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Ana Domingos
Ana I. Domingos is a Portuguese neuroscientist specialising in the treatment of obesity independently of food intake. Domingos is a full Professor of Neuroscience at the Department of Physiology, Anatomy and Genetics of the University of Oxford in the United Kingdom. Domingos is also a fellow, tutor and the director of studies in medicine at Lady Margaret Hall, Oxford. A trained mathematician, Domingos began her research career by pursuing a Ph.D in neurobiology at Rockefeller University. Supervised by Leslie Voshall, Domingos studied the sensory systems facilitating our sense of smell. As a post-doctoral research scientist, Domingos worked under Jeffrey Friedman, investigating how ones metabolism can influence the brain circuitry involved in sweetener cravings. Domingos founded her own laboratory in thGulbenkian Institutein Portugal where she made a number of key discoveries. Firstly, her laboratory discovered that a hormone produced by fat, called leptin, interacts with the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portugal
Portugal, officially the Portuguese Republic ( pt, República Portuguesa, links=yes ), is a country whose mainland is located on the Iberian Peninsula of Southwestern Europe, and whose territory also includes the Atlantic archipelagos of the Azores and Madeira. It features the westernmost point in continental Europe, and its Iberian portion is bordered to the west and south by the Atlantic Ocean and to the north and east by Spain, the sole country to have a land border with Portugal. Its two archipelagos form two autonomous regions with their own regional governments. Lisbon is the capital and largest city by population. Portugal is the oldest continuously existing nation state on the Iberian Peninsula and one of the oldest in Europe, its territory having been continuously settled, invaded and fought over since prehistoric times. It was inhabited by pre-Celtic and Celtic peoples who had contact with Phoenicians and Ancient Greek traders, it was ruled by the Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Lisbon
The University of Lisbon (ULisboa; pt, Universidade de Lisboa, ) is a public research university in Lisbon, and the largest university in Portugal. It was founded in 2013, from the merger of two previous public universities located in Lisbon, the former University of Lisbon (1911–2013) and the Technical University of Lisbon (1930–2013). History The first Portuguese university was established in Lisbon between 1288 and 1290, when Dinis I promulgated the letter ''Scientiae thesaurus mirabili'', granting several privileges to the students of the ''studium generale'' in Lisbon, proving that it was already founded on that date. There was an active participation in this educational activity by the Portuguese Crown and its king, through its commitment of part of the subsidy of the same, as by the fixed incomes of the Church. This institution moved several times between Lisbon and Coimbra, where it settled permanently in 1537. The current University of Lisbon is the result of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of Pound sterling, £29.1 billion in 2020, making it the fourth List of wealthiest charitable foundations, wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP Pound sterling, £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DPhil
A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a dissertation, and defend their work before a panel of other experts in the field. The completion of a PhD is often a requirement for employment as a university professor, researcher, or scientist in many fields. Individuals who have earned a Doctor of Philosophy degree may, in many jurisdictions, use the title ''Doctor'' (often abbreviated "Dr" or "Dr.") with their name, although the proper etiquette associated with this usage may also be subject to the professional ethics of their own scholarly field, culture, or society. Those who teach at universities or work in academic, educat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sympathomimetic Drug
Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. Examples of sympathomimetic effects include increases in heart rate, force of cardiac contraction, and blood pressure. The primary endogenous agonists of the sympathetic nervous system are the catecholamines (i.e., epinephrine drenaline norepinephrine oradrenaline and dopamine), which function as both neurotransmitters and hormones. Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or even delay premature labor, among other things. These drugs can act through several mechanisms, such as directly activating postsynaptic receptors, blocking breakdown and reuptake of certain neurotransmitters, or stimulating production and release of catecholamines. Mechanisms of action The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thermogenesis
Thermogenesis is the process of heat production in organisms. It occurs in all warm-blooded animals, and also in a few species of thermogenic plants such as the Eastern skunk cabbage, the Voodoo lily (''Sauromatum venosum''), and the giant water lilies of the genus ''Victoria''. The lodgepole pine dwarf mistletoe, ''Arceuthobium americanum'', disperses its seeds explosively through thermogenesis.Rolena A.J. deBruyn, Mark Paetkau, Kelly A. Ross, David V. Godfrey & Cynthia Ross Friedman (2015)"Thermogenesis-triggered seed dispersal in dwarf mistletoe" Types Depending on whether or not they are initiated through locomotion and intentional movement of the muscles, thermogenic processes can be classified as one of the following: * Exercise-associated thermogenesis (EAT) * Non-exercise activity thermogenesis (NEAT), energy expended for everything that is not sleeping, eating or sports-like exercise. * Diet-induced thermogenesis (DIT) Shivering One method to raise temperature is thr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anti-obesity Medication
Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control weight. These medications alter one of the fundamental processes of the human body, weight regulation, by altering either appetite, or absorption of calories. The main treatment modalities for overweight and individuals with obesity remain dieting ( healthy diet and caloric restriction) and physical exercise. In the United States orlistat (Xenical) and semaglutide (Wegovy) are currently approved by the FDA for long-term use. Xenical reduces intestinal fat absorption by inhibiting pancreatic lipase; Wegovy is a GLP-1 analogue, a class of drugs that is relatively recent and which has promise as an effective anti-obesity measure. Because of potential side effects, and limited evidence of small benefits in weight reduction for children and adolescents with obesity, it is recommended that anti-obesity medications only be prescribed for obesity where it is hoped that the benefits of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paradigm
In science and philosophy, a paradigm () is a distinct set of concepts or thought patterns, including theories, research methods, postulates, and standards for what constitute legitimate contributions to a field. Etymology ''Paradigm'' comes from Greek παράδειγμα (''paradeigma''), "pattern, example, sample" from the verb παραδείκνυμι (''paradeiknumi''), "exhibit, represent, expose" and that from παρά (''para''), "beside, beyond" and δείκνυμι (''deiknumi''), "to show, to point out". In classical (Greek-based) rhetoric, a paradeigma aims to provide an audience with an illustration of a similar occurrence. This illustration is not meant to take the audience to a conclusion, however it is used to help guide them get there. One way of how a ''paradeigma'' is meant to guide an audience would be exemplified by the role of a personal accountant. It is not the job of a personal accountant to tell a client exactly what (and what not) to spend money on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford
Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the University of Oxford, the oldest university in the English-speaking world; it has buildings in every style of English architecture since late Anglo-Saxon. Oxford's industries include motor manufacturing, education, publishing, information technology and science. History The history of Oxford in England dates back to its original settlement in the Saxon period. Originally of strategic significance due to its controlling location on the upper reaches of the River Thames at its junction with the River Cherwell, the town grew in national importance during the early Norman period, and in the late 12th century became home to the fledgling University of Oxford. The city was besieged during The Anarchy in 1142. The university rose to dom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (journal)
''Cell'' is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research, immunology, neuroscience, structural biology, microbiology, virology, physiology, biophysics, and computational biology. The journal was established in 1974 by Benjamin LewinElsevier: ''Cell'': Home (accessed 12 December 2008) and is published twice monthly by , an imprint of |
Lipolysis
Lipolysis is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and free fatty acids. It is used to mobilize stored energy during fasting or exercise, and usually occurs in fat adipocytes. The most important regulatory hormone in lipolysis is insulin; lipolysis can only occur when insulin action falls to low levels, as occurs during fasting. Other hormones that affect lipolysis include glucagon, epinephrine, norepinephrine, growth hormone, atrial natriuretic peptide, brain natriuretic peptide, and cortisol. Mechanisms In the body, stores of fat are referred to as adipose tissue. In these areas, intracellular triglycerides are stored in cytoplasmic lipid droplets. When lipase enzymes are phosphorylated, they can access lipid droplets and through multiple steps of hydrolysis, breakdown triglycerides into fatty acids and glycerol. Each step of hydrolysis leads to the removal of one fatty acid. The first step and the rate-limiting step of l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lisbon
Lisbon (; pt, Lisboa ) is the capital and largest city of Portugal, with an estimated population of 544,851 within its administrative limits in an area of 100.05 km2. Grande Lisboa, Lisbon's urban area extends beyond the city's administrative limits with a population of around 2.7 million people, being the List of urban areas of the European Union, 11th-most populous urban area in the European Union.Demographia: World Urban Areas - demographia.com, 06.2021 About 3 million people live in the Lisbon metropolitan area, making it the third largest metropolitan area in the Iberian Peninsula, after Madrid and Barcelona. It represents approximately 27% of the country's population. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
