Scottish Centre for Regenerative Medicine
The Centre for Regenerative Medicine (CRM) is a stem cell research centre at the University of Edinburgh in Scotland, dedicated to the study and development of new regenerative medicine, regenerative treatments for human diseases. The centre for ...
at the
University of Edinburgh
The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...
. He is best known as the leader of the research group that in 1996 first
cloned
Cloning is the process of producing individual organisms with identical or virtually identical DNA, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction. In the field of biotechnology, ...
Shinya Yamanaka
is a Japanese stem cell researcher and a Nobel Prize laureate. He serves as the director of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyo ...
Hampton Lucy
Hampton Lucy is a village and civil parish on the River Avon, northeast of Stratford-upon-Avon in Warwickshire England. The population of the civil parish as taken at the 2011 census was 566.
History
The grammar school at Hampton Lucy was ...
,
Warwickshire
Warwickshire (; abbreviated Warks) is a county in the West Midlands region of England. The county town is Warwick, and the largest town is Nuneaton. The county is famous for being the birthplace of William Shakespeare at Stratford-upon-Av ...
, England. Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from
diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...
for fifty years, which eventually caused him to become blind. He was a student of the former Boys' High School, in
Scarborough Scarborough or Scarboro may refer to:
People
* Scarborough (surname)
* Earl of Scarbrough
Places Australia
* Scarborough, Western Australia, suburb of Perth
* Scarborough, New South Wales, suburb of Wollongong
* Scarborough, Queensland, su ...
, where his father taught. Wilmut's early desire was to embark on a naval career, but he was unable to do so due to his colour blindness. As a school boy, Wilmut worked as a farm hand on weekends, which inspired him to study
Agriculture
Agriculture or farming is the practice of cultivating plants and livestock. Agriculture was the key development in the rise of sedentary human civilization, whereby farming of domesticated species created food surpluses that enabled people t ...
at the
University of Nottingham
, mottoeng = A city is built on wisdom
, established = 1798 – teacher training college1881 – University College Nottingham1948 – university status
, type = Public
, chancellor ...
.
In 1966, Wilmut spent 8 weeks working in the laboratory of
Christopher Polge
Ernest John Christopher Polge (16 August 1926 – 17 August 2006) was an English biologist, most noted for his work in cryopreservation.
The son of a Buckinghamshire farmer, he was educated at Bootham School in York, before going to the Univers ...
, who is credited with developing the technique of
cryopreservation
Cryo-preservation or cryo-conservation is a process where organisms, organelles, cells, tissues, extracellular matrix, organs, or any other biological constructs susceptible to damage caused by unregulated chemical kinetics are preserved by co ...
in 1949. The following year Wilmut joined Polge's laboratory to undertake a
Doctor of Philosophy
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...
degree at the
University of Cambridge
The University of Cambridge is a public collegiate research university in Cambridge, England. Founded in 1209 and granted a royal charter by Henry III in 1231, Cambridge is the world's third oldest surviving university and one of its most pr ...
from which he graduated in 1971 with a thesis on
semen cryopreservation
Semen cryopreservation (commonly called sperm banking or sperm freezing) is a procedure to preserve sperm cells. Semen can be used successfully indefinitely after cryopreservation. It can be used for sperm donation where the recipient wants the tr ...
Since his PhD, he has been involved in research focusing on gametes and embryogenesis, including working at the
Roslin Institute
The Roslin Institute is an animal sciences research institute at Easter Bush, Midlothian, Scotland, part of the University of Edinburgh, and is funded by the Biotechnology and Biological Sciences Research Council.
It is best known for creat ...
.
Wilmut was the leader of the research group that in 1996 first cloned a mammal, a lamb named Dolly. Dolly died of a respiratory disease in 2003. However, in 2008 Wilmut announced that he would abandon the technique of
somatic cell nuclear transfer
In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. The technique consists of taking an enucleated oocyte (egg cell) and implanting a ...
by which Dolly was created in favour of an alternative technique developed by
Shinya Yamanaka
is a Japanese stem cell researcher and a Nobel Prize laureate. He serves as the director of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyo ...
. This method has been used in mice to derive
pluripotent Pluripotency: These are the cells that can generate into any of the three Germ layers which imply Endodermal, Mesodermal, and Ectodermal cells except tissues like the placenta.
According to Latin terms, Pluripotentia means the ability for many thin ...
stem cells from differentiated adult skin cells, thus circumventing the need to generate embryonic stem cells. Wilmut believes that this method holds greater potential for the treatment of degenerative conditions such as
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
and to treat stroke and heart attack patients.
Wilmut led the team that created Dolly, but in 2006 admitted his colleague Keith Campbell deserved "66 per cent" of the invention that made Dolly's birth possible, and that the statement "I did not create Dolly" was accurate. His supervisory role is consistent with the post of
principal investigator
In many countries, the term principal investigator (PI) refers to the holder of an independent grant and the lead researcher for the grant project, usually in the sciences, such as a laboratory study or a clinical trial. The phrase is also often us ...
held by Wilmut at the time of Dolly's creation.
Wilmut is an Emeritus Professor at the
Scottish Centre for Regenerative Medicine
The Centre for Regenerative Medicine (CRM) is a stem cell research centre at the University of Edinburgh in Scotland, dedicated to the study and development of new regenerative medicine, regenerative treatments for human diseases. The centre for ...
at the
University of Edinburgh
The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...
New Year Honours
The New Year Honours is a part of the British honours system, with New Year's Day, 1 January, being marked by naming new members of orders of chivalry and recipients of other official honours. A number of other Commonwealth realms also mark this ...
for services to science.
In 2006 his book ''After Dolly: The Uses and Misuses of Human Cloning'' was published, co-authored with
Roger Highfield
Roger Ronald Highfield (born 1958 in Griffithstown, Wales) is an author, science journalist, broadcaster and Science Director at the Science Museum Group.
Education
Highfield was educated at Chase Side Primary School in Enfield and Christ's Ho ...
American Academy of Achievement
The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...
Fellow of the Academy of Medical Sciences
Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...
in 1999 and
Fellow of the Royal Society of Edinburgh
Fellowship of the Royal Society of Edinburgh (FRSE) is an award granted to individuals that the Royal Society of Edinburgh, Scotland's national academy of science and letters, judged to be "eminently distinguished in their subject". This socie ...
. He was elected an
EMBO Member
Membership of the European Molecular Biology Organization (EMBO) is an award granted by the European Molecular Biology Organization (EMBO) in recognition of "research excellence and the outstanding achievements made by a life scientist".
, 88 EMB ...
in 2003.
In 1997 Wilmut was ''
Time magazine
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on Ma ...