RhoGEF domain describes two distinct
structural domains with
guanine nucleotide exchange factor (GEF) activity to regulate
small GTPases in the
Rho family. Rho small GTPases are inactive when bound to
GDP but active when bound to
GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including
RhoA,
Rac1 and
Cdc42.
The largest class of RhoGEFs is composed of proteins containing the "
Dbl-homology" (DH) domain, which almost always is found together with a
pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.
A distinct class of RhoGEFs is those proteins containing the
DOCK/CZH/DHR-2 domain. This structure has no sequence similarity with DBL-homology domains.
Human proteins containing DH/PH RhoGEF domain
ABR;
AKAP13/ARHGEF13/Lbc;
ALS2;
ALS2CL
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most comm ...
;
ARHGEF1/p115-RhoGEF;
ARHGEF10
The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein
G proteins, a ...
;
ARHGEF10L
Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ''ARHGEF1'' gene. This protein is also called RhoGEF1 or p115-RhoGEF.
Function
Rho guanine nucleotide exchange factor 1 is guanine nucleotide exchange f ...
;
ARHGEF11/PDZ-RhoGEF.;
ARHGEF12/LARG;
ARHGEF15;
ARHGEF16;
ARHGEF17;
ARHGEF18;
ARHGEF19;
ARHGEF2;
ARHGEF25;
ARHGEF26;
ARHGEF28;
ARHGEF3;
ARHGEF33;
ARHGEF35;
ARHGEF37;
ARHGEF38;
ARHGEF39;
ARHGEF4;
ARHGEF40
Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ''ARHGEF4'' gene.
Function
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work throu ...
;
ARHGEF5
Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ''ARHGEF5'' gene.
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled re ...
;
ARHGEF6/alpha-PIX;
ARHGEF7/beta-PIX;
ARHGEF9;
BCR;
DNMBP;
ECT2
Protein ECT2 is a protein that in humans is encoded by the ''ECT2'' gene.
Function
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of t ...
;
ECT2L
Epithelial cell transforming sequence 2 oncogene-like is a protein that in humans is encoded by the ECT2L gene.
Clinical relevance
Recurrent mutations of this gene have been associated to cases of acute lymphoblastic leukaemia.
References
...
;
FARP1
FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the ''FARP1'' gene.
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondroc ...
;
FARP2
FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the ''FARP2'' gene.
Model organisms
Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called ''Fa ...
;
FGD1
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein th ...
;
FGD2;
FGD3;
FGD4;
FGD5;
FGD6;
ITSN1/Intersectin 1;
ITSN2/Intersectin 2;
KALRN/Kalirin;
MCF2;
MCF2L;
MCF2L2 MCF can refer to:
Transport and Manufacturing
* Modern Coach Factory, Raebareli, an Indian rail manufacturer
Science and technology
* Military-Civil Fusion, a Chinese economic strategy for technological dominance developed by Xi Jinping
* Magneti ...
;
NET1
Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the ''NET1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." me ...
;
NGEF;
OBSCN
Obscurin is a protein that in humans is encoded by the ''OBSCN'' gene. Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin. Obscurin is expressed in cardiac and skeletal muscle, and plays a role in ...
;
PLEKHG1;
PLEKHG2
Pleckstrin homology domain containing, family G member 2 (PLEKHG2) is a protein that in humans is encoded by the ''PLEKHG2'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian unit ...
;
PLEKHG3;
PLEKHG4
Puratrophin-1 is a protein that in humans is encoded by the ''PLEKHG4'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' ...
;
PLEKHG4B;
PLEKHG5
Pleckstrin homology domain containing, family G member 5 (PLEKHG5) is a protein that in humans is encoded by the ''PLEKHG5'' gene. Eight transcript variants encoding different isoforms have been found for this gene.
Function
This gene encode ...
;
PLEKHG6;
PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the ''PREX1'' gene.
Function
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family ...
;
PREX2
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.
Clinical relevance
Mutations in this gene have been recurrently seen in melanoma
Melanoma, also redundantl ...
;
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 ...
;
RASGRF2;
SPATA13;
TIAM1
T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the ''TIAM1'' gene.
Structure
TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, ...
;
TIAM2
Datuk Wira Poh Ah Tiam (; April 1, 1952 – March 15, 2007) was a Malaysian politician, businessman and community leader of Chinese descent. Poh was born in Kampung Belimbing, near Durian Tunggal, Malacca. He and his family moved to nearby ...
;
TRIO;
VAV1;
VAV2;
VAV3.
Human proteins containing DOCK/CZH RhoGEF domain
DOCK1/DOCK180;
DOCK2
Dock2 (Dedicator of cytokinesis 2), also known as DOCK2, is a large (~180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which ...
;
DOCK3/MOCA;
DOCK4
Dock4, (Dedicator of cytokinesis 4) also known as DOCK4, is a large (~190 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which ...
;
DOCK5
Dock5 (Dedicator of cytokinesis 5), also known as DOCK5, is a large (~180 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) whic ...
;
DOCK6/ZIR1;
DOCK7/ZIR2;
DOCK8/ZIR3;
DOCK9/Zizimin1;
DOCK10/Zizimin2;
DOCK11/Zizimin3
See also
*
GTPase
*
Small GTPase
*
Guanine nucleotide exchange factor
*
Rho family of GTPases
References
Further reading
*
*
*
Protein domains
Peripheral membrane proteins
{{membrane-protein-stub