6-Fluoro-''N'',''N''-dimethyltryptamine (6-Fluoro-DMT) is a
synthetic drug of the
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...
chemical class Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties. Whereas the structural properties are largely intrinsic, functional properties and the derived classificat ...
.
Pharmacology
Binding profile
6-Fluoro-DMT possess
affinity
Affinity may refer to:
Commerce, finance and law
* Affinity (law), kinship by marriage
* Affinity analysis, a market research and business management technique
* Affinity Credit Union, a Saskatchewan-based credit union
* Affinity Equity Partn ...
for the
5-HT1A (392.6 nM),
5-HT1B (217.7 nM),
5-HT1D (55.4 nM),
5-HT1E (460.8 nM),
5-HT2A (866 nM),
5-HT2B (29.8 nM),
5-HT2C (674.2 nM),
5-HT5A (960.5 nM),
5-HT6 (25.6 nM),
5-HT7 (40.8 nM),
D1 (547.3 nM),
D2 (610.4 nM),
D3 (866.8 nM),
D4 (1,454 nM),
D5 (6,291 nM),
α1A-adrenergic (173.3 nM),
α2B-adrenergic (295.5 nM),
α2C-adrenergic (148.8 nM),
H1 (46.6 nM),
H2 (925.4 nM),
I1 (898.4 nM),
1 (6,892 nM), and
2 (7,128 nM)
receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
s, as well as the
SERT (144.6 nM).
It has low/negligible (> 10,000 nM) affinity for the
5-HT3,
α1B-adrenergic,
α2A-adrenergic,
β1-adrenergic,
β2-adrenergic,
H3,
H4, and
M1-
M5 receptors, as well as the
DAT and
NET
Net or net may refer to:
Mathematics and physics
* Net (mathematics), a filter-like topological generalization of a sequence
* Net, a linear system of divisors of dimension 2
* Net (polyhedron), an arrangement of polygons that can be folded up ...
.
It has not been screened at
5-HT1F,
5-HT4,
α1D-adrenergic,
β3-adrenergic, or
VMAT1/
VMAT2.
See also
*
5-Fluoro-DMT
5-Fluoro-''N'',''N''-dimethyltryptamine (5-fluoro-DMT, 5F-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/C receptor af ...
*
5-Fluoro-αMT
*
5-Bromo-DMT
5-Bromo-DMT (5-bromo-''N'',''N''-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges ''Smenospongia aurea'' and ''Smenospongia echina'', as well as in ''Verongula rigida'' (0.00142% dry weight) alongside 5,6-Dibr ...
*
6-Fluoro-AMT
6-Fluoro-α-methyltryptamine (6-fluoro-AMT, 6F-AMT) is a tryptamine derivative related to compounds such as alpha-methyltryptamine and 5-MeO-AMT, which has been sold as a designer drug. Animal tests showed it to be somewhat less active than AMT ...
*
6-Fluoro-DET
6-Fluoro-DET (6F-DET, 6-fluoro-''N,N''-diethyltryptamine) is a substituted tryptamine derivative related to drugs such as DET and 5-fluoro-DET. It acts as a partial agonist at the 5-HT2A receptor, but while it produces similar physiological eff ...
References
External links
6-Fluoro-DET
{{Tryptamines
Tryptamines