Butein is a
chalcone of the
chalconoids. It can be found in ''
Toxicodendron vernicifluum
''Toxicodendron vernicifluum'' (formerly ''Rhus verniciflua''), also known by the common name Chinese lacquer tree, is an Asian tree species of genus ''Toxicodendron'' native to China and the Indian subcontinent, and cultivated in regions of C ...
'' (or formerly ''Rhus verniciflua''), ''
Dahlia
Dahlia (, ) is a genus of bushy, tuberous, herbaceous perennial plants native to Mexico and Central America. A member of the Asteraceae (former name: Compositae) family of dicotyledonous plants, its garden relatives thus include the sunflower, ...
'', ''
Butea'' (''
Butea monosperma'') and ''
Coreopsis
''Coreopsis'' () is a genus of flowering plants in the family Asteraceae. Common names include calliopsis and tickseed, a name shared with various other plants.
Description
These plants range from in height. The flowers are usually yellow wi ...
'' It has
antioxidative,
aldose reductase
In enzymology, aldose reductase (or aldehyde reductase) () is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the red ...
and
advanced glycation endproduct
Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases, such as diabetes, ath ...
s inhibitory effects.
It is also a
sirtuin-activating compound
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various ...
, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD
+ to remove acetyl groups from proteins. Buteins possess a high ability to inhibit aromatase process in the human body, for this reason, the use of these compounds in the treatment of
breast cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...
on the estrogen ground has been explored. The first attempts of sport pro-hormone supplementation with the use of buteins took place in Poland.
[S.Amboziak]
Aromatase in the dock"
09.2012
References
Chalconoids
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