple vapour rose. He noted that the vapour crystallised on cold surfaces, making dark crystals.
[Greenwood and Earnshaw, p. 794] Courtois suspected that this material was a new element but lacked funding to pursue it further.
Courtois gave samples to his friends,
Charles Bernard Desormes
Charles Bernard Desormes (; 3 June 1777 – 30 August 1862) was a French physicist and chemist. He determined the ratio of the specific heats of gases in 1819. He did this and almost all his scientific work in collaboration with his son-in-law N ...
(1777–1838) and
Nicolas Clément
Nicolas Clément (12 January 1779 – 21 November 1841) was a French physicist and chemist.
He was a colleague of Charles Desormes, with whom he conducted the Clément-Desormes experiment. The two chemists are also credited with determining a ...
(1779–1841), to continue research. He also gave some of the substance to
chemist
A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe t ...
Joseph Louis Gay-Lussac
Joseph Louis Gay-Lussac (, , ; 6 December 1778 – 9 May 1850) was a French chemist and physicist. He is known mostly for his discovery that water is made of two parts hydrogen and one part oxygen (with Alexander von Humboldt), for two laws ...
(1778–1850), and to
physicist
A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe.
Physicists generally are interested in the root or ultimate cau ...
André-Marie Ampère (1775–1836). On 29 November 1813, Desormes and Clément made Courtois' discovery public. They described the substance to a meeting of the Imperial
Institute of France
The (; ) is a French learned society, grouping five , including the Académie Française. It was established in 1795 at the direction of the National Convention. Located on the Quai de Conti in the 6th arrondissement of Paris, the institute m ...
. On 6 December, Gay-Lussac announced that the new substance was either an element or a compound of
oxygen
Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as ...
.
Gay-Lussac suggested the name ''"iode"'', from the
Ancient Greek
Ancient Greek includes the forms of the Greek language used in ancient Greece and the ancient world from around 1500 BC to 300 BC. It is often roughly divided into the following periods: Mycenaean Greek (), Dark Ages (), the Archaic p ...
(, "violet"), because of the colour of iodine vapor.
Ampère had given some of his sample to English chemist
Humphry Davy
Sir Humphry Davy, 1st Baronet, (17 December 177829 May 1829) was a British chemist and inventor who invented the Davy lamp and a very early form of arc lamp. He is also remembered for isolating, by using electricity, several elements for t ...
(1778–1829), who experimented on the substance and noted its similarity to
chlorine
Chlorine is a chemical element with the symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between them. Chlorine i ...
. Davy sent a letter dated 10 December to the
Royal Society of London
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
stating that he had identified a new element. Arguments erupted between Davy and Gay-Lussac over who identified iodine first, but both scientists acknowledged Courtois as the first to isolate the element.
In 1873 the French medical researcher
Casimir Joseph Davaine (1812–1882) discovered the antiseptic action of iodine.
Antonio Grossich (1849–1926), an Istrian-born surgeon, was among the first to use
sterilisation of the operative field. In 1908, he introduced tincture of iodine as a way to rapidly sterilise the human skin in the surgical field.
In early
periodic tables, iodine was often given the symbol ''J'', for ''Jod'', its name in
German
German(s) may refer to:
* Germany (of or related to)
** Germania (historical use)
* Germans, citizens of Germany, people of German ancestry, or native speakers of the German language
** For citizens of Germany, see also German nationality law
**Ge ...
.
Properties
![IodoAtomico](https://upload.wikimedia.org/wikipedia/commons/8/84/IodoAtomico.JPG)
Iodine is the fourth
halogen, being a member of group 17 in the periodic table, below
fluorine,
chlorine
Chlorine is a chemical element with the symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between them. Chlorine i ...
, and
bromine
Bromine is a chemical element with the symbol Br and atomic number 35. It is the third-lightest element in group 17 of the periodic table ( halogens) and is a volatile red-brown liquid at room temperature that evaporates readily to form a simi ...
; it is the heaviest stable member of its group. (The fifth and sixth halogens, the radioactive
astatine
Astatine is a chemical element with the symbol At and atomic number 85. It is the rarest naturally occurring element in the Earth's crust, occurring only as the decay product of various heavier elements. All of astatine's isotopes are short-li ...
and
tennessine
Tennessine is a synthetic chemical element with the symbol Ts and atomic number 117. It is the second-heaviest known element and the penultimate element of the 7th period of the periodic table.
The discovery of tennessine was officially anno ...
, are not well-studied due to their expense and inaccessibility in large quantities, but appear to show various unusual properties for the group due to
relativistic effects
Relativistic quantum chemistry combines relativistic mechanics with quantum chemistry to calculate elemental properties and structure, especially for the heavier elements of the periodic table. A prominent example is an explanation for the color of ...
.) Iodine has an electron configuration of
rd
105s
25p
5, with the seven electrons in the fifth and outermost shell being its
valence electron
In chemistry and physics, a valence electron is an electron in the outer shell associated with an atom, and that can participate in the formation of a chemical bond if the outer shell is not closed. In a single covalent bond, a shared pair form ...
s. Like the other halogens, it is one electron short of a full octet and is hence an oxidising agent, reacting with many elements in order to complete its outer shell, although in keeping with
periodic trend
Periodic trends are specific patterns that are present in the periodic table that illustrate different aspects of a certain element. They were discovered by the Russian chemist Dmitri Mendeleev in the year 1863. Major periodic trends include ato ...
s, it is the weakest oxidising agent among the stable halogens: it has the lowest
electronegativity
Electronegativity, symbolized as , is the tendency for an atom of a given chemical element to attract shared electrons (or electron density) when forming a chemical bond. An atom's electronegativity is affected by both its atomic number and the ...
among them, just 2.66 on the Pauling scale (compare fluorine, chlorine, and bromine at 3.98, 3.16, and 2.96 respectively; astatine continues the trend with an electronegativity of 2.2). Elemental iodine hence forms
diatomic molecule
Diatomic molecules () are molecules composed of only two atoms, of the same or different chemical elements. If a diatomic molecule consists of two atoms of the same element, such as hydrogen () or oxygen (), then it is said to be homonuclear. O ...
s with chemical formula I
2, where two iodine atoms share a pair of electrons in order to each achieve a stable octet for themselves; at high temperatures, these diatomic molecules reversibly dissociate a pair of iodine atoms. Similarly, the iodide anion, I
−, is the strongest reducing agent among the stable halogens, being the most easily oxidised back to diatomic I
2.
[Greenwood and Earnshaw, pp. 800–4] (Astatine goes further, being indeed unstable as At
− and readily oxidised to At
0 or At
+.)
The halogens darken in colour as the group is descended: fluorine is a very pale yellow, chlorine is greenish-yellow, bromine is reddish-brown, and iodine is violet.
Elemental iodine is slightly soluble in water, with one gram dissolving in 3450 ml at 20 °C and 1280 ml at 50 °C;
potassium iodide
Potassium iodide is a chemical compound, medication, and dietary supplement. It is a medication used for treating hyperthyroidism, in radiation emergencies, and for protecting the thyroid gland when certain types of radiopharmaceuticals are u ...
may be added to increase solubility via formation of
triiodide
In chemistry, triiodide usually refers to the triiodide ion, . This anion, one of the polyhalogen ions, is composed of three iodine atoms. It is formed by combining aqueous solutions of iodide salts and iodine. Some salts of the anion have bee ...
ions, among other polyiodides.
[Greenwood and Earnshaw, pp. 804–9] Nonpolar solvents such as
hexane
Hexane () is an organic compound, a straight-chain alkane with six carbon atoms and has the molecular formula C6H14.
It is a colorless liquid, odorless when pure, and with boiling points approximately . It is widely used as a cheap, relatively ...
and
carbon tetrachloride provide a higher solubility. Polar solutions, such as aqueous solutions, are brown, reflecting the role of these solvents as
Lewis bases; on the other hand, nonpolar solutions are violet, the color of iodine vapour.
Charge-transfer complexes form when iodine is dissolved in polar solvents, hence changing the colour. Iodine is violet when dissolved in carbon tetrachloride and saturated hydrocarbons but deep brown in
alcohols and
amine
In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen
Hydrogen is the chemical element wi ...
s, solvents that form charge-transfer adducts.
![Iodine-triphenylphosphine charge-transfer complex in dichloromethane](https://upload.wikimedia.org/wikipedia/commons/7/7c/Iodine-triphenylphosphine_charge-transfer_complex_in_dichloromethane.jpg)
The melting and boiling points of iodine are the highest among the halogens, conforming to the increasing trend down the group, since iodine has the largest electron cloud among them that is the most easily polarised, resulting in its molecules having the strongest
van der Waals interaction
In molecular physics, the van der Waals force is a distance-dependent interaction between atoms or molecules. Unlike ionic or covalent bonds, these attractions do not result from a chemical electronic bond; they are comparatively weak and the ...
s among the halogens. Similarly, iodine is the least volatile of the halogens, though the solid still can be observed to give off purple vapor.
Due to this property Iodine is commonly used to demonstrate
sublimation directly from
solid
Solid is one of the four fundamental states of matter (the others being liquid, gas, and plasma). The molecules in a solid are closely packed together and contain the least amount of kinetic energy. A solid is characterized by structural ...
to
gas
Gas is one of the four fundamental states of matter (the others being solid, liquid, and plasma).
A pure gas may be made up of individual atoms (e.g. a noble gas like neon), elemental molecules made from one type of atom (e.g. oxygen), or ...
, which gives rise to a misconception that it does not
melt in
atmospheric pressure
Atmospheric pressure, also known as barometric pressure (after the barometer), is the pressure within the atmosphere of Earth. The standard atmosphere (symbol: atm) is a unit of pressure defined as , which is equivalent to 1013.25 millibars, ...
. Because it has the largest
atomic radius
The atomic radius of a chemical element is a measure of the size of its atom, usually the mean or typical distance from the center of the nucleus to the outermost isolated electron. Since the boundary is not a well-defined physical entity, there ...
among the halogens, iodine has the lowest first
ionisation energy
Ionization, or Ionisation is the process by which an atom or a molecule acquires a negative or positive charge by gaining or losing electrons, often in conjunction with other chemical changes. The resulting electrically charged atom or molecule ...
, lowest
electron affinity
The electron affinity (''E''ea) of an atom or molecule is defined as the amount of energy released when an electron attaches to a neutral atom or molecule in the gaseous state to form an anion.
::X(g) + e− → X−(g) + energy
Note that this is ...
, lowest
electronegativity
Electronegativity, symbolized as , is the tendency for an atom of a given chemical element to attract shared electrons (or electron density) when forming a chemical bond. An atom's electronegativity is affected by both its atomic number and the ...
and lowest reactivity of the halogens.
![Iodine-unit-cell-3D-balls-B](https://upload.wikimedia.org/wikipedia/commons/0/0c/Iodine-unit-cell-3D-balls-B.png)
The interhalogen bond in diiodine is the weakest of all the halogens. As such, 1% of a sample of gaseous iodine at atmospheric pressure is dissociated into iodine atoms at 575 °C. Temperatures greater than 750 °C are required for fluorine, chlorine, and bromine to dissociate to a similar extent. Most bonds to iodine are weaker than the analogous bonds to the lighter halogens.
Gaseous iodine is composed of I
2 molecules with an I–I bond length of 266.6 pm. The I–I bond is one of the longest single bonds known. It is even longer (271.5 pm) in solid
orthorhombic crystalline iodine, which has the same crystal structure as chlorine and bromine. (The record is held by iodine's neighbour
xenon
Xenon is a chemical element with the symbol Xe and atomic number 54. It is a dense, colorless, odorless noble gas found in Earth's atmosphere in trace amounts. Although generally unreactive, it can undergo a few chemical reactions such as the ...
: the Xe–Xe bond length is 308.71 pm.) As such, within the iodine molecule, significant electronic interactions occur with the two next-nearest neighbours of each atom, and these interactions give rise, in bulk iodine, to a shiny appearance and
semiconducting
A semiconductor is a material which has an electrical resistivity and conductivity, electrical conductivity value falling between that of a electrical conductor, conductor, such as copper, and an insulator (electricity), insulator, such as glas ...
properties.
Iodine is a two-dimensional semiconductor with a
band gap
In solid-state physics, a band gap, also called an energy gap, is an energy range in a solid where no electronic states can exist. In graphs of the electronic band structure of solids, the band gap generally refers to the energy difference ( ...
of 1.3 eV (125 kJ/mol): it is a semiconductor in the plane of its crystalline layers and an insulator in the perpendicular direction.
Isotopes
Of the thirty-seven known
isotopes of iodine
There are 37 known isotopes of iodine (53I) from 108I to 144I; all undergo radioactive decay except 127I, which is stable. Iodine is thus a monoisotopic element.
Its longest-lived radioactive isotope, 129I, has a half-life of 15.7 million yea ...
, only one occurs in nature, iodine-127. The others are radioactive and have half-lives too short to be
primordial. As such, iodine is both
monoisotopic and
mononuclidic and its atomic weight is known to great precision, as it is a constant of nature.
The longest-lived of the radioactive isotopes of iodine is
iodine-129
Iodine-129 (129I) is a long-lived radioisotope of iodine which occurs naturally, but also is of special interest in the monitoring and effects of man-made nuclear fission products, where it serves as both tracer and potential radiological contamin ...
, which has a half-life of 15.7 million years, decaying via
beta decay
In nuclear physics, beta decay (β-decay) is a type of radioactive decay in which a beta particle (fast energetic electron or positron) is emitted from an atomic nucleus, transforming the original nuclide to an isobar of that nuclide. For ...
to stable
xenon
Xenon is a chemical element with the symbol Xe and atomic number 54. It is a dense, colorless, odorless noble gas found in Earth's atmosphere in trace amounts. Although generally unreactive, it can undergo a few chemical reactions such as the ...
-129.
Some iodine-129 was formed along with iodine-127 before the formation of the Solar System, but it has by now completely decayed away, making it an
extinct radionuclide
An extinct radionuclide is a radionuclide that was formed by nucleosynthesis before the formation of the Solar System, about 4.6 billion years ago, but has since decayed to virtually zero abundance and is no longer detectable as a primordial nuc ...
that is nevertheless still useful in dating the history of the early Solar System or very old groundwaters, due to its mobility in the environment. Its former presence may be determined from an excess of its
daughter
A daughter is a female offspring; a girl or a woman in relation to her parents. Daughterhood is the state of being someone's daughter. The male counterpart is a son. Analogously the name is used in several areas to show relations between group ...
xenon-129. Traces of iodine-129 still exist today, as it is also a
cosmogenic nuclide
Cosmogenic nuclides (or cosmogenic isotopes) are rare nuclides (isotopes) created when a high-energy cosmic ray interacts with the nucleus of an '' in situ'' Solar System atom, causing nucleons (protons and neutrons) to be expelled from the atom ...
, formed from
cosmic ray spallation
Cosmic ray spallation, also known as the x-process, is a set of naturally occurring nuclear reactions causing nucleosynthesis; it refers to the formation of chemical elements from the impact of cosmic rays on an object. Cosmic rays are highly ener ...
of atmospheric xenon: these traces make up 10
−14 to 10
−10 of all terrestrial iodine. It also occurs from open-air nuclear testing, and is not hazardous because of its very long half-life, the longest of all fission products. At the peak of thermonuclear testing in the 1960s and 1970s, iodine-129 still made up only about 10
−7 of all terrestrial iodine.
[SCOPE 50 - Radioecology after Chernobyl]
, the Scientific Committee on Problems of the Environment
The Scientific Committee on Problems of the Environment (SCOPE) was established by the 10th meeting of the Executive Committee of the International Council for Science (ICSU) in 1969. SCOPE's members include 38 national science academies and resear ...
(SCOPE), 1993. See table 1.9 in Section 1.4.5.2. Excited states of iodine-127 and iodine-129 are often used in
Mössbauer spectroscopy
Mössbauer spectroscopy is a spectroscopic technique based on the Mössbauer effect. This effect, discovered by Rudolf Mössbauer (sometimes written "Moessbauer", German: "Mößbauer") in 1958, consists of the nearly recoil-free emission and abs ...
.
The other iodine radioisotopes have much shorter half-lives, no longer than days.
Some of them have medical applications involving the
thyroid gland, where the iodine that enters the body is stored and concentrated.
Iodine-123
Iodine-123 (123I) is a radioactive isotope of iodine used in nuclear medicine imaging, including single-photon emission computed tomography (SPECT) or SPECT/CT exams. The isotope's half-life is 13.2230 hours; the decay by electron capture to tellu ...
has a half-life of thirteen hours and decays by
electron capture
Electron capture (K-electron capture, also K-capture, or L-electron capture, L-capture) is a process in which the proton-rich nucleus of an electrically neutral atom absorbs an inner atomic electron, usually from the K or L electron shells. Thi ...
to
tellurium-123
There are 39 known isotopes and 17 nuclear isomers of tellurium (52Te), with atomic masses that range from 104 to 142. These are listed in the table below.
Naturally-occurring tellurium on Earth consists of eight isotopes. Two of these have been ...
, emitting
gamma radiation; it is used in
nuclear medicine
Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is " radiology done inside out" because it records radiation emi ...
imaging, including
single photon emission computed tomography
Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera (that is, ...
(SPECT) and
X-ray computed tomography
An X-ray, or, much less commonly, X-radiation, is a penetrating form of high-energy electromagnetic radiation. Most X-rays have a wavelength ranging from 10 picometers to 10 nanometers, corresponding to frequencies in the range 30 ...
(X-Ray CT) scans.
Iodine-125 has a half-life of fifty-nine days, decaying by electron capture to
tellurium-125
There are 39 known isotopes and 17 nuclear isomers of tellurium (52Te), with atomic masses that range from 104 to 142. These are listed in the table below.
Naturally-occurring tellurium on Earth consists of eight isotopes. Two of these have been ...
and emitting low-energy gamma radiation; the second-longest-lived iodine radioisotope, it has uses in
biological assay
An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a ...
s,
nuclear medicine
Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is " radiology done inside out" because it records radiation emi ...
imaging and in
radiation therapy
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radi ...
as
brachytherapy
Brachytherapy is a form of radiation therapy where a sealed radiation source is placed inside or next to the area requiring treatment. ''Brachy'' is Greek for short. Brachytherapy is commonly used as an effective treatment for cervical, prost ...
to treat a number of conditions, including
prostate cancer,
uveal melanoma
Uveal melanoma is a type of eye cancer in the uvea of the eye. It is traditionally classed as originating in the iris, choroid, and ciliary body, but can also be divided into class I (low metastatic risk) and class II (high metastatic risk). Sym ...
s, and
brain tumours. Finally,
iodine-131
Iodine-131 (131I, I-131) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley. It has a radioactive decay half-life of about eight days. It is associated with nu ...
, with a half-life of eight days, beta decays to an excited state of stable
xenon-131 that then converts to the ground state by emitting gamma radiation. It is a common
fission product and thus is present in high levels in radioactive
fallout
Nuclear fallout is the residual radioactive material propelled into the upper atmosphere following a nuclear blast, so called because it "falls out" of the sky after the explosion and the shock wave has passed. It commonly refers to the radioac ...
. It may then be absorbed through contaminated food, and will also accumulate in the thyroid. As it decays, it may cause damage to the thyroid. The primary risk from exposure to high levels of iodine-131 is the chance occurrence of
radiogenic
A radiogenic nuclide is a nuclide that is produced by a process of radioactive decay. It may itself be radioactive (a radionuclide) or stable (a stable nuclide).
Radiogenic nuclides (more commonly referred to as radiogenic isotopes) form some ...
thyroid cancer
Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body. Symptoms can include swelling or a lump in the neck. C ...
in later life. Other risks include the possibility of non-cancerous growths and
thyroiditis
Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the neck below the laryngeal prominence, and makes hormones that control metabolism.
Signs and symptoms
There are many different signs and sympto ...
.
The usual means of protection against the negative effects of iodine-131 is by saturating the thyroid gland with stable iodine-127 in the form of
potassium iodide
Potassium iodide is a chemical compound, medication, and dietary supplement. It is a medication used for treating hyperthyroidism, in radiation emergencies, and for protecting the thyroid gland when certain types of radiopharmaceuticals are u ...
tablets, taken daily for optimal prophylaxis. However, iodine-131 may also be used for medicinal purposes in
radiation therapy
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radi ...
for this very reason, when tissue destruction is desired after iodine uptake by the tissue. Iodine-131 is also used as a
radioactive tracer
A radioactive tracer, radiotracer, or radioactive label is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by ...
.
Chemistry and compounds
Iodine is quite reactive, but it is much less reactive than the other halogens. For example, while chlorine gas will halogenate
carbon monoxide
Carbon monoxide (chemical formula CO) is a colorless, poisonous, odorless, tasteless, flammable gas that is slightly less dense than air. Carbon monoxide consists of one carbon atom and one oxygen atom connected by a triple bond. It is the simple ...
,
nitric oxide, and
sulfur dioxide (to
phosgene,
nitrosyl chloride
Nitrosyl chloride is the chemical compound with the formula NOCl. It is a yellow gas that is commonly encountered as a component of aqua regia, a mixture of 3 parts concentrated hydrochloric acid and 1 part of concentrated nitric acid. It is a st ...
, and
sulfuryl chloride
Sulfuryl chloride is an inorganic compound with the formula SO2Cl2. At room temperature, it is a colorless liquid with a pungent odor. Sulfuryl chloride is not found in nature, as can be inferred from its rapid hydrolysis.
Sulfuryl chloride is ...
respectively), iodine will not do so. Furthermore, iodination of metals tends to result in lower oxidation states than chlorination or bromination; for example,
rhenium
Rhenium is a chemical element with the symbol Re and atomic number 75. It is a silvery-gray, heavy, third-row transition metal in group 7 of the periodic table. With an estimated average concentration of 1 part per billion (ppb), rhenium is one ...
metal reacts with chlorine to form
rhenium hexachloride, but with bromine it forms only rhenium pentabromide and iodine can achieve only rhenium tetraiodide.
By the same token, however, since iodine has the lowest ionisation energy among the halogens and is the most easily oxidised of them, it has a more significant cationic chemistry and its higher oxidation states are rather more stable than those of bromine and chlorine, for example in
iodine heptafluoride
Iodine heptafluoride, also known as iodine(VII) fluoride or iodine fluoride, is an interhalogen compound with the chemical formula I F7. It has an unusual pentagonal bipyramidal structure, as predicted by VSEPR theory. The molecule can undergo ...
.
Charge-transfer complexes
The iodine molecule, I
2, dissolves in CCl
4 and aliphatic hydrocarbons to give bright violet solutions. In these solvents the absorption band maximum occurs in the 520 – 540 nm region and is assigned to a
* to ''σ''
* transition. When I
2 reacts with Lewis bases in these solvents a blue shift in I
2 peak is seen and the new peak (230 – 330 nm) arises that is due to the formation of adducts, which are referred to as charge-transfer complexes.
[Greenwood and Earnshaw, pp. 806-7]
Hydrogen iodide
The simplest compound of iodine is
hydrogen iodide, HI. It is a colourless gas that reacts with oxygen to give water and iodine. Although it is useful in
iodination reactions in the laboratory, it does not have large-scale industrial uses, unlike the other hydrogen halides. Commercially, it is usually made by reacting iodine with
hydrogen sulfide or
hydrazine:
[Greenwood and Earnshaw, pp. 809–12]
:2 I
2 + N
2H
4 4 HI + N
2
At room temperature, it is a colourless gas, like all of the hydrogen halides except
hydrogen fluoride, since hydrogen cannot form strong
hydrogen bonds to the large and only mildly electronegative iodine atom. It melts at −51.0 °C and boils at −35.1 °C. It is an
endothermic
In thermochemistry, an endothermic process () is any thermodynamic process with an increase in the enthalpy (or internal energy ) of the system.Oxtoby, D. W; Gillis, H.P., Butler, L. J. (2015).''Principle of Modern Chemistry'', Brooks Cole. ...
compound that can exothermically dissociate at room temperature, although the process is very slow unless a
catalyst
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
is present: the reaction between hydrogen and iodine at room temperature to give hydrogen iodide does not proceed to completion. The H–I
bond dissociation energy
The bond-dissociation energy (BDE, ''D''0, or ''DH°'') is one measure of the strength of a chemical bond . It can be defined as the standard enthalpy change when is cleaved by homolysis to give fragments A and B, which are usually radical ...
is likewise the smallest of the hydrogen halides, at 295 kJ/mol.
[Greenwood and Earnshaw, pp. 812–9]
Aqueous hydrogen iodide is known as
hydroiodic acid
Hydroiodic acid (or hydriodic acid) is an aqueous solution of hydrogen iodide (HI). It is a strong acid, one that is ionized completely in an aqueous solution. It is colorless. Concentrated solutions are usually 48% to 57% HI.
Reactions
Hy ...
, which is a strong acid. Hydrogen iodide is exceptionally soluble in water: one litre of water will dissolve 425 litres of hydrogen iodide, and the saturated solution has only four water molecules per molecule of hydrogen iodide. Commercial so-called "concentrated" hydroiodic acid usually contains 48–57% HI by mass; the solution forms an
azeotrope
An azeotrope () or a constant heating point mixture is a mixture of two or more liquids whose proportions cannot be altered or changed by simple distillation.Moore, Walter J. ''Physical Chemistry'', 3rd e Prentice-Hall 1962, pp. 140–142 This ...
with boiling point 126.7 °C at 56.7 g HI per 100 g solution. Hence hydroiodic acid cannot be concentrated past this point by evaporation of water.
Unlike
hydrogen fluoride, anhydrous liquid hydrogen iodide is difficult to work with as a solvent, because its boiling point is low, it has a small liquid range, its
dielectric constant is low and it does not dissociate appreciably into H
2I
+ and ions – the latter, in any case, are much less stable than the
bifluoride
The bifluoride ion is an inorganic anion with the chemical formula . The anion is colorless. Salts of bifluoride are commonly encountered in the reactions of fluoride salts with hydrofluoric acid. The commercial production of fluorine involves e ...
ions () due to the very weak hydrogen bonding between hydrogen and iodine, though its salts with very large and weakly polarising cations such as
Cs+ and
(R =
Me,
Et,
Bu''n'') may still be isolated. Anhydrous hydrogen iodide is a poor solvent, able to dissolve only small molecular compounds such as
nitrosyl chloride
Nitrosyl chloride is the chemical compound with the formula NOCl. It is a yellow gas that is commonly encountered as a component of aqua regia, a mixture of 3 parts concentrated hydrochloric acid and 1 part of concentrated nitric acid. It is a st ...
and
phenol
Phenol (also called carbolic acid) is an aromatic organic compound with the molecular formula . It is a white crystalline solid that is volatile. The molecule consists of a phenyl group () bonded to a hydroxy group (). Mildly acidic, it ...
, or salts with very low
lattice energies
In chemistry, the lattice energy is the energy change upon formation of one mole of a crystalline ionic compound from its constituent ions, which are assumed to initially be in the gaseous state. It is a measure of the cohesive forces that bin ...
such as tetraalkylammonium halides.
Other binary iodides
Nearly all elements in the periodic table form binary iodides. The exceptions are decidedly in the minority and stem in each case from one of three causes: extreme inertness and reluctance to participate in chemical reactions (the
noble gas
The noble gases (historically also the inert gases; sometimes referred to as aerogens) make up a class of chemical elements with similar properties; under standard conditions, they are all odorless, colorless, monatomic gases with very low ch ...
es); extreme nuclear instability hampering chemical investigation before decay and transmutation (many of the heaviest elements beyond
bismuth
Bismuth is a chemical element with the symbol Bi and atomic number 83. It is a post-transition metal and one of the pnictogens, with chemical properties resembling its lighter group 15 siblings arsenic and antimony. Elemental bismuth occurs ...
); and having an electronegativity higher than iodine's (
oxygen
Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as ...
,
nitrogen
Nitrogen is the chemical element with the symbol N and atomic number 7. Nitrogen is a nonmetal and the lightest member of group 15 of the periodic table, often called the pnictogens. It is a common element in the universe, estimated at se ...
, and the first three halogens), so that the resultant binary compounds are formally not iodides but rather oxides, nitrides, or halides of iodine. (Nonetheless,
nitrogen triiodide is named as an iodide as it is analogous to the other nitrogen trihalides.)
Given the large size of the iodide anion and iodine's weak oxidising power, high oxidation states are difficult to achieve in binary iodides, the maximum known being in the pentaiodides of
niobium,
tantalum
Tantalum is a chemical element with the symbol Ta and atomic number 73. Previously known as ''tantalium'', it is named after Tantalus, a villain in Greek mythology. Tantalum is a very hard, ductile, lustrous, blue-gray transition metal that ...
, and
protactinium
Protactinium (formerly protoactinium) is a chemical element with the symbol Pa and atomic number 91. It is a dense, silvery-gray actinide metal which readily reacts with oxygen, water vapor and inorganic acids. It forms various chemical compounds ...
. Iodides can be made by reaction of an element or its oxide, hydroxide, or carbonate with hydroiodic acid, and then dehydrated by mildly high temperatures combined with either low pressure or anhydrous hydrogen iodide gas. These methods work best when the iodide product is stable to hydrolysis; otherwise, the possibilities include high-temperature oxidative iodination of the element with iodine or hydrogen iodide, high-temperature iodination of a metal oxide or other halide by iodine, a volatile metal halide,
carbon tetraiodide
Carbon tetraiodide is a tetrahalomethane with the molecular formula CI4. Being bright red, it is a relatively rare example of a highly colored methane derivative. It is only 2.3% by weight carbon, although other methane derivatives are known with s ...
, or an organic iodide. For example,
molybdenum(IV) oxide
Molybdenum dioxide is the chemical compound with the chemical formula, formula MoO. It is a violet-colored solid and is a metallic conductor. The mineralogical form of this compound is called tugarinovite, and is only very rarely found.
Structur ...
reacts with
aluminium(III) iodide
Aluminium iodide is a chemical compound containing aluminium and iodine. Invariably, the name refers to a compound of the composition , formed by the reaction of aluminium and iodine or the action of on metal. The hexahydrate is obtained fr ...
at 230 °C to give
molybdenum(II) iodide
Molybdenum is a chemical element with the symbol Mo and atomic number 42 which is located in period 5 and group 6. The name is from Neo-Latin ''molybdaenum'', which is based on Ancient Greek ', meaning lead, since its ores were confused with lea ...
. An example involving halogen exchange is given below, involving the reaction of
tantalum(V) chloride with excess aluminium(III) iodide at 400 °C to give
tantalum(V) iodide
Tantalum(V) iodide is the inorganic compound with the formula Ta2I10. Its name comes from the compound's empirical formula, TaI5. It is a diamagnetic, black solid that hydrolyses readily. The compound adopts an edge-shared bioctahedral structure, ...
:
[Greenwood and Earnshaw, pp. 821–4]
:
3TaCl5 + \underset -> 3TaI5 + 5AlCl3
Lower iodides may be produced either through thermal decomposition or disproportionation, or by reducing the higher iodide with hydrogen or a metal, for example:
:
TaI5 + Ta ->text
Text may refer to:
Written word
* Text (literary theory), any object that can be read, including:
**Religious text, a writing that a religious tradition considers to be sacred
**Text, a verse or passage from scripture used in expository preachin ...
ceTa6I14
Most metal iodides with the metal in low oxidation states (+1 to +3) are ionic. Nonmetals tend to form covalent molecular iodides, as do metals in high oxidation states from +3 and above. Both ionic and covalent iodides are known for metals in oxidation state +3 (e.g.
scandium iodide
Scandium triiodide, also known as scandium iodide, is an inorganic compound with the formula ScI3 and is classified as a lanthanide iodide. This salt is a yellowish powder.Haeberle, N., 1973, Preparation of highly pure lanthanide iodides, Technisc ...
is mostly ionic, but
aluminium iodide
Aluminium iodide is a chemical compound containing aluminium and iodine. Invariably, the name refers to a compound of the composition , formed by the reaction of aluminium and iodine or the action of on metal. The hexahydrate is obtained f ...
is not). Ionic iodides MI
''n'' tend to have the lowest melting and boiling points among the halides MX
''n'' of the same element, because the electrostatic forces of attraction between the cations and anions are weakest for the large iodide anion. In contrast, covalent iodides tend to instead have the highest melting and boiling points among the halides of the same element, since iodine is the most polarisable of the halogens and, having the most electrons among them, can contribute the most to van der Waals forces. Naturally, exceptions abound in intermediate iodides where one trend gives way to the other. Similarly, solubilities in water of predominantly ionic iodides (e.g.
potassium
Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosph ...
and
calcium
Calcium is a chemical element with the symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar t ...
) are the greatest among ionic halides of that element, while those of covalent iodides (e.g.
silver
Silver is a chemical element with the symbol Ag (from the Latin ', derived from the Proto-Indo-European ''h₂erǵ'': "shiny" or "white") and atomic number 47. A soft, white, lustrous transition metal, it exhibits the highest electrical ...
) are the lowest of that element. In particular,
silver iodide is very insoluble in water and its formation is often used as a qualitative test for iodine.
Iodine halides
The halogens form many binary,
diamagnetic
Diamagnetic materials are repelled by a magnetic field; an applied magnetic field creates an induced magnetic field in them in the opposite direction, causing a repulsive force. In contrast, paramagnetic and ferromagnetic materials are attracted ...
interhalogen
In chemistry, an interhalogen compound is a molecule which contains two or more different halogen atoms ( fluorine, chlorine, bromine, iodine, or astatine) and no atoms of elements from any other group.
Most interhalogen compounds known are b ...
compounds with stoichiometries XY, XY
3, XY
5, and XY
7 (where X is heavier than Y), and iodine is no exception. Iodine forms all three possible diatomic interhalogens, a trifluoride and trichloride, as well as a pentafluoride and, exceptionally among the halogens, a heptafluoride. Numerous cationic and anionic derivatives are also characterised, such as the wine-red or bright orange compounds of and the dark brown or purplish black compounds of I
2Cl
+. Apart from these, some
pseudohalides are also known, such as
cyanogen iodide
Cyanogen iodide or iodine cyanide (ICN) is a pseudohalogen composed of iodine and the cyanide group. It is a highly toxic inorganic compound. It occurs as white crystals that react slowly with water to form hydrogen cyanide.
Synthesis
Cyanogen io ...
(ICN), iodine
thiocyanate
Thiocyanate (also known as rhodanide) is the anion . It is the conjugate base of thiocyanic acid. Common derivatives include the colourless salts potassium thiocyanate and sodium thiocyanate. Mercury(II) thiocyanate was formerly used in pyr ...
(ISCN), and iodine
azide (IN
3).
[Greenwood and Earnshaw, pp. 824–8]
Iodine monofluoride
Iodine monofluoride is an interhalogen compound of iodine and fluorine with formula IF. It is a chocolate-brown solid that decomposes at 0 °C, disproportionating to elemental iodine and iodine pentafluoride:
:5 IF → 2 I2 + IF5
However ...
(IF) is unstable at room temperature and disproportionates very readily and irreversibly to iodine and
iodine pentafluoride
Iodine pentafluoride is an interhalogen compound with chemical formula IF5. It is one of the fluorides of iodine. It is a colorless liquid, although impure samples appear yellow. It is used as a fluorination reagent and even a solvent in special ...
, and thus cannot be obtained pure. It can be synthesised from the reaction of iodine with fluorine gas in
trichlorofluoromethane
Trichlorofluoromethane, also called freon-11, CFC-11, or R-11, is a chlorofluorocarbon (CFC). It is a colorless, faintly ethereal, and sweetish-smelling liquid that boils around room temperature. CFC-11 is a Class 1 ozone-depleting substance ...
at −45 °C, with
iodine trifluoride
Iodine trifluoride is an interhalogen compound with the chemical formula IF3. It is a yellow solid which decomposes above −28 °C. It can be synthesised from the elements, but care must be taken to avoid the formation of IF5.
Reactions
F2 ...
in trichlorofluoromethane at −78 °C, or with
silver(I) fluoride
Silver(I) fluoride is the inorganic compound with the formula AgF. It is one of the three main fluorides of silver, the others being silver subfluoride and silver(II) fluoride. AgF has relatively few niche applications; it has been employed as ...
at 0 °C.
Iodine monochloride
Iodine monochloride is an interhalogen compound with the formula . It is a red-brown chemical compound that melts near room temperature. Because of the difference in the electronegativity of iodine and chlorine, this molecule is highly polar an ...
(ICl) and
iodine monobromide
Iodine monobromide is an interhalogen compound with the chemical symbol IBr. It is a dark red solid that melts near room temperature. Like iodine monochloride, IBr is used in some types of iodometry. It serves as a source of I+. Its Lewis acid p ...
(IBr), on the other hand, are moderately stable. The former, a volatile red-brown compound, was discovered independently by
Joseph Louis Gay-Lussac
Joseph Louis Gay-Lussac (, , ; 6 December 1778 – 9 May 1850) was a French chemist and physicist. He is known mostly for his discovery that water is made of two parts hydrogen and one part oxygen (with Alexander von Humboldt), for two laws ...
and
Humphry Davy
Sir Humphry Davy, 1st Baronet, (17 December 177829 May 1829) was a British chemist and inventor who invented the Davy lamp and a very early form of arc lamp. He is also remembered for isolating, by using electricity, several elements for t ...
in 1813–1814 not long after the discoveries of chlorine and iodine, and it mimics the intermediate halogen bromine so well that
Justus von Liebig was misled into mistaking bromine (which he had found) for iodine monochloride. Iodine monochloride and iodine monobromide may be prepared simply by reacting iodine with chlorine or bromine at room temperature and purified by
fractional crystallisation. Both are quite reactive and attack even
platinum
Platinum is a chemical element with the symbol Pt and atomic number 78. It is a dense, malleable, ductile, highly unreactive, precious, silverish-white transition metal. Its name originates from Spanish , a diminutive of "silver".
Pla ...
and
gold
Gold is a chemical element with the symbol Au (from la, aurum) and atomic number 79. This makes it one of the higher atomic number elements that occur naturally. It is a bright, slightly orange-yellow, dense, soft, malleable, and ductile me ...
, though not
boron,
carbon
Carbon () is a chemical element with the symbol C and atomic number 6. It is nonmetallic and tetravalent—its atom making four electrons available to form covalent chemical bonds. It belongs to group 14 of the periodic table. Carbon mak ...
,
cadmium
Cadmium is a chemical element with the symbol Cd and atomic number 48. This soft, silvery-white metal is chemically similar to the two other stable metals in group 12, zinc and mercury. Like zinc, it demonstrates oxidation state +2 in most of ...
,
lead
Lead is a chemical element with the symbol Pb (from the Latin ) and atomic number 82. It is a heavy metal that is denser than most common materials. Lead is soft and malleable, and also has a relatively low melting point. When freshly cu ...
,
zirconium
Zirconium is a chemical element with the symbol Zr and atomic number 40. The name ''zirconium'' is taken from the name of the mineral zircon, the most important source of zirconium. The word is related to Persian '' zargun'' (zircon; ''zar-gun'' ...
,
niobium,
molybdenum, and
tungsten
Tungsten, or wolfram, is a chemical element with the symbol W and atomic number 74. Tungsten is a rare metal found naturally on Earth almost exclusively as compounds with other elements. It was identified as a new element in 1781 and first isol ...
. Their reaction with organic compounds depends on conditions. Iodine chloride vapour tends to chlorinate
phenol
Phenol (also called carbolic acid) is an aromatic organic compound with the molecular formula . It is a white crystalline solid that is volatile. The molecule consists of a phenyl group () bonded to a hydroxy group (). Mildly acidic, it ...
and
salicyclic acid
Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a active metabolite, metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the ...
, since when iodine chloride undergoes homolytic dissociation, chlorine and iodine are produced and the former is more reactive. However, iodine chloride in tetrachloromethane solution results in iodination being the main reaction, since now heterolytic fission of the I–Cl bond occurs and I
+ attacks phenol as an electrophile. However, iodine monobromide tends to brominate phenol even in tetrachloromethane solution because it tends to dissociate into its elements in solution, and bromine is more reactive than iodine.
When liquid, iodine monochloride and iodine monobromide dissociate into and anions (X = Cl, Br); thus they are significant conductors of electricity and can be used as ionising solvents.
Iodine trifluoride
Iodine trifluoride is an interhalogen compound with the chemical formula IF3. It is a yellow solid which decomposes above −28 °C. It can be synthesised from the elements, but care must be taken to avoid the formation of IF5.
Reactions
F2 ...
(IF
3) is an unstable yellow solid that decomposes above −28 °C. It is thus little-known. It is difficult to produce because fluorine gas would tend to oxidise iodine all the way to the pentafluoride; reaction at low temperature with
xenon difluoride
Xenon difluoride is a powerful fluorinating agent with the chemical formula , and one of the most stable xenon compounds. Like most covalent inorganic fluorides it is moisture-sensitive. It decomposes on contact with water vapor, but is otherw ...
is necessary.
Iodine trichloride
Iodine trichloride is an interhalogen compound of iodine and chlorine. It is bright yellow but upon time and exposure to light it turns red due to the presence of elemental iodine. In the solid state is present as a planar dimer I2Cl6, with two ...
, which exists in the solid state as the planar dimer I
2Cl
6, is a bright yellow solid, synthesised by reacting iodine with liquid chlorine at −80 °C; caution is necessary during purification because it easily dissociates to iodine monochloride and chlorine and hence can act as a strong chlorinating agent. Liquid iodine trichloride conducts electricity, possibly indicating dissociation to and ions.
[Greenwood and Earnshaw, pp. 828–831]
Iodine pentafluoride
Iodine pentafluoride is an interhalogen compound with chemical formula IF5. It is one of the fluorides of iodine. It is a colorless liquid, although impure samples appear yellow. It is used as a fluorination reagent and even a solvent in special ...
(IF
5), a colourless, volatile liquid, is the most thermodynamically stable iodine fluoride, and can be made by reacting iodine with fluorine gas at room temperature. It is a fluorinating agent, but is mild enough to store in glass apparatus. Again, slight electrical conductivity is present in the liquid state because of dissociation to and . The
pentagonal bipyramidal iodine heptafluoride
Iodine heptafluoride, also known as iodine(VII) fluoride or iodine fluoride, is an interhalogen compound with the chemical formula I F7. It has an unusual pentagonal bipyramidal structure, as predicted by VSEPR theory. The molecule can undergo ...
(IF
7) is an extremely powerful fluorinating agent, behind only
chlorine trifluoride
Chlorine trifluoride is an interhalogen compound with the formula ClF3. This colorless, poisonous, corrosive, and extremely reactive gas condenses to a pale-greenish yellow liquid, the form in which it is most often sold (pressurized at room temp ...
,
chlorine pentafluoride
Chlorine pentafluoride is an interhalogen compound with formula ClF5. This colourless gas is a strong oxidant that was once a candidate oxidizer for rockets. The molecule adopts a square pyramidal structure with C4v symmetry, as confirmed by ...
, and
bromine pentafluoride
Bromine pentafluoride, Br F5, is an interhalogen compound and a fluoride of bromine. It is a strong fluorinating agent.
BrF5 finds use in oxygen isotope analysis. Laser ablation of solid silicates in the presence of BrF5 releases O2 for subseq ...
among the interhalogens: it reacts with almost all the elements even at low temperatures, fluorinates
Pyrex
Pyrex (trademarked as ''PYREX'' and ''pyrex'') is a brand introduced by Corning Inc. in 1915 for a line of clear, low-thermal-expansion borosilicate glass used for laboratory glassware and kitchenware. It was later expanded to include kitchenwa ...
glass to form iodine(VII) oxyfluoride (IOF
5), and sets carbon monoxide on fire.
[Greenwood and Earnshaw, pp. 832–835]
Iodine oxides and oxoacids
Iodine oxide
Iodine oxides are chemical compounds of oxygen and iodine. Iodine has only two stable oxides which are isolatable in bulk, iodine tetroxide and iodine pentoxide, but a number of other oxides are formed in trace quantities or have been hypothesize ...
s are the most stable of all the halogen oxides, because of the strong I–O bonds resulting from the large electronegativity difference between iodine and oxygen, and they have been known for the longest time.
The stable, white,
hygroscopic
Hygroscopy is the phenomenon of attracting and holding water molecules via either absorption or adsorption from the surrounding environment, which is usually at normal or room temperature. If water molecules become suspended among the substan ...
iodine pentoxide
Iodine pentoxide is the chemical compound with the formula I2O5. This iodine oxide is the anhydride of iodic acid, and the only stable oxide of iodine. It is produced by dehydrating iodic acid at 200 °C in a stream of dry air:
:2HIO3 → ...
(I
2O
5) has been known since its formation in 1813 by Gay-Lussac and Davy. It is most easily made by the dehydration of
iodic acid
Iodic acid is a white water-soluble solid with the chemical formula . Its robustness contrasts with the instability of chloric acid and bromic acid. Iodic acid features iodine in the oxidation state +5 and is one of the most stable oxo-acids of ...
(HIO
3), of which it is the anhydride. It will quickly oxidise carbon monoxide completely to
carbon dioxide
Carbon dioxide ( chemical formula ) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in the gas state at room temperature. In the air, carbon dioxide is trans ...
at room temperature, and is thus a useful reagent in determining carbon monoxide concentration. It also oxidises nitrogen oxide,
ethylene, and
hydrogen sulfide. It reacts with
sulfur trioxide and
peroxydisulfuryl difluoride (S
2O
6F
2) to form salts of the iodyl cation,
2">O2sup>+, and is reduced by concentrated
sulfuric acids to iodosyl salts involving
Osup>+. It may be fluorinated by fluorine, bromine trifluoride,
sulfur tetrafluoride, or
chloryl fluoride
Chloryl fluoride is the chemical compound with the formula ClO2F. It is commonly encountered as side-product in reactions of chlorine fluorides with oxygen sources. It is the acyl fluoride of chloric acid.
Preparation
ClO2F was first reported by ...
, resulting iodine pentafluoride, which also reacts with iodine pentoxide, giving iodine(V) oxyfluoride, IOF
3. A few other less stable oxides are known, notably I
4O
9 and I
2O
4; their structures have not been determined, but reasonable guesses are I
III(I
VO
3)
3 and
Osup>+
3">O3sup>− respectively.
[Greenwood and Earnshaw, pp. 851–3]
More important are the four oxoacids:
hypoiodous acid (HIO),
iodous acid
The iodite ion, or iodine dioxide anion, is the halite with the chemical formula . Within the ion the Iodine exists in the oxidation state of +3.
Iodite anion
Iodites (including iodous acid) are highly unstable and have been observed but never ...
(HIO
2),
iodic acid
Iodic acid is a white water-soluble solid with the chemical formula . Its robustness contrasts with the instability of chloric acid and bromic acid. Iodic acid features iodine in the oxidation state +5 and is one of the most stable oxo-acids of ...
(HIO
3), and
periodic acid
Periodic acid ( ) is the highest oxoacid of iodine, in which the iodine exists in oxidation state +7. Like all periodates it can exist in two forms: orthoperiodic acid, with the chemical formula , and metaperiodic acid, which has the formula . ...
(HIO
4 or H
5IO
6). When iodine dissolves in aqueous solution, the following reactions occur:
[Greenwood and Earnshaw, pp. 853–9]
:
Hypoiodous acid is unstable to disproportionation. The hypoiodite ions thus formed disproportionate immediately to give iodide and iodate:
:
Iodous acid and iodite are even less stable and exist only as a fleeting intermediate in the oxidation of iodide to iodate, if at all.
Iodates are by far the most important of these compounds, which can be made by oxidising
alkali metal iodides with oxygen at 600 °C and high pressure, or by oxidising iodine with
chlorates. Unlike chlorates, which disproportionate very slowly to form chloride and perchlorate, iodates are stable to disproportionation in both acidic and alkaline solutions. From these, salts of most metals can be obtained. Iodic acid is most easily made by oxidation of an aqueous iodine suspension by
electrolysis or fuming
nitric acid
Nitric acid is the inorganic compound with the formula . It is a highly corrosive mineral acid. The compound is colorless, but older samples tend to be yellow cast due to decomposition into oxides of nitrogen. Most commercially available nitri ...
. Iodate has the weakest oxidising power of the halates, but reacts the quickest.
[Greenwood and Earnshaw, pp. 863–4]
Many periodates are known, including not only the expected tetrahedral , but also square-pyramidal , octahedral orthoperiodate ,
3(OH)3">O3(OH)3sup>2−,
2O8(OH2)">2O8(OH2)sup>4−, and . They are usually made by oxidising alkaline
sodium iodate
Sodium iodate ( Na I O3) is the sodium salt of iodic acid. Sodium iodate is an oxidizing agent. It has few uses.
Preparation
It can be prepared by the reacting a sodium-containing base such as sodium hydroxide with iodic acid, for example:
: ...
electrochemically (with
lead(IV) oxide
Lead(IV) oxide is the inorganic compound with the formula PbO2. It is an oxide where lead is in an oxidation state of +4. It is a dark-brown solid which is insoluble in water. It exists in two crystalline forms. It has several important applicat ...
as the anode) or by chlorine gas:
[Greenwood and Earnshaw, pp. 872–5]
: + 6 OH
− → + 3 H
2O + 2 e
−
: + 6 OH
− + Cl
2 → + 2 Cl
− + 3 H
2O
They are thermodymically and kinetically powerful oxidising agents, quickly oxidising Mn
2+ to
, and cleaving
glycol
A diol is a chemical compound containing two hydroxyl groups ( groups). An aliphatic diol is also called a glycol. This pairing of functional groups is pervasive, and many subcategories have been identified.
The most common industrial diol is e ...
s, α-
diketone
In organic chemistry, a dicarbonyl is a molecule containing two carbonyl () groups. Although this term could refer to any organic compound containing two carbonyl groups, it is used more specifically to describe molecules in which both carbonyls ...
s, α-
ketol
In organic chemistry a hydroxy ketone (often referred to simply as a ketol) is a functional group consisting of a ketone flanked by a hydroxyl group. In the two main classes, the hydroxyl group can be placed in the alpha and beta carbon, alpha posi ...
s, α-
aminoalcohols, and α-
diamine
A diamine is an amine with exactly two amino groups. Diamines are used as monomers to prepare polyamides, polyimides, and polyureas. The term ''diamine'' refers mostly to primary diamines, as those are the most reactive.
In terms of quantities p ...
s.
Orthoperiodate especially stabilises high oxidation states among metals because of its very high negative charge of −5.
Orthoperiodic acid
Periodic acid ( ) is the highest oxoacid of iodine, in which the iodine exists in oxidation state +7. Like all periodates it can exist in two forms: orthoperiodic acid, with the chemical formula , and metaperiodic acid, which has the formula .
...
, H
5IO
6, is stable, and dehydrates at 100 °C in a vacuum to
metaperiodic acid
Periodic acid ( ) is the highest oxoacid of iodine, in which the iodine exists in oxidation state +7. Like all periodates it can exist in two forms: orthoperiodic acid, with the chemical formula , and metaperiodic acid, which has the formula .
...
, HIO
4. Attempting to go further does not result in the nonexistent iodine heptoxide (I
2O
7), but rather iodine pentoxide and oxygen. Periodic acid may be protonated by
sulfuric acid to give the cation, isoelectronic to Te(OH)
6 and , and giving salts with bisulfate and sulfate.
Polyiodine compounds
When iodine dissolves in strong acids, such as fuming sulfuric acid, a bright blue
paramagnetic
Paramagnetism is a form of magnetism whereby some materials are weakly attracted by an externally applied magnetic field, and form internal, induced magnetic fields in the direction of the applied magnetic field. In contrast with this behavior, ...
solution including cations is formed. A solid salt of the diiodine cation may be obtained by oxidising iodine with
antimony pentafluoride:
:2 I
2 + 5 SbF
5 2 I
2Sb
2F
11 + SbF
3
The salt I
2Sb
2F
11 is dark blue, and the blue
tantalum
Tantalum is a chemical element with the symbol Ta and atomic number 73. Previously known as ''tantalium'', it is named after Tantalus, a villain in Greek mythology. Tantalum is a very hard, ductile, lustrous, blue-gray transition metal that ...
analogue I
2Ta
2F
11 is also known. Whereas the I–I bond length in I
2 is 267 pm, that in is only 256 pm as the missing electron in the latter has been removed from an antibonding orbital, making the bond stronger and hence shorter. In
fluorosulfuric acid solution, deep-blue reversibly dimerises below −60 °C, forming red rectangular diamagnetic . Other polyiodine cations are not as well-characterised, including bent dark-brown or black and centrosymmetric ''C''
2''h'' green or black , known in the and salts among others.
[Greenwood and Earnshaw, pp. 842–4]
The only important polyiodide anion in aqueous solution is linear
triiodide
In chemistry, triiodide usually refers to the triiodide ion, . This anion, one of the polyhalogen ions, is composed of three iodine atoms. It is formed by combining aqueous solutions of iodide salts and iodine. Some salts of the anion have bee ...
, . Its formation explains why the solubility of iodine in water may be increased by the addition of potassium iodide solution:
:I
2 + I
− (''K''
eq = ~700 at 20 °C)
Many other polyiodides may be found when solutions containing iodine and iodide crystallise, such as , , , and , whose salts with large, weakly polarising cations such as
Cs+ may be isolated.
[Greenwood and Earnshaw, pp. 835–9]
Organoiodine compounds
![IBXAcid](https://upload.wikimedia.org/wikipedia/commons/2/25/IBXAcid.png)
Organoiodine compounds have been fundamental in the development of organic synthesis, such as in the
Hofmann elimination
Hofmann elimination is an elimination reaction of an amine to form alkenes. The least stable alkene (the one with the least number of substituents on the carbons of the double bond), called the Hofmann product, is formed. This tendency, known as ...
of
amine
In chemistry, amines (, ) are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (), wherein one or more hydrogen
Hydrogen is the chemical element wi ...
s, the
Williamson ether synthesis
The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and a deprotonated alcohol (alkoxide). This reaction was developed by Alexander Williamson in 1850. Typically it involves the reaction of an alkoxide io ...
, the
Wurtz coupling reaction, and in
Grignard reagents.
The
carbon
Carbon () is a chemical element with the symbol C and atomic number 6. It is nonmetallic and tetravalent—its atom making four electrons available to form covalent chemical bonds. It belongs to group 14 of the periodic table. Carbon mak ...
–iodine bond is a common functional group that forms part of core
organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, ...
; formally, these compounds may be thought of as organic derivatives of the iodide anion. The simplest organoiodine compounds,
alkyl iodide
Organoiodine compounds are organic compounds that contain one or more carbon–iodine bonds. They occur widely in organic chemistry, but are relatively rare in nature. The thyroxine hormones are organoiodine compounds that are required for he ...
s, may be synthesised by the reaction of
alcohols with
phosphorus triiodide
Phosphorus triiodide (PI3) is an inorganic compound with the formula PI3. A red solid, it is a common misconception that PI3 is too unstable to be stored; it is, in fact, commercially available. It is widely used in organic chemistry for convertin ...
; these may then be used in
nucleophilic substitution
In chemistry, a nucleophilic substitution is a class of chemical reactions in which an electron-rich chemical species (known as a nucleophile) replaces a functional group within another electron-deficient molecule (known as the electrophile). The ...
reactions, or for preparing
Grignard reagents. The C–I bond is the weakest of all the carbon–halogen bonds due to the minuscule difference in electronegativity between carbon (2.55) and iodine (2.66). As such, iodide is the best
leaving group In chemistry, a leaving group is defined by the IUPAC as an atom or group of atoms that detaches from the main or residual part of a substrate during a reaction or elementary step of a reaction. However, in common usage, the term is often limited ...
among the halogens, to such an extent that many organoiodine compounds turn yellow when stored over time due to decomposition into elemental iodine; as such, they are commonly used in
organic synthesis, because of the easy formation and cleavage of the C–I bond. They are also significantly denser than the other organohalogen compounds thanks to the high atomic weight of iodine.
A few organic oxidising agents like the
iodane
Iodane generally refers to any organic derivative of iodine. Without modifier, ''iodane'' is the systematic name for the parent hydride of iodine, HI. Thus, any organoiodine compound with general formula RI (e.g., iodomethane , or iodobenzene ) ...
s contain iodine in a higher oxidation state than −1, such as
2-iodoxybenzoic acid
2-Iodoxybenzoic acid (IBX) is an organic compound used in organic synthesis as an oxidizing agent. This periodinane is especially suited to oxidize alcohols to aldehydes. IBX is prepared from 2-iodobenzoic acid, potassium bromate, and sulfuric a ...
, a common reagent for the oxidation of alcohols to
aldehyde
In organic chemistry, an aldehyde () is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred to as an aldehyde but can also be classified as a formyl grou ...
s, and
iodobenzene dichloride
Iodobenzene dichloride (PhICl2) is a complex of iodobenzene with chlorine. As a reagent for organic chemistry, it is used as an oxidant and chlorinating agent.
Chemical structure
Single-crystal X-ray crystallography has been used to determine ...
(PhICl
2), used for the selective chlorination of
alkene
In organic chemistry, an alkene is a hydrocarbon containing a carbon–carbon double bond.
Alkene is often used as synonym of olefin, that is, any hydrocarbon containing one or more double bonds.H. Stephen Stoker (2015): General, Organic, an ...
s and
alkynes. One of the more well-known uses of organoiodine compounds is the so-called
iodoform test, where
iodoform
Iodoform (also known as triiodomethane and, inaccurately, as carbon triiodide) is the organoiodine compound with the chemical formula C H I3. A pale yellow, crystalline, volatile substance, it has a penetrating and distinctive odor (in older ch ...
(CHI
3) is produced by the exhaustive iodination of a
methyl ketone (or another compound capable of being oxidised to a methyl ketone), as follows:
:
Some drawbacks of using organoiodine compounds as compared to organochlorine or organobromine compounds is the greater expense and toxicity of the iodine derivatives, since iodine is expensive and organoiodine compounds are stronger alkylating agents. For example,
iodoacetamide
2-Iodoacetamide is an alkylating agent used for peptide mapping purposes. Its actions are similar to those of iodoacetate. It is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds. Also use ...
and
iodoacetic acid
Iodoacetic acid is a derivative of acetic acid. It is a toxic compound, because, like many alkyl halides, it is an alkylating agent.
It reacts with cysteine residues in proteins. It is often used to modify SH-groups to prevent the re-formation ...
denature proteins by irreversibly alkylating
cysteine residues and preventing the reformation of
disulfide
In biochemistry, a disulfide (or disulphide in British English) refers to a functional group with the structure . The linkage is also called an SS-bond or sometimes a disulfide bridge and is usually derived by the coupling of two thiol groups. In ...
linkages.
Halogen exchange to produce iodoalkanes by the
Finkelstein reaction
The Finkelstein reaction named after the German chemist Hans Finkelstein, is an SN2 reaction (Substitution Nucleophilic Bimolecular reaction) that involves the exchange of one halogen atom for another. It is an equilibrium reaction, but the react ...
is slightly complicated by the fact that iodide is a better leaving group than chloride or bromide. The difference is nevertheless small enough that the reaction can be driven to completion by exploiting the differential solubility of halide salts, or by using a large excess of the halide salt.
In the classic Finkelstein reaction, an
alkyl chloride or an
alkyl bromide
Organobromine compounds, also called organobromides, are organic compounds that contain carbon Chemical bond, bonded to bromine. The most pervasive is the naturally produced bromomethane.
One prominent application of synthetic organobromine comp ...
is converted to an
alkyl iodide
Organoiodine compounds are organic compounds that contain one or more carbon–iodine bonds. They occur widely in organic chemistry, but are relatively rare in nature. The thyroxine hormones are organoiodine compounds that are required for he ...
by treatment with a solution of
sodium iodide
Sodium iodide (chemical formula NaI) is an ionic compound formed from the chemical reaction of sodium metal and iodine. Under standard conditions, it is a white, water-soluble solid comprising a 1:1 mix of sodium cations (Na+) and iodide anions ...
in
acetone
Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour.
Acetone is miscib ...
. Sodium iodide is soluble in acetone and
sodium chloride and
sodium bromide
Sodium bromide is an inorganic compound with the formula Na Br. It is a high-melting white, crystalline solid that resembles sodium chloride. It is a widely used source of the bromide ion and has many applications.Michael J. Dagani, Henry J. Ba ...
are not. The reaction is driven toward products by
mass action due to the precipitation of the insoluble salt.
Occurrence and production
Iodine is the least abundant of the stable halogens, comprising only 0.46
parts per million
In science and engineering, the parts-per notation is a set of pseudo-units to describe small values of miscellaneous dimensionless quantities, e.g. mole fraction or mass fraction. Since these fractions are quantity-per-quantity measures, th ...
of Earth's crustal rocks (compare: fluorine 544 ppm, chlorine 126 ppm, bromine 2.5 ppm).
[Greenwood and Earnshaw, pp. 795–796.] Among the 84
elements which occur in significant quantities (elements 1–42, 44–60, 62–83, 90 and 92), it ranks 61st in abundance. Iodide minerals are rare, and most deposits that are concentrated enough for economical extraction are
iodate
An iodate is the polyatomic anion with the formula . It is the most common form of iodine in nature, as it comprises the major iodine-containing ores. Iodate salts are often colorless. They are the salts of iodic acid.
Structure
Iodate is pyr ...
minerals instead. Examples include
lautarite
Calcium iodate is any of two inorganic compounds with the formula Ca(IO3)2(H2O)x, where x = 0 or 1. Both are colourless salts that occur as the minerals lautarite and bruggenite, respectively. A third mineral form of calcium iodate is dietzeite, ...
, Ca(IO
3)
2, and
dietzeite, 7Ca(IO
3)
2·8CaCrO
4.
These are the minerals that occur as trace impurities in the
caliche
Caliche () is a sedimentary rock, a hardened natural cement of calcium carbonate that binds other materials—such as gravel, sand, clay, and silt. It occurs worldwide, in aridisol and mollisol soil orders—generally in arid or semiarid regions ...
, found in
Chile
Chile, officially the Republic of Chile, is a country in the western part of South America. It is the southernmost country in the world, and the closest to Antarctica, occupying a long and narrow strip of land between the Andes to the east a ...
, whose main product is
sodium nitrate. In total, they can contain at least 0.02% and at most 1% iodine by mass.
Sodium iodate
Sodium iodate ( Na I O3) is the sodium salt of iodic acid. Sodium iodate is an oxidizing agent. It has few uses.
Preparation
It can be prepared by the reacting a sodium-containing base such as sodium hydroxide with iodic acid, for example:
: ...
is extracted from the caliche and reduced to iodide by
sodium bisulfite
Sodium bisulfite (or sodium bisulphite, sodium hydrogen sulfite) is a chemical mixture with the approximate chemical formula NaHSO3. Sodium bisulfite in fact is not a real compound, but a mixture of salts that dissolve in water to give solutions ...
. This solution is then reacted with freshly extracted iodate, resulting in comproportionation to iodine, which may be filtered off.
The caliche was the main source of iodine in the 19th century and continues to be important today, replacing
kelp
Kelps are large brown algae seaweeds that make up the order Laminariales. There are about 30 different genera. Despite its appearance, kelp is not a plant - it is a heterokont, a completely unrelated group of organisms.
Kelp grows in "underwa ...
(which is no longer an economically viable source), but in the late 20th century
brines emerged as a comparable source. The Japanese
Minami Kanto gas field Minami (kanji 南, hiragana みなみ) is a Japanese word meaning " south".
Places
Japan
There are several Minami wards in Japan, most of them appropriately in the south part of a city:
*Minami, Tokushima, a village in Tokushima Prefectur ...
east of
Tokyo
Tokyo (; ja, 東京, , ), officially the Tokyo Metropolis ( ja, 東京都, label=none, ), is the capital and List of cities in Japan, largest city of Japan. Formerly known as Edo, its metropolitan area () is the most populous in the world, ...
and the American
Anadarko Basin
The Anadarko Basin is a geologic depositional and structural basin centered in the western part of the state of Oklahoma and the Texas Panhandle, and extending into southwestern Kansas and southeastern Colorado. The basin covers an area of . By ...
gas field in northwest
Oklahoma are the two largest such sources. The brine is hotter than 60 °C from the depth of the source. The
brine is first
purified and acidified using
sulfuric acid, then the iodide present is oxidised to iodine with
chlorine
Chlorine is a chemical element with the symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between them. Chlorine i ...
. An iodine solution is produced, but is dilute and must be concentrated. Air is blown into the solution to
evaporate the iodine, which is passed into an absorbing tower, where
sulfur dioxide reduces the iodine. The
hydrogen iodide (HI) is reacted with chlorine to precipitate the iodine. After filtering and purification the iodine is packed.
: 2 HI + Cl
2 → I
2↑ + 2 HCl
: I
2 + 2 H
2O + SO
2 → 2 HI + H
2SO
4
: 2 HI + Cl
2 → I
2↓ + 2 HCl
These sources ensure that Chile and Japan are the largest producers of iodine today.
Alternatively, the brine may be treated with
silver nitrate
Silver nitrate is an inorganic compound with chemical formula . It is a versatile precursor to many other silver compounds, such as those used in photography. It is far less sensitive to light than the halides. It was once called ''lunar causti ...
to precipitate out iodine as
silver iodide, which is then decomposed by reaction with iron to form metallic silver and a solution of
. The iodine may then be liberated by displacement with
chlorine
Chlorine is a chemical element with the symbol Cl and atomic number 17. The second-lightest of the halogens, it appears between fluorine and bromine in the periodic table and its properties are mostly intermediate between them. Chlorine i ...
.
[Greenwood and Earnshaw, p. 799.]
Applications
About half of all produced iodine goes into various organoiodine compounds, another 15% remains as the pure element, another 15% is used to form
potassium iodide
Potassium iodide is a chemical compound, medication, and dietary supplement. It is a medication used for treating hyperthyroidism, in radiation emergencies, and for protecting the thyroid gland when certain types of radiopharmaceuticals are u ...
, and another 15% for other inorganic iodine compounds.
Among the major uses of iodine compounds are
catalyst
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
s, animal feed supplements, stabilisers, dyes, colourants and pigments, pharmaceutical, sanitation (from
tincture of iodine
Tincture of iodine, iodine tincture, or weak iodine solution is an antiseptic. It is usually 2 to 7% elemental iodine, along with potassium iodide or sodium iodide, dissolved in a mixture of ethanol and water. Tincture solutions are characteriz ...
), and photography; minor uses include smog inhibition,
cloud seeding, and various uses in analytical chemistry.
Chemical analysis
![Testing seed for starch](https://upload.wikimedia.org/wikipedia/commons/c/c6/Testing_seed_for_starch.jpg)
The iodide and iodate anions are often used for quantitative volumetric analysis, for example in
iodometry
Iodometry, known as iodometric titration, is a method of volumetric chemical analysis, a redox titration where the appearance or disappearance of elementary iodine indicates the end point.
Note that iodometry involves indirect titration of iodi ...
. Iodine and starch form a blue complex, and this reaction is often used to test for either starch or iodine and as an
indicator
Indicator may refer to:
Biology
* Environmental indicator of environmental health (pressures, conditions and responses)
* Ecological indicator of ecosystem health (ecological processes)
* Health indicator, which is used to describe the health ...
in iodometry. The iodine test for starch is still used to detect
counterfeit banknotes printed on starch-containing paper.
The
iodine value
In chemistry, the iodine value (IV; also iodine adsorption value, iodine number or iodine index) is the mass of iodine in grams that is consumed by 100 grams of a chemical substance. Iodine numbers are often used to determine the degree of ...
is the mass of iodine in grams that is consumed by 100 grams of a
chemical substance
A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., w ...
typically fats or oils. Iodine numbers are often used to determine the amount of unsaturation in
fatty acid
In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, ...
s. This unsaturation is in the form of
double bond
In chemistry, a double bond is a covalent bond between two atoms involving four bonding electrons as opposed to two in a single bond. Double bonds occur most commonly between two carbon atoms, for example in alkenes. Many double bonds exist betwee ...
s, which react with iodine compounds.
Potassium tetraiodomercurate(II)
Potassium tetraiodomercurate(II) is an inorganic compound consisting of potassium cations and the tetraiodomercurate(II) anion. It is mainly used as Nessler's reagent, a 0.09 mol/L solution of potassium tetraiodomercurate(II) (K2 gI4 in 2.5&n ...
, K
2HgI
4, is also known as Nessler's reagent. It is often used as a sensitive spot test for
ammonia
Ammonia is an inorganic compound of nitrogen and hydrogen with the formula . A stable binary hydride, and the simplest pnictogen hydride, ammonia is a colourless gas with a distinct pungent smell. Biologically, it is a common nitrogenous wa ...
. Similarly,
Mayer's reagent
Mayer's reagent is an alkaloidal precipitating reagent used for the detection of alkaloids in natural products. Mayer's reagent is freshly prepared by dissolving a mixture of mercuric chloride (1.36 g) and of potassium iodide (5.00 g) in water (1 ...
(potassium tetraiodomercurate(II) solution) is used as a precipitating reagent to test for
alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
s. Aqueous alkaline iodine solution is used in the iodoform test for methyl ketones.
Spectroscopy
The spectrum of the iodine molecule, I
2, consists of (not exclusively) tens of thousands of sharp spectral lines in the wavelength range 500–700 nm. It is therefore a commonly used wavelength reference (secondary standard). By measuring with a
spectroscopic Doppler-free technique while focusing on one of these lines, the
hyperfine
In atomic physics, hyperfine structure is defined by small shifts in otherwise degenerate energy levels and the resulting splittings in those energy levels of atoms, molecules, and ions, due to electromagnetic multipole interaction between the nuc ...
structure of the iodine molecule reveals itself. A line is now resolved such that either 15 components (from even rotational quantum numbers, ''J''
even), or 21 components (from odd rotational quantum numbers, ''J''
odd) are measurable.
Cesium iodide and thallium-doped sodium iodide are used in crystal
scintillators for the detection of gamma rays. The efficiency is high and energy dispersive spectroscopy is possible, but the resolution is rather poor.
Spacecraft propulsion
Propulsion systems employing iodine as the
propellant can be built more compactly, with less mass (and cost), and operate more efficiently than the
gridded ion thruster
The gridded ion thruster is a common design for ion thrusters, a highly efficient low-thrust spacecraft propulsion method running on electrical power by using high-voltage grid electrodes to accelerate ions with electrostatic forces.
History
The ...
s that were utilized to propel previous spacecraft, such as Japan's
Hayabusa
was a robotic spacecraft developed by the Japan Aerospace Exploration Agency (JAXA) to return a sample of material from a small near-Earth asteroid named 25143 Itokawa to Earth for further analysis.
''Hayabusa'', formerly known as MUSES-C fo ...
probes, ESA's
GOCE
''Goce'' is an opera composed by Kiril Makedonski (1925–1984), written by Venko Markovski and dedicated to Gotse Delchev. The work was commissioned to be the very first opera performed by the Macedonian National Opera Company. It premiered o ...
satellite, or NASA's
DART
Dart or DART may refer to:
* Dart, the equipment in the game of darts
Arts, entertainment and media
* Dart (comics), an Image Comics superhero
* Dart, a character from ''G.I. Joe''
* Dart, a ''Thomas & Friends'' railway engine character
* Dar ...
mission, all of which used xenon as the
reaction mass
Working mass, also referred to as reaction mass, is a mass against which a system operates in order to produce acceleration.
In the case of a chemical rocket, for example, the reaction mass is the product of the burned fuel shot backwards to prov ...
. Iodine's
atomic weight
Relative atomic mass (symbol: ''A''; sometimes abbreviated RAM or r.a.m.), also known by the deprecated synonym atomic weight, is a dimensionless physical quantity defined as the ratio of the average mass of atoms of a chemical element in a giv ...
is only 3.3% less than that of xenon, while its first two
ionisation energies average 12% less; together, these make iodine ions a promising substitute.
Use of iodine should allow more widespread application of ion-thrust technology, particularly with smaller-scale space vehicles.
According to the
European Space Agency, "This small but potentially disruptive innovation could help to clear the skies of
space junk
Space debris (also known as space junk, space pollution, space waste, space trash, or space garbage) are defunct human-made objects in space—principally in Earth orbit—which no longer serve a useful function. These include derelict spacec ...
, by enabling tiny satellites to self-destruct cheaply and easily at the end of their missions, by steering themselves into the atmosphere where they would burn up."
In early 2021, the French group
ThrustMe
ThrustMe is a deep tech company that designs miniaturized aerospace thrusters for small satellites, increasing the life of satellites and making them more affordable.
The company builds gridded ion thrusters (NPT30) and cold gas thrusters (I2T5) ...
performed an in-orbit demonstration of an electric-powered
ion thruster
An ion thruster, ion drive, or ion engine is a form of electric propulsion used for spacecraft propulsion. It creates thrust by accelerating ions using electricity.
An ion thruster ionizes a neutral gas by extracting some electrons out of ...
for spacecraft, where iodine was used in lieu of
xenon
Xenon is a chemical element with the symbol Xe and atomic number 54. It is a dense, colorless, odorless noble gas found in Earth's atmosphere in trace amounts. Although generally unreactive, it can undergo a few chemical reactions such as the ...
as the source of
plasma, in order to generate
thrust
Thrust is a reaction force described quantitatively by Newton's third law. When a system expels or accelerates mass in one direction, the accelerated mass will cause a force of equal magnitude but opposite direction to be applied to that sys ...
by accelerating
ion
An ion () is an atom or molecule with a net electrical charge.
The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by conve ...
s with an
electrostatic
Electrostatics is a branch of physics that studies electric charges at rest ( static electricity).
Since classical times, it has been known that some materials, such as amber, attract lightweight particles after rubbing. The Greek word for amb ...
field.
Medicine
Elemental iodine
Elemental iodine is used as an
antiseptic
An antiseptic (from Greek ἀντί ''anti'', "against" and σηπτικός ''sēptikos'', "putrefactive") is an antimicrobial substance or compound that is applied to living tissue/skin to reduce the possibility of infection, sepsis, or putre ...
either as the element, or as the water-soluble
triiodide
In chemistry, triiodide usually refers to the triiodide ion, . This anion, one of the polyhalogen ions, is composed of three iodine atoms. It is formed by combining aqueous solutions of iodide salts and iodine. Some salts of the anion have bee ...
anion I
3− generated ''in situ'' by adding
iodide
An iodide ion is the ion I−. Compounds with iodine in formal oxidation state −1 are called iodides. In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. Worldwide, iodine de ...
to poorly water-soluble elemental iodine (the reverse chemical reaction makes some free elemental iodine available for antisepsis). Elemental iodine may also be used to treat
iodine deficiency
Iodine deficiency is a lack of the trace element iodine, an essential nutrient in the diet. It may result in metabolic problems such as goiter, sometimes as an endemic goiter as well as congenital iodine deficiency syndrome due to untreated cong ...
.
In the alternative, iodine may be produced from
iodophor
An iodophor is a preparation containing iodine complexed with a solubilizing agent, such as a surfactant or water-soluble polymers, for example, povidone (forming povidone-iodine). The result is a water-soluble material that releases free iodine ...
s, which contain iodine complexed with a solubilizing agent (the iodide ion may be thought of loosely as the iodophor in triiodide water solutions). Examples of such preparations include:
*
Tincture of iodine
Tincture of iodine, iodine tincture, or weak iodine solution is an antiseptic. It is usually 2 to 7% elemental iodine, along with potassium iodide or sodium iodide, dissolved in a mixture of ethanol and water. Tincture solutions are characteriz ...
: iodine in ethanol, or iodine and
sodium iodide
Sodium iodide (chemical formula NaI) is an ionic compound formed from the chemical reaction of sodium metal and iodine. Under standard conditions, it is a white, water-soluble solid comprising a 1:1 mix of sodium cations (Na+) and iodide anions ...
in a mixture of ethanol and water.
*
Lugol's iodine
Lugol's iodine, also known as aqueous iodine and strong iodine solution, is a solution of potassium iodide with iodine in water. It is a medication and disinfectant used for a number of purposes. Taken by mouth it is used to treat thyrotoxicos ...
: iodine and iodide in water alone, forming mostly triiodide. Unlike tincture of iodine, Lugol's iodine has a minimised amount of the free iodine (I
2) component.
*
Povidone iodine
Povidone-iodine (PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. It may be used both to disinfect the hands of healthcare providers and the skin of the person they are caring for. It may ...
(an
iodophor
An iodophor is a preparation containing iodine complexed with a solubilizing agent, such as a surfactant or water-soluble polymers, for example, povidone (forming povidone-iodine). The result is a water-soluble material that releases free iodine ...
).
* Iodine-V: iodine (I
2) and
fulvic acid Humic substances (HS) are organic compounds that are important components of humus, the major organic fraction of soil, peat, and coal (and also a constituent of many upland streams, dystrophic lakes, and ocean water). For a long era in the 19th an ...
form a
clathrate compound
A clathrate is a chemical substance consisting of a lattice that traps or contains molecules. The word ''clathrate'' is derived from the Latin (), meaning ‘with bars, latticed’. Most clathrate compounds are polymeric and completely envelop t ...
(iodine molecules are "caged" by fulvic acid in this
host-guest complex). A water-soluble, solid, stable, crystalline complex. Unlike other iodophors, Iodine-V only contains iodine in molecular (I
2) form.
The antimicrobial action of iodine is quick and works at low concentrations, and thus it is used in operating theatres. Its specific mode of action is unknown. It penetrates into microorganisms and attacks particular amino acids (such as
cysteine and
methionine),
nucleotides
Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules with ...
, and
fatty acid
In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, ...
s, ultimately resulting in
cell death
Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, as in programmed cell death, or may result from factors such as d ...
. It also has an
antiviral
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do no ...
action, but nonlipid viruses and
parvovirus
Parvoviruses are a family of animal viruses that constitute the family ''Parvoviridae''. They have linear, single-stranded DNA (ssDNA) genomes that typically contain two genes encoding for a replication initiator protein, called NS1, and the p ...
es are less sensitive than lipid enveloped viruses. Iodine probably attacks surface proteins of
enveloped viruses, and it may also destabilise membrane fatty acids by reacting with
unsaturated carbon bonds.
Other formulations
Before the advent of organic
chelating agent
Chelation is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom. These ligands ar ...
s, salts of iodide were given orally in the treatment of
lead
Lead is a chemical element with the symbol Pb (from the Latin ) and atomic number 82. It is a heavy metal that is denser than most common materials. Lead is soft and malleable, and also has a relatively low melting point. When freshly cu ...
or
mercury poisoning, such as heavily popularized by
Louis Melsens
Louis-Henri-Frédéric Melsens (July 11, 1814 in Leuven – April 20, 1886 in Brussels) was a Belgian physicist and chemist. In 1846, he became professor of chemistry at the Royal Veterinary School of Cureghem in Anderlecht, Brussels. Melsens ...
and many nineteenth and early twentieth century doctors.
["On the Employment of Iodide of Potassium as a Remedy for the Affections Caused by Lead and Mercury"]
in ''Br Foreign Med Chir Rev.'' 1853 Jan; 11(21): 201–224.
In medicine, a saturated solution of
potassium iodide
Potassium iodide is a chemical compound, medication, and dietary supplement. It is a medication used for treating hyperthyroidism, in radiation emergencies, and for protecting the thyroid gland when certain types of radiopharmaceuticals are u ...
is used to treat acute
thyrotoxicosis
Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormones by the thyroid gland. Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidism. ...
. It is also used to block uptake of
iodine-131
Iodine-131 (131I, I-131) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley. It has a radioactive decay half-life of about eight days. It is associated with nu ...
in the thyroid gland (see isotopes section above), when this isotope is used as part of radiopharmaceuticals (such as
iobenguane
Iobenguane, or MIBG, is an aralkylguanidine analog of the adrenergic neurotransmitter norepinephrine (noradrenaline), typically used as a radiopharmaceutical. It acts as a blocking agent for adrenergic neurons. When radiolabeled, it can be used ...
) that are not targeted to the thyroid or thyroid-type tissues.
Iodine-131 (usually as iodide) is a component of
nuclear fallout
Nuclear fallout is the residual radioactive material propelled into the upper atmosphere following a nuclear blast, so called because it "falls out" of the sky after the explosion and the shock wave has passed. It commonly refers to the radioac ...
, and is particularly dangerous owing to the thyroid gland's propensity to concentrate ingested iodine and retain it for periods longer than this isotope's radiological half-life of eight days. For this reason, people at risk of exposure to environmental radioactive iodine (iodine-131) in fallout may be instructed to take non-radioactive potassium iodide tablets. The typical adult dose is one 130 mg tablet per 24 hours, supplying 100 mg (100,000
micrograms
In the metric system, a microgram or microgramme is a unit of mass equal to one millionth () of a gram. The unit symbol is μg according to the International System of Units (SI); the recommended symbol in the United States and United Kingdom wh ...
) of ionic iodine. (The typical daily dose of iodine for normal health is of order 100 micrograms; see "Dietary Intake" below.) Ingestion of this large dose of non-radioactive iodine minimises the uptake of radioactive iodine by the thyroid gland.
![Diatrizoic acid](https://upload.wikimedia.org/wikipedia/commons/1/1c/Diatrizoic_acid.svg)
As an element with high
electron density
In quantum chemistry, electron density or electronic density is the measure of the probability of an electron being present at an infinitesimal element of space surrounding any given point. It is a scalar quantity depending upon three spatial va ...
and atomic number, iodine absorbs X-rays weaker than 33.3 keV due to the
photoelectric effect
The photoelectric effect is the emission of electrons when electromagnetic radiation, such as light, hits a material. Electrons emitted in this manner are called photoelectrons. The phenomenon is studied in condensed matter physics, and solid sta ...
of the innermost electrons. Organoiodine compounds are used with intravenous injection as X-ray
radiocontrast
Radiocontrast agents are substances used to enhance the visibility of internal structures in X-ray-based imaging techniques such as computed tomography ( contrast CT), projectional radiography, and fluoroscopy. Radiocontrast agents are typically i ...
agents. This application is often in conjunction with advanced X-ray techniques such as
angiography
Angiography or arteriography is a medical imaging technique used to visualize the inside, or lumen, of blood vessels and organs of the body, with particular interest in the arteries, veins, and the heart chambers. Modern angiography is perfor ...
and
CT scanning. At present, all water-soluble radiocontrast agents rely on iodine.
Others
The production of
ethylenediamine dihydroiodide
Ethylenediamine dihydroiodide (EDDI) is a water-soluble salt derived from ethylenediamine and hydroiodic acid. It is a colorless to light yellow crystalline powder. The salt consists of the ethylenediammonium dication C2H4(NH3)22+ and iodide anio ...
, provided as a
nutritional supplement
A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources or that are synthetic in order ...
for livestock, consumes a large portion of available iodine. Another significant use is a catalyst for the production of
acetic acid by the
Monsanto
The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best known product is Roundup, a glyphosate-based herbicide, developed in ...
and
Cativa process
The Cativa process is a method for the production of acetic acid by the carbonylation of methanol. The technology, which is similar to the Monsanto process, was developed by BP Chemicals and is under license by BP Plc. The process is based on an ...
es. In these technologies, which support the world's demand for acetic acid,
hydroiodic acid
Hydroiodic acid (or hydriodic acid) is an aqueous solution of hydrogen iodide (HI). It is a strong acid, one that is ionized completely in an aqueous solution. It is colorless. Concentrated solutions are usually 48% to 57% HI.
Reactions
Hy ...
converts the
methanol feedstock into methyl iodide, which undergoes
carbonylation
Carbonylation refers to reactions that introduce carbon monoxide into organic and inorganic substrates. Carbon monoxide is abundantly available and conveniently reactive, so it is widely used as a reactant in industrial chemistry. The term carbony ...
. Hydrolysis of the resulting acetyl iodide regenerates hydroiodic acid and gives acetic acid.
Inorganic iodides find specialised uses. Titanium, zirconium, hafnium, and
thorium
Thorium is a weakly radioactive metallic chemical element with the symbol Th and atomic number 90. Thorium is silvery and tarnishes black when it is exposed to air, forming thorium dioxide; it is moderately soft and malleable and has a high ...
are purified by the
van Arkel–de Boer process
The van Arkel–de Boer process, also known as the iodide process or crystal-bar process, was the first industrial process for the commercial production of pure ductile titanium, zirconium and some other metals. It was developed by Anton Eduard ...
, which involves the reversible formation of the tetraiodides of these elements. Silver iodide is a major ingredient to traditional photographic film. Thousands of kilograms of silver iodide are used annually for
cloud seeding to induce rain.
[
The organoiodine compound ]erythrosine
Erythrosine, also known as Red No. 3, is an organoiodine compound, specifically a derivative of fluorone. It is a pink dye which is primarily used for food coloring. It is the disodium salt of 2,4,5,7-tetraiodofluorescein. Its maximum absorba ...
is an important food coloring agent. Perfluoroalkyl iodides are precursors to important surfactants, such as perfluorooctanesulfonic acid
Perfluorooctanesulfonic acid (PFOS) (conjugate base perfluorooctanesulfonate) is a chemical compound having an eight-carbon fluorocarbon chain and a sulfonic acid functional group and thus a perfluorosulfonic acid. It is an anthropogenic (man-ma ...
.[
The ]iodine clock reaction
The iodine clock reaction is a classical chemical clock demonstration experiment to display chemical kinetics in action; it was discovered by Hans Heinrich Landolt in 1886. The iodine clock reaction exists in several variations, which each invol ...
(in which iodine also serves as a test for starch, forming a dark blue complex), is a popular educational demonstration experiment and example of a seemingly oscillating reaction (it is only the concentration of an intermediate product that oscillates).
Although iodine has widespread roles in many species, agents containing it can exert a ''differential'' effect upon different species in an agricultural system. The growth of all strains of ''Fusarium verticillioides
''Fusarium verticillioides'' is the most commonly reported fungal species infecting maize (''Zea mays''). ''Fusarium verticillioides'' is the accepted name of the species, which was also known as ''Fusarium moniliforme''. The species has also bee ...
'' is significantly inhibited by an iodine-containing fungistatic Fungistatics are anti-fungal agents that inhibit the growth of fungus (without killing the fungus). The term ''fungistatic'' may be used as both a noun and an adjective. Fungistatics have applications in agriculture, the food industry, the paint ind ...
(AJ1629-34EC) at concentrations that do not harm the crop. This might be a less toxic anti-fungal agricultural treatment due to its relatively natural chemistry.
I is used as the radiolabel
A radioactive tracer, radiotracer, or radioactive label is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by tr ...
in investigating which ligand
In coordination chemistry, a ligand is an ion or molecule ( functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's elec ...
s go to which plant pattern recognition receptor
Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. They are proteins expressed, mainly, by cells of ...
s (PRRs).
Biological role
Iodine is an essential element
In the context of nutrition, a mineral is a chemical element required as an essential nutrient by organisms to perform functions necessary for life. However, the four major structural elements in the human body by weight (oxygen, hydrogen, carbon ...
for life and, at atomic number ''Z'' = 53, is the heaviest element commonly needed by living organisms. (Lanthanum
Lanthanum is a chemical element with the symbol La and atomic number 57. It is a soft, ductile, silvery-white metal that tarnishes slowly when exposed to air. It is the eponym of the lanthanide series, a group of 15 similar elements between lant ...
and the other lanthanides, as well as tungsten
Tungsten, or wolfram, is a chemical element with the symbol W and atomic number 74. Tungsten is a rare metal found naturally on Earth almost exclusively as compounds with other elements. It was identified as a new element in 1781 and first isol ...
with ''Z'' = 74 and uranium
Uranium is a chemical element with the symbol U and atomic number 92. It is a silvery-grey metal in the actinide series of the periodic table. A uranium atom has 92 protons and 92 electrons, of which 6 are valence electrons. Uranium is weak ...
with ''Z'' = 92, are used by a few microorganisms.) It is required for the synthesis of the growth-regulating thyroid hormones thyroxine
File:Thyroid_system.svg, upright=1.5, The thyroid system of the thyroid hormones T3 and T4
rect 376 268 820 433 Thyroid-stimulating hormone
rect 411 200 849 266 Thyrotropin-releasing hormone
rect 297 168 502 200 Hypothalamus
rect 66 216 386 25 ...
and triiodothyronine
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
Production of T3 and its prohormone thyroxine ...
(T4 and T3 respectively, named after their number of iodine atoms). A deficiency of iodine leads to decreased production of T3 and T4 and a concomitant enlargement of the thyroid tissue in an attempt to obtain more iodine, causing the disease known as simple goitre
A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre can be associated with a thyroid that is not functioning properly.
Worldwide, over 90% of goitre cases are caused by iodine deficiency. The term is ...
. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. In humans, the ratio of T4 to T3 released into the blood is between 14:1 and 20:1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinase
Deiodinase (or "Monodeiodinase") is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.
Types
Types of deiodinases include:
Iodothyronine deiodinases catalyze release of iodine directly from the thyro ...
s (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine
3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor. T1AM is the most potent endogenous TAAR1 agonist yet ...
(T1a) and thyronamine
Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).
Types
The group includes:
* Thyronamine ...
(T0a'). All three isoforms of the deiodinases are selenium
Selenium is a chemical element with the symbol Se and atomic number 34. It is a nonmetal (more rarely considered a metalloid) with properties that are intermediate between the elements above and below in the periodic table, sulfur and tellurium, ...
-containing enzymes; thus dietary selenium is essential for T3 production.
Iodine accounts for 65% of the molecular weight of T4 and 59% of T3. Fifteen to 20 mg of iodine is concentrated in thyroid tissue and hormones, but 70% of all iodine in the body is found in other tissues, including mammary glands, eyes, gastric mucosa, fetal thymus, cerebro-spinal fluid and choroid plexus, arterial walls, the cervix, and salivary glands. In the cells of those tissues, iodide enters directly by sodium-iodide symporter
The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS), is a protein that in humans is encoded by the ''SLC5A5'' gene. It is a transmembrane glycoprotein with a molecular weight of 87 k Da and 13 transmembrane domains, w ...
(NIS). The action of iodine in mammary tissue is related to fetal and neonatal development, but in the other tissues, it is (at least) partially unknown.
Dietary intake
The daily levels of intake recommended by the United States National Academy of Medicine
The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Eng ...
are between 110 and 130 µg
In the metric system, a microgram or microgramme is a unit of mass equal to one millionth () of a gram. The unit symbol is μg according to the International System of Units (SI); the recommended symbol in the United States and United Kingdom whe ...
for infants up to 12 months, 90 µg for children up to eight years, 130 µg for children up to 13 years, 150 µg for adults, 220 µg for pregnant women and 290 µg for lactation. The Tolerable Upper Intake Level (UL) for adults is 1,100 μg/day. This upper limit was assessed by analyzing the effect of supplementation on thyroid-stimulating hormone
Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism ...
.
The thyroid gland needs no more than 70 μg/day to synthesise the requisite daily amounts of T4 and T3. The higher recommended daily allowance levels of iodine seem necessary for optimal function of a number of body systems, including lactation
Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process naturally occurs with all sexually mature female mammals, although it may predate mammals. The proces ...
, gastric mucosa
The gastric mucosa is the mucous membrane layer of the stomach, which contains the glands and the gastric pits. In humans, it is about 1 mm thick, and its surface is smooth, soft, and velvety. It consists of simple columnar epithelium, lamina ...
, salivary gland
The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts. Humans have three paired major salivary glands ( parotid, submandibular, and sublingual), as well as hundreds of minor salivary glands. Salivary ...
s, brain cells, choroid plexus
The choroid plexus, or plica choroidea, is a plexus of cells that arises from the tela choroidea in each of the ventricles of the brain. Regions of the choroid plexus produce and secrete most of the cerebrospinal fluid (CSF) of the central nerv ...
, thymus
The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or ''T cells'' mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. ...
, and arterial walls.
Natural sources of dietary iodine include seafood, such as fish, seaweeds (such as kelp
Kelps are large brown algae seaweeds that make up the order Laminariales. There are about 30 different genera. Despite its appearance, kelp is not a plant - it is a heterokont, a completely unrelated group of organisms.
Kelp grows in "underwa ...
) and shellfish, dairy products and eggs
Humans and human ancestors have scavenged and eaten animal eggs for millions of years. Humans in Southeast Asia had domesticated chickens and harvested their eggs for food by 1,500 BCE. The most widely consumed eggs are those of fowl, especial ...
so long as the animals received enough iodine, and plants grown on iodine-rich soil.[ ]Iodised salt
Iodised salt ( also spelled iodized salt) is table salt mixed with a minute amount of various salts of the element iodine. The ingestion of iodine prevents iodine deficiency. Worldwide, iodine deficiency affects about two billion people and is t ...
is fortified with iodine in the form of sodium iodide
Sodium iodide (chemical formula NaI) is an ionic compound formed from the chemical reaction of sodium metal and iodine. Under standard conditions, it is a white, water-soluble solid comprising a 1:1 mix of sodium cations (Na+) and iodide anions ...
.
As of 2000, the median intake of iodine from food in the United States was 240 to 300 μg/day for men and 190 to 210 μg/day for women. The general US population has adequate iodine nutrition, with women of childbearing age and pregnant women having a possible mild risk of deficiency. In Japan, consumption was considered much higher, ranging between 5,280 μg/day to 13,800 μg/day from dietary seaweed or kombu
''Konbu'' (from ja, 昆布, konbu or kombu) is edible kelp mostly from the family Laminariaceae and is widely eaten in East Asia. It may also be referred to as ''dasima'' ( ko, 다시마) or ''haidai'' ().
Kelp features in the diets of many ...
kelp, often in the form of kombu umami
Umami ( from ja, 旨味 ), or savoriness, is one of the five basic tastes. It has been described as savory and is characteristic of broths and cooked meats.
People taste umami through taste receptors that typically respond to glutamates and ...
extracts for soup stock and potato chips. However, new studies suggest that Japan's consumption is closer to 1,000–3,000 μg/day. The adult UL in Japan was last revised to 3,000 µg/day in 2015.
After iodine fortification programs such as iodisation of salt have been implemented, some cases of iodine-induced hyperthyroidism
Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormones by the thyroid gland. Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidis ...
have been observed (so-called Jod-Basedow phenomenon
The Jod-Basedow effect (also Jod-Basedow syndrome and Jod-Basedow phenomenon) is hyperthyroidism following administration of iodine or iodide, either as a dietary supplement, iodinated contrast medical imaging, or as a medication (mainly Amiodaron ...
). The condition seems to occur mainly in people over forty, and the risk appears higher when iodine deficiency is severe and the initial rise in iodine intake is high.
Deficiency
In areas where there is little iodine in the diet, typically remote inland areas and semi-arid equatorial climates where no marine foods are eaten, iodine deficiency
Iodine deficiency is a lack of the trace element iodine, an essential nutrient in the diet. It may result in metabolic problems such as goiter, sometimes as an endemic goiter as well as congenital iodine deficiency syndrome due to untreated cong ...
gives rise to hypothyroidism, symptoms of which are extreme fatigue, goitre
A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre can be associated with a thyroid that is not functioning properly.
Worldwide, over 90% of goitre cases are caused by iodine deficiency. The term is ...
, mental slowing, depression, weight gain, and low basal body temperatures. Iodine deficiency is the leading cause of preventable intellectual disability
Intellectual disability (ID), also known as general learning disability in the United Kingdom and formerly mental retardation, Rosa's Law, Pub. L. 111-256124 Stat. 2643(2010). is a generalized neurodevelopmental disorder characterized by signif ...
, a result that occurs primarily when babies or small children are rendered hypothyroid
Hypothyroidism (also called ''underactive thyroid'', ''low thyroid'' or ''hypothyreosis'') is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as po ...
ic by a lack of the element. The addition of iodine to table salt has largely eliminated this problem in wealthier nations, but iodine deficiency remains a serious public health problem in the developing world today. Iodine deficiency is also a problem in certain areas of Europe. Information processing, fine motor skills, and visual problem solving are improved by iodine repletion in moderately iodine-deficient children.
Precautions
Toxicity
Elemental iodine (I2) is toxic
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a subs ...
if taken orally undiluted. The lethal dose for an adult human is 30 mg/kg, which is about 2.1–2.4 grams for a human weighing 70 to 80 kg (even if experiments on rats demonstrated that these animals could survive after eating a 14000 mg/kg dose). Excess iodine can be more cytotoxic in the presence of selenium deficiency
Selenium deficiency occurs when an organism lacks the required levels of selenium, a critical nutrient in many species. Deficiency, although relatively rare in healthy well-nourished individuals, can have significant negative results, affecting the ...
. Iodine supplementation in selenium-deficient populations is, in theory, problematic, partly for this reason. The toxicity derives from its oxidizing properties, through which it denaturates proteins (including enzymes).
Elemental iodine is also a skin irritant. Direct contact with skin can cause damage, and solid iodine crystals should be handled with care. Solutions with high elemental iodine concentration, such as tincture of iodine
Tincture of iodine, iodine tincture, or weak iodine solution is an antiseptic. It is usually 2 to 7% elemental iodine, along with potassium iodide or sodium iodide, dissolved in a mixture of ethanol and water. Tincture solutions are characteriz ...
and Lugol's solution, are capable of causing tissue damage if used in prolonged cleaning or antisepsis; similarly, liquid Povidone-iodine
Povidone-iodine (PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. It may be used both to disinfect the hands of healthcare providers and the skin of the person they are caring for. It may ...
(Betadine) trapped against the skin resulted in chemical burns in some reported cases.
Occupational exposure
People can be exposed to iodine in the workplace by inhalation, ingestion, skin contact, and eye contact. The Occupational Safety and Health Administration
The Occupational Safety and Health Administration'' (OSHA ) is a large regulatory agency of the United States Department of Labor that originally had federal visitorial powers to inspect and examine workplaces. Congress established the agenc ...
(OSHA) has set the legal limit (Permissible exposure limit
The permissible exposure limit (PEL or OSHA PEL) is a legal limit in the United States for exposure of an employee to a chemical substance or physical agent such as high level noise. Permissible exposure limits are established by the Occupational ...
) for iodine exposure in the workplace at 0.1 ppm (1 mg/m3) during an 8-hour workday. The National Institute for Occupational Safety and Health
The National Institute for Occupational Safety and Health (NIOSH, ) is the United States federal agency responsible for conducting research and making recommendations for the prevention of work-related injury and illness. NIOSH is part of the C ...
(NIOSH) has set a Recommended exposure limit
A recommended exposure limit (REL) is an occupational exposure limit that has been recommended by the United States National Institute for Occupational Safety and Health. The REL is a level that NIOSH believes would be protective of worker safet ...
(REL) of 0.1 ppm (1 mg/m3) during an 8-hour workday. At levels of 2 ppm, iodine is immediately dangerous to life and health
The term immediately dangerous to life or health (IDLH) is defined by the US National Institute for Occupational Safety and Health (NIOSH) as exposure to airborne contaminants that is "likely to cause death or immediate or delayed permanent advers ...
.
Allergic reactions
Some people develop a hypersensitivity
Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune ...
to products and foods containing iodine. Applications of tincture of iodine or Betadine can cause rashes, sometimes severe.[DermNet New Zealand Trust]
Iodine
/ref> Parenteral
A route of administration in pharmacology and toxicology is the way by which a drug, fluid, poison, or other substance is taken into the body.
Routes of administration are generally classified by the location at which the substance is applied. ...
use of iodine-based contrast agents (see above) can cause reactions ranging from a mild rash to fatal anaphylaxis
Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of use of emergency medication on site. It typically causes more than one of the foll ...
. Such reactions have led to the misconception (widely held, even among physicians) that some people are allergic to iodine itself; even allergies to iodine-rich seafood have been so construed. In fact, there has never been a confirmed report of a true iodine allergy, and an allergy to elemental iodine or simple iodide salts is theoretically impossible. Hypersensitivity reactions to products and foods containing iodine are apparently related to their other molecular components;[UCSF Department of Radiology & Biomedical Imaging]
Iodine Allergy and Contrast Administration
/ref> thus, a person who has demonstrated an allergy to one food or product containing iodine may not have an allergic reaction to another. Patients with various food allergies (shellfish, egg, milk, etc.) do not have an increased risk for a contrast medium hypersensitivity. As with all medications, the patient's allergy history should be questioned and consulted before any containing iodine are administered.
US DEA List I status
Phosphorus
Phosphorus is a chemical element with the symbol P and atomic number 15. Elemental phosphorus exists in two major forms, white phosphorus and red phosphorus, but because it is highly reactive, phosphorus is never found as a free element on Ear ...
can reduce elemental iodine to hydroiodic acid
Hydroiodic acid (or hydriodic acid) is an aqueous solution of hydrogen iodide (HI). It is a strong acid, one that is ionized completely in an aqueous solution. It is colorless. Concentrated solutions are usually 48% to 57% HI.
Reactions
Hy ...
, which is a reagent effective for reducing ephedrine
Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in ...
or pseudoephedrine to methamphetamine. For this reason, iodine was designated by the United States Drug Enforcement Administration
The Drug Enforcement Administration (DEA; ) is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating drug trafficking and distribution within the U.S. It is the lead agency for domestic en ...
as a List I precursor chemical under 21 CFR 1310.02.
References
Bibliography
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Chemical elements
Halogens
Reactive nonmetals
Diatomic nonmetals
Dietary minerals
Oxidizing agents
Gases with color
Chemical elements with primitive orthorhombic structure