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Thomas Cremer
Thomas Cremer (born 7 July 1945 in Miesbach, Germany ), is a German professor of human genetics and anthropology with a main research focus on molecular cytogenetics and 3D/4D analyses of nuclear structure studied by fluorescence microscopy including super-resolution microscopy and live cell imaging. Thomas Cremer is the brother of the German physicist Christoph Cremer and Georg Cremer, Secretary General of the German Caritas Association. Biography Thomas Cremer was raised in Aachen. He studied medicine at the Human Medical School, Albert Ludwigs University of Freiburg, where he graduated in 1970 and received his doctoral degree in 1973. From 1974-1978 he was leader of a research group at the Institute of Anthropology and Human Genetics, University of Freiburg followed by a fellowship as research associate at the University of California, Irvine (1978) in the group oM.W. Berns From 1978-1996 he headed an independent research group at the Institute oAnthropology and Human Genetics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miesbach
Miesbach () is a town in Bavaria, Germany, and is the capital of the Miesbach district. The district is at an altitude of 697 metres above sea level. It covers an area of approximately 863.50 km² of alpine headlands and in 2017 had a population of 11,477. The town is located 48 km southeast of Munich. Lake Schliersee Schliersee is a small town (Markt) and a municipality in the district of Miesbach in Bavaria in Germany. It is named after the nearby Lake Schliersee. It comprises the districts Schliersee (town), , , , Josefsthal and Spitzingsee. Among the p ... and Lake Tegernsee, around which are the internationally renowned spas, Bad Wiessee, Rottach-Egern and Tegernsee, are nearby. Miesbach was founded around the year 1000 and was for hundreds of years the seat of the County of Hohenwaldeck. In the 19th century it became the center of the conservation movement for the traditional costumes, the Tracht. Miesbach also has a rich history as a pilgrimage and a mining ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Connecticut
Connecticut () is the southernmost state in the New England region of the Northeastern United States. It is bordered by Rhode Island to the east, Massachusetts to the north, New York to the west, and Long Island Sound to the south. Its capital is Hartford and its most populous city is Bridgeport. Historically the state is part of New England as well as the tri-state area with New York and New Jersey. The state is named for the Connecticut River which approximately bisects the state. The word "Connecticut" is derived from various anglicized spellings of "Quinnetuket”, a Mohegan-Pequot word for "long tidal river". Connecticut's first European settlers were Dutchmen who established a small, short-lived settlement called House of Hope in Hartford at the confluence of the Park and Connecticut Rivers. Half of Connecticut was initially claimed by the Dutch colony New Netherland, which included much of the land between the Connecticut and Delaware Rivers, although the firs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schleiden Medal
The Schleiden Medal is an award given by the Academy of Sciences Leopoldina, the National Academy of Germany, to honour outstanding achievements in the field of cellular biology. The award is named after botanist Matthias Jakob Schleiden. Recipients * 1955 : Emil Heitz * 1958 : Albert Frey-Wyssling * 1961 : Jean Brachet (co-recipient) * 1973 : Irene Manton & Torbjörn Caspersson * 1975 : Wilhelm Bernhard * 1977 : Ernst Wohlfarth-Bottermann * 1980 : Karl Lennert * 1983 : Berta Scharrer * 1985 : George Emil Palade * 1987 : Zdeněk Lojda * 1989 : A. G. Everson Pearse * 1991 : Peter Sitte * 1993 : Gottfried Schatz * 1995 : Philipp U. Heitz * 1998 : Avram Hershko * 1999 : Walter Neupert * 2001 : Kai Simons * 2003 : Ari Helenius * 2005 : Wolfgang Baumeister * 2007 : Alexander Varshavsky * 2009 : Thomas Cremer * 2011 : Tom Rapoport * 2013 : Ingrid Grummt * 2015 : Johannes Buchner * 2017 : Anthony A. Hyman * 2019 : Elena Conti * 2021 : Nikolaus Pfanner See also * List of biolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Comparative Genomic Hybridization
Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome). This technique was originally developed for the evaluation of the differences between the chromosomal complements of solid tumor and normal tissue, and has an improved resolution of 5–10 megabases compared to the more traditional cytogenetic analysis techniques of giemsa banding and fluorescence in situ hybridization (FISH) which are limited by the resolution of the microscope utilized.Strachan T, Read AP (2010) Human ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome Territories
In cell biology, chromosome territories are regions of the nucleus preferentially occupied by particular chromosomes. Interphase chromosomes are long DNA strands that are extensively folded, and are often described as appearing like a bowl of spaghetti. The chromosome territory concept holds that despite this apparent disorder, chromosomes largely occupy defined regions of the nucleus. Most eukaryotes are thought to have chromosome territories, although the budding yeast ''S. cerevisiae'' is an exception to this. Characteristics Chromosome territories are spheroid with diameters on the order of one to few micrometers. Nuclear compartments devoid of DNA called interchromatin compartments have been reported to tunnel into chromosome territories to facilitate molecular diffusion into the otherwise tightly packed chromosome-occupied regions. History and experimental support The concept of chromosome territories was proposed by Carl Rabl in 1885 based on studies of Salamandra mac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Nucleus
The cell nucleus (pl. nuclei; from Latin or , meaning ''kernel'' or ''seed'') is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support. The cell nucleus contains nearly all of the cell's genome. Nuclear DNA is often organized into multiple chromosomes – long stands of DNA dotted with various proteins, such as histones, that protect and organize the DNA. The genes within these chromosomes are structured in such a way to promote cell function. The nucleus maintains the integrity of genes and controls the activities of the cell by regulating gene expres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Situ Hybridization
''In situ'' hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA, RNA or modified nucleic acids strand (i.e., probe) to localize a specific DNA or RNA sequence in a portion or section of tissue (''in situ'') or if the tissue is small enough (e.g., plant seeds, ''Drosophila'' embryos), in the entire tissue (whole mount ISH), in cells, and in circulating tumor cells (CTCs). This is distinct from immunohistochemistry, which usually localizes proteins in tissue sections. In situ hybridization is used to reveal the location of specific nucleic acid sequences on chromosomes or in tissues, a crucial step for understanding the organization, regulation, and function of genes. The key techniques currently in use include ''in situ'' hybridization to mRNA with oligonucleotide and RNA probes (both radio-labeled and hapten-labeled), analysis with light and electron microscopes, whole mount ''in situ'' hybridization, double detection of RNAs and RNA plus prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytogenetic
Cytogenetics is essentially a branch of genetics, but is also a part of cell biology/cytology (a subdivision of human anatomy), that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis and meiosis. Techniques used include karyotyping, analysis of G-banded chromosomes, other cytogenetic banding techniques, as well as molecular cytogenetics such as fluorescent ''in situ'' hybridization (FISH) and comparative genomic hybridization (CGH). History Beginnings Chromosomes were first observed in plant cells by Carl Nägeli in 1842. Their behavior in animal (salamander) cells was described by Walther Flemming, the discoverer of mitosis, in 1882. The name was coined by another German anatomist, von Waldeyer in 1888. The next stage took place after the development of genetics in the early 20th century, when it was appreciated that the set of chromosomes (the karyotype) was the carrier of the genes. Levitsky seems to have been t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosomes
A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are the histones. These proteins, aided by chaperone proteins, bind to and condense the DNA molecule to maintain its integrity. These chromosomes display a complex three-dimensional structure, which plays a significant role in transcriptional regulation. Chromosomes are normally visible under a light microscope only during the metaphase of cell division (where all chromosomes are aligned in the center of the cell in their condensed form). Before this happens, each chromosome is duplicated (S phase), and both copies are joined by a centromere, resulting either in an X-shaped structure (pictured above), if the centromere is located equatorially, or a two-arm structure, if the centromere is located distally. The joined copies are now called sis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Regulation
Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Although as early as 1951, Barbara McClintock showed interaction between two genetic loci, Activator (''Ac'') and Dissociator (''Ds''), in the color formation of maize seeds, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetic
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene expression can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromatin
Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes in anaphase; the characteristic shapes of chromosomes visible during this stage are the result of DNA being coiled into highly condensed chromatin. The primary protein components of chromatin are histones. An octamer of two sets of four histone cores (Histone H2A, Histone H2B, Histone H3, and Histone H4) bind to DNA and function as "anchors" around which the strands are wound.Maeshima, K., Ide, S., & Babokhov, M. (2019). Dynamic chromatin organization without the 30-nm fiber. ''Current opinion in cell biology, 58,'' 95–104. https://doi.o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
