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Nicoletta Sacchi
Nicoletta Sacchi (born August 20, 1949) is an Italian professor of oncology at the Roswell Park Comprehensive Cancer Center. She is the co-discoverer of the acid guanidinium thiocyanate-phenol-chloroform extraction method to RNA extraction, extract RNA from biological samples with Trizol. As a consequence of this groundbreaking discovery she is now considered the most cited woman scientist in the world. Career Sacchi was born in Milan and studied for her PhD at the University of Milan in 1972, investigating the genetics of yeast. She remained within the fields of genetics for her postdoctoral training at the same University and Erasmus University Rotterdam, Erasmus University Rotterdam. Sacchi worked on the generation of Antibody, antibody repertoires by the Terminal deoxynucleotidyl transferase, TdT DNA polymerase in the lab of Georges J. F. Köhler, Georges Köhler at the Basel Institute for Immunology. She moved to the US in 1982 and switched to cancer research, focussing on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milan, Italy
Milan ( , , Lombard language, Lombard: ; it, Milano ) is a city in northern Italy, capital of Lombardy, and the List of cities in Italy, second-most populous city proper in Italy after Rome. The city proper has a population of about 1.4 million, while its Metropolitan City of Milan, metropolitan city has 3.26 million inhabitants. Its continuously built-up List of urban areas in the European Union, urban area (whose outer suburbs extend well beyond the boundaries of the administrative Metropolitan cities of Italy, metropolitan city and even stretch into the nearby country of Switzerland) is the fourth largest in the EU with 5.27 million inhabitants. According to national sources, the population within the wider Milan metropolitan area (also known as Greater Milan), is estimated between 8.2 million and 12.5 million making it by far the List of metropolitan areas of Italy, largest metropolitan area in Italy and List of metropolitan areas in Europe, one of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Terminal Deoxynucleotidyl Transferase
Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. TdT adds N-nucleotides to the V, D, and J exons of the TCR and BCR genes during antibody gene recombination, enabling the phenomenon of junctional diversity. In humans, terminal transferase is encoded by the ''DNTT'' gene. As a member of the X family of DNA polymerase enzymes, it works in conjunction with polymerase λ and polymerase μ, both of which belong to the same X family of polymerase enzymes. The diversity introduced by TdT has played an important role in the evolution of the vertebrate immune system, significantly increasing the variety of antigen receptors that a cell is equipped with to fight pathogens. Studies using TdT knockout mice have found drastic reductions (10-fold) in T-cell receptor (TCR) diversity compared w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orders, Decorations, And Medals Of Italy
The Italian honours system is a means to reward achievements or service to the Italian Republic, formerly the Kingdom of Italy including the Italian Social Republic. Orders of chivalry Italian Republic There are five orders of knighthood awarded in recognition of service to the Italian Republic. Below these sit a number of other decorations, associated and otherwise, that do not confer knighthoods. The degrees of knighthood, not all of which apply to all orders, are Knight (''Cavaliere'' abbreviated ''Cav.''), Officer (''Ufficiale'' abbreviated ''Uff.''), Commander (''Commendatore'' abbr. ''Comm.''), Grand Officer (''Grand'Ufficiale'', abbr. ''Gr. Uff.''), Knight Grand Cross (''Cavaliere di Gran Croce'', abbr. ''Cav. Gr. Croce'') and Knight Grand Cross with cordon (''Cavaliere di Gran Croce con cordone''). Italian citizens may not use within the territory of the Republic honours or distinctions conferred on them by non-national orders or foreign states, unless authorised ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
President Of Italy
The president of Italy, officially denoted as president of the Italian Republic ( it, Presidente della Repubblica Italiana) is the head of state of Italy. In that role, the president represents national unity, and guarantees that Italian politics comply with the Constitution. The president is the commander-in-chief of the Italian Armed Forces and chairs the High Council of the Judiciary. A president's term of office lasts for seven years. The incumbent president is former constitutional judge Sergio Mattarella, who was elected on 31 January 2015, and re-elected on 29 January 2022. Qualifications for office The framers of the Constitution of Italy intended for the president to be an elder statesman of some stature. Article 84 states that any Italian citizen who is fifty or older on election day and enjoys civil and political rights can be elected president. The article also states that the presidency is incompatible with any other office; therefore, the president-elect mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philadelphia
Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Since 1854, the city has been coextensive with Philadelphia County, the most populous county in Pennsylvania and the urban core of the Delaware Valley, the nation's seventh-largest and one of world's largest metropolitan regions, with 6.245 million residents . The city's population at the 2020 census was 1,603,797, and over 56 million people live within of Philadelphia. Philadelphia was founded in 1682 by William Penn, an English Quaker. The city served as capital of the Pennsylvania Colony during the British colonial era and went on to play a historic and vital role as the central meeting place for the nation's founding fathers whose plans and actions in Philadelphia ultimately inspired the American Revolution and the nation's inde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Institute For Scientific Information
The Institute for Scientific Information (ISI) was an academic publishing service, founded by Eugene Garfield in Philadelphia in 1956. ISI offered scientometric and bibliographic database services. Its specialty was citation indexing and analysis, a field pioneered by Garfield. Services ISI maintained citation databases covering thousands of academic journals, including a continuation of its longtime print-based indexing service the Science Citation Index (SCI), as well as the Social Sciences Citation Index (SSCI) and the Arts and Humanities Citation Index (AHCI). All of these were available via ISI's Web of Knowledge database service. This database allows a researcher to identify which articles have been cited most frequently, and who has cited them. The database provides some measure of the academic impact of the papers indexed in it, and may increase their impact by making them more visible and providing them with a quality label. Some anecdotal evidence suggests that appearing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Capital Flight
Human capital flight is the emigration or immigration of individuals who have received advanced training at home. The net benefits of human capital flight for the receiving country are sometimes referred to as a "brain gain" whereas the net costs for the sending country are sometimes referred to as a "brain drain". In occupations with a surplus of graduates, immigration of foreign-trained professionals can aggravate the underemployment of domestic graduates, whereas emigration from an area with a surplus of trained people leads to better opportunities for those remaining. But emigration may cause problems for the home country if the trained people are in short supply there. Research shows that there are significant economic benefits of human capital flight for the migrants themselves and for the receiving country. The impact on the country of origin is less straightforward, with research suggesting the impact can be positive, negative or mixed. Research also suggests that emigrat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenome
An epigenome consists of a record of the chemical changes to the DNA and histone proteins of an organism; these changes can be passed down to an organism's offspring via transgenerational stranded epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome. The epigenome is involved in regulating gene expression, development, tissue differentiation, and suppression of transposable elements. Unlike the underlying genome, which remains largely static within an individual, the epigenome can be dynamically altered by environmental conditions. Cancer Epigenetics is a currently active topic in cancer research. Human tumors undergo a major disruption of DNA methylation and histone modification patterns. The aberrant epigenetic landscape of the cancer cell is characterized by a global genomic hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, an altered histone code for c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins University
Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consistently ranks among the most prestigious universities in the United States and the world. The university was named for its first benefactor, the American entrepreneur and Quaker philanthropist Johns Hopkins. Hopkins' $7 million bequest to establish the university was the largest Philanthropy, philanthropic gift in U.S. history up to that time. Daniel Coit Gilman, who was inaugurated as :Presidents of Johns Hopkins University, Johns Hopkins's first president on February 22, 1876, led the university to revolutionize higher education in the U.S. by integrating teaching and research. In 1900, Johns Hopkins became a founding member of the American Association of Universities. The university has led all Higher education in the U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sidney Kimmel Comprehensive Cancer Center
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University is an NCI-Designated Comprehensive Cancer Center in Baltimore, MD. It was established in 1973 and received its NCI designation that same year as one of the first designated cancer centers in the country. SKCCC is a member of the National Comprehensive Cancer Network, an alliance of 27 comprehensive cancer centers in the US. The current director of SKCCC is William G. Nelson, M.D., Ph.D., who has been at JHU since 1992 and specializes in prostate cancer. Past directors have included Albert H. Owens Jr. and Martin Abeloff. Research SKCCC is a prolific research institution. Many of the over 100 research laboratories are part of specialized research programs, including the Brain Cancer, Breast & Ovarian Cancer, Cancer Biology, Cancer Chemical & Structural Biology, Cancer Immunology, Cancer Molecular & Functional Imaging, Cancer Prevention & Control, Hematologic Malignancies & Bone Marrow Transplant, Prostate C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leukemia
Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ''leukemia cells''. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of leukemia is unknown. A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. Risk factors include smoking, ionizing radiation, petrochemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of leukemia are also at higher risk. There are four main types of leukemia— acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship. NCI is the oldest and has the largest budget and research program of the 27 institutes and centers of the NIH ($6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides grants for cancer research. Additionally, the National Cancer Institute has intramural research programs in Bethesda, Maryland, and at the Frederick National Laboratory for Cancer Research at Fort Detrick in Frederick, Maryland. The NCI receives more than in funding each ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
