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The Roslin Institute
The Roslin Institute is an animal sciences research institute at Easter Bush, Midlothian, Scotland, part of the University of Edinburgh, and is funded by the Biotechnology and Biological Sciences Research Council. It is best known for creating Dolly the sheep, the first mammal to be successfully cloned from an adult cell. History Institute of Animal Genetics (1917–1980) The Roslin Institute has its roots in the University of Edinburgh's Institute of Animal Genetics (IAG), which was founded in 1917 under the direction of Francis Albert Eley Crew. Poultry Research Centre (1947–1986) The Poultry Research Centre (PRC) was founded in 1947 by the Agricultural Research Council (ARC). The new institute used expertise and material from the IAG, and its laboratories were located adjacent to the IAG's building on the university's King's Buildings campus. A second site housing larger experiments was located on the Bush Estate, south of Edinburgh. In 1971, the institute's experiment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Midlothian
Midlothian (; gd, Meadhan Lodainn) is a historic county, registration county, lieutenancy area and one of 32 council areas of Scotland used for local government. Midlothian lies in the east-central Lowlands, bordering the City of Edinburgh, East Lothian and the Scottish Borders. Midlothian emerged as a county in the Middle Ages under larger boundaries than the modern council area, including Edinburgh itself. The county was formally called the "shire of Edinburgh" or Edinburghshire until the twentieth century. It bordered West Lothian to the west, Lanarkshire, Peeblesshire and Selkirkshire to the south, and East Lothian, Berwickshire and Roxburghshire to the east. Traditional industries included mining, agriculture and fishing – although the modern council area is now landlocked. History Following the end of the Roman occupation of Britain, Lothian was populated by Brythonic-speaking ancient Britons and formed part of Gododdin, within the Hen Ogledd or Old North. In the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Babraham Institute
The Babraham Institute is a life sciences research institution and a partner organisation of the University of Cambridge. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buildings on the campus, surrounded by an extensive parkland estate, just south of Cambridge, England. It is an independent and charitable organization which is involved in biomedical research, including healthy aging and molecular biology. The director is Dr Simon Cook who also leads the Institute's signalling research programme. The Babraham Institute is a member of EU-LIFE, an alliance of leading life sciences research centres in Europe. History The institute is located on the historic Babraham Hall Estate (now called the Babraham Research Campus), situated six miles south-east of Cambridge University, near the Gog Magog Hills. It is close to where the ancient Roman Via Devana crossed the prehistoric Ickni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Developmental Biology
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. Perspectives The main processes involved in the embryogenesis, embryonic development of animals are: tissue patterning (via regional specification and patterned cellular differentiation, cell differentiation); tissue growth; and tissue morphogenesis. * Regional specification refers to the processes that create the spatial patterns in a ball or sheet of initially similar cells. This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), from animals to plants and microorganisms. Genes have been transferred within the same species, across species (creating transgenic organisms), and even across kingdoms. New genes can be introduced, or endogenous genes can be enhanced, altered, or knocked out. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with other genetic elements, including a promoter and terminator region and often a selectable marker. A number of techniques are a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantitative Genetics
Quantitative genetics deals with phenotypes that vary continuously (such as height or mass)—as opposed to discretely identifiable phenotypes and gene-products (such as eye-colour, or the presence of a particular biochemical). Both branches use the frequencies of different alleles of a gene in breeding populations (gamodemes), and combine them with concepts from simple Mendelian inheritance to analyze inheritance patterns across generations and descendant lines. While population genetics can focus on particular genes and their subsequent metabolic products, quantitative genetics focuses more on the outward phenotypes, and makes only summaries of the underlying genetics. Due to the continuous distribution of phenotypic values, quantitative genetics must employ many other statistical methods (such as the ''effect size'', the ''mean'' and the ''variance'') to link phenotypes (attributes) to genotypes. Some phenotypes may be analyzed either as discrete categories or as continuous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polly And Molly
Polly and Molly (born 1997), two ewes, were the first mammals to have been successfully cloned from an adult somatic cell and to be transgenic animals at the same time. This is not to be confused with Dolly the Sheep, the first animal to be successfully cloned from an adult somatic cell where there wasn’t modification carried out on the adult donor nucleus. Polly and Molly, like Dolly the Sheep, were cloned at the Roslin Institute in Edinburgh, Scotland. The creation of Polly and Molly built on the somatic nuclear transfer experiments that led to the cloning of Dolly the Sheep. The crucial difference was that in creating Polly and Molly, scientists used cells into which a new gene had been inserted. The gene chosen was a therapeutic protein to demonstrate the potential of such recombinant DNA technology combined with animal cloning. This could hopefully be used to produce pharmacological and therapeutic proteins to treat human diseases. The protein in question was the human blood ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keith Campbell (biologist)
Keith Henry Stockman Campbell (23 May 1954 – 5 October 2012) was a British biologist who was a member of the team at Roslin Institute that in 1996 first cloned a mammal, a Finnish Dorset lamb named Dolly, from fully differentiated adult mammary cells. He was Professor of Animal Development at the University of Nottingham. In 2008, he received the Shaw Prize for Medicine and Life Sciences jointly with Ian Wilmut and Shinya Yamanaka for "their works on the cell differentiation in mammals". Education Campbell was born in Birmingham, England, to an English mother and Scottish father. He started his education in Perth, Scotland, but, when he was eight years old, his family returned to Birmingham, where he attended King Edward VI Camp Hill School for Boys. He obtained his Bachelor of Science degree in microbiology from the Queen Elizabeth College, University of London (now part of King's College London). In 1983 Campbell was awarded the Marie Curie Research Scholarship, which led ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ian Wilmut
Sir Ian Wilmut, OBE FRS -- FMedSci FRSE (born 7 July 1944) is an English embryologist and Chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. He was appointed OBE in 1999 for services to embryo development and knighted in the 2008 New Year Honours. He together with Keith Campbell and Shinya Yamanaka jointly received the 2008 Shaw Prize for Medicine and Life Sciences "for their works on the cell differentiation in mammals." Early life and education Wilmut was born in Hampton Lucy, Warwickshire, England. Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from diabetes for fifty years, which eventually caused him to become blind. He was a student of the former Boys' High School, in Scarborough, where his father taught. Wilmut's early desire was to embark on a naval ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eleanor Riley
Eleanor Riley was Director of the Roslin Institute, Dean of Research at the Royal (Dick) School of Veterinary Studies, and professor of Immunology at the University of Edinburgh. Her research focusses on understanding the immune response of the host to malaria and other diseases using human data and mouse models. Education Riley gained her bachelor's degree in cell biology and veterinary science from the University of Bristol, before reading for a postgraduate diploma in veterinary disease from Cornell University and studying her PhD in immunology and parasitology at the University of Liverpool. Her thesis entitled '''The immunology of experimental Echinoccus granulosus'' ic''infection in mice was accepted in 1985. Career Riley worked for five years at the MRC Unit The Gambia. Riley joined the University of Edinburgh initially as a research fellow in 1990, before moving to the London School of Hygiene & Tropical Medicine (LSHTM) in 1998 as a professor of infectious diseas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HDR, Inc
HDR, Inc. is an employee-owned design firm, specializing in engineering, architecture, environmental, and construction services. HDR has worked on projects in all 50 U.S. states and in 60 countries, including notable projects such as the Hoover Dam Bypass, Fort Belvoir Community Hospital, and Roslin Institute building. The firm employs over 11,000 professionals and represents hundreds of disciplines in various markets. HDR is the 10th largest employee-owned company in the United States with revenues of $2.5 billion in 2021. Engineering News-Record' ranked HDR as the 5th largest design firm in the United States in 2022. History In 1917, the Henningson Engineering Company started as a civil engineering firm in Omaha, where HDR's headquarters remain today. Willard Richardson and Charles W. "Chuck" Durham joined the firm in 1939 as interns. Circa 1950, Richardson and Durham had purchased shares in the firm, and it became known as Henningson, Durham and Richardson, Inc. The company' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal (Dick) School Of Veterinary Studies
The Royal (Dick) School of Veterinary Studies, commonly referred to as the Dick Vet, is the veterinary school of the University of Edinburgh in Scotland and part of the College of Medicine and Veterinary Medicine the head of which is Moira Whyte. David Argyle has been Dean and Head of School since 1 November 2011. The school was ranked first in the UK by the UK Government in the 2014 Research Excellence Framework and the 2008 Research Assessment Exercise (RAE). The School was ranked second in the world in the ShanghaiRanking's Global Ranking of Academic Subjects 2020 – Veterinary Sciences, 3rd in the world by the QS World University Rankings for Veterinary Science in 2021, first in the UK for the fourth year running by The Guardian University Guide 2021, and first in the UK for the fifth year running by the ''Times'' and ''Sunday Times'' Good University Guide ranking for Veterinary Medicine. History Originally called the Highland Society's Veterinary School, Edinburgh, the D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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