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3,4-Ethylenedioxyamphetamine
3,4-Ethylenedioxyamphetamine (EDA), also known as EDA-6, is a drug of the substituted amphetamine, amphetamine family related to 3,4-methylenedioxyamphetamine (MDA). It is closely related to structural analog, analogues including 3,4-ethylenedioxymethamphetamine (EDMA), 3,4-ethylidenedioxyamphetamine (EIDA), and 3,4-isopropylidenedioxyamphetamine (IDA). EDMA, the ''N''-methyl group, methylated analogue of EDA, is known to be a serotonin–norepinephrine–dopamine releasing agent (SNDRA). According to Alexander Shulgin however, the drug only produced limited psychoactive drug, psychoactive effects in humans at doses in the range of 150 to 250mg. See also * 3,4-Ethylenedioxymethamphetamine (EDMA) * 3,4-Ethylenedioxymethcathinone (EDMC) * 3,4-Ethylidenedioxyamphetamine (EIDA) * 3,4-Isopropylidenedioxyamphetamine (IDA) * 3,4-Dimethoxyamphetamine (DMA) References Ethylenedioxyphenethylamines Monoamine releasing agents Substituted amphetamines {{Psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-Ethylidenedioxyamphetamine
3,4-Ethylidenedioxyamphetamine (EIDA) is a substituted derivative of 3,4-methylenedioxyamphetamine (MDA), which was developed by David Nichols and coworkers, in the course of research to determine the bulk tolerance around the benzodioxole portion of the MDA molecule. EIDA was found to produce similar effects to MDA in animals but with less than half the potency, while the isopropylidenedioxy derivative (IPIDA, IDA) did not substitute for MDA and instead had sedative and convulsant effects. This shows limited bulk tolerance at this position and (as with 2C-G-5) makes it likely the activity of EIDA will reside primarily in one enantiomer, although only the racemic mix has been studied as yet. See also * 3,4-Isopropylidenedioxyamphetamine (IDA) * Difluoromethylenedioxyamphetamine (DiFMDA) * F-2 (psychedelic) * 3,4-Ethylenedioxyamphetamine (EIDA) * 3,4-Ethylenedioxymethamphetamine (EDMA) * 3,4-Ethylenedioxymethcathinone 3,4-Ethylenedioxymethcathinone (EDMC), or 3,4-ethyle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-Dimethoxyamphetamine
3,4-Dimethoxyamphetamine (3,4-DMA), or simply dimethoxyamphetamine (DMA), is a psychedelic drug of the phenethylamine and amphetamine families. It is one of the dimethoxyamphetamine (DMA) series of positional isomers. The drug has been assessed in various biochemical and preclinical studies. It has been tried in humans at doses of up to 700mg intravenously, with mescaline-like effects reported. 3,4-DMA is also orally active and has produced sympathomimetic effects at a dose of 160mg. Its duration of action is unknown. Its affinity (Ki) for the rat serotonin 5-HT2A receptor has been assessed and was found to be 43,300nM. For comparison, the affinity of ''para''-methoxyamphetamine (PMA) was 33,600nM, of 2,5-dimethoxyamphetamine (2,5-DMA) was 5,200nM, and of 2,5-dimethoxy-4-methylamphetamine (DOM) was 100nM in the same study. 3,4-DMA also showed affinity for the 5-HT1 receptor (Ki = 64,600nM). The drug has additionally been found to be a monoamine oxidase inhibitor (MAOI), wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-Isopropylidenedioxyamphetamine
3,4-Isopropylidenedioxyamphetamine (IDA) is a monoamine releasing agent (MRA) of the amphetamine family related to 3,4-methylenedioxyamphetamine (MDA). It is considerably less potent than MDA as an MRA ''in vitro''. IDA fully substituted for MDMA and LSD in animal drug discrimination tests, albeit with 5- to 7-fold lower potency than MDA. See also * 3,4-Ethylidenedioxyamphetamine (EIDA) * 3,4-Ethylenedioxyamphetamine (EDA) * 3,4-Ethylenedioxymethamphetamine (EDMA) * 3,4-Ethylenedioxymethcathinone 3,4-Ethylenedioxymethcathinone (EDMC), or 3,4-ethylenedioxy-''N''-methylcathinone, is a monoamine releasing agent (MRA) of the cathinone family related to methylone (3,4-methylenedioxymethcathinone; MDMC). It is the β- keto or cathinone analog ... (EDMC) References Entactogens Methylenedioxyphenethylamines Monoamine releasing agents Psychedelic phenethylamines Substituted amphetamines {{Psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-ethylenedioxymethamphetamine
3,4-Ethylenedioxy-''N''-methylamphetamine (EDMA) is an entactogen drug of the methamphetamine class. It is an analogue of MDMA where the methylenedioxy ring has been replaced by an ethylenedioxy ring. EDMA was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the dosage is listed as 150–250 mg, and the duration listed as 3–5 hours. According to Shulgin, EDMA produces only mild psychedelic effects consisting of paresthesia, nystagmus, and hypnogogic imagery, with few to no other symptoms. It has been found that EDMA acts as a non-neurotoxic serotonin releasing agent with moderately diminished potency relative to MDMA, and with negligible effects on dopamine release. However, subsequent research found that EMDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) with values of 117nM for serotonin release, 325nM for norepinephrine release, and 597nM for dopamine release in rat brain synaptosomes. Compared to MDMA, EDMA was about half as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-isopropylidenedioxyamphetamine
3,4-Isopropylidenedioxyamphetamine (IDA) is a monoamine releasing agent (MRA) of the amphetamine family related to 3,4-methylenedioxyamphetamine (MDA). It is considerably less potent than MDA as an MRA ''in vitro''. IDA fully substituted for MDMA and LSD in animal drug discrimination tests, albeit with 5- to 7-fold lower potency than MDA. See also * 3,4-Ethylidenedioxyamphetamine (EIDA) * 3,4-Ethylenedioxyamphetamine (EDA) * 3,4-Ethylenedioxymethamphetamine (EDMA) * 3,4-Ethylenedioxymethcathinone 3,4-Ethylenedioxymethcathinone (EDMC), or 3,4-ethylenedioxy-''N''-methylcathinone, is a monoamine releasing agent (MRA) of the cathinone family related to methylone (3,4-methylenedioxymethcathinone; MDMC). It is the β- keto or cathinone analog ... (EDMC) References Entactogens Methylenedioxyphenethylamines Monoamine releasing agents Psychedelic phenethylamines Substituted amphetamines {{Psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-Ethylenedioxymethcathinone
3,4-Ethylenedioxymethcathinone (EDMC), or 3,4-ethylenedioxy-''N''-methylcathinone, is a monoamine releasing agent (MRA) of the cathinone family related to methylone (3,4-methylenedioxymethcathinone; MDMC). It is the β- keto or cathinone analogue of 3,4-ethylenedioxymethamphetamine (EDMA). EDMC acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA). Its values for induction of monoamine release are 347nM for serotonin, 327nM for norepinephrine, and 496nM for dopamine in rat brain synaptosomes. These potencies were about 1.4-fold, 2.2-fold, and 3.7-fold lower than those of methylone, respectively. The drug was first described in 2015, whereas EDMA has been described much earlier. See also * 3,4-Ethylenedioxyamphetamine 3,4-Ethylenedioxyamphetamine (EDA), also known as EDA-6, is a drug of the substituted amphetamine, amphetamine family related to 3,4-methylenedioxyamphetamine (MDA). It is closely related to structural analog, analogues including 3,4-eth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3,4-Ethylenedioxymethamphetamine
3,4-Ethylenedioxy-''N''-methylamphetamine (EDMA) is an entactogen drug of the methamphetamine class. It is an analogue of MDMA where the methylenedioxy ring has been replaced by an ethylenedioxy ring. EDMA was first synthesized by Alexander Shulgin. In his book ''PiHKAL'', the dosage is listed as 150–250 mg, and the duration listed as 3–5 hours. According to Shulgin, EDMA produces only mild psychedelic effects consisting of paresthesia, nystagmus, and hypnogogic imagery, with few to no other symptoms. It has been found that EDMA acts as a non-neurotoxic serotonin releasing agent with moderately diminished potency relative to MDMA, and with negligible effects on dopamine release. However, subsequent research found that EMDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) with values of 117nM for serotonin release, 325nM for norepinephrine release, and 597nM for dopamine release in rat brain synaptosomes. Compared to MDMA, EDMA was about half as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug injection, injection, smoking, ingestion, absorption (skin), absorption via a dermal patch, patch on the skin, suppository, or sublingual administration, dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to pharmacotherapy, treat, cure, preventive healthcare, prevent, or medical diagnosis, diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A Chemical Love Story
A, or a, is the first letter and the first vowel letter of the Latin alphabet, used in the modern English alphabet, and others worldwide. Its name in English is '' a'' (pronounced ), plural ''aes''. It is similar in shape to the Ancient Greek letter alpha, from which it derives. The uppercase version consists of the two slanting sides of a triangle, crossed in the middle by a horizontal bar. The lowercase version is often written in one of two forms: the double-storey and single-storey . The latter is commonly used in handwriting and fonts based on it, especially fonts intended to be read by children, and is also found in italic type. In English, '' a'' is the indefinite article, with the alternative form ''an''. Name In English, the name of the letter is the ''long A'' sound, pronounced . Its name in most other languages matches the letter's pronunciation in open syllables. History The earliest known ancestor of A is ''aleph''—the first letter of the Phoenician ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and pharmacology of such agents—in his mid-life and later, many through preparation in his home laboratory, and testing on himself. He is acknowledged to have introduced to broader use, in the late 1970s, the previously-synthesized compound MDMA ("ecstasy"), in research psychopharmacology and in combination with conventional therapy, the latter through presentations and academic publications, including to psychologists; and for the rediscovery, occasional discovery, and regular synthesis and personal use and distribution, of possibly hundreds of Psychoactive drug, psychoactive compounds (for their Psychedelic drug, psychedelic and MDMA-like empathogenic bioactivity, bioactivities). As such, Shulgin is seen both as a pioneering and a controversi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
