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3,5-Secoergoline
RU-27251, also known as 3,5-secoergoline or as 4-piperidin-3-yl-1''H''-indole, is a serotonin receptor modulator and dopamine receptor agonist of the partial ergoline family. Its affinity (KD) for the dopamine D2high receptor was 72nM and for the dopamine D2low receptor was 11,600nM. RU-27251 was first described in the scientific literature by 1983. See also * Partial ergoline * Secoergoline * Seco-LSD * FAEFHI * DEIMDHPCA DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide ( ... * WXVL_BT0793LQ2118 References Dopamine agonists Indoles Partial ergolines Piperidines Serotonin receptor modulators {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Secoergoline
Secoergoline is an structural analog, analogue of ergoline with one or more bonds removed and may refer to: * 3,5-Secoergoline (also known as RU-27251) * 8,10-Secoergoline (e.g., 8,10-seco-LSD also known as NDTDI) * 10,11-Secoergoline (e.g., 10,11-seco-LSD, CT-5252) Other secoergolines include partial clavines like chanoclavine and paliclavine. See also * Seco-LSD * Partial ergoline * Ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serotonin Receptor Modulator
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The serotonin (i.e., 5-hydroxytryptamine, hence "5-HT") receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. Serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation. They are the target of a variety of pharmaceutical and recreational drugs, includin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Ergolines
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ... and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indoles
Indole is an organic compound with the formula . Indole is classified as an aromatic Heterocyclic compound, heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole where one or more of the hydrogen atoms have been replaced by substituent groups. Indoles are widely distributed in nature, most notably as amino acid tryptophan and neurotransmitter serotonin. General properties and occurrence Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes. It also occurs in coal tar. It has been identified in cannabis. It is the main volatile compound in stinky tofu. When indole is a substituent on a larger molecule, it is called an ''indolyl group'' by systematic nomenclature. Indole undergoes electrophilic substitution, mainly at position ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dopamine Agonists
A dopamine agonist is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all G protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the D2-like family includes D2, D3 and D4 receptors. Dopamine agonists are primarily used in the treatment of the motor symptoms of Parkinson's disease, and to a lesser extent, in hyperprolactinemia and restless legs syndrome. They are also used off-label in the treatment of clinical depression. Impulse control disorders are associated with the use of dopamine agonists. Medical uses Parkinson's disease Dopamine agonists are mainly used in the treatment of Parkinson's disease. The cause of Parkinson's is not fully known but genetic factors, for example specific genetic mutations, and environmental triggers have been linked to the disease. In Parkinson's disease dopaminergic neurons that produce the neurotransmitter dopamine in the brain slowly br ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WXVL BT0793LQ2118
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole derivative and a "partial" or simplified ergoline which is closely related to the highly potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid indolic phenethylamine-containing compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A and 5-HT2C receptor agonist ''in vitro''. Its affinities () are in the ranges of 10–100nM for the serotonin 5-HT2A receptor and 100–1,000nM for the serotonin 5-HT2C receptor, while its activational potencies () are less than 10nM for the serotonin 5-HT2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEIMDHPCA
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the structural analogue, analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system (chemistry), ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid structure, rigid indole, indolic substituted phenethylamine, phenethylamine-containing chemical compound, compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor, 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C receptor agonist ''in vitro''. Its affinity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FAEFHI
FAEFHI, also known as 4-(2-aminoethyl)-5-hydroxyindole, is a serotonin receptor modulator of the indole group related to serotonin and other substituted tryptamine, tryptamines. It is a positional isomer of serotonin in which the ethyl group, ethylamine side chain at the 3 position of the indole ring system (chemistry), ring system has been moved to the 4 position. FAEFHI can also be thought of as a greatly simplified structural analog, analogue of LSD and hence partial ergoline. Although FAEFHI shows significant affinity (pharmacology), affinity for serotonin receptors, it had much lower affinity than serotonin or tryptamine (171-fold lower than serotonin and 5-fold lower than tryptamine). In addition, it did not show serotonin-like activity (i.e., serotonin receptor agonism) even at very high concentrations ''in vitro''. FAEFHI was first described in the scientific literature by 1984. See also * Partial ergoline * FHATHBIN * RU-27251 * DEIMDHPCA * WXVL_BT0793LQ2118 References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seco-LSD
Seco-LSD is an structural analog, analogue of LSD with one or more covalent bond, bonds removed and may refer to: * 3,5-Seco-LSD (also known as DEIMDHPCA) * 8,10-Seco-LSD (also known as NDTDI) * 10,11-Seco-LSD Additional seco-LSD compounds with more bonds removed include DEMPDHPCA, N-DEAOP-NMT, ''N''-DEAOP-NMT, and N-DEAOP-NMPEA, ''N''-DEAOP-NMPEA. See also * Secoergoline * Partial ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Literature
Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical contributions. These papers serve as essential sources of knowledge and are commonly referred to simply as "the literature" within specific research fields. The process of academic publishing involves disseminating research findings to a wider audience. Researchers submit their work to reputable journals or conferences, where it undergoes rigorous evaluation by experts in the field. This evaluation, known as peer review, ensures the quality, validity, and reliability of the research before it becomes part of the scientific literature. Peer-reviewed publications contribute significantly to advancing our understanding of the world and shaping future research endeavors. Original scientific research first published in scientific journals co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dopamine Receptor Modulator
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. Subtypes The existence of multiple types of receptors for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D2 Receptor
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the ''DRD2'' gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D2 receptor. The dopamine D2 receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined. Function D2 receptors are coupled to Gi subtype of G protein. This G protein-coupled receptor inhibits adenylyl cyclase activity. In mice, regulation of D2R surface expression by the neuronal calcium sensor-1 (NCS-1) in the dentate gyrus is involved in exploration, synaptic plasticity and memory formation. Studies have shown potential roles for D2R in retrieval of fear memories in the prelimbic cortex and in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
