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Xanthotoxol
Xanthotoxol is a furanocoumarin. It is one of the major active ingredients in ''Cnidium monnieri''.Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. He W, Chen W, Zhou Y, Tian Y and Liao F, Cell Mol Neurobiol., July 2013, volume 33, issue 5, pages 715-722, Metabolism * Xanthotoxol O-methyltransferase ( 8-hydroxyfuranocoumarin 8-O-methyltransferase) is an enzyme that uses S-adenosyl methionine and xanthotoxol to produce S-adenosylhomocysteine and O-methylxanthotoxol (xanthotoxin or methoxsalen Methoxsalen, sold under the brand name Oxsoralen among others, is a medication used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to ultraviolet (UVA) light from lamps or sunlight. Methox ...). References Furanocoumarins Phenols {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Xanthotoxol O-methyltransferase
8-hydroxyfuranocoumarin 8-O-methyltransferase (, ''furanocoumarin 8-methyltransferase'', ''furanocoumarin 8-O-methyl-transferase'', ''xanthotoxol 8-O-methyltransferase'', ''XMT'', ''SAM:xanthotoxol O-methyltransferase'', ''S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase'', ''xanthotoxol methyltransferase'', ''xanthotoxol O-methyltransferase'', ''S-adenosyl-L-methionine:xanthotoxol O-methyltransferase'', ''S-adenosyl-L-methionine-xanthotoxol O-methyltransferase'') is an enzyme with List of enzymes, systematic name ''S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase''. This enzyme catalysis, catalyses the following chemical reaction : (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin \rightleftharpoons S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction) : (2) S-adenosyl-L-methionine + xanthotoxol \rightleftharpoons S-adenosyl-L-homocysteine + xanthotoxin 8-hydroxyfuranocoumarin 8-O-methyltransferase converts xanthotoxol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
8-hydroxyfuranocoumarin 8-O-methyltransferase
8-hydroxyfuranocoumarin 8-O-methyltransferase (, ''furanocoumarin 8-methyltransferase'', ''furanocoumarin 8-O-methyl-transferase'', ''xanthotoxol 8-O-methyltransferase'', ''XMT'', ''SAM:xanthotoxol O-methyltransferase'', ''S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase'', ''xanthotoxol methyltransferase'', ''xanthotoxol O-methyltransferase'', ''S-adenosyl-L-methionine:xanthotoxol O-methyltransferase'', ''S-adenosyl-L-methionine-xanthotoxol O-methyltransferase'') is an enzyme with systematic name ''S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase''. This enzyme catalyses the following chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ... : (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin \rightleftharpoons S-adenosyl-L-h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methoxsalen
Methoxsalen, sold under the brand name Oxsoralen among others, is a medication used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to ultraviolet (UVA) light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. Levels of individual patient PUVA exposure were originally determined using the Fitzpatrick scale. The scale was developed after patients demonstrated symptoms of phototoxicity after oral ingestion of methoxsalen followed by PUVA therapy. Chemically, methoxsalen belongs to a class of organic natural molecules known as furanocoumarins. They consist of coumarin annulated with furan. It can also be injected and used topically. Natural sources In 1947, methoxsalen was isolated (under the name "ammoidin") from the plant ''Ammi majus'', bishop's weed. In 1970, Nielsen extracted 8-methoxypsoralen from four species of the genus '' Heracleum'' in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cnidium Monnieri
''Cnidium monnieri'' (L.) Cusson ex Juss., Monnier's snowparsley, is a flowering plant species in the genus ''Cnidium''. Also known as Shechuangzi, Osthole, Jashoshi, Cnidii Fructus (Fruits of Cnidium). It may be confused with ''Bacopa monnieri'', ''Ligusticum officinale'' (syn. ''Cnidium officinale''), both similar but different plants. The coumarins osthol, imperatorin and xanthotoxol can be found in ''C. monnieri''. Naming ''Cnidium monnieri'' was already described and the name validly published by Carl Linnaeus. It was Pierre Cusson, however, who reclassified it into today's valid botanical systematics in 1787. Taxonomy ''Cnidium monnieri'' is a species in the genus ''Cnidium'' which contains approximately 11 to 35 species and belongs to thfamilyof thApiaceae(carrot family). Characteristics Plants annual, 10–60(–80) cm. Taproot 2–3 mm thick. Stem solitary, striate, scabrous. Lower petioles 3–8 cm; blade ovate-lanceolate, 3–8 × 2–5 cm, 2â ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Furanocoumarin
The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. Most of the plant species found to contain furanocoumarins belong to a handful of plant families. The families Apiaceae and Rutaceae include the largest numbers of plant species that contain furanocoumarins. The families Moraceae and Fabaceae include a few widely distributed plant species that contain furanocoumarins. Generally furanocoumarins are most abundant in plants that have flowered and in ripe seeds and fruits. (An exception is the common fig where furanocoumarins are found chiefly in the milky sap of the leaves and shoots but not the fruits. Cited in McGovern and Barkley 2000, section&nbsPhytophotodermatitis) During the early stages of plant growth, their presence is not easily detected. Structure The chemical structure of furanocoumarins consists of a furan ring fused with a coumarin. The furan ring may be fused in various ways producing several differen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Furanocoumarins
The furanocoumarins, or furocoumarins, are a class of organic chemical compounds produced by a variety of plants. Most of the plant species found to contain furanocoumarins belong to a handful of plant families. The families Apiaceae and Rutaceae include the largest numbers of plant species that contain furanocoumarins. The families Moraceae and Fabaceae include a few widely distributed plant species that contain furanocoumarins. Generally furanocoumarins are most abundant in plants that have flowered and in ripe seeds and fruits. (An exception is the common fig where furanocoumarins are found chiefly in the milky sap of the leaves and shoots but not the fruits. Cited in McGovern and Barkley 2000, section&nbsPhytophotodermatitis) During the early stages of plant growth, their presence is not easily detected. Structure The chemical structure of furanocoumarins consists of a furan ring fused with a coumarin. The furan ring may be fused in various ways producing several differen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
