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Secoergoline
Secoergoline is an structural analog, analogue of ergoline with one or more bonds removed and may refer to: * 3,5-Secoergoline (also known as RU-27251) * 8,10-Secoergoline (e.g., 8,10-seco-LSD also known as NDTDI) * 10,11-Secoergoline (e.g., 10,11-seco-LSD, CT-5252) Other secoergolines include partial clavines like chanoclavine and paliclavine. See also * Seco-LSD * Partial ergoline * Ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergoline
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,5-Secoergoline
RU-27251, also known as 3,5-secoergoline or as 4-piperidin-3-yl-1''H''-indole, is a serotonin receptor modulator and dopamine receptor agonist of the partial ergoline family. Its affinity (KD) for the dopamine D2high receptor was 72nM and for the dopamine D2low receptor was 11,600nM. RU-27251 was first described in the scientific literature by 1983. See also * Partial ergoline * Secoergoline * Seco-LSD * FAEFHI * DEIMDHPCA DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide ( ... * WXVL_BT0793LQ2118 References Dopamine agonists Indoles Partial ergolines Piperidines Serotonin receptor modulators {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
10,11-seco-LSD
10,11-Seco-LSD is a partial lysergamide and cyclized tryptamine related to lysergic acid diethylamide (LSD). It is the seco structural analog, analogue of LSD in which the covalent bond, bond between the 10 and 11 positions of the ergoline ring system (chemistry), ring system has been broken. 10,11-Seco-LSD was described in a patent by David E. Olson and colleagues at Delix Therapeutics in 2021. Its pharmacology was not described. See also * Partial lysergamide * Seco-LSD * Secoergoline * NDTDI (8,10-seco-LSD) * DEIMDHPCA (3,5-seco-LSD) References Carboxamides Diethylamino compounds N,N-Dialkyltryptamines Partial ergolines Tetrahydropyridines {{Hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CT-5252
CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent bond between the 10 and 11 positions of the ergoline ring system (chemistry), ring system has been broken to conformational constraint, unconstrain the chemical structure, structure. The drug produces specific LSD-like behavioral changes in guinea pigs but with only about 1/48th the potency (pharmacology), potency of LSD. It also causes seizures at slightly higher doses than those that cause LSD-like effects. CT-5252 was first described in the scientific literature in 1969. The structural analog, analogue of CT-5252 with an ''N'',''N''-diethyl-carboxamide moiety (chemistry), moiety on the tetrahydropyridine ring (chemistry), ring instead of the carboxylate functional group, group (i.e., more analogous to LSD) has also been assessed and descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seco-LSD
Seco-LSD is an structural analog, analogue of LSD with one or more covalent bond, bonds removed and may refer to: * 3,5-Seco-LSD (also known as DEIMDHPCA) * 8,10-Seco-LSD (also known as NDTDI) * 10,11-Seco-LSD Additional seco-LSD compounds with more bonds removed include DEMPDHPCA, N-DEAOP-NMT, ''N''-DEAOP-NMT, and N-DEAOP-NMPEA, ''N''-DEAOP-NMPEA. See also * Secoergoline * Partial ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secosteroid
A secosteroid () is a type of steroid with a "broken" ring. The word ''secosteroid ''derives from the Latin verb ''secare'' meaning "to cut", and 'steroid'. Secosteroids are described as a subclass of steroids under the IUPAC nomenclature. Some sources instead describe them as compounds derived from steroids. Types or subclasses of secosteroids are defined by the carbon atoms of the parent steroid skeleton where the ring cleavage has taken place. For example, 9,10-secosteroids are derived from cleavage of the bond between carbon atoms C9 and C10 of the steroid B-ring (similarly 5,6-secosteroids, 13,14-secosteroids, etc.). The prototypical secosteroid is cholecalciferol Cholecalciferol, also known as vitamin D3, colecalciferol or calciol, is a type of vitamin D that is produced by the skin when exposed to UV light, UVB light; it is found in certain foods and can be taken as a dietary supplement. Cholecalcife ... (vitamin D3). Its IUPAC systematic is "(5''Z'',7''E'')-(3'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronicity, isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analog (chemistry), functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is virtual screening, screened for structural analogs of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ergoline
Ergoline is a core structure in many alkaloids and their synthetic derivatives. Ergoline alkaloids were first characterized in ergot. Some of these are implicated in the condition of ergotism, which can take a convulsive form or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful. Annual world production of ergot alkaloids has been estimated at 5,000–8,000 kg of all ergopeptines and 10,000–15,000 kg of lysergic acid, used primarily in the manufacture of semi-synthetic derivatives. Others, such as lysergic acid diethylamide, better known as LSD, a Semisynthesis, semi-synthetic derivative, and ergine, a natural derivative found in ''Argyreia nervosa'', ''Ipomoea tricolor'' and related species, are known Psychedelic drug, psychedelic substances. Natural occurrence Ergoline alkaloids are found in fungi such as Claviceps purpurea, Claviceps paspali, and the related Periglandula, which have a permanent, symbiotic bond with numerous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
8,10-seco-LSD
NDTDI, also known as 8,10-seco-LSD, is a tricyclic tryptamine derivative which is thought to act as a serotonin receptor agonist, though its pharmacology has not been studied in detail. It is a structurally simplified analogue of the psychedelic drug lysergic acid diethylamide (LSD) and is reported to retain similar effects, though with many times lower potency. NDTDI is specifically the analogue of LSD in which the carbon atom at position 9 of the ergoline ring system has been removed. It has been sold as a designer drug since 2016 and was first identified by a forensic laboratory in Slovenia in 2017. NDTDI was made illegal in Latvia in March 2017. The simplified analogue of NDTDI and LSD in which the carbons at positions 9 and 10 of the ergoline ring system have been removed, resulting in a fully non-rigid tryptamine derivative, is ''N''-DEAOP-NMT. See also * Partial lysergamide * List of miscellaneous 5-HT2A receptor agonists * Seco-LSD * RU-27849 * Bay R 1531 * DEIMDH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clavine
Ergoline is a core structure in many alkaloids and their synthetic derivatives. Ergoline alkaloids were first characterized in ergot. Some of these are implicated in the condition of ergotism, which can take a convulsive form or a gangrenous form. Even so, many ergoline alkaloids have been found to be clinically useful. Annual world production of ergot alkaloids has been estimated at 5,000–8,000 kg of all ergopeptines and 10,000–15,000 kg of lysergic acid, used primarily in the manufacture of semi-synthetic derivatives. Others, such as lysergic acid diethylamide, better known as LSD, a semi-synthetic derivative, and ergine, a natural derivative found in ''Argyreia nervosa'', ''Ipomoea tricolor'' and related species, are known psychedelic substances. Natural occurrence Ergoline alkaloids are found in fungi such as Claviceps purpurea, Claviceps paspali, and the related Periglandula, which have a permanent, symbiotic bond with numerous flowering vines, most notably, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
