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Polio Virus
A poliovirus, the causative agent of polio (also known as poliomyelitis), is a serotype of the species ''Enterovirus C'', in the family of ''Picornaviridae''. There are three poliovirus serotypes: types 1, 2, and 3. Poliovirus is composed of an RNA genome and a protein capsid. The genome is a single-stranded positive-sense RNA (+ssRNA) genome that is about 7500 nucleotides long. The viral particle is about 30 nm in diameter with icosahedral symmetry. Because of its short genome and its simple composition—only RNA and a nonenveloped icosahedral protein coat that encapsulates it—poliovirus is widely regarded as the simplest significant virus. Poliovirus was first isolated in 1909 by Karl Landsteiner and Erwin Popper. The structure of the virus was first elucidated in 1958 using X-ray diffraction by a team at Birkbeck College led by Rosalind Franklin, showing the polio virus to have icosahedral symmetry. In 1981, the poliovirus genome was published by two different tea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transmission Electron Microscopy
Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a sensor such as a scintillator attached to a charge-coupled device. Transmission electron microscopes are capable of imaging at a significantly higher resolution than light microscopes, owing to the smaller de Broglie wavelength of electrons. This enables the instrument to capture fine detail—even as small as a single column of atoms, which is thousands of times smaller than a resolvable object seen in a light microscope. Transmission electron microscopy is a major analytical method i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Envelope
A viral envelope is the outermost layer of many types of viruses. It protects the genetic material in their life cycle when traveling between host cells. Not all viruses have envelopes. Numerous human pathogenic viruses in circulation are encased in lipid bilayers, and they infect their target cells by causing the viral envelope and cell membrane to fuse. Although there are effective vaccines against some of these viruses, there is no preventative or curative medicine for the majority of them. In most cases, the known vaccines operate by inducing antibodies that prevent the pathogen from entering cells. This happens in the case of enveloped viruses when the antibodies bind to the viral envelope proteins. The membrane fusion event that triggers viral entrance is caused by the viral fusion protein. Many enveloped viruses only have one protein visible on the surface of the particle, which is required for both mediating adhesion to the cell surface and for the subsequent membrane fusi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scripps Research Institute
Scripps Research, previously known as The Scripps Research Institute (TSRI), is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, technicians, graduate students, and administrative and other staff, making it the largest private, non-profit biomedical research organization in the United States and among the largest in the world. The institute holds over 1,100 patents, has produced 11 FDA-approved therapeutics, and has generated over 50 spin-off companies. According to the 2017 Nature Innovation Index, Scripps Research is the #1 most influential research institution in the world. The Scripps Research graduate program is ranked 9th nationally in the biological sciences, 6th for organic chemistry, and 6th for biochemistry. In 2022, their Jupiter, FL campus became a part of the University of Florida. Jupiter-base ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Hogle
James Martin Hogle (born July 16, 1951) is an American biophysicist who discovered the structure of poliovirus in 1985. He is an emeritus Edward S. Harkness Professor at Harvard Medical School where he was also Chair of the Biophysics Program, as well as a faculty dean for Dudley House and a faculty director at Peabody Terrace. Early life and education Hogle was born in Detroit and grew up in Minneapolis, where he lived from the age of 9. After receiving a B.A. in biochemistry from the University of Minnesota, Hogle was accepted to both the oncology program and the biochemistry program at the University of Wisconsin–Madison, and chose biochemistry because he was "afraid (oncology) might be too specialized." He interviewed virologist Roland Rueckert, who was not available at the time, and did a summer rotation in the laboratory of pioneering X-ray crystallographer Muttaiya Sundaralingam, where he was "immediately hooked" on crystallography. Hogle worked on a number of projects a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stony Brook University
Stony Brook University (SBU), officially the State University of New York at Stony Brook, is a public research university in Stony Brook, New York. Along with the University at Buffalo, it is one of the State University of New York system's two flagship institutions. Its campus consists of 213 buildings on over of land in Suffolk County and it is the largest public university (by area) in the state of New York. Opened in 1957 in Oyster Bay as the State University College on Long Island, the institution moved to Stony Brook in 1962. In 2001, Stony Brook was elected to the Association of American Universities, a selective group of major research universities in North America. It is also a member of the larger Universities Research Association. It is classified among "R1: Doctoral Universities – Very high research activity". Stony Brook University, in partnership with Battelle, manages Brookhaven National Laboratory, a national laboratory of the United States Depart ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eckard Wimmer
Eckard Wimmer (born 22 May 1936) is a German American virologist, organic chemist and distinguished professor of molecular genetics and microbiology at Stony Brook University. He is best known for his seminal work on the molecular biology of poliovirus and the first chemical synthesis of a viral genome capable of infection and subsequent production of live viruses. Life and career Eckard Albert Friedrich Wimmer was born on May 22, 1936, in Berlin, Germany. At the onset of World War II, Wimmer at age three lost his father; at age nine, his mother fled together with his two older brothers to Saxony, East Germany, where he finished elementary school and high school. He studied Chemistry at the University of Rostock from 1953 to 1956, and then fled to West Germany to continue his Chemistry studies at University of Göttingen. In 1962 he earned the degree of Doctor rerum naturalium (Dr. rer. nat.) in the Organic Chemistry of natural products under the guidance of Hans Brockmann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naomi Kitamura
Naomi or Naomie may refer to: People and biblical figures * Naomi (given name), a female given name and a list of people with the name * Naomi (biblical figure), Ruth's mother-in-law in the Old Testament Book of Ruth * Naomi (Romanian singer) (born 1977), a.k.a. Naomy * Naomi (wrestler) (born 1987), professional wrestler * Terra Naomi, American indie folk singer-songwriter Arts and entertainment Fictional entities * Naomi, a character in the 2009 American fantasy comedy movie '' 17 Again'' * Naomi Bohannon, a character in the TV series ''Hell on Wheels'' * Naomi, Florida, a fictional town in the Kate DiCamillo novel ''Because of Winn-Dixie'' * Naomi Turner, a character in the American animated television series ''Elena of Avalor'' Music * Naomi Awards, a former British music award * ''Naomi'' (album), by American band The Cave Singers * "Naomi" (song), by Neutral Milk Hotel Other uses in arts and entertainment * ''Naomi'' (novel), a 1924 novel by Jun'ichirō Tanizaki * ''Nao ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the most prestigious and highly ranked academic institutions in the world. Founded in response to the increasing industrialization of the United States, MIT adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. MIT is one of three private land grant universities in the United States, the others being Cornell University and Tuskegee University. The institute has an urban campus that extends more than a mile (1.6 km) alongside the Charles River, and encompasses a number of major off-campus facilities such as the MIT Lincoln Laboratory, the Bates Center, and the Haystack Observatory, as well as affiliated laboratories such as the Broad and Whitehead Institutes. , 98 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Baltimore
David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is President Emeritus and Distinguished Professor of Biology at the California Institute of Technology (Caltech), where he served as president from 1997 to 2006. He also served as the director of the Joint Center for Translational Medicine, which joined Caltech and UCLA in a program to translate basic scientific discoveries into clinical realities. He also formerly served as president of Rockefeller University from 1990 to 1991, founder and director of the Whitehead Institute of Biomedical Research from 1982 to 1990, and was president of the American Association for the Advancement of Science in 2007. Baltimore has profoundly influenced international science, including key contributions to immunology, virology, cancer research, biotechnology, and recombinant DNA research, through his accomplishments as a researcher, administrator, educat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vincent Racaniello
Vincent R. Racaniello (born January 2, 1953) is a Higgins Professor in the Department of Microbiology and Immunology at Columbia University's College of Physicians and Surgeons. He is a co-author of a textbook on virology, ''Principles of Virology''. Racaniello has received the Irma T. Hirschl, Searle Scholars, Eli Lilly, Julius Youngner and NIH Merit awards. He has also been a Harvey Society Lecturer at Rockefeller University, the Hilleman Lecturer at the University of Chicago, and university lecturer at Columbia University. Spring of 2022, ETH Zurich awarded Racaniello the Richard R. Ernst award and lecture for his scientific communication work. He was also the keynote speaker for the American Society for Virology, at its 2018 meeting. Racaniello has served on the editorial boards of scientific journals, including the ''Journal of Virology'', and is a community editor for the open access journal ''PLOS Pathogens''. He also served as the 2015 president of the American Socie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosalind Franklin
Rosalind Elsie Franklin (25 July 192016 April 1958) was a British chemist and X-ray crystallographer whose work was central to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, coal, and graphite. Although her works on coal and viruses were appreciated in her lifetime, her contributions to the discovery of the structure of DNA were largely unrecognized during her life, for which she has been variously referred to as the "wronged heroine", the "dark lady of DNA", the "forgotten heroine", a "feminist icon", and the "Sylvia Plath of molecular biology". She graduated in 1941 with a degree in natural sciences from Newnham College, Cambridge, and then enrolled for a PhD in physical chemistry under Ronald George Wreyford Norrish, the 1920 Chair of Physical Chemistry at the University of Cambridge. Disappointed by Norrish's lack of enthusiasm, she took up a research position under the British Coal Utilisation Research Ass ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Birkbeck College
Birkbeck, University of London (formally Birkbeck College, University of London), is a public university, public research university, located in Bloomsbury, London, England, and a constituent college, member institution of the federal University of London. Established in 1823 as the London Mechanics' Institute by its founder, Sir George Birkbeck, and its supporters, Jeremy Bentham, John Hobhouse, 1st Baron Broughton, J. C. Hobhouse and Henry Brougham, 1st Baron Brougham and Vaux, Henry Brougham, Birkbeck is one of the few universities to specialise in evening higher education in the United Kingdom. Birkbeck's main building is based in the area of Bloomsbury in London Borough of Camden in Central London. Birkbeck offers over 200 undergraduate and postgraduate programmes that can be studied either part-time or full-time, though nearly all lectures are given in the evening. Birkbeck's academic activities are organised into five constituent faculties which are subdivided into ninete ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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