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CT-5252
CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent bond between the 10 and 11 positions of the ergoline ring system (chemistry), ring system has been broken to conformational constraint, unconstrain the chemical structure, structure. The drug produces specific LSD-like behavioral changes in guinea pigs but with only about 1/48th the potency (pharmacology), potency of LSD. It also causes seizures at slightly higher doses than those that cause LSD-like effects. CT-5252 was first described in the scientific literature in 1969. The structural analog, analogue of CT-5252 with an ''N'',''N''-diethyl-carboxamide moiety (chemistry), moiety on the tetrahydropyridine ring (chemistry), ring instead of the carboxylate functional group, group (i.e., more analogous to LSD) has also been assessed and descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-DEAOP-NMT
''N''-(3-Diethylamino-3-oxopropyl)-''N''-methyltryptamine (''N''-DEAOP-NMT) is a substituted tryptamine, tryptamine chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is the structural analog, analogue of LSD in which two of LSD's carbon atoms in the ergoline ring (chemistry), ring, those at positions 9 and 10, have been removed. This in turn renders the ''N''-DEAOP-NMT molecule flexible and makes it a conformational constraint, non-rigid tryptamine rather than an ergoline. The compound is pharmacology, pharmacologically active, as are a number of its analogues and derivatives, with activities of the compounds including serotonin 5-HT2A receptor, 5-HT2A receptor agonist, agonism and LSD- or hallucinogen-like effects. Pharmacology ''N''-DEAOP-NMT has been found to produce quantifiable oxytocic effects in animals. However, in co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simplified/partial LSD Analogue
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Lysergamide
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5, are serotonin 5-HT2A receptor agonists and have psychedelic-like and/or psychoplastogenic effects. Some, like 8-OH-DPAT and LY-178210, are selective serotonin 5-HT1A receptor agonists. Others, like rotigotine, nolomirole, and RU-28251, are dopamine D2-like receptor agonists. Par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Tryptamine
Substituted tryptamines, or simply tryptamines, also known as serotonin analogues (i.e., 5-hydroxytryptamine analogues), are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring, joined to an amino group, amino (NH2) group via an ethyl (−CH2–CH2−) side chain, sidechain. In substituted tryptamines, the indole ring, sidechain, and/or amino group are modified by substituting another group for one of the hydrogen (H) atoms. Well-known tryptamines include serotonin, an important neurotransmitter, and melatonin, a hormone involved in regulating the sleep-wake cycle. Tryptamine alkaloids are found in fungi, plants and animals; and sometimes used by humans for the neurological or psychotropic effects of the substance. Prominent examples of tryptamine alkaloids include psilocybin (from "psilocybin mushrooms") and dimethyltryptamine, DMT. In South America, dimethyltryptamine is obtained f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEIMDHPCA
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the structural analogue, analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system (chemistry), ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid structure, rigid indole, indolic substituted phenethylamine, phenethylamine-containing chemical compound, compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor, 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C receptor agonist ''in vitro''. Its affinity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NDTDI
NDTDI, also known as 8,10-seco-LSD, is a tricyclic tryptamine derivative which is thought to act as a serotonin receptor agonist, though its pharmacology has not been studied in detail. It is a structurally simplified analogue of the psychedelic drug lysergic acid diethylamide (LSD) and is reported to retain similar effects, though with many times lower potency. NDTDI is specifically the analogue of LSD in which the carbon atom at position 9 of the ergoline ring system has been removed. It has been sold as a designer drug since 2016 and was first identified by a forensic laboratory in Slovenia in 2017. NDTDI was made illegal in Latvia in March 2017. The simplified analogue of NDTDI and LSD in which the carbons at positions 9 and 10 of the ergoline ring system have been removed, resulting in a fully non-rigid tryptamine derivative, is ''N''-DEAOP-NMT. See also * Partial lysergamide * List of miscellaneous 5-HT2A receptor agonists * Seco-LSD * RU-27849 * Bay R 1531 * DEIMD ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-28306
RU-28306 is a synthetic indole alkaloid derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT1 and 5-HT2 subtypes. It can be regarded as a conformationally restricted tricyclic derivative of DMT or a structurally simplified derivative of LSD. The binding affinity of racemic RU-28306 is closer to that of DMT than LSD, though with relatively higher affinity for 5-HT2 subtypes and lower for 5-HT1. It has been sold as a designer drug and was first reported to the EMCDDA by a forensic laboratory in Slovenia in 2017. It was subsequently patented by Delix Therapeutics in 2021. See also * Partial lysergamide * RU-27849 * Bay R 1531 * NDTDI * ''N''-DEAOP-NMT * CT-5252 CT-5252 is a substituted tryptamine, tryptamine-like non-rigid structure, less-rigid structural analogue, analogue of lysergic acid diethylamide (LSD). It is a 10,11-secoergoline; that is, an substituted ergoline, ergoline in which the covalent b ... * RU-24,969 * 4,5-DHP-DMT References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-27849
RU-27849 is a serotonin receptor modulator. It can be regarded as a conformationally restricted tricyclic derivative of tryptamine or a structurally simplified derivative of LSD. This molecule was developed during structure–activity relationship (SAR) studies of LSD. It shows affinity for serotonin receptors, including for the serotonin 5-HT1, 5-HT1A, and 5-HT2 receptors ( = 267–520nM, 325–326nM, and 1,964–2,900nM, respectively). RU-27849's affinities for serotonin receptors are similar to but lower than those of tryptamine and dimethyltryptamine (DMT). It shows very weak affinity for dopamine receptors and weak associated activity. The 6-methoxy derivative of RU-27849, which is to RU-27849 as 5-methoxytryptamine is to tryptamine, appears to have much higher affinity for serotonin receptors than RU-27849 itself ( ≈ 50nM). A number of other derivatives also exist, including FHATHBIN (6-hydroxy), RU-28306 (''N'',''N''-dimethyl), RU-28251 (''N'',''N''-dipropyl), Bay ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bromoarenes
In organic chemistry, an aryl halide (also known as a haloarene) is an aromatic compound in which one or more hydrogen atoms directly bonded to an aromatic ring are replaced by a halide ion (such as fluorine F''−'', chlorine Cl−1,−3,−5, bromine Br−1, or iodine I−). Aryl halides are distinct from haloalkanes (alkyl halides) due to significant differences in their methods of preparation, chemical reactivity, and physical properties. The most common and important members of this class are aryl chlorides, but the group encompasses a wide range of derivatives with diverse applications in organic synthesis, pharmaceuticals, and materials science. Classification according to halide Aryl fluorides Aryl fluorides are used as synthetic intermediates, e.g. for the preparation of pharmaceuticals, pesticides, and liquid crystals. The conversion of diazonium salts is a well established route to aryl fluorides. Thus, anilines are precursors to aryl fluorides. In the classic Schiemann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetate Esters
An acetate is a salt formed by the combination of acetic acid with a base (e.g. alkaline, earthy, metallic, nonmetallic, or radical base). "Acetate" also describes the conjugate base or ion (specifically, the negatively charged ion called an anion) typically found in aqueous solution and written with the chemical formula . The neutral molecules formed by the combination of the acetate ion and a ''positive'' ion (called a cation) are also commonly called "acetates" (hence, ''acetate of lead'', ''acetate of aluminium'', etc.). The simplest of these is hydrogen acetate (called acetic acid) with corresponding salts, esters, and the polyatomic anion , or . Most of the approximately 5 million tonnes of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In nature, acetate is the most common building block for biosynthesis. Nomenclature and common formula When part of a salt, the formula of the acetate ion is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Group
In organic chemistry, a functional group is any substituent or moiety (chemistry), moiety in a molecule that causes the molecule's characteristic chemical reactions. The same functional group will undergo the same or similar chemical reactions regardless of the rest of the molecule's composition. This enables systematic prediction of chemical reactions and behavior of chemical compounds and the design of chemical synthesis. The Reactivity (chemistry), reactivity of a functional group can be modified by other functional groups nearby. Functional group interconversion can be used in retrosynthetic analysis to plan organic synthesis. A functional group is a group of atoms in a molecule with distinctive Chemical property, chemical properties, regardless of the other atoms in the molecule. The atoms in a functional group are linked to each other and to the rest of the molecule by covalent bonds. For repeating units of polymers, functional groups attach to their Chemical polarity, nonp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carboxylate
In organic chemistry, a carboxylate is the conjugate base of a carboxylic acid, (or ). It is an anion, an ion with negative charge. Carboxylate salts are salts that have the general formula , where M is a metal and ''n'' is 1, 2,.... Carboxylate esters have the general formula (also written as ), where R and R′ are organic groups. Synthesis Carboxylate ions can be formed by deprotonation of carboxylic acids. Such acids typically have p''K''a of less than 5, meaning that they can be deprotonated by many bases, such as sodium hydroxide or sodium bicarbonate. : Resonance stabilization of the carboxylate ion Carboxylic acids easily dissociate into a carboxylate anion and a positively charged hydrogen ion (proton), much more readily than alcohols do (into an alkoxide ion and a proton), because the carboxylate ion is stabilized by resonance. The negative charge that is left after deprotonation of the carboxyl group is delocalized between the two electronegat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
