George Ledlie Prize
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The George Ledlie Prize is awarded by the "President and Fellows of Harvard College" for contributions to science.


George Ledlie

George Hees Ledlie was born at Palatine Bridge, New York and attended private schools and colleges to prepare for Harvard, from where he graduated in 1884. In 1909 he reported to Harvard in a hand-written note that his full name had become George Ledlie – thus dropping his middle name Hees, the maiden name of his mother. Ledlie was a St. Louis and New York newspaper executive and an associate of publisher
Joseph Pulitzer Joseph Pulitzer ( ; born Pulitzer József, ; April 10, 1847 – October 29, 1911) was a Hungarian-American politician and newspaper publisher of the '' St. Louis Post-Dispatch'' and the ''New York World''. He became a leading national figure in ...
. George (Hees) Ledlie died on 16 April 1927, and the Harvard George Ledlie Prize became a bequest that year. As a philanthropist, Ledlie donated an amount to Harvard, with the following conditions: "Bequest of George Ledlie, 1884, the net income to be paid not oftener than once in every two years as a prize to a person in any way connected with said University, who, in the judgement of said University since the last awarding of the said prize, has by research, discovery or otherwise made the most valuable contribution to science, or in any way for the benefit of mankind, ... and known as the George Ledlie Prize." The amount of this initial bequest was $1,000, and it has varied little with time. The prize is sought not for its monetary value, but for its recognition of the significance of scientific work carried out by the recipient. Thomas Weller, 1954
Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
winner for his research into
polio Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe s ...
, said of his Ledlie Award: "In 1963 in recognition of my isolation of the CMV and rubella viruses I was greatly pleased by the award by Harvard of the George Ledlie prize, an award given every two years to the Harvard faculty member considered to have made the major contribution to human welfare."
Robert Burns Woodward Robert Burns Woodward (April 10, 1917 – July 8, 1979) was an American organic chemist. He is considered by many to be the most preeminent synthetic organic chemist of the twentieth century, having made many key contributions to the subject, e ...
, Morris Loeb Professor of Chemistry, as the University's "leading contributor to science and the benefit of mankind," was the first person awarded the newly established George Ledlie Prize. It was given based on his research into the synthesis of
quinine Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to '' Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal le ...
, and analyses and syntheses of increasingly complicated molecules, including
cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...
,
cortisone Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enz ...
,
lysergic acid Lysergic acid, also known as -lysergic acid and (+)-lysergic acid, is a precursor for a wide range of ergoline alkaloids that are produced by the ergot fungus and found in the seeds of '' Turbina corymbosa'' (ololiuhqui), '' Argyreia nervosa'' ...
(LSD), strychnine,
reserpine Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces m ...
, and chlorophyll. The Ledlie Prize has been awarded in fields as diverse as chemistry, entomology, sociology, education, physics, and molecular biology. Over the years it has gained prestige as an award, and is prized by members of the Harvard faculty. Upon receipt of her Ledlie Prize, physicist
Lene Hau Lene Vestergaard Hau (; born November 13, 1959) is a Danish physicist and educator. She is the Mallinckrodt Professor of Physics and of Applied Physics at Harvard University. In 1999, she led a Harvard University team who, by use of a Bose–E ...
explained her reaction in these terms: “I am very honored to receive the prize. It is really wonderful to receive this kind of recognition from your home institution,”. Psychologist
Howard Gardner Howard Earl Gardner (born July 11, 1943) is an American developmental psychologist and the John H. and Elisabeth A. Hobbs Research Professor of Cognition and Education at the Harvard Graduate School of Education at Harvard University. He is curr ...
, winner of the 1999-2000 Ledlie stated that: "It’s especially heartwarming when an institution you identify with selects you as somebody they think well of."


Past winners

Past winners of the Ledlie Award have included: * Thomas Huckle Weller: for growing polio virus in tissue culture, * Gerald Gabrielse: for his "stunning" scientific accomplishment of creating and observing
antimatter In modern physics, antimatter is defined as matter composed of the antiparticles (or "partners") of the corresponding particles in "ordinary" matter. Antimatter occurs in natural processes like cosmic ray collisions and some types of radioac ...
* Sara Lawrence-Lightfoot: for portraiture, an approach to
social science Social science is one of the branches of science, devoted to the study of societies and the relationships among individuals within those societies. The term was formerly used to refer to the field of sociology, the original "science of so ...
methodology In its most common sense, methodology is the study of research methods. However, the term can also refer to the methods themselves or to the philosophical discussion of associated background assumptions. A method is a structured procedure for br ...
that bridges the realms of
aesthetics Aesthetics, or esthetics, is a branch of philosophy that deals with the nature of beauty and taste, as well as the philosophy of art (its own area of philosophy that comes out of aesthetics). It examines aesthetic values, often expressed t ...
and empiricism * Douglas Melton: for stem cell research regarding the genes, cells, and tissues that direct
pancreatic The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an endocr ...
organogenesis *
Mark Ptashne Mark Ptashne (born June 5, 1940, in Chicago) is a molecular biologist. He is the Ludwig Chair of Molecular Biology at Memorial Sloan–Kettering Cancer Center in New York City. Ptashne grew up in Chicago. He earned his undergraduate degree at Re ...
: for the study of repressor molecules in cellular genetic function * Stephen C. Harrison: for the study of human tumor viruses and the proteins involved in infection by AIDS viruses, * Lene Vestergaard Hau: for research using a Bose-Einstein Condensate to slow light, which is expected to improve fiber optics and quantum computing *
Judah Folkman Moses Judah Folkman (February 24, 1933 – January 14, 2008) was an American medical scientist best known for his research on tumor angiogenesis, the process by which a tumor attracts blood vessels to nourish itself and sustain its existence. He ...
: for research focused on the study of angiogenesis to prevent and treat cancer and other diseases * Carroll M. Williams: for research on the
juvenile hormone Juvenile hormones (JHs) are a group of acyclic sesquiterpenoids that regulate many aspects of insect physiology. The first discovery of a JH was by Vincent Wigglesworth. JHs regulate development, reproduction, diapause, and polyphenisms.The chem ...
in insects * L. Mahadevan: for research that focuses on the science of everyday things and solving such seemingly-mundane puzzles as the wrinkling of skin, the flutter of flags, the crumpling of paper, how the
Venus flytrap The Venus flytrap (''Dionaea muscipula'') is a carnivorous plant native to subtropical wetlands on the East Coast of the United States in North Carolina and South Carolina. It catches its prey—chiefly insects and arachnids—with a trapping ...
snaps up its prey etc. * Michael B. McElroy: for research on
planetary atmospheres An atmosphere () is a layer of gas or layers of gases that envelop a planet, and is held in place by the gravity of the planetary body. A planet retains an atmosphere when the gravity is great and the temperature of the atmosphere is low. A ...
, oceanography, stratospheric ozone depletion,
air quality Air pollution is the contamination of air due to the presence of substances in the atmosphere that are harmful to the health of humans and other living beings, or cause damage to the climate or to materials. There are many different types ...
,
climate change In common usage, climate change describes global warming—the ongoing increase in global average temperature—and its effects on Earth's climate system. Climate change in a broader sense also includes previous long-term changes to ...
, and carbon dioxide budgets ESRL Annual Meeting
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References

Harvard University Awards by university and college in the United States