|
Atypical SLCs
Atypical Solute Carrier Families (Atypical SLCs) are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families. Atypical major facilitator superfamily transport families Most atypical SLCs are families within the major facilitator superfamily (MFS). These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers. They are, however, not named according to the SLC root system, or classified into any of the existing SLC families. ATMFs are categorised based on their sequence similarity and phylogenetic closeness. Some Atypical SLC of MFS type are: OCA2, CLN3, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, MFSD4A, MFSD4B, MFSD5, MFSD6, MFSD6L, M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Facilitator Superfamily
The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. Function The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the import or export of target substrates. The MFS family was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drugs, metabolites, oligosaccharides, amino acids and oxyanions were all transported by MFS family members. These protein energetically drive transport utilizing the electrochemical gradient of the target substrate (uniporter), or act as a cotransporter where transport is coupled to the movement of a second substrate. Fold The basic fold of the MFS transporter is built around 12, or in some cases, 14 transmembrane helices (TMH), with two 6- (or 7- ) helix bundles formed by the N and C terminal homo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNC93B1
Unc-93 homolog B1 (''C. elegans''), also known as UNC93B1, is a protein which in humans is encoded by the ''UNC93B1'' gene. Function This gene encodes a protein with similarity to the ''Caenorhabditis elegans'' unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. Molecular biology The gene is located on long arm of chromosome 11 (11q13) on the minus (Crick) strand and was first identified in 2002. This protein is an intrinsic membrane protein that spans the membrane twelve times. It is found in the endoplasmic reticulum and is highly conserved. Clinical importance Unc93B1 protein appears to be involved in the innate immune response. Defects in the protein predispose to hypersensitity to infections with herpes simplex virus and mouse cytomegalovirus. The mechanism is unclear but Unc93B1 is known to interact with the toll-like receptors TLR3, TLR7 and TLR9 and it appears to be involved in the trafficking of these rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNC93A
Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene. Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans. It belongs to the atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein. UNC93A is closely related to UNC93B1 and MFSD11 Major facilitator superfamily The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. Function The major fac .... UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in ''in vivo'' samples. It is expressed in neurons, with staining close to the plasma membrane. Read also for functional studies in C.elegans. For you who are interested to read more about Unc93A in different species, see: References Further reading * Human proteins [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd14b
Major facilitator superfamily domain containing 14B (MFSD14B, HIATL1) is an atypical solute carrier of MFS type. It locates to intracellular membranes. HGNC The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature. The HGNC approves a ''unique'' and ''meaningful'' name for every known human gene, based on a q ...:23376 TCDB: 2.A.1.2.30 MFSD14B cluster to AMTF1, together with MFSD9, MFSD10 and MFSD14A. References {{Reflist Protein superfamilies Solute carrier family Transmembrane proteins Transport proteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Facilitator Superfamily Domain Containing 14a
Major facilitator superfamily domain containing 14A (MFSD14A, HIAT1) is a protein that in humans is encoded by the MFSD14A gene. MFSD14A is an atypical solute carrier of MFS type. HGNC:23363 MFSD14A cluster to AMTF1, together with MFSD9, MFSD10 and MFSD14B Major facilitator superfamily domain containing 14B (MFSD14B, HIATL1) is an atypical solute carrier of MFS type. It locates to intracellular membranes. HGNC The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisa .... References {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd11
Major facilitator superfamily domain containing 11 (MFSD11) is an atypical Solute carrier found in plasma membranes. HGNC The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature. The HGNC approves a ''unique'' and ''meaningful'' name for every known human gene, based on a q ... ID:25458 TCDB: 2.A.1.58.3 MFSD11 cluster to AMTF10. References Solute carrier family {{gene-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MFSD9
Major facilitator superfamily domain-containing protein 9 is a protein that in humans is encoded by the MFSD9 gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba .... It is a potential solute carrier, and called atypical solute carrier since it is not named according to the SLC nomenclature. It is expressed both in central and peripheral organs. References Transport proteins {{Protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MFSD8
Major facilitator superfamily domain containing 8 also called MFSD8 is a protein that in humans is encoded by the ''MFSD8'' gene. MFSD8 is an atypical SLC, thus a predicted SLC transporter. It clusters phylogenetically to the Atypical MFS Transporter family 2 ( AMTF2). Function MFSD8 is a ubiquitous integral membrane protein which contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein, likely localizes to lysosomal membranes. Clinical significance Mutations in the MFSD8 gene have been of neuronal ceroid lipofuscinosis Neuronal ceroid lipofuscinosis is the general name for a family of at least eight genetically separate neurodegenerative lysosomal storage diseases that result from excessive accumulation of lipopigments (lipofuscin) in the body's tissues. These l .... References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd3
Major facilitator superfamily domain containing 3 (MFSD3) is a protein belonging to the MFS Pfam clan. It is an Atypical solute carrier located to the neuronal plasma membrane. HGNC The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature. The HGNC approves a ''unique'' and ''meaningful'' name for every known human gene, based on a q ...:25157 TCDB: 2.A.1.25.4 MFSD3 belongs to AMTF15. References Solute carrier family {{gene-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Family
A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes a corresponding protein with a 1:1 relationship. The term "protein family" should not be confused with Family (biology), family as it is used in taxonomy. Proteins in a family descend from a common ancestor and typically have similar protein structure, three-dimensional structures, functions, and significant Sequence homology, sequence similarity. The most important of these is sequence similarity (usually amino-acid sequence), since it is the strictest indicator of homology and therefore the clearest indicator of common ancestry. A fairly well developed framework exists for evaluating the significance of similarity between a group of sequences using sequence alignment methods. Proteins that do not share a common ancestor are very unlikely to show statistically significant sequence similarity, making sequence alignment a powerf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
