Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''NMT1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
It belongs to the
protein N-terminal methyltransferase
Protein N-terminal methyltransferase (, ''NMT1 (gene)'', ''METTL11A (gene)'') is an enzyme with systematic name ''S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-(protein) methyltransferase''. This enzyme catalyses the following chemical reaction
: ...
and
glycylpeptide N-tetradecanoyltransferase
In enzymology, a glycylpeptide N-tetradecanoyltransferase () is an enzyme that catalyzes the chemical reaction
:tetradecanoyl-CoA + glycylpeptide \rightleftharpoons CoA + N-tetradecanoylglycylpeptide
Thus, the two substrates of this enzyme ar ...
family of enzymes.
References
Further reading
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See also
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Myristoylation
Myristoylation is a lipidation modification where a myristoyl group, derived from myristic acid, is covalently attached by an amide bond to the alpha-amino group of an N-terminus, N-terminal glycine residue. Myristic acid is a 14-carbon saturat ...
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N-myristoyltransferase 2
External links
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EC 2.3.1
Human proteins
{{gene-17-stub