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Alcino J. Silva
Alcino J. Silva (born April 9, 1961) is a Portuguese-American neuroscientist who was the recipient of the 2008 Order of Prince Henry and elected as a fellow of the American Association for the Advancement of Science in 2013 for his contributions to the molecular cellular cognition of memory, a field he pioneered with the publication of two articles in ''Science'' in 1992. Silva is a Distinguished Professor of neurobiology, psychiatry and psychology at the David Geffen School of Medicine at UCLA, director of the Integrated Center for Learning and Memory at UCLA, and the Founding President of the Molecular and Cellular Cognition Society. He is former scientific director of the Division of Intramural Research Programs at the National Institute of Mental Health, having also served as member of the Board of Regents of the University of Minho, Portugal. Early years Silva was born in Portugal in 1961, but spent his early years in Luanda, Angola. He left Africa when he was 12 and in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marco De Canaveses Municipality
Marco de Canaveses () is a city and municipality on Porto district, in northern Portugal. The population in 2011 was 53,450, in an area of 201.89 km². The city itself had a population of 9,042 in 2001. Geography The city of Marco Canaveses is strongly influenced by its topography, with mainly areas at altitudes between 200 and 600 meters, reaching the highest levels in Aboboreira and Montedeiras Mountains. The highest point of the county is situated at an altitude of 962 meters, in Aboboreira Mountain, which is shared by the municipalities of Marco de Canaveses, Amarante and Baião. In Montedeiras Mountain is reached a peak of 640 meters. To the north it lies the Marão Mountain, in the municipality of Amarante. The region is also traversed by two of the most important Portuguese rivers, the Douro, Douro river and Tâmega river. The Douro, reaching from "Trás-os-Montes" region (interior north of Portugal), east to west course, limits the county to the south, separating it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurobiology
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular and cellular studies of individual neurons to imaging of sensory, motor and cognitive tasks in the brain. History The earliest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Targeting
Gene targeting (also, replacement strategy based on homologous recombination) is a genetic technique that uses homologous recombination to modify an endogenous gene. The method can be used to delete a gene, remove exons, add a gene and modify individual base pairs (introduce point mutations). The process of gene targeting provides a way to alter specific genes in order to better identify their biological roles. Gene targeting can be permanent or conditional. Conditions can be a specific time during development / life of the organism or limitation to a specific tissue, for example. Gene targeting requires the creation of a specific vector for each gene of interest. However, it can be used for any gene, regardless of transcriptional activity or gene size. Methods In general, DNA containing part of the gene to be targeted, a reporter gene, and a (dominant) selectable marker is assembled in bacteria. Gene targeting methods are established for several model organisms and may vary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mario Capecchi
Mario Ramberg Capecchi (born 6 October 1937) is an Italian-born molecular geneticist and a co-awardee of the 2007 Nobel Prize in Physiology or Medicine for discovering a method to create mice in which a specific gene is turned off, known as knockout mice. He shared the prize with Martin Evans and Oliver Smithies. He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine. Life Mario Capecchi was born in Verona, Italy, as the only child of Luciano Capecchi and Lucy Ramberg, an Italian-born daughter of American-born Impressionist painter Lucy Dodd Ramberg and German archaeologist Walter Ramberg. His parents weren't married, and due to the chaos in Europe caused by World War II, the story of his early life is remarkable, but the details are unclear. In 1941 he and his mother were living near Bolzano, about 160 miles north of his father in Reggio Emilia when his mother was arrested and deported for pamphleteering and belonging ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epistemology
Epistemology (; ), or the theory of knowledge, is the branch of philosophy concerned with knowledge. Epistemology is considered a major subfield of philosophy, along with other major subfields such as ethics, logic, and metaphysics. Epistemologists study the nature, origin, and scope of knowledge, epistemic justification, the rationality of belief, and various related issues. Debates in epistemology are generally clustered around four core areas: # The philosophical analysis of the nature of knowledge and the conditions required for a belief to constitute knowledge, such as truth and justification # Potential sources of knowledge and justified belief, such as perception, reason, memory, and testimony # The structure of a body of knowledge or justified belief, including whether all justified beliefs must be derived from justified foundational beliefs or whether justification requires only a coherent set of beliefs # Philosophical skepticism, which questions the possibili ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Methylation
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation, repression of transposable elements, aging, and carcinogenesis. As of 2016, two nucleobases have been found on which natural, enzymatic DNA methylation takes place: adenine and cytosine. The modified bases are N6-methyladenineD. B. Dunn, J. D. Smith: ''The occurrence of 6-methylaminopurine in deoxyribonucleic acids.'' In: ''Biochem J.'' 68(4), Apr 1958, S. 627–636. PMID 13522672. ., 5-methylcytosineB. F. Vanyushin, S. G. Tkacheva, A. N. Belozersky: ''Rare bases in animal DNA.'' In: ''Nature.'' 225, 1970, S. 948–949. PMID 4391887. and N4- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetic
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene expression can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Raymond L
Raymond is a male given name. It was borrowed into English from French (older French spellings were Reimund and Raimund, whereas the modern English and French spellings are identical). It originated as the Germanic ᚱᚨᚷᛁᚾᛗᚢᚾᛞ (''Raginmund'') or ᚱᛖᚷᛁᚾᛗᚢᚾᛞ (''Reginmund''). ''Ragin'' (Gothic) and ''regin'' (Old German) meant "counsel". The Old High German ''mund'' originally meant "hand", but came to mean "protection". This etymology suggests that the name originated in the Early Middle Ages, possibly from Latin. Alternatively, the name can also be derived from Germanic Hraidmund, the first element being ''Hraid'', possibly meaning "fame" (compare ''Hrod'', found in names such as Robert, Roderick, Rudolph, Roland, Rodney and Roger) and ''mund'' meaning "protector". Despite the German and French origins of the English name, some of its early uses in English documents appear in Latinized form. As a surname, its first recorded appearance in Bri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genetics
Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, clinical genetics, and genetic counseling. Genes are the common factor of the qualities of most human-inherited traits. Study of human genetics can answer questions about human nature, can help understand diseases and the development of effective treatment and help us to understand the genetics of human life. This article describes only basic features of human genetics; for the genetics of disorders please see: medical genetics. Genetic differences and inheritance patterns Inheritance of traits for humans are based upon Gregor Mendel's model of inheritance. Mendel deduced that inheritance depends upon discrete units of inheritance, called factors or genes. Autosomal dominant inheritance Autosomal tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carnation Revolution
The Carnation Revolution ( pt, Revolução dos Cravos), also known as the 25 April ( pt, 25 de Abril, links=no), was a military coup by left-leaning military officers that overthrew the authoritarian Estado Novo regime on 25 April 1974 in Lisbon, producing major social, economic, territorial, demographic, and political changes in Portugal and its overseas colonies through the Processo Revolucionário Em Curso. It resulted in the Portuguese transition to democracy and the end of the Portuguese Colonial War. The revolution began as a coup organised by the Armed Forces Movement ( pt, Movimento das Forças Armadas, links=no, MFA), composed of military officers who opposed the regime, but it was soon coupled with an unanticipated, popular civil resistance campaign. Negotiations with African independence movements began, and by the end of 1974, Portuguese troops were withdrawn from Portuguese Guinea, which became a UN member state. This was followed in 1975 by the independence of C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Luanda
Luanda () is the capital and largest city in Angola. It is Angola's primary port, and its major industrial, cultural and urban centre. Located on Angola's northern Atlantic coast, Luanda is Angola's administrative centre, its chief seaport, and also the capital of the Luanda Province. Luanda and its metropolitan area is the most populous Portuguese-speaking capital city in the world and the most populous Lusophone city outside Brazil, with over 8.3 million inhabitants in 2020 (a third of Angola's population). Among the oldest colonial cities of Africa, it was founded in January 1576 as ''São Paulo da Assunção de Loanda'' by Portuguese explorer Paulo Dias de Novais. The city served as the centre of the slave trade to Brazil before its prohibition. At the start of the Angolan Civil War in 1975, most of the white Portuguese left as refugees, principally for Portugal. Luanda's population increased greatly from refugees fleeing the war, but its infrastructure was inadequate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portugal
Portugal, officially the Portuguese Republic ( pt, República Portuguesa, links=yes ), is a country whose mainland is located on the Iberian Peninsula of Southwestern Europe, and whose territory also includes the Atlantic archipelagos of the Azores and Madeira. It features the westernmost point in continental Europe, and its Iberian portion is bordered to the west and south by the Atlantic Ocean and to the north and east by Spain, the sole country to have a land border with Portugal. Its two archipelagos form two autonomous regions with their own regional governments. Lisbon is the capital and largest city by population. Portugal is the oldest continuously existing nation state on the Iberian Peninsula and one of the oldest in Europe, its territory having been continuously settled, invaded and fought over since prehistoric times. It was inhabited by pre-Celtic and Celtic peoples who had contact with Phoenicians and Ancient Greek traders, it was ruled by the Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
