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Sharon Ann Whelan Weiss is an American
pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in t ...
who is best known for her contribution to the subspecialty of soft tissue pathology. She is the main author of ''Soft Tissue Tumors'', one of the most widely used textbooks in the field of
sarcoma A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal ( connective tissue) origin. Connective tissue is a broad term that includes bone, cartilage, fat, vascular, or hematopoietic tissues, and sar ...
and soft tissue pathology. She is also well known for her seminal descriptions of multiple
soft tissue Soft tissue is all the tissue in the body that is not hardened by the processes of ossification or calcification such as bones and teeth. Soft tissue connects, surrounds or supports internal organs and bones, and includes muscle, tendons, ...
tumor A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
s, such as
epithelioid hemangioendothelioma Epithelioid hemangioendothelioma (eHAE) is a rare tumor, first characterized by Sharon Weiss and Franz Enzinger in 1982 that both clinically and histologically is intermediate between angiosarcoma and hemangioma. However, a distinct, disease-defin ...
and pleomorphic hyalinizing angiectatic tumor of soft parts ("PHAT" which is categorized as a rare and locally aggressive neoplasm occurring in the lower extremities of a patient) among others. She has also mentored and trained other well-known soft tissue pathologists.


Early life and education

Weiss was born in 1945 in
Lynn, Massachusetts Lynn is the eighth-largest municipality in Massachusetts and the largest city in Essex County. Situated on the Atlantic Ocean, north of the Boston city line at Suffolk Downs, Lynn is part of Greater Boston's urban inner core. Settled by E ...
, the oldest of six children. Her father was an Army surgeon. She received her undergraduate education at Wellesley College in
Wellesley, Massachusetts Wellesley () is a town in Norfolk County, Massachusetts, United States. Wellesley is part of Greater Boston. The population was 29,550 at the time of the 2020 census. Wellesley College, Babson College, and a campus of Massachusetts Bay Communit ...
, where she graduated with a B.A. in 1966. Upon graduation she married fellow physician Bernard Weiss. She received her medical education at
Johns Hopkins University School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...
(M.D., 1971) and residency training in
Anatomic Pathology Anatomical pathology (''Commonwealth'') or Anatomic pathology (''U.S.'') is a medical specialty that is concerned with the diagnosis of disease based on the gross examination, macroscopic, Histopathology, microscopic, biochemical, immu ...
at
Johns Hopkins Hospital The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 m ...
(1972–1975) in
Baltimore, Maryland Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...
. She was the first female to serve as Chief Resident of Pathology in the history of the hospital.


Career

From 1976 to 1989 she worked as a soft tissue pathologist at the
Armed Forces Institute of Pathology The Armed Forces Institute of Pathology (AFIP) (1862 – September 15, 2011) was a U.S. government institution concerned with diagnostic consultation, education, and research in the medical specialty of pathology. Overview It was founded in ...
(AFIP) under the mentoring of Dr. Franz Enzinger, one of the fathers of the field of soft tissue pathology. In 1989 she moved to the
University of Michigan , mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As o ...
in Ann Arbor, Michigan, where she served as the A. James French Professor of Pathology, Director of Anatomic Pathology, and Chief of Surgical Pathology. In 1998 she became Professor of Pathology and Laboratory Medicine at
Emory University Hospital Emory University Hospital is a 733-bed facility in Atlanta, Georgia, specializing in the care of acutely ill adults. Emory University Hospital is staffed exclusively by Emory University School of Medicine faculty who also are members of The Emor ...
in
Atlanta, Georgia Atlanta ( ) is the capital and most populous city of the U.S. state of Georgia. It is the seat of Fulton County, the most populous county in Georgia, but its territory falls in both Fulton and DeKalb counties. With a population of 498,7 ...
. She is the director of the expert consultation service at Emory University Hospital, where she provides diagnostic second opinions on sarcomas and other soft tissue pathology cases. She is also the Associate Dean for Faculty Development, a position she has held since 2006.Emory School of Medicine Faculty Bio


Professional involvement and honors

Weiss served as President of the
United States and Canadian Academy of Pathology The United States and Canadian Academy of Pathology, abbreviated USCAP, is the largest North American organization of pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to th ...
(1997–1998) and currently serves as a Trustee of the American Board of Pathology (2005 to present).


Initial characterization of new soft tissue pathologic entities

Her contributions to the field have been described as "monumental". She was the first to describe/characterize the following soft tissue pathologic entities: *
Epithelioid hemangioendothelioma Epithelioid hemangioendothelioma (eHAE) is a rare tumor, first characterized by Sharon Weiss and Franz Enzinger in 1982 that both clinically and histologically is intermediate between angiosarcoma and hemangioma. However, a distinct, disease-defin ...
(1982) *
Kaposiform hemangioendothelioma A vascular tumor is a tumor of vascular system, vascular origin; a soft tissue growth that can be either Benign tumor, benign or malignant, formed from blood vessels or lymph vessels. Examples of vascular tumors include hemangiomas, lymphangiomas, ...
(1993) *Myxoid variant of
malignant fibrous histiocytoma Undifferentiated pleomorphic sarcoma (UPS), also termed pleomorphic myofibrosarcoma, high-grade myofibroblastic sarcoma, and high-grade myofibrosarcoma, is characterized by the World Health Organization (WHO), 2020, as a rare, poorly differentiate ...
(myxofibrosarcoma)(1977) *
Neuroblastoma Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in th ...
-like Neurilemoma (
Schwannoma A schwannoma (or neurilemmoma) is a usually benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves. Schwannomas are homogeneous tumors, consisting only of Schwann cells ...
) *Palisaded Myofibroblastoma (1989), described earlier that year by Saul Suster *
Paraganglioma A paraganglioma is a rare neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and abdomen). When the same type of tumor is found in the adrenal gland, they are referred to as a pheochromocytoma. They a ...
-like dermal
melanocytic tumor Melanocytic tumors are neoplasm, tumors developed from melanocytes. Types

* Melanocytic nevus * Melanocytic tumors of uncertain malignant potential * Melanoma Tumor {{med-sign-stub ...
*Pleomorphic hyalinizing angiectatic tumor of soft parts (so-called "PHAT")(1996) *Sclerosing
Rhabdomyosarcoma Rhabdomyosarcoma (RMS) is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully differentiate into myocytes of skeletal muscle. Cells of the tumor are identified as rhabdomyoblasts. There are four subt ...
(2002) *Spindle cell hemangioma (formerly spindle cell hemangioendothelioma)(1986)


See also

*
List of pathologists A list of people notable in the field of pathology. A * John Abercrombie, Scottish physician, neuropathologist and philosopher. * Maude Abbott (1869–1940), Canadian pathologist, one of the earliest women graduated in medicine, expert in co ...


References

{{DEFAULTSORT:Weiss, Sharon Living people American pathologists Emory University faculty 1945 births Women pathologists 20th-century American women scientists University of Michigan faculty American women academics 21st-century American women