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Deguelia Utilis
''Deguelia utilis'', syn. ''Lonchocarpus utilis'' (cubé, (common) lancepod or barbasco) is plant species in the family Fabaceae. It is native to the tropical forests of Peru, as well as of Brazil and Guyana, growing from above sea level. Cubé resin, the root extract from cubé and from barbasco ('' Lonchocarpus urucu''), is used as a commercial insecticide and piscicide (fish poison). The major active ingredients are rotenone and deguelin. Although "organic" (produced by nature) rotenone is no longer considered an environmentally safe chemical. Miscellaneous Cubé is toxic to insects, fish, and other pets. The primary threat to humans and other mammals comes from inhaling the powdered root or root extract. See also * Lonchocarpus ''Lonchocarpus'' is a plant genus in the legume family (biology), family (Fabaceae). The species are called lancepods due to their fruit resembling an ornate lance tip or a few beads on a string. ''Cubé'' resin is produced from the roots of ...
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Alexander Hanchett Smith
Alexander Hanchett Smith (December 12, 1904 – December 12, 1986) was an American mycologist known for his extensive contributions to the taxonomy and phylogeny of the higher fungi, especially the agarics. Early life Smith, born in Crandon, Wisconsin, was the second child of Ruth M. and Edward A. Schmidt, who later changed their name to Smith. After the death of his mother in his teens, Smith and family moved to West De Pere, Wisconsin, to live with their paternal grandparents. Education Smith graduated from high school in West De Pere in 1923. A year later, he entered Lawrence College in Appleton, Wisconsin, where he received a B.A. degree in 1928. He applied for a fellowship at the University of Michigan and began graduate studies in botany in the fall of 1928 with the eminent mycologist Calvin H. Kauffman as his advisor. Kauffman died before Smith completed his degree, so he continued his studies under professor Edwin Butterworth Mains, eventually earning his M.A. in 1929 ...
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Barbasco
Barbasco is the name of several plants that contain poisonous chemical compounds that have been used for fishing by indigenous populations of the Americas: * ''Lonchocarpus urucu'', used by Shuar and Nukak peoples as a poison for fishing. * ''Deguelia utilis'', used in Brazil and Peru as a poison for fishing. * '' Jacquinia barbasco'', an evergreen. * One of several inedible wild Mexican yam (''Dioscorea mexicana'' and ''Dioscorea composita'') from which progesterone Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the m ...
can be synthesized. {{Plant common name ...
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Fabaceae
The Fabaceae or Leguminosae,International Code of Nomenclature for algae, fungi, and plants.
Article 18.5 states: "The following names, of long usage, are treated as validly published: ....Leguminosae (nom. alt.: Fabaceae; type: Faba Mill. Vicia L.; ... When the Papilionaceae are regarded as a family distinct from the remainder of the Leguminosae, the name Papilionaceae is conserved against Leguminosae." English pronunciations are as follows: , and .
commonly known as the legume, pea, or bean family, are a large and agriculturally important of

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Peru
, image_flag = Flag of Peru.svg , image_coat = Escudo nacional del Perú.svg , other_symbol = Great Seal of the State , other_symbol_type = Seal (emblem), National seal , national_motto = "Firm and Happy for the Union" , national_anthem = "National Anthem of Peru" , march = "March of Flags" , image_map = PER orthographic.svg , map_caption = , image_map2 = , capital = Lima , coordinates = , largest_city = capital , official_languages = Peruvian Spanish, Spanish , languages_type = Co-official languages , languages = , ethnic_groups = , ethnic_groups_year = 2017 , demonym = Peruvians, Peruvian , government_type = Unitary state, Unitary Semi-presidential system, semi-presidential republic , leader_title1 = President of Peru, President ...
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Brazil
Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area and the seventh most populous. Its capital is Brasília, and its most populous city is São Paulo. The federation is composed of the union of the 26 States of Brazil, states and the Federal District (Brazil), Federal District. It is the largest country to have Portuguese language, Portuguese as an List of territorial entities where Portuguese is an official language, official language and the only one in the Americas; one of the most Multiculturalism, multicultural and ethnically diverse nations, due to over a century of mass Immigration to Brazil, immigration from around the world; and the most populous Catholic Church by country, Roman Catholic-majority country. Bounded by the Atlantic Ocean on the east, Brazil has a Coastline of Brazi ...
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Guyana
Guyana ( or ), officially the Cooperative Republic of Guyana, is a country on the northern mainland of South America. Guyana is an indigenous word which means "Land of Many Waters". The capital city is Georgetown. Guyana is bordered by the Atlantic Ocean to the north, Brazil to the south and southwest, Venezuela to the west, and Suriname to the east. With , Guyana is the third-smallest sovereign state by area in mainland South America after Uruguay and Suriname, and is the second-least populous sovereign state in South America after Suriname; it is also one of the least densely populated countries on Earth. It has a wide variety of natural habitats and very high biodiversity. The region known as "the Guianas" consists of the large shield landmass north of the Amazon River and east of the Orinoco River known as the "land of many waters". Nine indigenous tribes reside in Guyana: the Wai Wai, Macushi, Patamona, Lokono, Kalina, Wapishana, Pemon, Akawaio and Warao. Histo ...
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Sea Level
Mean sea level (MSL, often shortened to sea level) is an average surface level of one or more among Earth's coastal bodies of water from which heights such as elevation may be measured. The global MSL is a type of vertical datuma standardised geodetic datumthat is used, for example, as a chart datum in cartography and marine navigation, or, in aviation, as the standard sea level at which atmospheric pressure is measured to calibrate altitude and, consequently, aircraft flight levels. A common and relatively straightforward mean sea-level standard is instead the midpoint between a mean low and mean high tide at a particular location. Sea levels can be affected by many factors and are known to have varied greatly over geological time scales. Current sea level rise is mainly caused by human-induced climate change. When temperatures rise, Glacier, mountain glaciers and the Ice sheet, polar ice caps melt, increasing the amount of water in water bodies. Because most of human settlem ...
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Lonchocarpus Urucu
''Lonchocarpus urucu'', or barbasco, is plant in the family Fabaceae. It is native to the tropical forests of Peru, as well as of Brazil and Guyana, growing from above sea level. It was also recorded in Venezuela. Cubé resin, the root extract from Barbasco and from cubé (''Lonchocarpus utilis''), is used as a commercial insecticide and piscicide (fish poison). The major active ingredients are rotenone and deguelin. Although "organic" (produced by nature), rotenone is no longer considered an environmentally safe chemical. Taxonomic status The taxonomic status as a species with the name Lonchocarpus urucu ist still to be resolved, as it is also considered a variety of Deguelia rufescens: ''Deguelia rufescens var. urucu'' (Killip & A.C.Sm.) A.M.G.Azeved. Toxicity Barbasco is toxic to insects, fish, and other pests. The primary threat to humans and other mammals comes from inhaling the powdered root or root extract. It has been used by the Shuar people of Ecuador and the Nukak p ...
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Insecticide
Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to be a major factor behind the increase in the 20th-century's agricultural productivity. Nearly all insecticides have the potential to significantly alter ecosystems; many are toxic to humans and/or animals; some become concentrated as they spread along the food chain. Insecticides can be classified into two major groups: systemic insecticides, which have residual or long term activity; and contact insecticides, which have no residual activity. The mode of action describes how the pesticide kills or inactivates a pest. It provides another way of classifying insecticides. Mode of action can be important in understanding whether an insecticide will be toxic to unrelated species, such as fish, birds and mammals. Insecticides may be repellent ...
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Rotenone
Rotenone is an odorless, colorless, crystalline isoflavone used as a broad-spectrum insecticide, piscicide, and pesticide. It occurs naturally in the seeds and stems of several plants, such as the jicama vine plant, and the roots of several members of Fabaceae. It was the first described member of the family of chemical compounds known as rotenoids. Discovery The earliest record of the now-known rotenone-containing plants used for killing leaf-eating caterpillars was in 1848, and for centuries, the same plants were used to poison fish. The active chemical component was first isolated in 1895 by a French botanist, Emmanuel Geoffroy, who called it ''nicouline'', from a specimen of ''Robinia nicou'', now called ''Lonchocarpus nicou'', while traveling in French Guiana. He wrote about this research in his thesis, published in 1895 after his death from a parasitic disease. In 1902 Kazuo Nagai, Japanese chemical engineer of the Government-General of Taiwan, isolated a pure crystalline ...
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Deguelin
Deguelin is a derivative of rotenone. Both are compounds classified as rotenoids of the flavonoid family and are naturally occurring insecticides. They can be produced by extraction from several plant species belonging to three genera of the legume family, Fabaceae: ''Lonchocarpus'', ''Derris'', or ''Tephrosia''. Cubé resin, the root extract from cubé (''Lonchocarpus utilis'') and from barbasco (''Lonchocarpus urucu''), is used as a commercial insecticide and piscicide (fish poison). The major active ingredients are rotenone and deguelin. Although "organic" (produced by nature) cubé resin is no longer considered environmentally safe. Rat pharmacokinetics * Mean residence time (MRT) = 6.98 h * Terminal half-life (t1/2(gamma)) = 9.26 h * Area under the curve (AUC) = 57.3 ng h/ml * Total clearance (Cl) = 4.37 L/h per kg * Apparent volume of distribution (V) = 3.421 L/kg * Volume of distribution at steady-state (Vss) = 30.46 L/kg * Tissue distributions after i.v. (intraveno ...
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