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8,10-Seco-LSD
NDTDI, also known as 8,10-seco-LSD, is a tricyclic tryptamine derivative which is thought to act as a serotonin receptor agonist, though its pharmacology has not been studied in detail. It is a structurally simplified analogue of the psychedelic drug lysergic acid diethylamide (LSD) and is reported to retain similar effects, though with many times lower potency. NDTDI is specifically the analogue of LSD in which the carbon atom at position 9 of the ergoline ring system has been removed. It has been sold as a designer drug since 2016 and was first identified by a forensic laboratory in Slovenia in 2017. NDTDI was made illegal in Latvia in March 2017. The simplified analogue of NDTDI and LSD in which the carbons at positions 9 and 10 of the ergoline ring system have been removed, resulting in a fully non-rigid tryptamine derivative, is ''N''-DEAOP-NMT. See also * Partial lysergamide * List of miscellaneous 5-HT2A receptor agonists * Seco-LSD * RU-27849 * Bay R 1531 * DEIMDH ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seco-LSD
Seco-LSD is an structural analog, analogue of LSD with one or more covalent bond, bonds removed and may refer to: * 3,5-Seco-LSD (also known as DEIMDHPCA) * 8,10-Seco-LSD (also known as NDTDI) * 10,11-Seco-LSD Additional seco-LSD compounds with more bonds removed include DEMPDHPCA, N-DEAOP-NMT, ''N''-DEAOP-NMT, and N-DEAOP-NMPEA, ''N''-DEAOP-NMPEA. See also * Secoergoline * Partial ergoline * Secosteroid {{Chemistry index Partial ergolines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simplified/partial LSD Analogue
Partial or simplified ergolines and lysergamides are structural analog, analogues of ergolines and substituted lysergamide, lysergamides like LSD in which one or more atoms or covalent bond, bonds, for instance within the ergoline ring system (chemistry), ring system, have been removed. Additional chemical substituent, substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded substituted tryptamine, tryptamine and substituted phenethylamine, phenethylamine moiety (chemistry), moieties within its chemical structure, structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin receptor agonist, serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5 (drug), LPH-5, are serotonin 5-HT2A receptor, 5-HT2A receptor agon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory
A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurement may be performed. Laboratories are found in a variety of settings such as schools, universities, privately owned research institutions, corporate research and testing facilities, government regulatory and forensic investigation centers, physicians' offices, clinics, hospitals, regional and national referral centers, and even occasionally personal residences. Overview The organisation and contents of laboratories are determined by the differing requirements of the specialists working within. A physics laboratory might contain a particle accelerator or vacuum chamber, while a metallurgy laboratory could have apparatus for casting or refining metals or for testing their strength. A chemist or biologist might use a wet laboratory, while a psychologist's laboratory might be a room with one-way mirrors and hidden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEMPDHPCA
DEMPDHPCA is a serotonin 5-HT2 receptor agonist and a cyclized phenethylamine and simplified or partial ergoline that is structurally related to the serotonergic psychedelic lysergic acid diethylamide (LSD). It is the analogue of LSD in which the carbon and nitrogen atoms at positions 1 through 4 of the ergoline ring system have been removed. Pharmacology DEMPDHPCA produces gross behavioral effects very similar to those of psychedelics like LSD in rodents and has been assumed to act as a hallucinogen likewise. However, the drug has not been tested in humans. DEMPDHPCA is much less potent than LSD in rodents, which was active at a dose of 0.16μmol/kg by intraperitoneal injection, whereas DEMPDHPCA was active at doses of 10 to 35μmol/kg. On the other hand, DEMPDHPCA was more potent than dimethyltryptamine (DMT) and is more potent than mescaline. Like LSD, the drug has been found to act as a potent serotonin 5-HT2A and 5-HT2C receptor agonist ''in vitro''. The affinitie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DEIMDHPCA
DEIMDHPCA, also known as 3,5-seco-LSD, is an indole chemical derivative, derivative and a "partial" or simplified ergoline which is closely related to the highly potency (pharmacology), potent serotonergic psychedelic lysergic acid diethylamide (LSD). It is specifically the structural analogue, analogue of LSD in which one of LSD's carbon atoms in the ergoline ring system (chemistry), ring system, the carbon at position 4, has been removed. This in turn renders the DEIMDHPCA molecule more flexible and makes it a partially rigid structure, rigid indole, indolic substituted phenethylamine, phenethylamine-containing chemical compound, compound rather than an ergoline. DEIMDHPCA is known to be a highly potent serotonin 5-HT2 receptor, 5-HT2 receptor agonist similarly to LSD and to produce psychoplastogenic effects. Pharmacology Like LSD, the drug is known to be a highly potent serotonin 5-HT2A receptor, 5-HT2A and 5-HT2C receptor, 5-HT2C receptor agonist ''in vitro''. Its affinity ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bay R 1531
Bay R 1531, also known as LY-197206, is a tricyclic tryptamine derivative. It acts as a selective serotonin 5-HT1A receptor agonist. It was investigated unsuccessfully for the treatment of stroke but continues to be used in scientific research. It shows very high affinity for the serotonin 5-HT1A receptor (Ki = 1.3nM). See also * Partial lysergamide * 8-OH-DPAT * RDS-127 RDS-127 is a drug which is used in scientific research. It acts as a D2-like receptor agonist and also has some serotonin and adrenergic agonist effects, as well as some anticholinergic action, and produces both anorectic and pro-sexual eff ... * RU-27849 * RU-28306 * LY-178210 * LY-293,284 * NDTDI * ''N''-DEAOP-NMT * CT-5252 References {{Tryptamines Alpha-Alkyltryptamines N,N-Dialkyltryptamines Heterocyclic compounds with 3 rings 5-Methoxytryptamines Partial ergolines Serotonin receptor agonists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RU-27849
RU-27849 is a serotonin receptor modulator. It can be regarded as a conformationally restricted tricyclic derivative of tryptamine or a structurally simplified derivative of LSD. This molecule was developed during structure–activity relationship (SAR) studies of LSD. It shows affinity for serotonin receptors, including for the serotonin 5-HT1, 5-HT1A, and 5-HT2 receptors ( = 267–520nM, 325–326nM, and 1,964–2,900nM, respectively). RU-27849's affinities for serotonin receptors are similar to but lower than those of tryptamine and dimethyltryptamine (DMT). It shows very weak affinity for dopamine receptors and weak associated activity. The 6-methoxy derivative of RU-27849, which is to RU-27849 as 5-methoxytryptamine is to tryptamine, appears to have much higher affinity for serotonin receptors than RU-27849 itself ( ≈ 50nM). A number of other derivatives also exist, including FHATHBIN (6-hydroxy), RU-28306 (''N'',''N''-dimethyl), RU-28251 (''N'',''N''-dipropyl), Bay ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Miscellaneous 5-HT2A Receptor Agonists
This is a list of miscellaneous agonists of the serotonin receptor subtype 5-HT2A (and other 5-HT2 subtypes to a varying extent) that fall outside the common structural classes. Most agonists at this receptor are either substituted phenethylamine derivatives from the 2C, DOx and 25-NB groups, or substituted tryptamines and related compounds along with more complex derivatives of these such as lysergamides and iboga-type alkaloids. There are however numerous 5-HT2A receptor agonists which do not fall within any of these groups, some representative examples of which are listed below. Ki and EC50 values vary depending on the assay conditions used and so may not be directly comparable between sources. Many of these compounds have been designed to be non-psychoactive derivatives for medical applications, and it should not be assumed that a compound which acts as a 5-HT2A agonist will necessarily be psychedelic in nature. See also * Partial lysergamide * DPCPX * LY-341,495 * Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Partial Lysergamide
Partial or simplified ergolines and lysergamides are analogues of ergolines and lysergamides like LSD in which one or more atoms or bonds, for instance within the ergoline ring system, have been removed. Additional substitutions may also be added, for instance on the A ring of the ergoline nucleus. It is notable that the ergoline ring system contains embedded tryptamine and phenethylamine moieties within its structure, and so some partial ergolines are simple tryptamines, cyclized tryptamines, simple phenethylamines, and/or cyclized phenethylamines. In terms of pharmacology, partial lysergamides include serotonin and dopamine receptor agonists. Some, like NDTDI, DEMPDHPCA, DEIMDHPCA, and LPH-5, are serotonin 5-HT2A receptor agonists and have psychedelic-like and/or psychoplastogenic effects. Some, like 8-OH-DPAT and LY-178210, are selective serotonin 5-HT1A receptor agonists. Others, like rotigotine, nolomirole, and RU-28251, are dopamine D2-like receptor agonists. Par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Iowa
The University of Iowa (U of I, UIowa, or Iowa) is a public university, public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is organized into 12 colleges offering more than 200 areas of study and 7 professional degrees. On an urban 1,880-acre campus on the banks of the Iowa River, the University of Iowa is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". In fiscal year 2021, research expenditures at Iowa totaled $818 million. The university was the original developer of the Master of Fine Arts degree, and it operates the Iowa Writers' Workshop, whose alumni include 17 of the university's 46 Pulitzer Prize winners. Iowa is a member of the Association of American Universities and the Universities Research Association. Among public universities in the United States, UI was the first to beco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David E
David (; , "beloved one") was a king of ancient Israel and Judah and the third king of the United Monarchy, according to the Hebrew Bible and Old Testament. The Tel Dan stele, an Aramaic-inscribed stone erected by a king of Aram-Damascus in the late 9th/early 8th centuries BCE to commemorate a victory over two enemy kings, contains the phrase (), which is translated as " House of David" by most scholars. The Mesha Stele, erected by King Mesha of Moab in the 9th century BCE, may also refer to the "House of David", although this is disputed. According to Jewish works such as the '' Seder Olam Rabbah'', '' Seder Olam Zutta'', and '' Sefer ha-Qabbalah'' (all written over a thousand years later), David ascended the throne as the king of Judah in 885 BCE. Apart from this, all that is known of David comes from biblical literature, the historicity of which has been extensively challenged,Writing and Rewriting the Story of Solomon in Ancient Israel; by Isaac Kalimi; pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
