|
Alexandra Newton
Alexandra C. Newton is Distinguished Professor of pharmacology at the University of California, San Diego. Newton runs a multidisciplinary Protein kinase C and Cell signaling biochemistry and cell biology research group in the School of Medicine, investigating molecular mechanisms of signal transduction in the Phospholipase C (PLC) and Phosphoinositide 3-kinase (PI3 kinase, or PI3-K) signaling pathways. She has been continuously funded by the US National Institutes of Health since 1988. Early life and education Newton was born in Cape Town, South Africa, and was schooled in Vancouver, Athens, and Aix-en-Provence. She graduated in 1980 from the Simon Fraser University in Canada, where she was awarded a 1st-class honours degree in biochemistry and French literature. She received her PhD in chemistry in 1986 from Stanford University, working with Wray H. Huestis on a thesis examining band 3, a red cell membrane protein. Career Following her PhD defense, Newton took up a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cape Town
Cape Town ( af, Kaapstad; , xh, iKapa) is one of South Africa's three capital cities, serving as the seat of the Parliament of South Africa. It is the legislative capital of the country, the oldest city in the country, and the second largest (after Johannesburg). Colloquially named the ''Mother City'', it is the largest city of the Western Cape province, and is managed by the City of Cape Town metropolitan municipality. The other two capitals are Pretoria, the executive capital, located in Gauteng, where the Presidency is based, and Bloemfontein, the judicial capital in the Free State, where the Supreme Court of Appeal is located. Cape Town is ranked as a Beta world city by the Globalization and World Cities Research Network. The city is known for its harbour, for its natural setting in the Cape Floristic Region, and for landmarks such as Table Mountain and Cape Point. Cape Town is home to 66% of the Western Cape's population. In 2014, Cape Town was named the best place ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phospholipase C
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Phospholipase C's role in signal transduction is its cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which serve as second messengers. Activators of each PLC vary, but typically include heterotrimeric G protein subunits, protein tyrosine kinases, small G proteins, Ca2+, and phospholipids. There are thirteen kinds of mammalian phospholipase C that are classified into six isotypes (β, γ, δ, ε, ζ, η) according to structure. Each PLC has unique and overlapping controls over expression and subcellular distribution. Variants Mammalian variants The extensive number of functions exerte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phospholipids
Phospholipids, are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typically have omega-3 fatty acids EPA and DHA integrated as part of the phospholipid molecule. The phosphate group can be modified with simple organic molecules such as choline, ethanolamine or serine. Phospholipids are a key component of all cell membranes. They can form lipid bilayers because of their amphiphilic characteristic. In eukaryotes, cell membranes also contain another class of lipid, sterol, interspersed among the phospholipids. The combination provides fluidity in two dimensions combined with mechanical strength against rupture. Purified phospholipids are produced commercially and have found applications in nanotechnology and materials science. The first phospholipid identified in 1847 as such in biological tissues was lecith ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License. Protein phosphorylation often activates (or deactivates) many enzymes. Glucose Phosphorylation of sugars is often the first stage in their catabolism. Phosphorylation allows cells to accumulate sugars because the phosphate group prevents the molecules from diffusing back across their transporter. Phosphorylation of glucose is a key reaction in sugar metabolism. The chemical equation for the conversion of D-glucose to D-glucose-6-phosphate in the first step of glycolysis is given by :D-glucose + ATP → D-glucose-6-phosphate + ADP : ΔG° = −16.7 kJ/mol (° indicates measurement at standard condition) Hepatic cells are freely permeable to glucose, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Union Of Biochemistry And Molecular Biology
The International Union of Biochemistry and Molecular Biology (IUBMB) is an international non-governmental organisation concerned with biochemistry and molecular biology. Formed in 1955 as the International Union of Biochemistry (IUB), the union has presently 79 member countries and regions (as of 2020).IUBMB: the first half-century. /ref> The Union is devoted to promoting research and education in biochemistry and molecular biology throughout the world and gives particular attention to areas where the subject is still in its early development History The first Congress of Biochemistry ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Associate Professor
Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. Overview In the ''North American system'', used in the United States and many other countries, it is a position between assistant professor and a full professorship. In this system an associate professorship is typically the first promotion obtained after gaining a faculty position, and in the United States it is usually connected to tenure. In the '' Commonwealth system'' (Canada included), the title associate professor is traditionally used in place of reader in certain countries.UK Academic Job Titles Explained academicpositions.com Like the reader title it ranks above senior lecturer – which corresponds to associ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Assistant Professor
Assistant Professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States and Canada. Overview This position is generally taken after earning a doctoral degree and generally after several years of holding one or more Postdoctoral Researcher positions. It is below the position of Associate Professor at most universities and is equivalent to the rank of Lecturer at most Commonwealth universities. In the United States, Assistant Professor is often the first position held in a tenure track, although it can also be a non-tenure track position. A typical professorship sequence is Assistant Professor, Associate Professor, and Full Professor in order. After 7 years, if successful, Assistant Professors can get tenure and also get promotion to Associate Professor. There is high demand for vacant tenure-track Assistant Professor positions, often with hundreds of applicants. Less than 20% of doctoral graduates move ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daniel E
Daniel is a masculine given name and a surname of Hebrew origin. It means "God is my judge"Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxford University Press, 2nd edition, , p. 68. (cf. Gabriel—"God is my strength"), and derives from two early biblical figures, primary among them Daniel from the Book of Daniel. It is a common given name for males, and is also used as a surname. It is also the basis for various derived given names and surnames. Background The name evolved into over 100 different spellings in countries around the world. Nicknames (Dan, Danny) are common in both English and Hebrew; "Dan" may also be a complete given name rather than a nickname. The name "Daniil" (Даниил) is common in Russia. Feminine versions (Danielle, Danièle, Daniela, Daniella, Dani, Danitza) are prevalent as well. It has been particularly well-used in Ireland. The Dutch names "Daan" and "Daniël" are also variations of Daniel. A related surname developed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Literature
French literature () generally speaking, is literature written in the French language, particularly by citizens of France; it may also refer to literature written by people living in France who speak traditional languages of France other than French. Literature written in the French language, by citizens of other nations such as Belgium, Switzerland, Canada, Senegal, Tunisia, Algeria, Morocco, etc. is referred to as Francophone literature. France itself ranks first on the list of Nobel Prizes in literature by country. For centuries, French literature has been an object of national pride for French people, and it has been one of the most influential components of the literature of Europe. One of the first known examples of French literature is the Song of Roland, the first major work in a series of poems known as, " chansons de geste". The French language is a Romance language derived from Latin and heavily influenced principally by Celtic and Frankish. Beginning in the 11th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all areas of the life sciences are being uncovered and developed through biochemical methodology and research. Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis which allows biological molecules to give rise to the processes that occur within living cells and between cells,Karp (2009), p. 2. in turn relating greatly to the understanding of tissues and organs, as well as organism structure and function.Miller (2012). p. 62. Biochemistry is closely related to molecular biology, which is the study of the molecular mechanisms of biological phenomena.As ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aix-en-Provence
Aix-en-Provence (, , ; oc, label= Provençal, Ais de Provença in classical norm, or in Mistralian norm, ; la, Aquae Sextiae), or simply Aix ( medieval Occitan: ''Aics''), is a city and commune in southern France, about north of Marseille. A former capital of Provence, it is the subprefecture of the arrondissement of Aix-en-Provence, in the department of Bouches-du-Rhône, in the region of Provence-Alpes-Côte d'Azur. The population of Aix-en-Provence is approximately 145,000. Its inhabitants are called ''Aixois'' or, less commonly, ''Aquisextains''. History Aix (''Aquae Sextiae'') was founded in 123 BC by the Roman consul Sextius Calvinus, who gave his name to its springs, following the destruction of the nearby Gallic oppidum at Entremont. In 102 BC its vicinity was the scene of the Battle of Aquae Sextiae, where the Romans under Gaius Marius defeated the Ambrones and Teutones, with mass suicides among the captured women, which passed into Roman legends of Germani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Athens
Athens ( ; el, Αθήνα, Athína ; grc, Ἀθῆναι, Athênai (pl.) ) is both the capital and largest city of Greece. With a population close to four million, it is also the seventh largest city in the European Union. Athens dominates and is the capital of the Attica region and is one of the world's oldest cities, with its recorded history spanning over 3,400 years and its earliest human presence beginning somewhere between the 11th and 7th millennia BC. Classical Athens was a powerful city-state. It was a centre for the arts, learning and philosophy, and the home of Plato's Academy and Aristotle's Lyceum. It is widely referred to as the cradle of Western civilization and the birthplace of democracy, largely because of its cultural and political influence on the European continent—particularly Ancient Rome. In modern times, Athens is a large cosmopolitan metropolis and central to economic, financial, industrial, maritime, political and cultural life in Gre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpeg/1200px-Aix_(52402216).jpeg "Click for more on -> Aix-en-Provence")
