RU-27251, also known as 3,5-secoergoline or as 4-piperidin-3-yl-1''H''-indole, is a

serotonin receptor modulator 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both ex ...

and

dopamine receptor agonist A dopamine agonist is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all G protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the D2-like ...

of the

partial ergoline Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (ch ...

family. Its

affinity Affinity may refer to: Commerce, finance and law * Affinity (law), kinship by marriage * Affinity analysis, a market research and business management technique * Affinity Credit Union, a Saskatchewan-based credit union * Affinity Equity Pa ...

(K_D) for the

dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...

D₂^high receptor was 72nM and for the dopamine D₂^low receptor was 11,600nM. RU-27251 was first described in the

scientific literature Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical ...

by 1983.

References

Dopamine agonists Indoles Partial ergolines Piperidines Serotonin receptor modulators {{Nervous-system-drug-stub

See also

References