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Sharon Weiss
Sharon Ann Whelan Weiss is an American pathologist who is best known for her contribution to the subspecialty of soft tissue pathology. She is the main author of ''Soft Tissue Tumors'', one of the most widely used textbooks in the field of sarcoma and soft tissue pathology. She is also well known for her seminal descriptions of multiple soft tissue tumors, such as epithelioid hemangioendothelioma and pleomorphic hyalinizing angiectatic tumor of soft parts ("PHAT" which is categorized as a rare and locally aggressive neoplasm occurring in the lower extremities of a patient) among others. She has also mentored and trained other well-known soft tissue pathologists. Early life and education Weiss was born in 1945 in Lynn, Massachusetts, the oldest of six children. Her father was an Army surgeon. She received her undergraduate education at Wellesley College in Wellesley, Massachusetts, where she graduated with a B.A. in 1966. Upon graduation she married fellow physician Bernard W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lynn, Massachusetts
Lynn is the eighth-largest municipality in Massachusetts and the largest city in Essex County. Situated on the Atlantic Ocean, north of the Boston city line at Suffolk Downs, Lynn is part of Greater Boston's urban inner core. Settled by Europeans in 1629, Lynn is the 5th oldest colonial settlement in the Commonwealth. An early industrial center, Lynn was long colloquially referred to as the "City of Sin", owing to its historical reputation for crime and vice. Today, however, the city is known for its contemporary public art, immigrant population, historic architecture, downtown cultural district, loft-style apartments, and public parks and open spaces, which include the oceanfront Lynn Shore Reservation; the 2,200-acre, Frederick Law Olmsted-designed Lynn Woods Reservation; and the High Rock Tower Reservation, High Rock Reservation and Park designed by Olmsted Brothers, Olmsted's sons. Lynn also is home to Lynn Heritage State Park, the southernmost portion of the Essex Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pleomorphism (cytology)
Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and/or their nuclei. Several key determinants of cell and nuclear size, like ploidy and the regulation of cellular metabolism, are commonly disrupted in tumors. Therefore, cellular and nuclear pleomorphism is one of the earliest hallmarks of cancer progression and a feature characteristic of malignant neoplasms and dysplasia. Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction. A rare type of rhabdomyosarcoma that is found in adults is known as pleomorphic rhabdomyosarcoma. Despite the prevalence of pleomorphism in human pathology, its role in disease progression is unclear. In epithelial tissue, pleomorphism in cellular size can induce packing defects and disperse aberrant cells. But the consequence of atypical cell and nuclear morphology in other tissues is unknown. See also *Anaplasia *Cell growt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malignant Fibrous Histiocytoma
Undifferentiated pleomorphic sarcoma (UPS), also termed pleomorphic myofibrosarcoma, high-grade myofibroblastic sarcoma, and high-grade myofibrosarcoma, is characterized by the World Health Organization (WHO), 2020, as a rare, poorly differentiated neoplasm, i.e. an abnormal growth of cells that have an unclear identity and/or cell of origin. WHO classified it as one of the undifferentiated/unclassified sarcomas in the category of tumors of uncertain differentiation. Sarcomas are cancers known or thought to derive from mesenchymal stem cells that typically develop in bone, muscle, fat, blood vessels, lymphatic vessels, tendons, and ligaments. More than 70 sarcoma subtypes have been described. The UPS subtype of these sarcomas consists of tumor cells that are poorly differentiated and may appear as spindle-shaped cells, histiocytes, and giant cells. UPS is considered a diagnosis that defies formal sub-classification after thorough histologic, immunohistochemical, and ultrastructural ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kaposiform Hemangioendothelioma
A vascular tumor is a tumor of vascular origin; a soft tissue growth that can be either benign or malignant, formed from blood vessels or lymph vessels. Examples of vascular tumors include hemangiomas, lymphangiomas, hemangioendotheliomas, Kaposi's sarcomas, angiosarcomas, and hemangioblastomas. An angioma refers to any type of benign vascular tumor. Some vascular tumors can be associated with serious blood-clotting disorders, making correct diagnosis critical. A vascular tumor may be described in terms of being ''highly vascularized'', or ''poorly vascularized'', referring to the degree of blood supply to the tumor. Classification Vascular tumors make up one of the classifications of vascular anomalies. The other grouping is vascular malformations. Vascular tumors can be further subclassified as being benign, borderline or aggressive, and malignant. Vascular tumors are described as ''proliferative'', and vascular malformations as ''nonproliferative''. Types A vascular tumor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epithelioid Hemangioendothelioma
Epithelioid hemangioendothelioma (eHAE) is a rare tumor, first characterized by Sharon Weiss and Franz Enzinger in 1982 that both clinically and histologically is intermediate between angiosarcoma and hemangioma. However, a distinct, disease-defining genetic alteration recently described for EHE indicates that it is an entirely separate entity from both angiosarcoma and hemangioma. EHE is a soft tissue sarcoma and is generally considered a vascular cancer insofar as the ‘lesional’ cells have surface markers typical of endothelial cells (cells lining the interior of blood vessels). EHE was originally described as occurring most commonly in the veins of the extremities (arms and legs) and two organs, the liver and lungs. It has since been described in organs throughout the body. In addition to liver and lungs, bones and skin have been the most frequent organs. Before the initial description of Weiss, the tumor had been reported under a variety of other names, including histiocy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atlanta, Georgia
Atlanta ( ) is the capital and most populous city of the U.S. state of Georgia. It is the seat of Fulton County, the most populous county in Georgia, but its territory falls in both Fulton and DeKalb counties. With a population of 498,715 living within the city limits, it is the eighth most populous city in the Southeast and 38th most populous city in the United States according to the 2020 U.S. census. It is the core of the much larger Atlanta metropolitan area, which is home to more than 6.1 million people, making it the eighth-largest metropolitan area in the United States. Situated among the foothills of the Appalachian Mountains at an elevation of just over above sea level, it features unique topography that includes rolling hills, lush greenery, and the most dense urban tree coverage of any major city in the United States. Atlanta was originally founded as the terminus of a major state-sponsored railroad, but it soon became the convergence point among several rai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emory University Hospital
Emory University Hospital is a 733-bed facility in Atlanta, Georgia, specializing in the care of acutely ill adults. Emory University Hospital is staffed exclusively by Emory University School of Medicine faculty who also are members of The Emory Clinic. The hospital is renowned as one of the nation's leaders in cardiology and cardiac surgery, oncology, transplantation, ophthalmology, and the neurosciences. History Emory University Hospital's history dates back over a century. In March 1904, its predecessor, Wesley Memorial Hospital, was chartered with 50 beds. The hospital was housed in a downtown Atlanta mansion that had been spared from destruction by General Sherman's army during the Civil War. By November 1922, the hospital had grown too large for its quarters and moved to its current DeKalb County site on the Emory University campus. The new 275-bed facility was a gift of Asa G. Candler, philanthropist and founder of The Coca-Cola Company. In the mid-1930s, its name was c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ann Arbor, Michigan
Ann Arbor is a city in the U.S. state of Michigan and the county seat of Washtenaw County, Michigan, Washtenaw County. The 2020 United States census, 2020 census recorded its population to be 123,851. It is the principal city of the Ann Arbor List of metropolitan statistical areas, Metropolitan Statistical Area, which encompasses all of Washtenaw County. Ann Arbor is also included in the Metro Detroit, Greater Detroit Combined statistical area, Combined Statistical Area and the Great Lakes megalopolis, the most populated and largest Megaregions of the United States, megalopolis in North America. Ann Arbor is home to the University of Michigan. The university significantly shapes Ann Arbor's economy as it employs about 30,000 workers, including about 12,000 in the University of Michigan Health System, medical center. The city's economy is also centered on high technology, with several companies drawn to the area by the university's research and development infrastructure. Ann A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Armed Forces Institute Of Pathology
The Armed Forces Institute of Pathology (AFIP) (1862 – September 15, 2011) was a U.S. government institution concerned with diagnostic consultation, education, and research in the medical specialty of pathology. Overview It was founded in 1862 as the Army Medical Museum in Washington, D.C., on the grounds of the Walter Reed Army Medical Center (WRAMC). It primarily provided second opinion diagnostic consultations on pathologic specimens such as biopsies from military, veteran, and civilian medical, dental, and veterinary sources. The unique character of the AFIP rested in the expertise of its civilian and military staff of diagnostic pathologists whose daily work consisted of the study of cases that are difficult to diagnose owing to their rarity or their variation from the ordinary. The accumulation of such cases has resulted in a rich repository of lesions, numbering over three million, that have been the basis of major pathological studies. Examples are the published rep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Baltimore, Maryland
Baltimore ( , locally: or ) is the most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic, and the 30th most populous city in the United States with a population of 585,708 in 2020. Baltimore was designated an independent city by the Constitution of Maryland in 1851, and today is the most populous independent city in the United States. As of 2021, the population of the Baltimore metropolitan area was estimated to be 2,838,327, making it the 20th largest metropolitan area in the country. Baltimore is located about north northeast of Washington, D.C., making it a principal city in the Washington–Baltimore combined statistical area (CSA), the third-largest CSA in the nation, with a 2021 estimated population of 9,946,526. Prior to European colonization, the Baltimore region was used as hunting grounds by the Susquehannock Native Americans, who were primarily settled further northwest than where the city was later built. Colonis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johns Hopkins Hospital
The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 money, worth 163.9 million dollars in 2021) by city merchant, banker/financier, civic leader and philanthropist Johns Hopkins (1795–1873). Johns Hopkins Hospital and its School of Medicine are considered to be the founding institutions of modern American medicine and the birthplace of numerous famous medical traditions including rounds, residents and house staff. Many medical specialties were formed at the hospital including neurosurgery, by Harvey Cushing and Walter Dandy; cardiac surgery by Alfred Blalock; and child psychiatry, by Leo Kanner. Attached to the hospital is the Johns Hopkins Children’s Center which serves infants, children, teens, and young adults aged 0–21. Johns Hopkins Hospital is widely regarded as one of the world' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anatomic Pathology
Anatomical pathology (''Commonwealth'') or Anatomic pathology (''U.S.'') is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues. Over the last century, surgical pathology has evolved tremendously: from historical examination of whole bodies (autopsy) to a more modernized practice, centered on the diagnosis and prognosis of cancer to guide treatment decision-making in oncology. Its modern founder was the Italian scientist Giovan Battista Morgagni from Forlì. Anatomical pathology is one of two branches of pathology, the other being clinical pathology, the diagnosis of disease through the laboratory analysis of bodily fluids or tissues. Often, pathologists practice both anatomical and clinical pathology, a combination known as general pathology. Similar specialties exist in veterinary pathology. Differences with clinical pathology Anatomic pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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