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UNC93A
Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene. Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans. It belongs to the atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein. UNC93A is closely related to UNC93B1 and MFSD11 Major facilitator superfamily The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. Function The major fac .... UNC93A is affected by amino acid deprivation in cell cortex cultures and starvation in ''in vivo'' samples. It is expressed in neurons, with staining close to the plasma membrane. Read also for functional studies in C.elegans. For you who are interested to read more about Unc93A in different species, see: References Further reading * Human proteins [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Facilitator Superfamily
The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. Function The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the import or export of target substrates. The MFS family was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drugs, metabolites, oligosaccharides, amino acids and oxyanions were all transported by MFS family members. These protein energetically drive transport utilizing the electrochemical gradient of the target substrate (uniporter), or act as a cotransporter where transport is coupled to the movement of a second substrate. Fold The basic fold of the MFS transporter is built around 12, or in some cases, 14 transmembrane helices (TMH), with two 6- (or 7- ) helix bundles formed by the N and C terminal homo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atypical SLCs
Atypical Solute Carrier Families (Atypical SLCs) are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carrier families (SLCs). However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families. Atypical major facilitator superfamily transport families Most atypical SLCs are families within the major facilitator superfamily (MFS). These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers. They are, however, not named according to the SLC root system, or classified into any of the existing SLC families. ATMFs are categorised based on their sequence similarity and phylogenetic closeness. Some Atypical SLC of MFS type are: OCA2, CLN3, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, MFSD4A, MFSD4B, MFSD5, MFSD6, MFSD6L, M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UNC93B1
Unc-93 homolog B1 (''C. elegans''), also known as UNC93B1, is a protein which in humans is encoded by the ''UNC93B1'' gene. Function This gene encodes a protein with similarity to the ''Caenorhabditis elegans'' unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. Molecular biology The gene is located on long arm of chromosome 11 (11q13) on the minus (Crick) strand and was first identified in 2002. This protein is an intrinsic membrane protein that spans the membrane twelve times. It is found in the endoplasmic reticulum and is highly conserved. Clinical importance Unc93B1 protein appears to be involved in the innate immune response. Defects in the protein predispose to hypersensitity to infections with herpes simplex virus and mouse cytomegalovirus. The mechanism is unclear but Unc93B1 is known to interact with the toll-like receptors TLR3, TLR7 and TLR9 and it appears to be involved in the trafficking of these rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mfsd11
Major facilitator superfamily domain containing 11 (MFSD11) is an atypical Solute carrier found in plasma membranes. HGNC The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature. The HGNC approves a ''unique'' and ''meaningful'' name for every known human gene, based on a q ... ID:25458 TCDB: 2.A.1.58.3 MFSD11 cluster to AMTF10. References Solute carrier family {{gene-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
