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Life-process Model Of Addiction
The life-process model of addiction is the view that addiction is not a disease but rather a habitual response and a source of gratification and security that can be understood only in the context of social relationships and experiences. This model of addiction is in opposition to the disease model of addiction. It was originated and advocated by Stanton Peele in his book ''The Truth About Addiction and Recovery'' (with Archie Brodsky and Mary Arnold, 1991). Proponents of the life-process model argue that unitary biological mechanisms cannot account for addictive behavior and thus do not support using the term ''disease''. They instead emphasize the individual's ability to overcome addiction by augmenting life options and coping mechanics, pursuing values and purpose, repairing relationships, and expressing personal agency — all of which occur through normal human development. Indeed, the disease model impedes these natural life processes. The biological mechanisms typically cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substance Dependence
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption of the drug. A ''drug addiction'', a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An ''addictive drug'' is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral and drug addictions, but not dependence. The International Classification of Diseases classifies substance dependence as a mental and behavioural disorder. Within the framework of the 4th edition of the ''Diagn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ΔFosB
Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (''FOSB'') gene. The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants, ΔFosB and further truncated Δ2ΔFosB, are all involved in osteosclerosis, although Δ2ΔFosB lacks a known transactivation domain, in turn preventing it from affecting transcription through the AP-1 complex. The ΔFosB splice variant has been identified as playing a central, ''crucial'' (necessary and sufficient) role in the development and maintenance of addiction. ΔFosB overexpression ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substance Use Disorder
Substance use disorder (SUD) is the persistent use of drugs (including alcohol) despite substantial harm and adverse consequences as a result of their use. Substance use disorders are characterized by an array of mental/emotional, physical, and behavioral problems such as chronic guilt; an inability to reduce or stop consuming the substance(s) despite repeated attempts; operating vehicles while intoxicated; and physiological withdrawal symptoms. Drug classes that are commonly involved in SUD include: alcohol (alcoholism); cannabis; opioids; stimulants such as nicotine (including tobacco), cocaine and amphetamines; benzodiazepines; barbiturates; and other or unknown substances. In the Diagnostic and Statistical Manual of Mental Disorders 5th edition (2013), also known as DSM-5, the DSM-IV diagnoses of substance abuse and substance dependence were merged into the category of substance use disorders. The severity of substance use disorders can vary widely; in the DSM-5 diagnosi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SMART Recovery
SMART Recovery is an international non-profit organization that provides assistance to individuals seeking abstinence from addiction. SMART stands for Self-Management and Recovery Training. The SMART approach is secular and research-based, using cognitive behavioral therapy (CBT) and non-confrontational motivational methods. SMART Recovery is an alternative to Alcoholics Anonymous (AA) and other twelve-step programs. SMART differs from AA in that addiction is viewed by the organization as a dysfunctional habit, rather than a disease as it is framed in AA, while allowing that it is possible that certain people have a predisposition toward addictive behavior. SMART Recovery does not focus on spiritual growth as a key component of behavior modification and thus does not encourage individuals to admit powerlessness over addictions, nor use the concept of a "Higher Power". History After Jack Trimpey, founder of Rational Recovery (RR), decided to turn RR into a for-profit organiza ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moderation Management
Moderation Management (MM) is a secular non-profit organization providing peer-run support groups for anyone who would like to reduce their alcohol consumption. MM was founded in 1994 to create an alternative to Alcoholics Anonymous and similar addiction recovery groups for non-dependent problem drinkers who do not necessarily want to stop drinking, but moderate their amount of alcohol consumed to reduce its detrimental consequences. Methodology Moderation Management allows members to set their own drinking goals as they feel appropriate. MM encourages members to follow particular drinking guidelines, limits, goal setting techniques, and a nine-step cognitive-behavioral change program. The MM limits and guidelines were derived from the work of Dr. Martha Sanchez-Craig. MM members are encouraged, but do not need to follow, the suggested guidelines, limits and steps. MM does not view non-dependent problem drinkers as alcoholics, but rather people with a bad, but controllable, habit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcoholics Anonymous
Alcoholics Anonymous (AA) is an international mutual aid fellowship of alcoholics dedicated to abstinence-based recovery from alcoholism through its spiritually-inclined Twelve Step program. Following its Twelve Traditions, AA is non-professional, non-denominational, as well as apolitical and unaffiliated. In 2020 AA estimated its worldwide membership to be over two million with 75% of those in the U.S. and Canada. Despite viewing the disease model of alcoholism as an outside issue on which it has no opinion, AA is commonly associated with its popularity since many of its members took a large role in spreading it. Regarding its effectiveness, a 2020 scientific review saw clinical interventions encouraging increased AA participation resulting in higher abstinence rates over other clinical interventions while probably reducing health costs. AA marks 1935 for its start when Bill Wilson (Bill W.) first commiserated alcoholic to alcoholic with Bob Smith (Dr. Bob) who, along wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene M
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gene– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric J
Eric J Dubowsky also known as Eric J, is a Grammy, Emmy, ARIA, and APRA award-winning mixer, songwriter and record producer. Eric grew up in the New York City suburb of Tenafly, New Jersey and graduated from Tenafly High School in 1993. After attending Syracuse University he worked at Greene St. Recording in New York City, the home of early hip-hop artists Run-DMC, and Public Enemy. It was here Eric assisted engineer/producer, Rod Hui. That led to a job working with Atlantic Records producer Arif Mardin in 1998. Eric has worked with artists such as Flume, Weezer, ODESZA, Twenty One Pilots, Chet Faker, Brandy, Jeff Bhasker, Andy Grammer, Tove Lo, St. Vincent, The Chemical Brothers, Alessia Cara, Dua Lipa, Demi Lovato, Angus & Julia Stone, Freeform Five, Ruel, Kimbra, Mansionair, Panama, Kylie Minogue, Meg Mac, Yuka Honda, Flight Facilities, Joss Stone, The Rubens, Marc Kinchen, Lisa Mitchell, Carolina Liar, and actress Emmy Rossum. Eric received the 2014 ARIA award ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CREB
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: '' c-fos'', BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain and has been shown to be integral in the formation of spatial memory. CREB downreg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disease
A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that are associated with specific signs and symptoms. A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different diseases, including various forms of immunodeficiency, hypersensitivity, allergies and autoimmune disorders. In humans, ''disease'' is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person affected, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Behavior
Behavior (American English) or behaviour (British English) is the range of actions and mannerisms made by individuals, organisms, systems or artificial entities in some environment. These systems can include other systems or organisms as well as the inanimate physical environment. It is the computed response of the system or organism to various stimuli or inputs, whether internal or external, conscious or subconscious, overt or covert, and voluntary or involuntary. Taking a behavior informatics perspective, a behavior consists of actor, operation, interactions, and their properties. This can be represented as a behavior vector. Models Biology Although disagreement exists as to how to precisely define behavior in a biological context, one common interpretation based on a meta-analysis of scientific literature states that "behavior is the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal and/or external sti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Process
Biological processes are those processes that are vital for an organism to live, and that shape its capacities for interacting with its environment. Biological processes are made of many chemical reactions or other events that are involved in the persistence and transformation of life forms. Metabolism and homeostasis are examples. Biological processes within an organism can also work as bioindicators. Scientists are able to look at an individual's biological processes to monitor the effects of environmental changes. Regulation of biological processes occurs when any process is modulated in its frequency, rate or extent. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. * Homeostasis: regulation of the internal environment to maintain a constant state; for example, sweating to reduce temperature * Organization: being structurally composed of one or more cel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
