3,4-Ethylenedioxymethcathinone (EDMC), or 3,4-ethylenedioxy-''N''-methylcathinone, is a
monoamine releasing agent (MRA) of the
cathinone
Cathinone (; also known as β-ketoamphetamine) is a monoamine alkaloid found in the shrub ''Catha edulis'' (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to t ...
family related to
methylone
Methylone, also known as 3,4-methylenedioxy-''N''-methylcathinone (MDMC), is an entactogen and stimulant drug of the amphetamine, cathinone, and benzodioxole families related to 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"). It is th ...
(3,4-methylenedioxymethcathinone; MDMC).
It is the β-
keto or cathinone
analogue of
3,4-ethylenedioxymethamphetamine (EDMA).
EDMC acts as a
serotonin–norepinephrine–dopamine releasing agent
A serotonin–norepinephrine–dopamine releasing agent (SNDRA), also known as a triple releasing agent (TRA), is a type of drug which induces the release of serotonin, norepinephrine/epinephrine, and dopamine in the brain and body. SNDRAs produc ...
(SNDRA).
Its values for induction of monoamine release are 347nM for
serotonin
Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...
, 327nM for
norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic compound, organic chemical in the catecholamine family that functions in the brain and human body, body as a hormone, neurotransmitter and neuromodulator. The ...
, and 496nM for
dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...
in rat brain
synaptosomes.
These
potencies were about 1.4-fold, 2.2-fold, and 3.7-fold lower than those of methylone, respectively.
The drug was first described in 2015, whereas EDMA has been described much earlier.
See also
*
3,4-Ethylenedioxyamphetamine
3,4-Ethylenedioxyamphetamine (EDA), also known as EDA-6, is a drug of the substituted amphetamine, amphetamine family related to 3,4-methylenedioxyamphetamine (MDA). It is closely related to structural analog, analogues including 3,4-ethylenediox ...
(EDA)
*
3,4-Ethylidenedioxyamphetamine (EIDA)
*
3,4-Isopropylidenedioxyamphetamine (IDA)
References
{{Phenethylamines
Cathinones
Ethylenedioxyphenethylamines
Methamphetamines
Serotonin-norepinephrine-dopamine releasing agents