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Brain Disease Model Of Addiction
The disease model of addiction describes an addiction as a disease with biological, neurological, genetic, and environmental sources of origin. The traditional medical model of disease requires only that an abnormal condition be present that causes discomfort, dysfunction, or distress to the affected individual. The contemporary medical model attributes addiction, in part, to changes in the brain's mesolimbic pathway. The medical model also takes into consideration that such disease may be the result of other biological, psychological or sociological entities despite an incomplete understanding of the mechanisms of these entities. The common biomolecular mechanisms underlying all forms of addiction – CREB and ΔFosB – were reviewed by Eric J. Nestler in a 2013 review. Genetic factors and mental disorders can contribute to the severity of drug addiction. Approximately fifty percent of the chance a person will develop an addiction can be attributed to genetic factors."Addictio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substance Dependence
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption of the drug. A ''drug addiction'', a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An ''addictive drug'' is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral and drug addictions, but not dependence. The International Classification of Diseases classifies substance dependence as a mental and behavioural disorder. Within the framework of the 4th edition of the ''Diagn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Model
''Medical model'' is the term coined by psychiatrist R. D. Laing in his ''The Politics of the Family and Other Essays'' (1971), for the "set of procedures in which all doctors are trained". It includes complaint, history, physical examination, ancillary tests if needed, diagnosis, treatment, and prognosis with and without treatment. The medical model embodies basic assumptions about medicine that drive research and theorizing about physical or psychological difficulties on a basis of causation and remediation. It can be contrasted with other models that make different basic assumptions. Examples include holistic model of the alternative health movement and the social model of the disability rights movement, as well as to biopsychosocial and recovery models of mental disorders. For example, Gregory Bateson's double bind theory of schizophrenia focuses on environmental rather than medical causes. These models are not mutually exclusive. A model is not a statement of abso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disease
A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that are associated with specific signs and symptoms. A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different diseases, including various forms of immunodeficiency, hypersensitivity, allergies and autoimmune disorders. In humans, ''disease'' is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person affected, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Brain
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and occipital lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesolimbic Pathway
The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. The pathway connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain. The ventral striatum includes the nucleus accumbens and the olfactory tubercle. The release of dopamine from the mesolimbic pathway into the nucleus accumbens regulates incentive salience (e.g. motivation and desire for rewarding stimuli) and facilitates reinforcement and reward-related motor function learning; it may also play a role in the subjective perception of pleasure. The dysregulation of the mesolimbic pathway and its output neurons in the nucleus accumbens plays a significant role in the development and maintenance of an addiction. Anatomy The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine-releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumben ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CREB
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: '' c-fos'', BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain and has been shown to be integral in the formation of spatial memory. CREB downreg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ΔFosB
Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (''FOSB'') gene. The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants, ΔFosB and further truncated Δ2ΔFosB, are all involved in osteosclerosis, although Δ2ΔFosB lacks a known transactivation domain, in turn preventing it from affecting transcription through the AP-1 complex. The ΔFosB splice variant has been identified as playing a central, ''crucial'' (necessary and sufficient) role in the development and maintenance of addiction. ΔFosB overexpression ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric J
Eric J Dubowsky also known as Eric J, is a Grammy, Emmy, ARIA, and APRA award-winning mixer, songwriter and record producer. Eric grew up in the New York City suburb of Tenafly, New Jersey and graduated from Tenafly High School in 1993. After attending Syracuse University he worked at Greene St. Recording in New York City, the home of early hip-hop artists Run-DMC, and Public Enemy. It was here Eric assisted engineer/producer, Rod Hui. That led to a job working with Atlantic Records producer Arif Mardin in 1998. Eric has worked with artists such as Flume, Weezer, ODESZA, Twenty One Pilots, Chet Faker, Brandy, Jeff Bhasker, Andy Grammer, Tove Lo, St. Vincent, The Chemical Brothers, Alessia Cara, Dua Lipa, Demi Lovato, Angus & Julia Stone, Freeform Five, Ruel, Kimbra, Mansionair, Panama, Kylie Minogue, Meg Mac, Yuka Honda, Flight Facilities, Joss Stone, The Rubens, Marc Kinchen, Lisa Mitchell, Carolina Liar, and actress Emmy Rossum. Eric received the 2014 ARIA award ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life-process Model Of Addiction
The life-process model of addiction is the view that addiction is not a disease but rather a habitual response and a source of gratification and security that can be understood only in the context of social relationships and experiences. This model of addiction is in opposition to the disease model of addiction. It was originated and advocated by Stanton Peele in his book ''The Truth About Addiction and Recovery'' (with Archie Brodsky and Mary Arnold, 1991). Proponents of the life-process model argue that unitary biological mechanisms cannot account for addictive behavior and thus do not support using the term ''disease''. They instead emphasize the individual's ability to overcome addiction by augmenting life options and coping mechanics, pursuing values and purpose, repairing relationships, and expressing personal agency — all of which occur through normal human development. Indeed, the disease model impedes these natural life processes. The biological mechanisms typically cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Social Stigma
Social stigma is the disapproval of, or discrimination against, an individual or group based on perceived characteristics that serve to distinguish them from other members of a society. Social stigmas are commonly related to culture, gender, race, socioeconomic class, age, sexual orientation, body image, physical disability, intelligence or lack thereof, and health. Some stigma may be obvious, while others are known as concealable stigmas that must be revealed through disclosure. Stigma can also be against oneself, stemming from negatively viewed personal attributes in a way that can result in a "spoiled identity" (i.e., self-stigma). Description Stigma (plural stigmas or ''stigmata'') is a Greek word that in its origins referred to a type of marking or the tattoo that was cut or burned into the skin of people with criminal records, slaves, or those seen as traitors in order to visibly identify them as supposedly blemished or morally polluted persons. These individuals were to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harm Reduction
Harm reduction, or harm minimization, refers to a range of public health policies designed to lessen the negative social and/or physical consequences associated with various human behaviors, both legal and illegal. Harm reduction is used to decrease negative consequences of recreational drug use and sexual activity without requiring abstinence, recognizing that those unable or unwilling to stop can still make positive change to protect themselves and others. Harm reduction is most commonly applied to approaches that reduce adverse consequences from drug use, and harm reduction programs now operate across a range of services and in different regions of the world. As of 2020, some 86 countries had one or more programs using a harm reduction approach to substance use, primarily aimed at reducing blood-borne infections resulting from use of contaminated injecting equipment. Needle-exchange programmes reduce the likelihood of people who use heroin and other substances sharing the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andrew Tatarsky
Andrew Tatarsky (born August 11, 1955) is an American psychologist and the founder and director of the Center for Optimal Living. He teaches in New York City as the Professor of Professional Practice for the Harm Reduction Psychotherapy Certificate Program at the New School for Social Research. Tatarsky is known for developing Integrative Harm Reduction Therapy (IHRP), a treatment for the spectrum of substance use disorders and other high-risk behaviors. Education Tatarsky attended the City College of New York, where he graduated with Research Honors in psychology, summa cum laude in 1977. At the City College of New York he was elected member of the Phi Beta Kappa Society and received the Bernard A. Ackerman Research Award. He received his Ph.D. in clinical psychology from the City College of the City University of New York in 1986. He is currently a candidate at the Postdoctoral Program in Psychotherapy and Psychoanalysis, New York University; New York, N.Y. Career Early ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
