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Butein
Butein is a chalcone of the chalconoids. It can be found in ''Toxicodendron vernicifluum'' (or formerly ''Rhus verniciflua''), ''Dahlia'', '' Butea'' ('' Butea monosperma'') and ''Coreopsis'' It has antioxidative, aldose reductase and advanced glycation endproducts inhibitory effects. It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. Buteins possess a high ability to inhibit aromatase process in the human body, for this reason, the use of these compounds in the treatment of breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ... on the estrogen ground has been explored. The first attempts of sport pro-hormone supplementation with the use of buteins took place i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sirtuin-activating Compound
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging-related diseases. Context Leonard P. Guarente is recognized as the leading proponent of the hypothesis that caloric restriction slows aging by activation of Sirtuins. STACs have been discovered by Konrad Howitz of Biomol Inc and biologist David Sinclair. In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003). Other examples of such products are butein, piceatannol, isoliquiritigenin, fisetin, and quercetin. Sirtuins depend on the crucial cellular molecule called nicotinamide adenine dinucleotide (NAD+) for their function. Falling NAD+ levels during aging may adversely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicodendron Vernicifluum
''Toxicodendron vernicifluum'' (formerly ''Rhus verniciflua''), also known by the common name Chinese lacquer tree, is an Asian tree species of genus ''Toxicodendron'' native to China and the Indian subcontinent, and cultivated in regions of China, Japan and Korea. Other common names include ''Japanese lacquer tree'', ''Japanese sumac'', and ''varnish tree''. The trees are cultivated and tapped for their toxic sap, which is used as a highly durable lacquer to make Chinese, Japanese, and Korean lacquerware. The trees grow up to 20 metres tall with large leaves, each containing from 7 to 19 leaflets (most often 11–13). The sap contains the allergenic compound urushiol, which gets its name from this species' Japanese name urushi (); "urushi" is also used in English as a collective term for all kinds of Asian lacquerware made from the sap of this and related Asian tree species, as opposed to European "lacquer" or Japanning made from other materials. Urushiol is also the oil foun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chalcone
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids. Chemical properties Chalcones have two absorption maxima at 280 nm and 340 nm. Synthesis Chalcone is usually prepared by an aldol condensation between benzaldehyde and acetophenone. : This reaction, which can be carried out without any solvent, is so reliable that it is used in as an example of green chemistry in undergraduate education. Biosynthesis Chalcones and chalconoids are synthesized in plants as secondary metabolites. The enzyme chalcone synthase, a type III polyketide synthase, is responsible for the biosynthesis of these compounds. The enzyme is found in all "higher" (vascular) and several "lower" ( non-vascular) plants. Potential pharmacology Chalcones and their derivatives demonstrate a wide range of biological activities including anti-inflammation. Some 2′-amino ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chalconoid
Chalconoids Greek: χαλκός ''khalkós'', "copper", due to its color), also known as ''chalcones'', are natural phenols related to chalcone. They form the central core for a variety of important biological compounds. They show antibacterial, antifungal, antitumor and anti-inflammatory properties. Some chalconoids demonstrated the ability to block voltage-dependent potassium channels. Chalcones are also natural aromatase inhibitors. Chalcones are aromatic ketones with two phenyl rings that are also intermediates in the synthesis of many biological compounds. The closure of hydroxychalcones causes the formation of the flavonoid structure. Flavonoids are substances in the plant secondary metabolism with an array of biological activities. Chalconoids are also intermediates in the Auwers synthesis of flavones. Chemical properties Biosynthesis and metabolism Chalcone synthase is an enzyme responsible for the production of chalconoids in plants. Chalcone isomerase is responsi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dahlia
Dahlia (, ) is a genus of bushy, tuberous, herbaceous perennial plants native to Mexico and Central America. A member of the Asteraceae (former name: Compositae) family of dicotyledonous plants, its garden relatives thus include the sunflower, daisy, chrysanthemum, and zinnia. There are 49 species of this genus, with hybrids commonly grown as garden plants. Flower forms are variable, with one head per stem; these can be as small as diameter or up to ("dinner plate"). This great variety results from dahlias being octoploids—that is, they have eight sets of homologous chromosomes, whereas most plants have only two. In addition, dahlias also contain many transposons—genetic pieces that move from place to place upon an allele—which contributes to their manifesting such great diversity. The stems are leafy, ranging in height from as low as to more than . The majority of species do not produce scented flowers. Like most plants that do not attract pollinating insects throug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Butea
''Butea'' is a genus of flowering plants belonging to the pea family, Fabaceae. It is sometimes considered to have only two species, '' B. monosperma'' and '' B. superba'',Gwilym Lewis, Brian Schrire, Barbara MacKinder, and Mike Lock. 2005. ''Legumes of the World''. Royal Botanic Gardens, Kew: Richmond, England. or is expanded to include four or five species. '' Butea monosperma'' is used for timber, resin, fodder, herbal medicine, and dyeing. ''Butea'' is also a host to the lac insect, which produces natural lacquer.Munivenkatappa Sanjappa. 1987. "Revision of the genera ''Butea'' Roxb. ex Willd. and ''Meizotropis'' Voigt (Fabaceae)". ''Bulletin of the Botanical Survey of India'' 29:199-225. Taxonomy ''Butea'' is named after John Stuart, 3rd Earl of Bute (1713-1792), member of parliament, prime minister for one year, and a patron of botany.Umberto Quattrocchi. 2000. ''CRC World Dictionary of Plant Names'' volume I. CRC Press: Boca Raton; New York; Washington, DC; USA. London, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Butea Monosperma
''Butea monosperma'' is a species of '' Butea'' native to tropical and sub-tropical parts of the South Asia and Southeast Asia, ranging across Pakistan, India, Bangladesh, Nepal, Sri Lanka, Myanmar, Thailand, Laos, Cambodia, Vietnam, Malaysia, and western Indonesia. Common names include flame-of-the-forest, palash, and bastard teak. Revered as sacred by Hindus, it's prized for producing an abundance of vivid blooms, but it's also cultivated elsewhere as an ornamental. ''Butea monosperma'', which grows slowly, creates a stunning specimen tree. Description It is a small-sized dry-season deciduous tree, growing to tall. It is a slow-growing tree: young trees have a growth rate of a few feet per year. The leaves are pinnate, with an petiole and three leaflets, each leaflet long. The flowers are long, bright orange-red, and produced in racemes up to long. The fruit is a pod long and broad.Huxley, A., ed. (1992). ''New RHS Dictionary of Gardening''. Macmillan . Flowers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coreopsis
''Coreopsis'' () is a genus of flowering plants in the family Asteraceae. Common names include calliopsis and tickseed, a name shared with various other plants. Description These plants range from in height. The flowers are usually yellow with a toothed tip, but may also be yellow-and-red bicolor. They have showy flower heads with involucral bracts in two distinct series of eight each, the outer being commonly connate at the base. The flat fruits are small and dry and look like insects. There are 75–80 species of ''Coreopsis'', all of which are native to North, Central, and South America. The name ''Coreopsis'' is derived from the Greek words κόρις (''koris''), meaning " bedbug", and ὄψις (''opsis''), meaning "view", referring to the shape of the achene. Taxonomy ''Coreopsis'' is a variable genus closely related to ''Bidens''. In fact, neither ''Coreopsis'' nor ''Bidens'', as defined in the 20th century, is strictly monophyletic. ''Coreopsis'' is best described ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antioxidant
Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. This can lead to polymerization and other chain reactions. They are frequently added to industrial products, such as fuels and lubricants, to prevent oxidation, and to foods to prevent spoilage, in particular the rancidification of oils and fats. In cells, antioxidants such as glutathione, mycothiol or bacillithiol, and enzyme systems like superoxide dismutase, can prevent damage from oxidative stress. The only dietary antioxidants are vitamins A, C, and E, but the term ''antioxidant'' has also been applied to numerous other dietary compounds that only have antioxidant properties in vitro, with little evidence for antioxidant properties in vivo. Dietary supplements marketed as antioxidants have not been shown to maintain health or prevent disease in humans. History As part of their adaptation from marine life, terrestrial plants began producing non-marine antioxi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aldose Reductase
In enzymology, aldose reductase (or aldehyde reductase) () is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. Reactions Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in polyol pathway of glucose metabolism. The second and last step in the pathway is catalyzed by sorbitol dehydrogenase, which catalyzes the NAD-linked oxidation of sorbitol to fructose. Thus, the polyol pathway results in conversion of glucose to fructose with stoichiometric utilization of NADPH and production of NADH. ;glucose + NADPH + H+ \rightleftharpoons sorbitol + NADP+ Galactose is also a substrate for the polyol pathway, but the corresponding keto sugar is not produced because sorbitol dehydrogenase is incapable of oxidizing galactitol. Ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Advanced Glycation Endproduct
Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer's disease. Dietary sources Animal-derived foods that are high in fat and protein are generally AGE-rich and are prone to further AGE formation during cooking. However, only low molecular weight AGEs are absorbed through diet, and vegetarians have been found to have higher concentrations of overall AGEs compared to non-vegetarians. Therefore, it is unclear whether dietary AGEs contribute to disease and aging, or whether only endogenous AGEs (those produced in the body) matter. This does not free diet from potentially negatively influencing AGE, but potentially implies that dietary AGE may deserve less attention than other aspects of diet that lead to elevated blood sugar levels and form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. About 5–10% of cases are the result of a genetic predisposition inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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_flowers_in_Kolkata_I_IMG_4225.jpg "Click for more on -> Butea Monosperma")
