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Nellie Kershaw
Nellie Kershaw (c. 1891 – 14 March 1924) was an English textile worker from Rochdale, Lancashire. Her death due to pulmonary asbestosis was the first such case to be described in medical literature, and the first published account of disease attributed to occupational asbestos exposure. Before his publication of the case in the '' British Medical Journal'', Dr William Edmund Cooke had already testified at Kershaw's inquest that "mineral particles in the lungs originated from asbestos and were, beyond reasonable doubt, the primary cause of the fibrosis of the lungs and therefore of death". Her employers, Turner Brothers Asbestos, accepted no liability for her injuries, paid no compensation to her bereaved family and refused to contribute towards funeral expenses as it "would create a precedent and admit responsibility". She was buried in an unmarked pauper's grave. The subsequent inquiries into her death led to the publication of the first Asbestos Industry Regulations in 1931. ...
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Rochdale
Rochdale ( ) is a large town in Greater Manchester, England, at the foothills of the South Pennines in the dale on the River Roch, northwest of Oldham and northeast of Manchester. It is the administrative centre of the Metropolitan Borough of Rochdale, which had a population of 211,699 in the 2011 census. Located within the historic boundaries of the county of Lancashire. Rochdale's recorded history begins with an entry in the Domesday Book of 1086 under "Recedham Manor". The ancient parish of Rochdale was a division of the hundred of Salford and one of the largest ecclesiastical parishes in England, comprising several townships. By 1251, Rochdale had become important enough to have been granted a Royal charter. Rochdale flourished into a centre of northern England's woollen trade, and by the early 18th century was described as being "remarkable for many wealthy merchants". Rochdale rose to prominence in the 19th century as a mill town and centre for textile manufactu ...
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Slater
A slater, or slate mason, is a tradesperson who covers buildings with slate. Tools of the trade The various tools of the slater's trade are all drop-forged. The slater's hammer is forged in one single piece, from crucible-cast steel, and has a leather handle. It consists of a claw for drawing nails, a sheer edge for cutting slate, and a head with a sharp point at one end for punching holes in slate and with a hammer head at the other. The ripper is also forged from crucible-cast steel and is long. It consists of a blade and a hook, and is used for removing broken slate. The hook can be used to cut and remove slating nails. The slater's stake is T-shaped. The vertical bar of the "T" is pointed to allow it to be driven into a rafter or other woodworking surface. The horizontal bar of the "T" is used to support slates whilst working on them (cutting, punching, or smoothing) with other tools. The long bar of the stake can also be used as a straight edge for marking. The z ...
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Micrometre
The micrometre ( international spelling as used by the International Bureau of Weights and Measures; SI symbol: μm) or micrometer (American spelling), also commonly known as a micron, is a unit of length in the International System of Units (SI) equalling (SI standard prefix "micro-" = ); that is, one millionth of a metre (or one thousandth of a millimetre, , or about ). The nearest smaller common SI unit is the nanometre, equivalent to one thousandth of a micrometre, one millionth of a millimetre or one billionth of a metre (). The micrometre is a common unit of measurement for wavelengths of infrared radiation as well as sizes of biological cells and bacteria, and for grading wool by the diameter of the fibres. The width of a single human hair ranges from approximately 20 to . The longest human chromosome, chromosome 1, is approximately in length. Examples Between 1 μm and 10 μm: * 1–10 μm – length of a typical bacterium * 3–8 μm – width of st ...
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Fibrosis
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue. Repeated injuries, chronic inflammation and repair are susceptible to fibrosis where an accidental excessive accumulation of extracellular matrix components, such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar. In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing. Defin ...
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Leigh, Greater Manchester
Leigh is a town in the Metropolitan Borough of Wigan, Greater Manchester, England, on low-lying land northwest of Chat Moss. Within the boundaries of the historic county of Lancashire, Leigh was originally the centre of a large ecclesiastical parish covering six vills or townships. When the three townships of Pennington, Westleigh and Bedford merged in 1875, forming the Leigh Local Board District, Leigh became the official name for the town, although it had been applied to the area of Pennington and Westleigh around the parish church for many centuries. The town became an urban district in 1894 when part of Atherton was added. In 1899 Leigh became a municipal borough. The first town hall was built on King Street and replaced by the present building in 1907. Originally an agricultural area (noted for dairy farming), domestic spinning and weaving led to a considerable silk industry and, in the 20th century, the cotton industry. Leigh also exploited the underlying coal meas ...
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Wigan
Wigan ( ) is a large town in Greater Manchester, England, on the River Douglas. The town is midway between the two cities of Manchester, to the south-east, and Liverpool, to the south-west. Bolton lies to the north-east and Warrington to the south. It is the largest settlement in the Metropolitan Borough of Wigan and is its administrative centre. The town has a population of 107,732 and the wider borough of 330,713. Wigan was formerly within the historic county of Lancashire. Wigan was in the territory of the Brigantes, an ancient Celtic tribe that ruled much of what is now northern England. The Brigantes were subjugated in the Roman conquest of Britain and the Roman settlement of ''Coccium'' was established where Wigan lies. Wigan was incorporated as a borough in 1246, following the issue of a charter by King Henry III of England. At the end of the Middle Ages, it was one of four boroughs in Lancashire established by Royal charter. The Industrial Revolution saw ...
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Microbiology
Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, protistology, mycology, immunology, and parasitology. Eukaryotic microorganisms possess membrane-bound organelles and include fungi and protists, whereas prokaryotic organisms—all of which are microorganisms—are conventionally classified as lacking membrane-bound organelles and include Bacteria and Archaea. Microbiologists traditionally relied on culture, staining, and microscopy. However, less than 1% of the microorganisms present in common environments can be cultured in isolation using current means. Microbiologists often rely on molecular biology tools such as DNA sequence based identification, for example the 16S rRNA gene sequence used for bacteria identification. Viruses have been variably classified as organisms, as the ...
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Pathology
Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area which includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue, cell, and body fluid samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases (as in the statement "the many different forms of cancer have diverse pathologies", in which case a more proper choice of word would be " pathophysiologies"), and the affix ''pathy'' is sometimes used to indicate a state of disease in cases of both physical ailment (as in cardi ...
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Barristers In England And Wales
Barristers in England and Wales are one of the two main categories of lawyer in England and Wales, the other being solicitors. Barristers have traditionally had the role of handling cases for representation in court, both defence and prosecution. (The word "lawyer" is a generic one, referring to a person who practises in law, which could also be deemed to include other legal practitioners such as chartered legal executives.) Origin of the profession The work of senior legal professionals in England and Wales is divided between solicitors and barristers. Both are trained in law but serve differing functions in the practice of law. Historically, the superior courts were based in London, the capital city. To dispense justice throughout the country, a judge and court personnel would periodically travel a regional circuit to deal with cases that had arisen there. From this developed a body of lawyers who were on socially familiar terms with the judges, had training and experience in ...
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Heart Failure
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome, a group of signs and symptoms caused by an impairment of the heart's blood pumping function. Symptoms typically include shortness of breath, excessive fatigue, and leg swelling. The shortness of breath may occur with exertion or while lying down, and may wake people up during the night. Chest pain, including angina, is not usually caused by heart failure, but may occur if the heart failure was caused by a heart attack. The severity of the heart failure is measured by the severity of symptoms during exercise. Other conditions that may have symptoms similar to heart failure include obesity, kidney failure, liver disease, anemia, and thyroid disease. Common causes of heart failure include coronary artery disease, heart attack, high blood pressure, atrial fibrillation, valvular heart disease, excessive alcohol consumption, infection, and cardiomyopathy. These cause heart failure by alterin ...
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Tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis. Around 10% of latent infections progress to active disease which, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus, fever, night sweats, and weight loss. It was historically referred to as consumption due to the weight loss associated with the disease. Infection of other organs can cause a wide range of symptoms. Tuberculosis is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze. People with Latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke. Diagnosis of active ...
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Autopsy
An autopsy (post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death or to evaluate any disease or injury that may be present for research or educational purposes. (The term " necropsy" is generally reserved for non-human animals). Autopsies are usually performed by a specialized medical doctor called a pathologist. In most cases, a medical examiner or coroner can determine the cause of death. However, only a small portion of deaths require an autopsy to be performed, under certain circumstances. Purposes of performance Autopsies are performed for either legal or medical purposes. Autopsies can be performed when any of the following information is desired: * Determine if death was natural or unnatural * Injury source and extent on the corpse * Manner of death must be determined * Post mortem interval * Determining the dece ...
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