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Santa Fe de la Vera Cruz (Spanish pronunciation: [ˈsanta ˈfe ðe la ˈβeɾa ˈkɾus]; usually called just Santa Fe) is the capital city of the province of Santa Fe, Argentina. It is situated in north-eastern Argentina, near the junction of the Paraná and Salado rivers. It lies 15 kilometres (9.3 mi) from the Hernandarias Subfluvial Tunnel that connects it to the city of Paraná. The city is also connected by canal with the port of Colastiné on the Paraná River. Santa Fe de la Vera Cruz has about 391,164 inhabitants as per the 2010 census [INDEC]. The metropolitan area has a population of 653,073, making it the eighth largest in Argentina. The third largest city in Argentina is Rosario, also located in Santa Fe Province. Rosario has a population of 1.24 million and it is the largest city in Argentina not to be a provincial capital.

Santa Fe de la Vera Cruz is linked to Rosario (170 km (106 mi) to the south), the largest city in the province, by the Brigadier Estanislao López Highway and by National Route 11, which continues south towards Buenos Aires, and it is home to Sauce Viejo Airport with daily direct flights to Rosario and Aeroparque Jorge Newbery in Buenos Aires.

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