Ultrasonography Of Early Hepatocellular Carcinoma
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Ultrasound is
sound wave In physics, sound is a vibration that propagates as an acoustic wave, through a transmission medium such as a gas, liquid or solid. In human physiology and psychology, sound is the ''reception'' of such waves and their ''perception'' by the ...
s with
frequencies Frequency is the number of occurrences of a repeating event per unit of time. It is also occasionally referred to as ''temporal frequency'' for clarity, and is distinct from ''angular frequency''. Frequency is measured in hertz (Hz) which is eq ...
higher than the upper audible limit of human hearing. Ultrasound is not different from "normal" (audible) sound in its physical properties, except that humans cannot hear it. This limit varies from person to person and is approximately 20
kilohertz The hertz (symbol: Hz) is the unit of frequency in the International System of Units (SI), equivalent to one event (or cycle) per second. The hertz is an SI derived unit whose expression in terms of SI base units is s−1, meaning that one h ...
(20,000 hertz) in healthy young adults. Ultrasound devices operate with frequencies from 20 kHz up to several gigahertz. Ultrasound is used in many different fields. Ultrasonic devices are used to detect objects and measure distances. Ultrasound imaging or sonography is often used in
medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...
. In the
nondestructive testing Nondestructive testing (NDT) is any of a wide group of analysis techniques used in science and technology industry to evaluate the properties of a material, component or system without causing damage. The terms nondestructive examination (NDE), n ...
of products and structures, ultrasound is used to detect invisible flaws. Industrially, ultrasound is used for cleaning, mixing, and accelerating chemical processes. Animals such as
bat Bats are mammals of the order Chiroptera.''cheir'', "hand" and πτερόν''pteron'', "wing". With their forelimbs adapted as wings, they are the only mammals capable of true and sustained flight. Bats are more agile in flight than most bi ...
s and
porpoise Porpoises are a group of fully aquatic marine mammals, all of which are classified under the family Phocoenidae, parvorder Odontoceti (toothed whales). Although similar in appearance to dolphins, they are more closely related to narwhals an ...
s use ultrasound for locating
prey Predation is a biological interaction where one organism, the predator, kills and eats another organism, its prey. It is one of a family of common feeding behaviours that includes parasitism and micropredation (which usually do not kill the ...
and obstacles.


History

Acoustics Acoustics is a branch of physics that deals with the study of mechanical waves in gases, liquids, and solids including topics such as vibration, sound, ultrasound and infrasound. A scientist who works in the field of acoustics is an acoustician ...
, the science of
sound In physics, sound is a vibration that propagates as an acoustic wave, through a transmission medium such as a gas, liquid or solid. In human physiology and psychology, sound is the ''reception'' of such waves and their ''perception'' by the ...
, starts as far back as
Pythagoras Pythagoras of Samos ( grc, Πυθαγόρας ὁ Σάμιος, Pythagóras ho Sámios, Pythagoras the Samos, Samian, or simply ; in Ionian Greek; ) was an ancient Ionians, Ionian Ancient Greek philosophy, Greek philosopher and the eponymou ...
in the 6th century BC, who wrote on the mathematical properties of stringed instruments. Echolocation in bats was discovered by Lazzaro Spallanzani in 1794, when he demonstrated that bats hunted and navigated by inaudible sound, not vision.
Francis Galton Sir Francis Galton, FRS FRAI (; 16 February 1822 – 17 January 1911), was an English Victorian era polymath: a statistician, sociologist, psychologist, anthropologist, tropical explorer, geographer, inventor, meteorologist, proto- ...
in 1893 invented the Galton whistle, an adjustable whistle that produced ultrasound, which he used to measure the hearing range of humans and other animals, demonstrating that many animals could hear sounds above the hearing range of humans. The first technological application of ultrasound was an attempt to detect
submarine A submarine (or sub) is a watercraft capable of independent operation underwater. It differs from a submersible, which has more limited underwater capability. The term is also sometimes used historically or colloquially to refer to remotely op ...
s by
Paul Langevin Paul Langevin (; ; 23 January 1872 – 19 December 1946) was a French physicist who developed Langevin dynamics and the Langevin equation. He was one of the founders of the ''Comité de vigilance des intellectuels antifascistes'', an ant ...
in 1917. The piezoelectric effect, discovered by Jacques and
Pierre Curie Pierre Curie ( , ; 15 May 1859 – 19 April 1906) was a French physicist, a pioneer in crystallography, magnetism, piezoelectricity, and radioactivity. In 1903, he received the Nobel Prize in Physics with his wife, Marie Curie, and Henri Becqu ...
in 1880, was useful in
transducer A transducer is a device that converts energy from one form to another. Usually a transducer converts a signal in one form of energy to a signal in another. Transducers are often employed at the boundaries of automation, measurement, and contr ...
s to generate and detect ultrasonic waves in air and water.


Definition

Ultrasound is defined by the
American National Standards Institute The American National Standards Institute (ANSI ) is a private non-profit organization that oversees the development of voluntary consensus standards for products, services, processes, systems, and personnel in the United States. The organi ...
as "
sound In physics, sound is a vibration that propagates as an acoustic wave, through a transmission medium such as a gas, liquid or solid. In human physiology and psychology, sound is the ''reception'' of such waves and their ''perception'' by the ...
at frequencies greater than 20 kHz". In air at atmospheric pressure, ultrasonic waves have
wavelength In physics, the wavelength is the spatial period of a periodic wave—the distance over which the wave's shape repeats. It is the distance between consecutive corresponding points of the same phase on the wave, such as two adjacent crests, tro ...
s of 1.9 cm or less.


Perception


Humans

The upper frequency limit in humans (approximately 20 kHz) is due to limitations of the middle ear.
Auditory sensation Auditory means of or relating to the process of hearing: * Auditory system, the neurological structures and pathways of sound perception ** Auditory bulla, part of auditory system found in mammals other than primates ** Auditory nerve, also known ...
can occur if high‐intensity ultrasound is fed directly into the
human skull The skull is a bone protective cavity for the brain. The skull is composed of four types of bone i.e., cranial bones, facial bones, ear ossicles and hyoid bone. However two parts are more prominent: the cranium and the mandible. In humans, the ...
and reaches the
cochlea The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus. A core component of the cochlea is the Organ of Corti, the sensory org ...
through bone conduction, without passing through the middle ear. Children can hear some high-pitched sounds that older adults cannot hear, because in humans the upper limit pitch of hearing tends to decrease with age. An American
cell phone A mobile phone, cellular phone, cell phone, cellphone, handphone, hand phone or pocket phone, sometimes shortened to simply mobile, cell, or just phone, is a portable telephone that can make and receive calls over a radio frequency link whil ...
company has used this to create ring signals that supposedly are only audible to younger humans, but many older people can hear the signals, which may be because of the considerable variation of age-related deterioration in the upper hearing threshold. The Mosquito is an electronic device that uses a high pitched frequency to deter loitering by young people.


Animals

Bats use a variety of ultrasonic ranging ( echolocation) techniques to detect their prey. They can detect frequencies beyond 100 kHz, possibly up to 200 kHz. Many insects have good ultrasonic hearing, and most of these are
nocturnal Nocturnality is an animal behavior characterized by being active during the night and sleeping during the day. The common adjective is "nocturnal", versus diurnal meaning the opposite. Nocturnal creatures generally have highly developed sens ...
insects listening for echolocating
bat Bats are mammals of the order Chiroptera.''cheir'', "hand" and πτερόν''pteron'', "wing". With their forelimbs adapted as wings, they are the only mammals capable of true and sustained flight. Bats are more agile in flight than most bi ...
s. These include many groups of
moth Moths are a paraphyletic group of insects that includes all members of the order Lepidoptera that are not butterflies, with moths making up the vast majority of the order. There are thought to be approximately 160,000 species of moth, many of w ...
s,
beetles Beetles are insects that form the order Coleoptera (), in the superorder Endopterygota. Their front pair of wings are hardened into wing-cases, elytra, distinguishing them from most other insects. The Coleoptera, with about 400,000 describ ...
, praying mantises and
lacewings The insect order Neuroptera, or net-winged insects, includes the lacewings, mantidflies, antlions, and their relatives. The order consists of some 6,000 species. Neuroptera can be grouped together with the Megaloptera and Raphidioptera in the ...
. Upon hearing a bat, some insects will make evasive manoeuvres to escape being caught. Ultrasonic frequencies trigger a reflex action in the
noctuid The Noctuidae, commonly known as owlet moths, cutworms or armyworms, are a family of moths. They are considered the most controversial family in the superfamily Noctuoidea because many of the clades are constantly changing, along with the other f ...
moth that causes it to drop slightly in its flight to evade attack.
Tiger moth The de Havilland DH.82 Tiger Moth is a 1930s British biplane designed by Geoffrey de Havilland and built by the de Havilland Aircraft Company. It was operated by the Royal Air Force (RAF) and other operators as a primary trainer aircraft. ...
s also emit clicks which may disturb bats' echolocation, and in other cases may advertise the fact that they are
poison Poison is a chemical substance that has a detrimental effect to life. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broa ...
ous by emitting sound. Dogs and cats' hearing range extends into the ultrasound; the top end of a dog's hearing range is about 45 kHz, while a cat's is 64 kHz. The wild ancestors of cats and dogs evolved this higher hearing range to hear high-frequency sounds made by their preferred prey, small rodents. A
dog whistle A dog whistle (also known as silent whistle or Galton's whistle) is a type of whistle that emits sound in the ultrasonic range, which humans cannot hear but some other animals can, including dogs and domestic cats, and is used in their training ...
is a whistle that emits ultrasound, used for training and calling dogs. The frequency of most dog whistles is within the range of 23 to 54 kHz. Toothed whales, including dolphins, can hear ultrasound and use such sounds in their navigational system (
biosonar Echolocation, also called bio sonar, is a biological sonar used by several animal species. Echolocating animals emit calls out to the environment and listen to the echoes of those calls that return from various objects near them. They use these ...
) to orient and to capture prey.
Porpoises Porpoises are a group of fully aquatic marine mammals, all of which are classified under the family Phocoenidae, parvorder Odontoceti (toothed whales). Although similar in appearance to dolphins, they are more closely related to narwhals an ...
have the highest known upper hearing limit at around 160 kHz. Several types of fish can detect ultrasound. In the order Clupeiformes, members of the subfamily
Alosinae The Alosinae, or the shads,Alosinae
(
shad The Alosinae, or the shads,Alosinae
) have been shown to be able to detect sounds up to 180 kHz, while the other subfamilies (e.g.
herring Herring are forage fish, mostly belonging to the family of Clupeidae. Herring often move in large schools around fishing banks and near the coast, found particularly in shallow, temperate waters of the North Pacific and North Atlantic Oceans, i ...
s) can hear only up to 4 kHz. Contrary to popular belief, birds cannot hear ultrasonic sound. Ultrasound generator/speaker systems are sold as electronic pest control devices, which are claimed to frighten away
rodent Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are na ...
s and
insect Insects (from Latin ') are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body ( head, thorax and abdomen), three pairs ...
s, but there is no scientific evidence that the devices work.


Detection and ranging


Non-contact sensor

An ultrasonic level or sensing system requires no contact with the target. For many processes in the medical, pharmaceutical, military and general industries this is an advantage over inline sensors that may contaminate the liquids inside a vessel or tube or that may be clogged by the product. Both continuous wave and pulsed systems are used. The principle behind a pulsed-ultrasonic technology is that the transmit signal consists of short bursts of ultrasonic energy. After each burst, the electronics looks for a return signal within a small window of time corresponding to the time it takes for the energy to pass through the vessel. Only a signal received during this window will qualify for additional signal processing. A popular consumer application of ultrasonic ranging was the Polaroid SX-70 camera, which included a lightweight transducer system to focus the camera automatically. Polaroid later licensed this ultrasound technology and it became the basis of a variety of ultrasonic products.


Motion sensors and flow measurement

A common ultrasound application is an automatic door opener, where an ultrasonic sensor detects a person's approach and opens the door. Ultrasonic sensors are also used to detect intruders; the ultrasound can cover a wide area from a single point. The flow in pipes or open channels can be measured by ultrasonic flowmeters, which measure the average velocity of flowing liquid. In
rheology Rheology (; ) is the study of the flow of matter, primarily in a fluid ( liquid or gas) state, but also as "soft solids" or solids under conditions in which they respond with plastic flow rather than deforming elastically in response to an appl ...
, an acoustic rheometer relies on the principle of ultrasound. In
fluid mechanics Fluid mechanics is the branch of physics concerned with the mechanics of fluids ( liquids, gases, and plasmas) and the forces on them. It has applications in a wide range of disciplines, including mechanical, aerospace, civil, chemical and bio ...
, fluid flow can be measured using an
ultrasonic flow meter An ultrasonic flow meter is a type of flow meter that measures the velocity of a fluid with ultrasound to calculate volume flow. Using ultrasonic transducers, the flow meter can measure the average velocity along the path of an emitted beam of ...
.


Nondestructive testing

Ultrasonic testing Ultrasonic testing (UT) is a family of non-destructive testing techniques based on the propagation of ultrasonic waves in the object or material tested. In most common UT applications, very short ultrasonic pulse-waves with center frequencies ...
is a type of
nondestructive testing Nondestructive testing (NDT) is any of a wide group of analysis techniques used in science and technology industry to evaluate the properties of a material, component or system without causing damage. The terms nondestructive examination (NDE), n ...
commonly used to find flaws in materials and to measure the thickness of objects. Frequencies of 2 to 10 MHz are common, but for special purposes other frequencies are used. Inspection may be manual or automated and is an essential part of modern manufacturing processes. Most
metal A metal (from Greek μέταλλον ''métallon'', "mine, quarry, metal") is a material that, when freshly prepared, polished, or fractured, shows a lustrous appearance, and conducts electricity and heat relatively well. Metals are typicall ...
s can be inspected as well as
plastics Plastics are a wide range of synthetic polymers, synthetic or semi-synthetic materials that use polymers as a main ingredient. Their Plasticity (physics), plasticity makes it possible for plastics to be Injection moulding, moulded, Extrusion, e ...
and
aerospace Aerospace is a term used to collectively refer to the atmosphere and outer space. Aerospace activity is very diverse, with a multitude of commercial, industrial and military applications. Aerospace engineering consists of aeronautics and astrona ...
composites. Lower frequency ultrasound (50–500 kHz) can also be used to inspect less dense materials such as
wood Wood is a porous and fibrous structural tissue found in the stems and roots of trees and other woody plants. It is an organic materiala natural composite of cellulose fibers that are strong in tension and embedded in a matrix of lignin th ...
,
concrete Concrete is a composite material composed of fine and coarse aggregate bonded together with a fluid cement (cement paste) that hardens (cures) over time. Concrete is the second-most-used substance in the world after water, and is the most wi ...
and
cement A cement is a binder, a chemical substance used for construction that sets, hardens, and adheres to other materials to bind them together. Cement is seldom used on its own, but rather to bind sand and gravel ( aggregate) together. Cement mix ...
. Ultrasound inspection of welded joints has been an alternative to
radiography Radiography is an imaging technique using X-rays, gamma rays, or similar ionizing radiation and non-ionizing radiation to view the internal form of an object. Applications of radiography include medical radiography ("diagnostic" and "therapeut ...
for
nondestructive testing Nondestructive testing (NDT) is any of a wide group of analysis techniques used in science and technology industry to evaluate the properties of a material, component or system without causing damage. The terms nondestructive examination (NDE), n ...
since the 1960s. Ultrasonic inspection eliminates the use of ionizing radiation, with safety and cost benefits. Ultrasound can also provide additional information such as the depth of flaws in a welded joint. Ultrasonic inspection has progressed from manual methods to computerized systems that automate much of the process. An ultrasonic test of a joint can identify the existence of flaws, measure their size, and identify their location. Not all welded materials are equally amenable to ultrasonic inspection; some materials have a large grain size that produces a high level of background noise in measurements.
Ultrasonic thickness measurement In the field of industrial ultrasonic testing, ultrasonic thickness measurement (UTM) is a method of performing non-destructive measurement (gauging) of the local thickness of a solid element (typically made of metal, if using ultrasound testing ...
is one technique used to monitor quality of welds.


Ultrasonic range finding

A common use of ultrasound is in underwater range finding; this use is also called
Sonar Sonar (sound navigation and ranging or sonic navigation and ranging) is a technique that uses sound propagation (usually underwater, as in submarine navigation) to navigation, navigate, measure distances (ranging), communicate with or detect o ...
. An ultrasonic pulse is generated in a particular direction. If there is an object in the path of this pulse, part or all of the pulse will be reflected back to the transmitter as an echo and can be detected through the receiver path. By measuring the difference in time between the pulse being transmitted and the echo being received, it is possible to determine the distance. The measured travel time of Sonar pulses in water is strongly dependent on the temperature and the salinity of the water. Ultrasonic ranging is also applied for measurement in air and for short distances. For example, hand-held ultrasonic measuring tools can rapidly measure the layout of rooms. Although range finding underwater is performed at both sub-audible and audible frequencies for great distances (1 to several kilometers), ultrasonic range finding is used when distances are shorter and the accuracy of the distance measurement is desired to be finer. Ultrasonic measurements may be limited through barrier layers with large salinity, temperature or vortex differentials. Ranging in water varies from about hundreds to thousands of meters, but can be performed with centimeters to meters accuracy


Ultrasound Identification (USID)

Ultrasound Identification Ultrasound Identification is a real-time locating system (RTLS) or indoor positioning system (IPS) technology used to automatically determine and identify the location of objects with room accuracy. The approach is using simple, inexpensive nodes ...
(USID) is a
Real-Time Locating System Real-time locating systems (RTLS), also known as real-time tracking systems, are used to automatically identify and track the location of objects or people in real time, usually within a building or other contained area. Wireless RTLS tags are ...
(RTLS) or
Indoor Positioning System An indoor positioning system (IPS) is a network of devices used to locate people or objects where GPS and other satellite technologies lack precision or fail entirely, such as inside multistory buildings, airports, alleys, parking garages, and und ...
(IPS) technology used to automatically track and identify the location of objects in real time using simple, inexpensive nodes (badges/tags) attached to or embedded in objects and devices, which then transmit an ultrasound signal to communicate their location to microphone sensors.


Imaging

The potential for ultrasonic imaging of objects, with a 3 GHz sound wave producing resolution comparable to an optical image, was recognized by Sokolov in 1939, but techniques of the time produced relatively low-contrast images with poor sensitivity. Ultrasonic imaging uses frequencies of 2 megahertz and higher; the shorter wavelength allows resolution of small internal details in structures and tissues. The power density is generally less than 1 watt per square centimetre to avoid heating and cavitation effects in the object under examination. High and ultra high ultrasound waves are used in
acoustic microscopy Acoustic microscopy is microscopy that employs very high or ultra high frequency ultrasound. Acoustic microscopes operate non-destructively and penetrate most solid materials to make visible images of internal features, including defects such as ...
, with frequencies up to 4 gigahertz. Ultrasonic imaging applications include industrial nondestructive testing, quality control and medical uses.


Acoustic microscopy

Acoustic microscopy Acoustic microscopy is microscopy that employs very high or ultra high frequency ultrasound. Acoustic microscopes operate non-destructively and penetrate most solid materials to make visible images of internal features, including defects such as ...
is the technique of using sound waves to visualize structures too small to be resolved by the human eye. Frequencies up to several gigahertz are used in acoustic microscopes. The reflection and diffraction of sound waves from microscopic structures can yield information not available with light.


Human medicine

Medical ultrasound Medical ultrasound includes diagnostic techniques (mainly imaging techniques) using ultrasound, as well as therapeutic applications of ultrasound. In diagnosis, it is used to create an image of internal body structures such as tendons, muscles ...
is an ultrasound-based diagnostic
medical imaging Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to rev ...
technique used to visualize muscles, tendons, and many internal organs to capture their size, structure and any pathological
lesion A lesion is any damage or abnormal change in the tissue of an organism, usually caused by disease or trauma. ''Lesion'' is derived from the Latin "injury". Lesions may occur in plants as well as animals. Types There is no designated classifi ...
s with real time tomographic images. Ultrasound has been used by
radiologists Radiology ( ) is the medical discipline that uses medical imaging to diagnose diseases and guide their treatment, within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiatio ...
and sonographers to image the human body for at least 50 years and has become a widely used diagnostic tool. The technology is relatively inexpensive and portable, especially when compared with other techniques, such as
magnetic resonance imaging Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio wave ...
(MRI) and
computed tomography A computed tomography scan (CT scan; formerly called computed axial tomography scan or CAT scan) is a medical imaging technique used to obtain detailed internal images of the body. The personnel that perform CT scans are called radiographers ...
(CT). Ultrasound is also used to visualize fetuses during routine and emergency prenatal care. Such diagnostic applications used during
pregnancy Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but ca ...
are referred to as obstetric sonography. As currently applied in the medical field, properly performed ultrasound poses no known risks to the patient. Sonography does not use
ionizing radiation Ionizing radiation (or ionising radiation), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. Some particles can travel ...
, and the power levels used for imaging are too low to cause adverse heating or pressure effects in tissue. Although the long-term effects due to ultrasound exposure at diagnostic intensity are still unknown, currently most doctors feel that the benefits to patients outweigh the risks. The ALARA (As Low As Reasonably Achievable) principle has been advocated for an ultrasound examination that is, keeping the scanning time and power settings as low as possible but consistent with diagnostic imaging and that by that principle nonmedical uses, which by definition are not necessary, are actively discouraged. Ultrasound is also increasingly being used in trauma and first aid cases, with
emergency ultrasound Emergency ultrasound employing point-of-care ultrasound (POCUS) is the application of ultrasound at the point of care to make immediate patient-care decisions. It is performed by the health care professional caring for the injured or ill persons. T ...
becoming a staple of most EMT response teams. Furthermore, ultrasound is used in remote diagnosis cases where teleconsultation is required, such as scientific experiments in space or mobile sports team diagnosis. According to RadiologyInfo, ultrasounds are useful in the detection of
pelvic The pelvis (plural pelves or pelvises) is the lower part of the trunk, between the abdomen and the thighs (sometimes also called pelvic region), together with its embedded skeleton (sometimes also called bony pelvis, or pelvic skeleton). The ...
abnormalities and can involve techniques known as
abdominal The abdomen (colloquially called the belly, tummy, midriff, tucky or stomach) is the part of the body between the thorax (chest) and pelvis, in humans and in other vertebrates. The abdomen is the front part of the abdominal segment of the torso. ...
(transabdominal) ultrasound,
vagina In mammals, the vagina is the elastic, muscular part of the female genital tract. In humans, it extends from the vestibule to the cervix. The outer vaginal opening is normally partly covered by a thin layer of mucosal tissue called the hymen ...
l (transvaginal or endovaginal) ultrasound in women, and also rectal (transrectal) ultrasound in men.


Veterinary medicine

Diagnostic ultrasound is used externally in horses for evaluation of soft tissue and tendon injuries, and internally in particular for reproductive workevaluation of the reproductive tract of the mare and pregnancy detection. It may also be used in an external manner in stallions for evaluation of testicular condition and diameter as well as internally for reproductive evaluation (deferent duct etc.). By 2005, ultrasound technology began to be used by the beef
cattle Cattle (''Bos taurus'') are large, domesticated, cloven-hooved, herbivores. They are a prominent modern member of the subfamily Bovinae and the most widespread species of the genus ''Bos''. Adult females are referred to as cows and adult mal ...
industry to improve animal health and the yield of cattle operations. Ultrasound is used to evaluate fat thickness, rib eye area, and intramuscular fat in living animals. It is also used to evaluate the health and characteristics of unborn calves. Ultrasound technology provides a means for cattle producers to obtain information that can be used to improve the breeding and husbandry of cattle. The technology can be expensive, and it requires a substantial time commitment for continuous data collection and operator training. Nevertheless, this technology has proven useful in managing and running a cattle breeding operation.


Processing and power

High-power applications of ultrasound often use frequencies between 20 kHz and a few hundred kHz. Intensities can be very high; above 10 watts per square centimeter, cavitation can be inducted in liquid media, and some applications use up to 1000 watts per square centimeter. Such high intensities can induce chemical changes or produce significant effects by direct mechanical action, and can inactivate harmful microorganisms.


Physical therapy

Ultrasound has been used since the 1940s by physical and occupational therapists for treating
connective tissue Connective tissue is one of the four primary types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesenchyme derived from the mesoderm the middle embryonic germ layer. Connective tiss ...
:
ligament A ligament is the fibrous connective tissue that connects bones to other bones. It is also known as ''articular ligament'', ''articular larua'', ''fibrous ligament'', or ''true ligament''. Other ligaments in the body include the: * Peritoneal li ...
s,
tendon A tendon or sinew is a tough, high-tensile-strength band of dense fibrous connective tissue that connects muscle to bone. It is able to transmit the mechanical forces of muscle contraction to the skeletal system without sacrificing its ability ...
s, and
fascia A fascia (; plural fasciae or fascias; adjective fascial; from Latin: "band") is a band or sheet of connective tissue, primarily collagen, beneath the skin that attaches to, stabilizes, encloses, and separates muscles and other internal organs. ...
(and also scar tissue). Conditions for which ultrasound may be used for treatment include the follow examples: ligament
sprain A sprain, also known as a torn ligament, is an acute soft tissue injury of the ligaments within a joint, often caused by a sudden movement abruptly forcing the joint to exceed its functional range of motion. Ligaments are tough, inelastic fibers ...
s, muscle strains,
tendonitis Tendinopathy, a type of tendon disorder that results in pain, swelling, and impaired function. The pain is typically worse with movement. It most commonly occurs around the shoulder (rotator cuff tendinitis, biceps tendinitis), elbow (tennis elb ...
, joint inflammation, plantar fasciitis,
metatarsalgia Metatarsalgia, literally metatarsal pain and colloquially known as a stone bruise, is any painful foot condition affecting the metatarsal region of the foot. This is a common problem that can affect the joints and bones of the metatarsals. Meta ...
, facet irritation, impingement syndrome,
bursitis Bursitis is the inflammation of one or more bursae (fluid filled sacs) of synovial fluid in the body. They are lined with a synovial membrane that secretes a lubricating synovial fluid. There are more than 150 bursae in the human body. The bursa ...
,
rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involv ...
,
osteoarthritis Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone which affects 1 in 7 adults in the United States. It is believed to be the fourth leading cause of disability in the w ...
, and scar tissue adhesion.


Biomedical applications

Ultrasound has diagnostic and therapeutic applications, which can be highly beneficial when used with dosage precautions. Relatively high power ultrasound can break up stony deposits or tissue, accelerate the effect of drugs in a targeted area, assist in the measurement of the elastic properties of tissue, and can be used to sort cells or small particles for research.


Ultrasonic impact treatment

Ultrasonic impact treatment Ultrasonic impact treatment (UIT) is a metallurgical processing technique, similar to work hardening, in which ultrasonic energy is applied to a metal object. This technique is part of the High Frequency Mechanical Impact (HFMI) processes. Other ...
(UIT) uses ultrasound to enhance the mechanical and physical properties of metals. It is a metallurgical processing technique in which ultrasonic energy is applied to a metal object. Ultrasonic treatment can result in controlled residual compressive stress, grain refinement and grain size reduction. Low and high cycle fatigue are enhanced and have been documented to provide increases up to ten times greater than non-UIT specimens. Additionally, UIT has proven effective in addressing
stress corrosion cracking Stress corrosion cracking (SCC) is the growth of crack formation in a corrosive environment. It can lead to unexpected and sudden failure of normally ductile metal alloys subjected to a tensile stress, especially at elevated temperature. SCC ...
,
corrosion fatigue Corrosion fatigue is fatigue in a corrosive environment. It is the mechanical degradation of a material under the joint action of corrosion and cyclic loading. Nearly all engineering structures experience some form of alternating stress, and are ...
and related issues. When the UIT tool, made up of the ultrasonic transducer, pins and other components, comes into contact with the work piece it acoustically couples with the work piece, creating harmonic resonance. This harmonic resonance is performed at a carefully calibrated frequency, to which metals respond very favorably. Depending on the desired effects of treatment a combination of different frequencies and displacement amplitude is applied. These frequencies range between 25 and 55 kHz, with the displacement amplitude of the resonant body of between 22 and 50 µm (0.00087 and 0.0020 in). UIT devices rely on
magnetostrictive Magnetostriction (cf. electrostriction) is a property of magnetic materials that causes them to change their shape or dimensions during the process of magnetization. The variation of materials' magnetization due to the applied magnetic field chan ...
transducers.


Processing

Ultrasonication offers great potential in the processing of liquids and slurries, by improving the mixing and chemical reactions in various applications and industries. Ultrasonication generates alternating low-pressure and high-pressure waves in liquids, leading to the formation and violent collapse of small
vacuum A vacuum is a space devoid of matter. The word is derived from the Latin adjective ''vacuus'' for "vacant" or "void". An approximation to such vacuum is a region with a gaseous pressure much less than atmospheric pressure. Physicists often dis ...
bubbles. This phenomenon is termed
cavitation Cavitation is a phenomenon in which the static pressure of a liquid reduces to below the liquid's vapour pressure, leading to the formation of small vapor-filled cavities in the liquid. When subjected to higher pressure, these cavities, cal ...
and causes high speed impinging liquid jets and strong hydrodynamic shear-forces. These effects are used for the deagglomeration and milling of micrometre and nanometre-size materials as well as for the disintegration of cells or the mixing of reactants. In this aspect, ultrasonication is an alternative to high-speed mixers and agitator bead mills. Ultrasonic foils under the moving wire in a paper machine will use the shock waves from the imploding bubbles to distribute the cellulose fibres more uniformly in the produced paper web, which will make a stronger paper with more even surfaces. Furthermore, chemical reactions benefit from the free radicals created by the cavitation as well as from the energy input and the material transfer through boundary layers. For many processes, this sonochemical (see
sonochemistry In chemistry, the study of sonochemistry is concerned with understanding the effect of ultrasound in forming acoustic cavitation in liquids, resulting in the initiation or enhancement of the chemical activity in the solution. Therefore, the chemical ...
) effect leads to a substantial reduction in the reaction time, like in the transesterification of oil into
biodiesel Biodiesel is a form of diesel fuel derived from plants or animals and consisting of long-chain fatty acid esters. It is typically made by chemically reacting lipids such as animal fat (tallow), soybean oil, or some other vegetable oil with ...
. Substantial ultrasonic intensity and high ultrasonic vibration amplitudes are required for many processing applications, such as nano-crystallization, nano-emulsification, deagglomeration, extraction, cell disruption, as well as many others. Commonly, a process is first tested on a laboratory scale to prove feasibility and establish some of the required ultrasonic exposure parameters. After this phase is complete, the process is transferred to a pilot (bench) scale for flow-through pre-production optimization and then to an industrial scale for continuous production. During these scale-up steps, it is essential to make sure that all local exposure conditions (ultrasonic amplitude,
cavitation Cavitation is a phenomenon in which the static pressure of a liquid reduces to below the liquid's vapour pressure, leading to the formation of small vapor-filled cavities in the liquid. When subjected to higher pressure, these cavities, cal ...
intensity, time spent in the active cavitation zone, etc.) stay the same. If this condition is met, the quality of the final product remains at the optimized level, while the productivity is increased by a predictable "scale-up factor". The productivity increase results from the fact that laboratory, bench and industrial-scale ultrasonic processor systems incorporate progressively larger ultrasonic horns, able to generate progressively larger high-intensity
cavitation Cavitation is a phenomenon in which the static pressure of a liquid reduces to below the liquid's vapour pressure, leading to the formation of small vapor-filled cavities in the liquid. When subjected to higher pressure, these cavities, cal ...
zones and, therefore, to process more material per unit of time. This is called "direct scalability". It is important to point out that increasing the power of the ultrasonic processor alone does ''not'' result in direct scalability, since it may be (and frequently is) accompanied by a reduction in the ultrasonic amplitude and cavitation intensity. During direct scale-up, all processing conditions must be maintained, while the power rating of the equipment is increased in order to enable the operation of a larger ultrasonic horn.


Ultrasonic manipulation and characterization of particles

A researcher at the Industrial Materials Research Institute, Alessandro Malutta, devised an experiment that demonstrated the trapping action of ultrasonic standing waves on wood pulp fibers diluted in water and their parallel orienting into the equidistant pressure planes. The time to orient the fibers in equidistant planes is measured with a laser and an electro-optical sensor. This could provide the paper industry a quick on-line fiber size measurement system. A somewhat different implementation was demonstrated at Pennsylvania State University using a microchip which generated a pair of perpendicular standing surface acoustic waves allowing to position particles equidistant to each other on a grid. This experiment, called
acoustic tweezers Acoustic tweezers (or acoustical tweezers) are used to manipulate the position and movement of very small objects with sound waves. Strictly speaking, only a single-beam based configuration can be called acoustical tweezers. However, the broad con ...
, can be used for applications in material sciences, biology, physics, chemistry and nanotechnology.


Ultrasonic cleaning

Ultrasonic cleaner Ultrasonic cleaning is a process that uses ultrasound (usually from 20 to 40 kHz) to agitate a fluid, with a cleaning effect. Ultrasonic cleaners come in a variety of sizes, from small desktop units with an internal volume of less than , to larg ...
s, sometimes mistakenly called ''
supersonic Supersonic speed is the speed of an object that exceeds the speed of sound ( Mach 1). For objects traveling in dry air of a temperature of 20 °C (68 °F) at sea level, this speed is approximately . Speeds greater than five times ...
cleaners'', are used at frequencies from 20 to 40
kHz The hertz (symbol: Hz) is the unit of frequency in the International System of Units (SI), equivalent to one event (or cycle) per second. The hertz is an SI derived unit whose expression in terms of SI base units is s−1, meaning that on ...
for
jewellery Jewellery ( UK) or jewelry (U.S.) consists of decorative items worn for personal adornment, such as brooches, rings, necklaces, earrings, pendants, bracelets, and cufflinks. Jewellery may be attached to the body or the clothes. From a wester ...
,
lenses A lens is a transmissive optical device which focuses or disperses a light beam by means of refraction. A simple lens consists of a single piece of transparent material, while a compound lens consists of several simple lenses (''elements''), ...
and other optical parts,
watch A watch is a portable timepiece intended to be carried or worn by a person. It is designed to keep a consistent movement despite the motions caused by the person's activities. A wristwatch is designed to be worn around the wrist, attached by ...
es,
dental instrument Dental instruments are tools that dental professionals use to provide dental treatment. They include tools to examine, manipulate, treat, restore, and remove teeth and surrounding oral structures. Examination instruments These tools allow dental ...
s, surgical instruments, diving regulators and
industrial Industrial may refer to: Industry * Industrial archaeology, the study of the history of the industry * Industrial engineering, engineering dealing with the optimization of complex industrial processes or systems * Industrial city, a city dominate ...
parts. An ultrasonic cleaner works mostly by energy released from the collapse of millions of microscopic
cavitation Cavitation is a phenomenon in which the static pressure of a liquid reduces to below the liquid's vapour pressure, leading to the formation of small vapor-filled cavities in the liquid. When subjected to higher pressure, these cavities, cal ...
s near the dirty surface. The bubbles made by cavitation collapse form tiny shockwaves that break up and disperse contaminants on the object's surface.


Ultrasonic disintegration

Similar to ultrasonic cleaning, biological cells including
bacteria Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
can be disintegrated. High power ultrasound produces
cavitation Cavitation is a phenomenon in which the static pressure of a liquid reduces to below the liquid's vapour pressure, leading to the formation of small vapor-filled cavities in the liquid. When subjected to higher pressure, these cavities, cal ...
that facilitates particle disintegration or reactions. This has uses in biological science for analytical or chemical purposes ( sonication and
sonoporation Sonoporation, or cellular sonication, is the sonication, use of sound (typically ultrasonic frequencies) for modifying the permeability of the cell membrane, cell plasma membrane. This technique is usually used in molecular biology and non-viral g ...
) and in killing bacteria in
sewage Sewage (or domestic sewage, domestic wastewater, municipal wastewater) is a type of wastewater that is produced by a community of people. It is typically transported through a sewer system. Sewage consists of wastewater discharged from residenc ...
. High power ultrasound can disintegrate corn slurry and enhance liquefaction and saccharification for higher ethanol yield in dry corn milling plants.


Ultrasonic humidifier

The ultrasonic humidifier, one type of nebulizer (a device that creates a very fine spray), is a popular type of humidifier. It works by vibrating a metal plate at ultrasonic frequencies to nebulize (sometimes incorrectly called "atomize") the water. Because the water is not heated for evaporation, it produces a cool mist. The ultrasonic pressure waves nebulize not only the water but also materials in the water including calcium, other minerals, viruses, fungi, bacteria, and other impurities. Illness caused by impurities that reside in a humidifier's reservoir fall under the heading of "Humidifier Fever". Ultrasonic humidifiers are frequently used in aeroponics, where they are generally referred to as
fogger A fogger is any device that creates a fog, typically containing an insecticide for killing insects and other arthropods. Foggers are often used by consumers as a low cost alternative to professional pest control services. The number of foggers nee ...
s.


Ultrasonic welding

In ultrasonic welding of plastics, high frequency (15 kHz to 40 kHz) low amplitude vibration is used to create heat by way of friction between the materials to be joined. The interface of the two parts is specially designed to concentrate the energy for maximum weld strength.


Sonochemistry

Power ultrasound in the 20–100 kHz range is used in
chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...
. The ultrasound does not interact directly with
molecule A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and bioch ...
s to induce the chemical change, as its typical wavelength (in the millimeter range) is too long compared to the molecules. Instead, the energy causes
cavitation Cavitation is a phenomenon in which the static pressure of a liquid reduces to below the liquid's vapour pressure, leading to the formation of small vapor-filled cavities in the liquid. When subjected to higher pressure, these cavities, cal ...
which generates extremes of temperature and pressure in the liquid where the reaction happens. Ultrasound also breaks up solids and removes passivating layers of inert material to give a larger
surface area The surface area of a solid object is a measure of the total area that the surface of the object occupies. The mathematical definition of surface area in the presence of curved surfaces is considerably more involved than the definition of arc ...
for the reaction to occur over. Both of these effects make the reaction faster. In 2008, Atul Kumar reported synthesis of Hantzsch esters and polyhydroquinoline derivatives via multi-component reaction protocol in aqueous micelles using ultrasound. Ultrasound is used in
extraction Extraction may refer to: Science and technology Biology and medicine * Comedo extraction, a method of acne treatment * Dental extraction, the surgical removal of a tooth from the mouth Computing and information science * Data extraction, the pro ...
, using different frequencies.


Wireless communication

In July 2015, ''
The Economist ''The Economist'' is a British weekly newspaper printed in demitab format and published digitally. It focuses on current affairs, international business, politics, technology, and culture. Based in London, the newspaper is owned by The Econo ...
'' reported that researchers at the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...
have conducted ultrasound studies using
graphene Graphene () is an allotrope of carbon consisting of a single layer of atoms arranged in a hexagonal lattice nanostructure.
diaphragm (acoustics), diaphragms. The thinness and low weight of graphene combined with its strength make it an effective material to use in ultrasound communications. One suggested application of the technology would be underwater communications, where radio waves typically do not travel well. Ultrasonic signals have been used in "audio beacons" for cross-device tracking of Internet users.


Other uses

Ultrasound when applied in specific configurations can produce short bursts of light in an exotic phenomenon known as
sonoluminescence Sonoluminescence is the emission of light from imploding bubbles in a liquid when excited by sound. History The sonoluminescence effect was first discovered at the University of Cologne in 1934 as a result of work on sonar. Hermann Frenzel and ...
. This phenomenon is being investigated partly because of the possibility of
bubble fusion Bubble fusion is the non-technical name for a nuclear fusion reaction hypothesized to occur inside extraordinarily large collapsing gas bubbles created in a liquid during Sonic cavitation, acoustic cavitation. The more technical name is sonofusion ...
(a nuclear fusion reaction hypothesized to occur during sonoluminescence). Ultrasound is used when characterizing particulates through the technique of ultrasound attenuation spectroscopy or by observing
electroacoustic phenomena Electroacoustic phenomena arise when ultrasound propagates through a fluid containing ions. The associated particle motion generates electric signals because ions have electric charge. This coupling between ultrasound and electric field is called el ...
or by transcranial pulsed ultrasound. Audio can be propagated by
modulated ultrasound Ultrasound can be modulated to carry an audio signal (like radio signals are modulated). This is often used to carry messages underwater, in underwater diving communicators, and short-range (under five miles) communication with submarines; the re ...
. A formerly popular consumer application of ultrasound was in television
remote control In electronics, a remote control (also known as a remote or clicker) is an electronic device used to operate another device from a distance, usually wirelessly. In consumer electronics, a remote control can be used to operate devices such as ...
s for adjusting volume and changing channels. Introduced by
Zenith The zenith (, ) is an imaginary point directly "above" a particular location, on the celestial sphere. "Above" means in the vertical direction (plumb line) opposite to the gravity direction at that location (nadir). The zenith is the "highest" ...
in the late 1950s, the system used a hand-held remote control containing short rod resonators struck by small hammers, and a microphone on the set. Filters and detectors discriminated between the various operations. The principal advantages were that no battery was needed in the hand-held control box and, unlike radio waves, the ultrasound was unlikely to affect neighboring sets. Ultrasound remained in use until displaced by infrared systems starting in the late 1980s.


Safety

Occupational exposure to ultrasound in excess of 120 dB may lead to hearing loss. Exposure in excess of 155 dB may produce heating effects that are harmful to the human body, and it has been calculated that exposures above 180 dB may lead to death. The UK's independent Advisory Group on Non-ionising Radiation (AGNIR) produced a report in 2010, which was published by the UK Health Protection Agency (HPA). This report recommended an exposure limit for the general public to airborne ultrasound sound pressure levels (SPL) of 70 dB (at 20 kHz), and 100 dB (at 25 kHz and above).


See also

*
Acoustic droplet ejection Acoustic droplet ejection (ADE) uses a pulse of ultrasound to move low volumes of fluids (typically nanoliters or picoliters) without any physical contact. This technology focuses acoustic energy into a fluid sample in order to eject droplets as s ...
*
Acoustic emission Acoustic emission (AE) is the phenomenon of radiation of acoustic (elastic) waves in solids that occurs when a material undergoes irreversible changes in its internal structure, for example as a result of crack formation or plastic deformation due t ...
* Bat detector * Delay-line memory * Infrasound — sound at extremely low frequencies * Isochoic *
Laser ultrasonics Laser-ultrasonics uses lasers to generate and detect ultrasonic waves.C.B. Scruby and L.E. Drain, Laser Ultrasonics, (Adam Hilger: Bristol), 1990. It is a non-contact technique used to measure materials thickness, detect flaws and carry out material ...
* Phased array ultrasonics *
Picosecond ultrasonics Picosecond ultrasonics is a type of ultrasonics that uses ultra-high frequency ultrasound generated by ultrashort light pulses. It is a non-destructive technique in which picosecond acoustic pulses penetrate into thin films or nanostructures to r ...
* Sonomicrometry *
Sound from ultrasound Sound from ultrasound is the name given here to the generation of audible sound from modulated ultrasound without using an active receiver. This happens when the modulated ultrasound passes through a nonlinear medium which acts, intentionally or u ...
(also known as hypersonic sound) * Surface acoustic wave * Ultrasonic motor *
Ultrasonic attenuation In physics, attenuation (in some contexts, extinction) is the gradual loss of flux intensity through a medium. For instance, dark glasses attenuate sunlight, lead attenuates X-rays, and water and air attenuate both light and sound at variable a ...
* Ultrasound attenuation spectroscopy


References


Further reading

* *


External links


Guidelines for the Safe Use of Ultrasound
valuable insight on the boundary conditions tending towards abuse of ultrasound {{Authority control Acoustics Sound