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Acoustic Droplet Ejection
Acoustic droplet ejection (ADE) uses a pulse of ultrasound to move low volumes of fluids (typically nanoliters or picoliters) without any physical contact. This technology focuses acoustic energy into a fluid sample in order to eject droplets as small as a picoliter. ADE technology is a very gentle process, and it can be used to transfer proteins, high molecular weight DNA and live cells without damage or loss of viability. This feature makes the technology suitable for a wide variety of applications including proteomics and cell-based assays. History Acoustic droplet ejection was first reported in 1927 by Robert W. Wood and Alfred Loomis, who noted that when a high-power acoustic generator was immersed in an oil bath, a mound formed on the surface of the oil and, like a “miniature volcano,” ejected a continuous stream of droplets. Ripples that appear in a glass of water placed on a loud speaker show that acoustic energy can be converted to kinetic energy in a fluid. If th ...
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ADE Droplet
Ade, Adé, or ADE may refer to: Aeronautics *Ada Air's ICAO code *Aden International Airport's IATA code *Aeronautical Development Establishment, a laboratory of the DRDO in India Medical * Adverse Drug Event *Antibody-dependent enhancement * ADE (chemotherapy), a chemotherapy regimen consisting of Ara-C (cytarabine), Daunorubicin and Etoposide People *Ade (given name) * Ade (surname) *Adé (singer) Places * Adé, Chad, a city in Chad * Adé, Hautes-Pyrénées, a commune in France * Ade, Indiana, an unincorporated place in the US * Ade, Maharashtra, a small village in Maharashtra state, India Other uses *Acoustic droplet ejection *Ade (drink suffix) *ADE classification, a mathematics classification *Adele language, a Niger-Congo language of Ghana and Togo *Algebraic differential equation, a kind of differential equation *Amsterdam Dance Event, an electronic music conference and club festival *Adenine, a nucleobase *Adobe Digital Editions *Application Development Environment *Ar ...
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High Throughput Screening
High-throughput screening (HTS) is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology, materials science and chemistry. Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can quickly recognize active compounds, antibodies, or genes that modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the noninteraction or role of a particular location. Assay plate preparation The key labware or testing vessel of HTS is the microtiter plate, which is a small container, usually disposable and made of plastic, that features a grid of small, open divots called ''wells''. In general, microplates for HTS have either 96, 192, 384, 1536, 3456 or 6144 wells. Thes ...
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Microtechnology
Microtechnology deals with technology whose features have dimensions of the order of one micrometre (one millionth of a metre, or 10−6 metre, or 1μm). It focuses on physical and chemical processes as well as the production or manipulation of structures with one-micrometre magnitude. Development Around 1970, scientists learned that by arraying large numbers of microscopic transistors on a single chip, microelectronic circuits could be built that dramatically improved performance, functionality, and reliability, all while reducing cost and increasing volume. This development led to the Information Revolution. More recently, scientists have learned that not only electrical devices, but also mechanical devices, may be miniaturized and batch-fabricated, promising the same benefits to the mechanical world as integrated circuit technology has given to the electrical world. While electronics now provide the ‘brains’ for today's advanced systems and products, micro-mechanical devic ...
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Ultrasound
Ultrasound is sound waves with frequency, frequencies higher than the upper audible limit of human hearing range, hearing. Ultrasound is not different from "normal" (audible) sound in its physical properties, except that humans cannot hear it. This limit varies from person to person and is approximately 20 Hertz, kilohertz (20,000 hertz) in healthy young adults. Ultrasound devices operate with frequencies from 20 kHz up to several gigahertz. Ultrasound is used in many different fields. Ultrasonic devices are used to detect objects and measure distances. Ultrasound imaging or sonography is often used in medicine. In the nondestructive testing of products and structures, ultrasound is used to detect invisible flaws. Industrially, ultrasound is used for cleaning, mixing, and accelerating chemical processes. Animals such as bats and porpoises use ultrasound for locating Predation, prey and obstacles. History Acoustics, the science of sound, starts as far back as Pyth ...
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Acoustics
Acoustics is a branch of physics that deals with the study of mechanical waves in gases, liquids, and solids including topics such as vibration, sound, ultrasound and infrasound. A scientist who works in the field of acoustics is an acoustician while someone working in the field of acoustics technology may be called an Acoustical engineering, acoustical engineer. The application of acoustics is present in almost all aspects of modern society with the most obvious being the audio and noise control industries. Hearing (sense), Hearing is one of the most crucial means of survival in the animal world and speech is one of the most distinctive characteristics of human development and culture. Accordingly, the science of acoustics spreads across many facets of human society—music, medicine, architecture, industrial production, warfare and more. Likewise, animal species such as songbirds and frogs use sound and hearing as a key element of mating rituals or for marking territories. Art, ...
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Acoustic Droplet Vaporization
Acoustic droplet vaporization (ADV) is the process by which superheated liquid droplets are phase-transitioned into gas bubbles by means of ultrasound. Perfluorocarbons and halocarbons are often used for the dispersed medium, which forms the core of the droplet. The surfactant, which forms a stabilizing shell around the dispersive medium, is usually composed of albumin or lipids. There exist two main hypothesis that explain the mechanism by which ultrasound induces vaporization. One poses that the ultrasonic field interacts with the dispersed medium so as to cause vaporization in the bubble core. The other suggests that shockwaves from inertial cavitation, occurring near or within the droplet, cause the dispersed medium to vaporize. See also * Acoustic droplet ejection Acoustic droplet ejection (ADE) uses a pulse of ultrasound to move low volumes of fluids (typically nanoliters or picoliters) without any physical contact. This technology focuses acoustic energy into a ...
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Direct Loading Of Mass Spectrometers
Direct may refer to: Mathematics * Directed set, in order theory * Direct limit of (pre), sheaves * Direct sum of modules, a construction in abstract algebra which combines several vector spaces Computing * Direct access (other), a method of accessing data in a database * Direct connect (other), various methods of telecommunications and computer networking * Direct memory access, access to memory by hardware subsystems independently of the CPU Entertainment * ''Direct'' (Tower of Power album) * ''Direct'' (Vangelis album) * ''Direct'' (EP), by The 77s Other uses * Nintendo Direct, an online presentation frequently held by Nintendo * Mars Direct, a proposal for a crewed mission to Mars * DIRECT, a proposed space shuttle-derived launch vehicle * DirectX, a proprietary dynamic media platform * Direct current, a direct flow of electricity * Direct examination, the in-trial questioning of a witness by the party who has called him or her to testify ...
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Reducing Plastic Waste In Biological Research
Reduction, reduced, or reduce may refer to: Science and technology Chemistry * Reduction (chemistry), part of a reduction-oxidation (redox) reaction in which atoms have their oxidation state changed. ** Organic redox reaction, a redox reaction that takes place with organic compounds ** Ore reduction: see smelting Computing and algorithms * Reduction (complexity), a transformation of one problem into another problem * Reduction (recursion theory), given sets A and B of natural numbers, is it possible to effectively convert a method for deciding membership in B into a method for deciding membership in A? * Bit Rate Reduction, an audio compression method * Data reduction, simplifying data in order to facilitate analysis * Graph reduction, an efficient version of non-strict evaluation * L-reduction, a transformation of optimization problems which keeps the approximability features * Partial order reduction, a technique for reducing the size of the state-space to be searched by ...
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Assay Miniaturization
An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity. The measured entity is often called the analyte, the measurand, or the target of the assay. The analyte can be a drug, biochemical substance, chemical element or compound, or cell in an organism or organic sample. An assay usually aims to measure an analyte's intensive property and express it in the relevant measurement unit (e.g. molarity, density, functional activity in enzyme international units, degree of effect in comparison to a standard, etc.). If the assay involves exogenous reactants (the reagents), then their quantities are kept fixed (or in excess) so that the quantity and quality of the target are the only limiting factors. The difference in the assay outcome is used to deduce the unknown quality or quantity ...
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Microelectromechanical Systems
Microelectromechanical systems (MEMS), also written as micro-electro-mechanical systems (or microelectronic and microelectromechanical systems) and the related micromechatronics and microsystems constitute the technology of microscopic devices, particularly those with moving parts. They merge at the nanoscale into nanoelectromechanical systems (NEMS) and nanotechnology. MEMS are also referred to as micromachines in Japan and microsystem technology (MST) in Europe. MEMS are made up of components between 1 and 100 micrometers in size (i.e., 0.001 to 0.1 mm), and MEMS devices generally range in size from 20 micrometres to a millimetre (i.e., 0.02 to 1.0 mm), although components arranged in arrays (e.g., digital micromirror devices) can be more than 1000 mm2. They usually consist of a central unit that processes data (an integrated circuit chip such as microprocessor) and several components that interact with the surroundings (such as microsensors). Because of the la ...
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Acoustic Transfer1
Acoustic may refer to: Music Albums * ''Acoustic'' (Above & Beyond album), 2014 * ''Acoustic'' (Deine Lakaien album), 2007 * ''Acoustic'' (Everything but the Girl album), 1992 * ''Acoustic'' (John Lennon album), 2004 * ''Acoustic'' (Love Amongst Ruin album), 2011 * ''Acoustic'' (Nitty Gritty Dirt Band album), 1994 * ''Acoustic'' (Nouvelle Vague album), 2009 * ''Acoustic'' (Simple Minds album), 2016 * ''The Acoustic'', by Ektomorf, 2012 * ''Acoustic'', by Oumou Sangaré, 2020 EPs and singles * ''Acoustic'' (Bayside EP), 2006 * ''Acoustic'' (Britt Nicole EP), 2010 * ''Acoustic'' (Coldplay EP), 2000 * ''Acoustic'' (Lights EP), 2010 * ''Acoustic'' (Second Coming EP), an acoustic version of ''13'', 2003 * ''Acoustic'', by Brandi Carlile, 2004 * ''Acoustic'', by Gabrielle Aplin, 2010 * ''Acoustic'', by Press to Meco, 2019 * "Acoustic" (single), "Follow You Home" and "Refugees", by Embrace, 2014 Companies * ''Acoustic'' (magazine) * ''Acoustic Guitar'' (magazine) * Acou ...
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