HLA-B46

	HLA-B46 HLA-B46 (B46) is an HLA- B serotype. The serotype identifies the gene products of HLA-B4601 allele. B4601 resulted from a rare, interlocus, gene conversion between B62, probably B1501, and a HLA-C allele. B4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma (Myanmar or Laos, untested). B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (geneti ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	HLA-B HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and borders fourteen countries by land, the most of any country in the world, tied with Russia. Covering an area of approximately , it is the world's third largest country by total land area. The country consists of 22 provinces, five autonomous regions, four municipalities, and two Special Administrative Regions (Hong Kong and Macau). The national capital is Beijing, and the most populous city and financial center is Shanghai. Modern Chinese trace their origins to a cradle of civilization in the fertile basin of the Yellow River in the North China Plain. The semi-legendary Xia dynasty in the 21st century BCE and the well-attested Shang and Zhou dynasties developed a bureaucratic political system to serve hereditary monarchies, or dyna ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Naxi People Naxi may refer to: * Naxi people (), an ethnic group mainly living in southwest provinces of China * Naxi language, the language of the Naxi people * Naxi District Naxi District (Tibetan: Jang; ) is a county-level district of the city of Luzhou, Sichuan Province Sichuan (; zh, c=, labels=no, ; zh, p=Sìchuān; alternatively romanized as Szechuan or Szechwan; formerly also referred to as "West Ch ... (), Luzhou, Sichuan {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north toward the East China Sea, Philippine Sea, and Taiwan in the south. Japan is a part of the Ring of Fire, and spans Japanese archipelago, an archipelago of List of islands of Japan, 6852 islands covering ; the five main islands are Hokkaido, Honshu (the "mainland"), Shikoku, Kyushu, and Okinawa Island, Okinawa. Tokyo is the Capital of Japan, nation's capital and largest city, followed by Yokohama, Osaka, Nagoya, Sapporo, Fukuoka, Kobe, and Kyoto. Japan is the List of countries and dependencies by population, eleventh most populous country in the world, as well as one of the List of countries and dependencies by population density, most densely populated and Urbanization by country, urbanized. About three-fourths of Geography of Japan, the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Aichi is a prefecture of Japan located in the Chūbu region of Honshū. Aichi Prefecture has a population of 7,552,873 () and a geographic area of with a population density of . Aichi Prefecture borders Mie Prefecture to the west, Gifu Prefecture and Nagano Prefecture to the north, and Shizuoka Prefecture to the east. Overview Nagoya is the capital and largest city of Aichi Prefecture, and the fourth-largest city in Japan, with other major cities including Toyota, Okazaki, and Ichinomiya. Aichi Prefecture and Nagoya form the core of the Chūkyō metropolitan area, the third-largest metropolitan area in Japan and one of the largest metropolitan areas in the world. Aichi Prefecture is located on Japan's Pacific Ocean coast and forms part of the Tōkai region, a subregion of the Chūbu region and Kansai region. Aichi Prefecture is home to the Toyota Motor Corporation. Aichi Prefecture had many locations with the Higashiyama Zoo and Botanical Gardens, The Chubu Centrair Inte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Guangxi Guangxi (; ; Chinese postal romanization, alternately romanized as Kwanghsi; ; za, Gvangjsih, italics=yes), officially the Guangxi Zhuang Autonomous Region (GZAR), is an Autonomous regions of China, autonomous region of the People's Republic of China, located in South China and bordering Vietnam (Hà Giang Province, Hà Giang, Cao Bằng Province, Cao Bằng, Lạng Sơn Province, Lạng Sơn, and Quảng Ninh Provinces) and the Gulf of Tonkin. Formerly a Provinces of China, province, Guangxi became an autonomous region in 1958. Its current capital is Nanning. Guangxi's location, in mountainous terrain in the far south of China, has placed it on the frontier of Chinese civilization throughout much of History of China, Chinese history. The current name "Guang" means "expanse" and has been associated with the region since the creation of Guang Prefecture in 226 AD. It was given Administrative divisions of the Yuan dynasty, provincial level status during the Yuan dynasty, but ev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Maonan People The Maonan people (; Maonan: ''Anan'', literally "local people") are one of the 56 ethnic groups officially recognized by the People's Republic of China. There are a total of 101,192 Maonan as of 2010, mostly living northern Guangxi and southern Guizhou in southern China. The Maonan people's autonyms are ''ʔai1 na:n6 ''(a Maonan person), ''kjɔŋ5 na:n6'' (the Maonan people). Their language is called ''va6 na:n6'' (Lu 2008:33).Lu, Tian Qiao (2008). ''A Grammar of Maonan''. Boca Raton, Florida: Universal Publishers. . Language Society More than 80% of the Maonan share the same surname: ''Tan'' (). Maonan with the surname ''Tan'' believe that they are descended from the old inhabitants of the province of Hunan that migrated to Guangxi and married Maonan women. Other common surnames found in this ethnic group are: '' Lu'' (卢/盧), ''Liu'' (刘/劉), ''Shi'' (石), ''Tan'' (覃), '' Wei'' (韦/韋) and '' Yuan'' (袁). The towns of the Maonan do not surpass more than 100 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Wuhan Wuhan (, ; ; ) is the capital of Hubei, Hubei Province in the China, People's Republic of China. It is the largest city in Hubei and the most populous city in Central China, with a population of over eleven million, the List of cities in China by population, ninth-most populous Chinese city and one of the nine National Central City, National Central Cities of China. The name "Wuhan" came from the city's historical origin from the conglomeration of Wuchang District, Wuchang, Hankou District, Hankou, and Hanyang District, Hanyang, which are collectively known as the "Three Towns of Wuhan" (). Wuhan lies in the eastern Jianghan Plain, at the confluence of the Yangtze river and its largest tributary, the Han River (Hubei), Han River, and is known as "Nine Provinces' Thoroughfare" (). Wuhan has historically served as a busy city port for commerce and trading. Other historical events taking place in Wuhan include the Wuchang Uprising of 1911, which led to the end of 2,000 years of d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Southern Min Southern Min (), Minnan (Mandarin pronunciation: ) or Banlam (), is a group of linguistically similar and historically related Sinitic languages that form a branch of Min Chinese spoken in Fujian (especially the Minnan region), most of Taiwan (many citizens are descendants of settlers from Fujian), Eastern Guangdong, Hainan, and Southern Zhejiang. The Minnan dialects are also spoken by descendants of emigrants from these areas in diaspora, most notably the Philippines, Indonesia, Malaysia, Singapore, San Francisco, Los Angeles and New York City. It is the most populous branch of Min Chinese, spoken by an estimated 48 million people in c. 2017–2018. In common parlance and in the narrower sense, Southern Min refers to the Quanzhang or Hokkien-Taiwanese variety of Southern Min originating from Southern Fujian in Mainland China. This is spoken mainly in Fujian, Taiwan, as well as certain parts of Southeast Asia. The Quanzhang variety is often called simply "Minnan Proper". It is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Guangzhou Guangzhou (, ; ; or ; ), also known as Canton () and alternatively romanized as Kwongchow or Kwangchow, is the capital and largest city of Guangdong province in southern China. Located on the Pearl River about north-northwest of Hong Kong and north of Macau, Guangzhou has a history of over 2,200 years and was a major terminus of the maritime Silk Road; it continues to serve as a major port and transportation hub as well as being one of China's three largest cities. For a long time, the only Chinese port accessible to most foreign traders, Guangzhou was captured by the British during the First Opium War. No longer enjoying a monopoly after the war, it lost trade to other ports such as Hong Kong and Shanghai, but continued to serve as a major transshipment port. Due to a high urban population and large volumes of port traffic, Guangzhou is classified as a Large-Port Megacity, the largest type of port-city in the world. Due to worldwide travel restrictions at the beginni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Hakka People The Hakka (), sometimes also referred to as Hakka Han, or Hakka Chinese, or Hakkas are a Han Chinese subgroup whose ancestral homes are chiefly in the Hakka-speaking provincial areas of Guangdong, Fujian, Jiangxi, Guangxi, Sichuan, Hunan, Zhejiang, Hainan, Guizhou in China, as well as in Taoyuan City, Hsinchu County, Miaoli County, Pingtung County, and Kaohsiung City in Taiwan. The Chinese characters for ''Hakka'' () literally mean "guest families". Unlike other Han Chinese subgroups, the Hakkas are not named after a geographical region, e.g. a province, county or city, in China. The word ''Hakka'' or "guest families" is Cantonese in origin and originally refers to the Northern Chinese refugees fleeing social unrest, upheaval and invasions in northern parts of China (such as Gansu and Henan) during the Qin dynasty who then seek refuge in the Cantonese provinces such as Guangdong and Guangxi, thus the original meaning of the word implies that they are guests living in the C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Hong Kong Hong Kong ( (US) or (UK); , ), officially the Hong Kong Special Administrative Region of the People's Republic of China ( abbr. Hong Kong SAR or HKSAR), is a city and special administrative region of China on the eastern Pearl River Delta in South China. With 7.5 million residents of various nationalities in a territory, Hong Kong is one of the most densely populated places in the world. Hong Kong is also a major global financial centre and one of the most developed cities in the world. Hong Kong was established as a colony of the British Empire after the Qing Empire ceded Hong Kong Island from Xin'an County at the end of the First Opium War in 1841 then again in 1842.. The colony expanded to the Kowloon Peninsula in 1860 after the Second Opium War and was further extended when Britain obtained a 99-year lease of the New Territories in 1898... British Hong Kong was occupied by Imperial Japan from 1941 to 1945 during World War II; British administration resume ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]