UNC93A
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Unc-93 homolog A (C. elegans) is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the UNC93A
gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
. Unc93A is a
major facilitator superfamily The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. Function The major facilitator superfamily (MFS) are ...
(MFS), and a putative solute carrier in humans. It belongs to the
atypical SLCs Atypical Solute Carrier Families (Atypical SLCs) are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name a ...
that was recently listed. It is therefore presumed that UNC93A is a transporter protein. UNC93A is closely related to
UNC93B1 Unc-93 homolog B1 (''C. elegans''), also known as UNC93B1, is a protein which in humans is encoded by the ''UNC93B1'' gene. Function This gene encodes a protein with similarity to the ''Caenorhabditis elegans'' unc93 protein. The Unc93 protein ...
and
MFSD11 Major facilitator superfamily The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. Function The major fac ...
. UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in ''in vivo'' samples. It is expressed in neurons, with staining close to the plasma membrane. Read also for functional studies in C.elegans. For you who are interested to read more about Unc93A in different species, see:


References


Further reading

* Human proteins {{gene-6-stub