Actin-binding proteins (also known as ABPs) are proteins that bind to actin. This may mean ability to bind actin monomers, or polymers, or both. Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding calponin homology domain. This is a list of actin-binding proteins in alphabetical order.

0–9

* 25kDa * 25kDa ABP from aorta p185neu * 30akDA 110 kD dimer ABP * 30bkDa 110 kD (Drebrin) * 34kDA * 45kDa * p53 * p58gag * p116rip

A

a-actinin Actinin is a microfilament protein. Alpha-actinin-1 is necessary for the attachment of actin myofilaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, ...

* Abl * AbLIM Actin-Interacting MAPKKK * ABP120 * ABP140 * Abp1p * ABP280 (Filamin) * ABP50 (EF-1a) * Acan 125 (Carmil) * ActA * Actibind * Actin * Actinfilin * Actinogelin * Actin-regulating kinases * Actin-Related Proteins * Actobindin * Actolinkin * Actopaxin * Actophorin * Acumentin (= L-plastin) * Adducin * ADF/Cofilin * Adseverin (scinderin) *

Afadin Afadin is a protein that in humans is encoded by the ''AFDN'' gene. Function Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused ...

* AFAP-110 * Affixin * Aginactin * AIP1 * Aldolase * Angiogenin * Anillin * Annexins * Aplyronine * Archvillin *

Arginine kinase In enzymology, arginine kinase () is an enzyme that catalyzes the chemical reaction :ATP + L-arginine \rightleftharpoons ADP + Nω-phospho-L-arginine Thus, the two substrates of this enzyme are ATP and L-arginine, whereas its two products are ...

* Arp2/3 complex

B

* Band 4.1 * Band 4.9(Dematin) * b-actinin * b-Cap73 * Bifocal * Bistramide A * BPAG1 * Brevin ( Gelsolin)

C

* c-Abl * Calpactin (Annexin) * CHO1 * Cortactin * CamKinase II * Calponin * Chondramide * Cortexillin * CAP * Caltropin * CH-ILKBP * CPb3 *

Cap100 "Where U Been?" is a song by American rapper 2 Chainz from his second studio album ''B.O.A.T.S. II: Me Time''. (2013) The song was released as the album's first promotional single on August 1, 2013. It was Record production, produced by frequent c ...

* Calvasculin * Ciboulot * Coactosin *

CAP23 A cap is a flat headgear, usually with a visor. Caps have crowns that fit very close to the head. They made their first appearance as early as 3200 BC. Caps typically have a visor, or no brim at all. They are popular in casual and informal se ...

* CARMIL * Acan125 * Cingulin * Cytovillin (Ezrin) * CapZ/Capping Protein * a-Catenin * Cofilin * CR16 * Caldesmon *

CCT CCT may refer to: Computation * Computational complexity theory * Computer-Controlled Teletext, an electronic circuit, see Teletext * Internet Computer Chess Tournament Economics * Compulsory Competitive Tendering, see Best value * Conditional ca ...

* Comitin * Calicin * Centuarin *

Coronin Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to humans. Discovery Initially, ...

D

* DBP40 * Drebrin * Dematin (Band 4.9) * Dynacortin *

Destrin Destrin or DSTN (also known as actin depolymerizing factor or ADF) is a protein which in humans is encoded by the ''DSTN'' gene. Destrin is a component protein in microfilaments. The product of this gene belongs to the actin-binding proteins A ...

(ADF/cofilin) * Dystonins * Diaphanous * Dystroglycan *

DNase I Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding ...

* Dystrophin * Doliculide * Dolastatins

E

* EAST * Endossin * EF-1a (ABP50) *

Eps15 Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the ''EPS15'' gene. Function This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved i ...

* EF-1b * EPLIN * EF-2 * Epsin * EGF receptor * ERK * ENC-1 * ERM proteins ( ezrin, radixin, moesin, plus

merlin Merlin ( cy, Myrddin, kw, Marzhin, br, Merzhin) is a mythical figure prominently featured in the legend of King Arthur and best known as a mage, with several other main roles. His usual depiction, based on an amalgamation of historic and le ...

) * END3p * Ezrin (the E of ERM protein family)

F

* F17R * Fodrin (spectrin) * Fascin * Formins * Fessilin * Frabin * FHL3 *

Fragmin Dalteparin is a low molecular weight heparin. It is marketed as Fragmin. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism to reduce the risk of a stroke ...

* Fhos * FLNA (filamin A) * Fimbrin (plastin)

G

* GAP43 * Glycogenins *

Gas2 Growth arrest-specific protein 2 is a protein that in humans is encoded by the ''GAS2'' gene. The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis ...

* G-proteins * Gastrin-Binding Protein * Gelactins I-IV *

Gelsolins Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency. Cell ...

* Girdin * Glucokinase

H

Harmonin b Harmonin is a protein that in humans is encoded by the USH1C gene. It is expressed in sensory cells of the inner ear and retina, where it plays a role in hearing, balance, and vision. Mutations at the USH1C locus cause Usher syndrome type ...

* Hrp36 * Hexokinase * Hrp65-2 * Hectochlorin * HS1 (actin binding protein) * Helicase II * Hsp27 *

HIP1 Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene. Hip-1 is a protein that interacts with the huntingtin protein. It is known to contain a protein domain, domain homologous to the death ef ...

(Huntingtin Interacting protein 1) * Hsp70 * Histactophilin * Hsp90 * Histidine rich protein II *

Hsp100 Endopeptidase Clp (, ''endopeptidase Ti'', ''caseinolytic protease'', ''protease Ti'', ''ATP-dependent Clp protease'', '' ClpP'', ''Clp protease''). This enzyme catalyses the following chemical reaction : Hydrolysis of proteins to small peptides ...

I

* Inhibitor of apoptosis (IAP) * Insertin * Interaptin * IP3Kinase A (Inositol 1,4,5-trisphosphate 3-kinase A) * IQGAP * Integrins

J

* Jaspisamide A * Jasplakinolide

K

* Kabiramide C * Kaptin * Kettin *

Kelch protein Kelch proteins (and Kelch-like proteins) are a widespread group of proteins that contain multiple Kelch motifs. The kelch domain generally occurs as a set of five to seven kelch tandem repeats that form a β-propeller tertiary structure. Kelch-r ...

L

5-Lipoxygenase Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ''ALOX5'' gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase fa ...

* Limatin * Lim Kinases *

Lim Proteins Lim or LIM may refer to: Name * Lim (Korean surname), a common Korean surname * Lim (Chinese surname), Hokkien, Hakka, Teochew and Hainanese spelling of the Chinese family name "Lin" * Liza Lim (born 1966), Australian classical composer Abbre ...

L-plastin Plastin-2 is a protein that in humans is encoded by the ''LCP1'' gene. Function Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, ...

* Lymphocyte Specific Protein 1 (LSP1)

M

* MACF1 * MacMARKS * Mena *

Myopodin Myopodin protein, also called Synaptopodin-2 is a protein that in humans is encoded by the ''SYNPO2'' gene. Myopodin is expressed in cardiac, smooth muscle and skeletal muscle, and localizes to Z-disc structures. Structure Myopodin is a 1 ...

* MAP1A *

Merlin Merlin ( cy, Myrddin, kw, Marzhin, br, Merzhin) is a mythical figure prominently featured in the legend of King Arthur and best known as a mage, with several other main roles. His usual depiction, based on an amalgamation of historic and le ...

(related to the ERM proteins) * Myosins * MAP-1C *

Metavinculin In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cel ...

* Moesin (the M of ERM proteins) * Myosin light chain kinase * MAL * Mip-90 * Myosin Light Chain A1 * MARKS *

MIM MIM or Mim may refer to: Places * Mim, Ahafo, Ghana * Mim Lake, Ghana * Mim Bour, or Mim Mountains, Ghana Education * Master of Management, a post-graduate master's degree * Master of Information Management, an interdisciplinary degree progra ...

* MAYP * Mycalolide (a macroglide drug) * Mayven * Myelin basic protein

N

* Naphthylphthalamic acid binding protein (NPA) N-RAP *

Nebulin Nebulin is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. Nebulin in humans is coded for by the gene ''NEB''. It is a very large protein (600–900 kDa) and binds as many as 200 actin monomer ...

* N-WASP * Neurabin *Nullo * Neurexins *

Neurocalcin Neurocalcin is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It expressed in mammalian brains. It possesses a Ca2+/ myristoyl switch The subclass of neurocalcins are brain-specific prote ...

* Nexillin

O

OYE2 Oye is Spanish for "hey" or "listen". Oye or Oye! or OYE may refer to: Geography * Oye, Ekiti, a town and LGA in Ekiti State. *Oye-Plage, a commune in Pas-de-Calais, France *Oyes, a commune in Marne, France People *Kenneth A. Oye, an American po ...

P

* Palladin * Plastin * p30 *

PAK Pak or PAK may refer to: Places * Pakistan (country code PAK) * Pak, Afghanistan * Pak Island, in the Admiralty Islands group of Papua New Guinea * Pak Tea House, a café in Lahore, Punjab, Pakistan Arts and entertainment * PAK (band), an Amer ...

(p21-activated Kinase) * Plectin * p47PHOX * Parvin (actopaxin) * Prefoldin * p53 *

PASK PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the ''PASK'' gene. PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. P ...

(Proline, Alanine rich Ste20 related Kinase) * Presenilin I *p58 * Phalloidin (not a protein; a small cyclic peptide) * Profilin * p185neu * Ponticulin *

Protein kinase C In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ...

* Porin * P.IB * Prk1p (actin regulating kinase)

R

* Radixin (the R of ERM proteins) * Rapsyn * Rhizopodin * RPL45 * RTX toxin (Vibrio cholerae) * RVS 167

S

* Sac6 * Sla1p * Srv2 (CAP) * S-adenosyl-L-homocysteine hydrolase, (SAHH) *

Sla2p SLA may refer to: Geography * Martín Miguel de Güemes International Airport, Salta, Argentina, IATA code Science and engineering * Sealed lead-acid battery * Second-language acquisition * Short long arms suspension, in vehicles *Soluble liver a ...

Synaptopodin Synaptopodin is a protein that in humans is encoded by the ''SYNPO'' gene. Function Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's asso ...

* Scinderin (adseverin) * Synapsins * Scruin * Spectrin *Severin * Spectraplakins * SVSII * Shot (Short stop) * Spire * Shroom * Smitin (Smooth Musc.Titin) *

Supervillin Supervillin is a protein that in humans is encoded by the ''SVIL'' gene. Function This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy ...

* SipA *

Smoothelin Smoothelin is a protein that in humans is encoded by the ''SMTN'' gene. This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton ...

* Sucrose synthetase * SipC * Sra-1 *

Spinophilin Neurabin-2 is a protein that in humans is encoded by the ''PPP1R9B'' gene. Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions ...

* Ssk2p *

Swinholide Swinholides are Protein dimer, dimeric 42 carbon-ring Polyketide, polyketides that exhibit a 2-fold axis of symmetry. Found mostly in the marine sponge Theonella, swinholides encompass cytotoxic and antifungal activities via disruption of the acti ...

T

* Talin protein * Toxophilin * Twinfilin * Tau * Trabeculin *Twinstar * TCP-1 * Transgelin * Transgelin 2 * Transgelin 3 * Tensin *

Tropomodulin Tropomodulin (TMOD) is a protein which binds and caps the minus end of actin (the "pointed" end), regulating the length of actin filaments in muscle and non-muscle cells. The protein functions by physically blocking the spontaneous dissociation ...

Thymosin Thymosins are small proteins present in many animal tissues. They are named thymosins because they were originally isolated from the thymus, but most are now known to be present in many other tissues. Thymosins have diverse biological activities, ...

* Tropomyosin * Titin * Troponin * TOR2 *

Tubulin bIV Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily. α- and β-tubulins polymerize into microtubules, a major component of the eukaryotic cyt ...

U

* Ulapualide * Utrophin * Unc-87 * Unc-60 ( ADF/cofilins)

V

* VASP * Vav * Verprolin * VDAC * Vibrio cholerae RTX toxin *

Villin Villin-1 is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border. Villin-1 is encoded by the ''VIL1'' gene. Villin-1 contains multiple gelsolin-like domains capped by a small (8.5 kDa) "headp ...

* Vinculin * Vitamin D-binding protein

W

WIP WIP or WiP may refer to: Political parties * Wildrose Independence Party of Alberta, a political party in Alberta, Canada * Western Independence Party of Manitoba, a former Canadian provincial political party * Western Independence Party of Sas ...

* WASp

Y

* Y-box proteins * YpkA (YopO)

Z

Zipper protein A zipper, zip, fly, or zip fastener, formerly known as a clasp locker, is a commonly used device for binding together two edges of textile, fabric or other flexible material. Used in clothing (e.g. jackets and jeans), luggage and other Bag, ba ...

* Zo-1 * Zyxin

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See also

References

External links