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Plastin
Plastin is part of a family of actin-bundling proteins, specifically the α-actinin family of actin-binding protein, which are found in many lifeforms, from humans and other animals to plants and yeasts. These proteins are known to cross-link actin filaments into bundles for various cell purposes.Members of plastin include: * LCP1 * PLS1 * PLS3 Structure The structure of plastin has been evolutionarily maintained within organisms who utilize this protein, which includes humans and lower eukaryotic organisms. Plastin structures are known for their EF-hand Ca2+- and actin-binding domains that assist in assembling actin into higher-order bundles. Plastins have two actin-binding domains (ABD) in each of their polypeptide in which each ABD contains two of 125-residue calponin-homology (CH) components. This structure allows for plastins to cross-link actin filaments into their bundles in order to perform various tasks. Function Plastin, along with other actin-binding proteins, hel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plastin Structure
Plastin is part of a family of actin-bundling proteins, specifically the Actinin, α-actinin family of actin-binding protein, which are found in many lifeforms, from humans and other animals to plants and yeasts. These proteins are known to cross-link actin filaments into bundles for various cell purposes.Members of plastin include: * LCP1 * PLS1 * PLS3 Structure The structure of plastin has been evolutionarily maintained within organisms who utilize this protein, which includes humans and lower eukaryotic organisms. Plastin structures are known for their EF hand, EF-hand Ca2+- and actin-binding domains that assist in assembling actin into higher-order bundles. Plastins have two Actin-binding domain, actin-binding domains (ABD) in each of their polypeptide in which each ABD contains two of 125-residue Calponin homology (CH) domain, calponin-homology (CH) components. This structure allows for plastins to cross-link actin filaments into their bundles in order to perform various task ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LCP1
Plastin-2 is a protein that in humans is encoded by the ''LCP1'' gene. Function Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non- hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transform ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLS3
Plastin-3 is a highly conserved protein that in humans is encoded by the ''PLS3'' gene on the X chromosome. Function Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N-terminus. Clinical significance Defects in PLS3 are associated with osteoporosis and bone fracture in humans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actin-binding Domain
Actin-binding proteins (also known as ABPs) are binding protein, proteins that bind to actin. This may mean ability to bind actin monomers, or polymers, or both. Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding calponin homology domain. This is a list of actin-binding proteins in alphabetical order. 0–9 *25kDa *25kDa ABP from aorta p185neu *30akDA 110 kD dimer ABP *30bkDa 110 kD (Drebrin) *34kDA *45kDa *p53 *p58gag *p116rip A *a-actinin *Abl gene, Abl *AbLIM Actin-Interacting MAPKKK *ABP120 *ABP140 *Abp1p *ABP280 (Filamin) *ABP50 (EF-1a) *Acan 125 (Carmil) *Actin assembly-inducing protein, ActA *Actibind *Actin *Actinfilin *Actinogelin *Actin-regulating kinases *Actin-Related Proteins *Actobindin *Actolinkin *Actopaxin *Actophorin *Acumentin (= L-plastin) *Adducin *Cofilin, ADF/Cofilin *Adseverin (scinderin) *Afadin *AFAP-110 *Affixin *Aginactin *AIP1 *Aldolase *Angiogenin *Anillin *Annexin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fimbrin
Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Fimbrin is an actin cross-linking protein important in the formation of filopodia. Structure Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. Like other members of this superfamily, which include α-actinin, β-spectrin, dystrophin, ABP-120 and filamin, it has a conserved 27 kDa actin-binding domain that contains a tandem duplication of a sequence that is homologous to calponin. In addition to cross-linking actin filaments into bundles and networks, CH domains also bind intermediate filaments and some signal transduction proteins to the actin cytoskeleton. Structural comparison of actin filaments and fimbrin CH domain-decorated actin filaments has revealed changes in the actin structure due to fimbrin-mediated cross-linking that may affect the actin filaments' affinity for other actin-binding proteins and may be part of the regulation of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLS1
Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Fimbrin is an actin cross-linking protein important in the formation of filopodia. Structure Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. Like other members of this superfamily, which include α-actinin, β- spectrin, dystrophin, ABP-120 and filamin, it has a conserved 27 kDa actin-binding domain that contains a tandem duplication of a sequence that is homologous to calponin. In addition to cross-linking actin filaments into bundles and networks, CH domains also bind intermediate filaments and some signal transduction proteins to the actin cytoskeleton. Structural comparison of actin filaments and fimbrin CH domain-decorated actin filaments has revealed changes in the actin structure due to fimbrin-mediated cross-linking that may affect the actin filaments' affinity for other actin-binding proteins and may be part of the regulation o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microvillus
Microvilli (singular: microvillus) are microscopic cellular membrane protrusions that increase the surface area for diffusion and minimize any increase in volume, and are involved in a wide variety of functions, including absorption, secretion, cellular adhesion, and mechanotransduction. Structure Microvilli are covered in plasma membrane, which encloses cytoplasm and microfilaments. Though these are cellular extensions, there are little or no cellular organelles present in the microvilli. Each microvillus has a dense bundle of cross-linked actin filaments, which serves as its structural core. 20 to 30 tightly bundled actin filaments are cross-linked by bundling proteins fimbrin (or plastin-1), villin and espin to form the core of the microvilli. In the enterocyte microvillus, the structural core is attached to the plasma membrane along its length by lateral arms made of myosin 1a and Ca2+ binding protein calmodulin. Myosin 1a functions through a binding site for filamentous ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of over 100 μM; its mass is roughly 42 kDa, with a diameter of 4 to 7 nm. An actin protein is the monomeric subunit of two types of filaments in cells: microfilaments, one of the three major components of the cytoskeleton, and thin filaments, part of the contractile apparatus in muscle cells. It can be present as either a free monomer called G-actin (globular) or as part of a linear polymer microfilament called F-actin (filamentous), both of which are essential for such important cellular functions as the mobility and contraction of cells during cell division. Actin participates in many important cellular processes, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement, cell sign ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Screen Shot 2023-04-24 At 9
Screen or Screens may refer to: Arts * Screen printing (also called ''silkscreening''), a method of printing * Big screen, a nickname associated with the motion picture industry * Split screen (filmmaking), a film composition paradigm in which multiple distinct film sequences are shown simultaneously and next to each other * Stochastic screening and Halftone photographic screening, methods of simulating grays with one-color printing Filtration and selection processes * Screening (economics), the process of identifying or selecting members of a population based on one or more selection criteria * Screening (biology), idem, on a scientific basis, ** of which a genetic screen is a procedure to identify a particular kind of phenotype ** the Irwin screen is a toxicological procedure * Sieve, a mesh used to separate fine particles from coarse ones * Mechanical screening, a unit operation in material handling which separates product into multiple grades by particle size Media and mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epithelium
Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellular matrix. Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. An example is the epidermis, the outermost layer of the skin. There are three principal shapes of epithelial cell: squamous (scaly), columnar, and cuboidal. These can be arranged in a singular layer of cells as simple epithelium, either squamous, columnar, or cuboidal, or in layers of two or more cells deep as stratified (layered), or ''compound'', either squamous, columnar or cuboidal. In some tissues, a layer of columnar cells may appear to be stratified due to the placement of the nuclei. This sort of tissue is called pseudostratified. All glands are made up of epithe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesenchymal Stem Cell
Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). Structure Definition While the terms ''mesenchymal stem cell'' (MSC) and ''marrow stromal cell'' have been used interchangeably for many years, neither term is sufficiently descriptive: * Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. * Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. While this is an accurate description for one function of MSCs, the term fails to convey the relatively recently discove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phagocytosis
Phagocytosis () is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. It is one type of endocytosis. A cell that performs phagocytosis is called a phagocyte. In a multicellular organism's immune system, phagocytosis is a major mechanism used to remove pathogens and cell debris. The ingested material is then digested in the phagosome. Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytized. Some protozoa use phagocytosis as means to obtain nutrients. History Phagocytosis was first noted by Canadian physician William Osler (1876), and later studied and named by Élie Metchnikoff (1880, 1883). In immune system Phagocytosis is one main mechanisms of the innate immune defense. It is one of the first processes responding to infection, and is also one of the initiating branches of an adaptive immune response. Although mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
