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George Lignac
George Otto Emil Lignac (30 August 1891 – 5 September 1954) was a Dutch pathologist-anatomist. Lignac was born in Passoeroean, Java, Dutch East Indies, where his father worked as a civil servant. He studied medicine at Leiden and then returned to the Dutch East Indies and was a teacher at the STOVIA (''School tot Opleiding van Indische Artsen'' or "school for the training of Indian physicians") in Batavia. He returned to the Netherlands and was appointed professor of pathology, general diseases, pathological anatomy, and juridical medicine in Leiden in 1934. He published work on skin pigmentation, cysteine metabolism and the carcinogenic nature of benzol and many more. The Abderhalden–Kaufmann–Lignac syndrome is named for Emil Abderhalden, Eduard Kaufmann Eduard Kaufmann (24 March 1860, Bonn – 15 December 1931, Göttingen) was a German physician. The disease Abderhalden–Kaufmann–Lignac syndrome is named for him. Career Kaufmann studied in Bonn and Berlin, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Java (island)
Java (; id, Jawa, ; jv, ꦗꦮ; su, ) is one of the Greater Sunda Islands in Indonesia. It is bordered by the Indian Ocean to the south and the Java Sea to the north. With a population of 151.6 million people, Java is the world's most populous island, home to approximately 56% of the Indonesian population. Indonesia's capital city, Jakarta, is on Java's northwestern coast. Many of the best known events in Indonesian history took place on Java. It was the centre of powerful Hindu-Buddhist empires, the Islamic sultanates, and the core of the colonial Dutch East Indies. Java was also the center of the Indonesian struggle for independence during the 1930s and 1940s. Java dominates Indonesia politically, economically and culturally. Four of Indonesia's eight UNESCO world heritage sites are located in Java: Ujung Kulon National Park, Borobudur Temple, Prambanan Temple, and Sangiran Early Man Site. Formed by volcanic eruptions due to geologic subduction of the Austral ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cysteine
Cysteine (symbol Cys or C; ) is a semiessential proteinogenic amino acid with the formula . The thiol side chain in cysteine often participates in enzymatic reactions as a nucleophile. When present as a deprotonated catalytic residue, sometimes the symbol Cyz is used. The deprotonated form can generally be described by the symbol Cym as well. The thiol is susceptible to oxidation to give the disulfide derivative cystine, which serves an important structural role in many proteins. In this case, the symbol Cyx is sometimes used. When used as a food additive, it has the E number E920. Cysteine is encoded by the codons UGU and UGC. The sulfur-containing amino acids cysteine and methionine are more easily oxidized than the other amino acids. Structure Like other amino acids (not as a residue of a protein), cysteine exists as a zwitterion. Cysteine has chirality in the older / notation based on homology to - and -glyceraldehyde. In the newer ''R''/''S'' system of designating chi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1891 Births
Events January–March * January 1 ** Paying of old age pensions begins in Germany. ** A strike of 500 Hungarian steel workers occurs; 3,000 men are out of work as a consequence. **Germany takes formal possession of its new African territories. * January 2 – A. L. Drummond of New York is appointed Chief of the Treasury Secret Service. * January 4 – The Earl of Zetland issues a declaration regarding the famine in the western counties of Ireland. * January 5 **The Australian shearers' strike, that leads indirectly to the foundation of the Australian Labor Party, begins. **A fight between the United States and Indians breaks out near Pine Ridge agency. ** Henry B. Brown, of Michigan, is sworn in as an Associate Justice of the Supreme Court. **A fight between railway strikers and police breaks out at Motherwell, Scotland. * January 6 – Encounters continue, between strikers and the authorities at Glasgow. * January 7 ** General Miles' force ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Accidents And Incidents In Aviation
An aviation accident is defined by the Convention on International Civil Aviation Annex 13 as an occurrence associated with the operation of an aircraft, which takes place from the time any person boards the aircraft with the ''intention of flight'' until all such persons have disembarked, and in which a) a person is fatally or seriously injured, b) the aircraft sustains significant damage or structural failure, or c) the aircraft goes missing or becomes completely inaccessible. Annex 13 defines an aviation incident as an occurrence, other than an accident, associated with the operation of an aircraft that affects or could affect the safety of operation. A hull loss occurs if an aircraft is damaged beyond repair, lost, or becomes completely inaccessible. The first fatal aviation accident was the crash of a Rozière balloon near Wimereux, France, on June 15, 1785, killing the balloon's inventor, Jean-François Pilâtre de Rozier, and the other occupant, Pierre Romain. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fanconi Syndrome
Fanconi syndrome or Fanconi's syndrome (, ) is a syndrome of inadequate reabsorption in the proximal renal tubules of the kidney. The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from toxic heavy metals), or by adverse drug reactions. It results in various small molecules of metabolism being passed into the urine instead of being reabsorbed from the tubular fluid (for example, glucose, amino acids, uric acid, phosphate, and bicarbonate). Fanconi syndrome affects the proximal tubules, namely, the proximal convoluted tubule (PCT), which is the first part of the tubule to process fluid after it is filtered through the glomerulus, and the proximal straight tubule (pars recta), which leads to the descending limb of loop of Henle. Different forms of Fanconi syndrome can affect different functions of the proximal tubule, and result in different complications. The loss of bicarbonate results in type 2 or proximal renal tubular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eduard Kaufmann
Eduard Kaufmann (24 March 1860, Bonn – 15 December 1931, Göttingen) was a German physician. The disease Abderhalden–Kaufmann–Lignac syndrome is named for him. Career Kaufmann studied in Bonn and Berlin, and earned his doctorate from the University of Bonn in 1884. He was appointed privatdozent for anatomical pathology in Breslau three years later, and assisted at Emil Ponfick’s institute. In 1896 Kaufmann became prosector at Allerheiligenhospital in Breslau and professor in 1897. In 1898 he became professor of pathology and anatomical pathology and head of the Pathological Anatomical Institute of the University of Basel. Kaufmann moved in 1907 to Göttingen and finally withdrew from active work in 1927. Kaufmann undertook the first study of cartilage changes in achondroplasia. His textbook on pathological anatomy, "''Lehrbuch der speciellen pathologischen Anatomie''", has been tractitioners He was the author of significant works involving chondrodystrophy and on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emil Abderhalden
Emil Abderhalden (9 March 1877 – 5 August 1950) was a Swiss biochemist and physiologist. His main findings, though disputed already in the 1910s, were not finally rejected until the late 1990s. Whether his misleading findings were based on fraud or simply the result of a lack of scientific rigor remains unclear. Abderhalden's drying pistol, used in chemistry, was first described by one of his students in a textbook Abderhalden edited. Biography Emil Abderhalden was born in Oberuzwil in the Canton of St. Gallen in Switzerland. He moved to Basel to study at the University of Basel. During his time in Basel, he joined the rowing club and was founder member of FC Basel. Eleven men attended the meeting of founding Fussball Club Basel on 15 November 1893. Abderhalden played his first game for the club in the home game in the Stadion Schützenmatte on 22 September 1894 as Basel won 2–0 against FC Gymnasia. Abderhalden left the club in January 1895. Abderhalden studied medicine a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abderhalden–Kaufmann–Lignac Syndrome
Abderhalden–Kaufmann–Lignac syndrome (AKL syndrome), also called nephropathic cystinosis, is an autosomal recessive renal disorder of childhood comprising cystinosis and renal rickets. Presentation Affected children are developmentally delayed with dwarfism, rickets and osteoporosis. Renal tubular disease is usually present causing aminoaciduria, glycosuria and hypokalemia. Cysteine deposition is most evident in the conjunctiva and cornea. Diagnosis Eponym It is named for Emil Abderhalden Emil Abderhalden (9 March 1877 – 5 August 1950) was a Swiss biochemist and physiologist. His main findings, though disputed already in the 1910s, were not finally rejected until the late 1990s. Whether his misleading findings were based on f ..., Eduard Kaufmann and George Lignac. See also * Cystinosin References External links Autosomal recessive disorders Syndromes affecting the kidneys {{Genetic-disorder-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzene
Benzene is an organic chemical compound with the molecular formula C6H6. The benzene molecule is composed of six carbon atoms joined in a planar ring with one hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms, benzene is classed as a hydrocarbon. Benzene is a natural constituent of petroleum and is one of the elementary petrochemicals. Due to the cyclic continuous pi bonds between the carbon atoms, benzene is classed as an aromatic hydrocarbon. Benzene is a colorless and highly flammable liquid with a sweet smell, and is partially responsible for the aroma of gasoline. It is used primarily as a precursor to the manufacture of chemicals with more complex structure, such as ethylbenzene and cumene, of which billions of kilograms are produced annually. Although benzene is a major industrial chemical, it finds limited use in consumer items because of its toxicity. History Discovery The word "''benzene''" derives from "''gum benzoin''" (benzoin res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Skin Color
Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among individuals is caused by variation in pigmentation, which is the result of genetics (inherited from one's biological parents and or individual gene alleles), exposure to the sun, natural and sexual selection, or all of these. Differences across populations evolved through natural or sexual selection, because of social norms and differences in environment, as well as regulations of the biochemical effects of ultraviolet radiation penetrating the skin. The actual skin color of different humans is affected by many substances, although the single most important substance is the pigment melanin. Melanin is produced within the skin in cells called melanocytes and it is the main determinant of the skin color of darker-skin humans. The skin color of people with light skin is determined mainly by the bluish-white connective tissue under the dermis and by the hemoglobin circulating in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leiden
Leiden (; in English and archaic Dutch also Leyden) is a city and municipality in the province of South Holland, Netherlands. The municipality of Leiden has a population of 119,713, but the city forms one densely connected agglomeration with its suburbs Oegstgeest, Leiderdorp, Voorschoten and Zoeterwoude with 206,647 inhabitants. The Netherlands Central Bureau of Statistics (CBS) further includes Katwijk in the agglomeration which makes the total population of the Leiden urban agglomeration 270,879, and in the larger Leiden urban area also Teylingen, Noordwijk, and Noordwijkerhout are included with in total 348,868 inhabitants. Leiden is located on the Oude Rijn, at a distance of some from The Hague to its south and some from Amsterdam to its north. The recreational area of the Kaag Lakes (Kagerplassen) lies just to the northeast of Leiden. A university city since 1575, Leiden has been one of Europe's most prominent scientific centres for more than four centuries. Leide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forensic Medicine
Forensic medicine is a broad term used to describe a group of medical specialties which deal with the examination and diagnosis of individuals who have been injured by or who have died because of external or unnatural causes such as poisoning, assault, suicide and other forms of violence, and apply findings to law (i.e. court cases). Forensic medicine is a multi-disciplinary branch which includes the practice of forensic pathology, forensic psychiatry, forensic dentistry, forensic radiology and forensic toxicology Forensic toxicology is the use of toxicology and disciplines such as analytical chemistry, pharmacology and clinical chemistry to aid medical or legal investigation of death, poisoning, and drug use. The primary concern for forensic toxicology is .... There are two main categories of forensic medicine; Clinical forensic medicine; Pathological forensics medicine, with the differing factor being the condition of the patients. In clinical forensic medicine it is the invest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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