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Yury Verlinsky
Yury Verlinsky (1 September 1943 – 16 July 2009) was a Russian-American medical researcher specializing in embryonic and cellular genetics (genetic Cell biology, cytology). He is best known as a pioneer in prenatal diagnosis for detecting genetic and chromosomal disorders six weeks earlier than standard amniocentesis. The founding father of pre-implantation genetic diagnosis (PGD) and embryo analysis prior to in-vitro fertilization (IVF), Verlinsky used his polar body biopsy technique to detect potential birth defects in offspring. It is now accepted worldwide as the standard for the most efficient and effective means of analyzing the chromosomal status of an embryo. With the help of his research, PGD can be used to prevent more than 200 different genetic disorders and diseases. Early years and education Verlinsky was born in Ishim, Tyumen Oblast, Siberia, in the former Soviet Union, one of two sons of Simon Verlinsky and Dora Verlinskaya. His mother was an accountant and his ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ishim, Tyumen Oblast
Ishim (russian: Иши́м) is a town in the south of Tyumen Oblast, Russia. Population: It was previously known as ''Korkina Sloboda'' (until 1782). History It was founded in 1670 as the village of Korkina Sloboda. In 1721, by the order of Tsar Peter the Great the village gained the right to establish Nikolskaya Trade Fair which rapidly became one of the most important trade fairs in Siberia. This trade fair took place twice a year on the Saint Nicholas day (19 December and 22 May) until 1919. In 1782, by the order of Empress Catherine the Great, Korkina Sloboda was renamed Ishim and was granted town status. In 1918, Ishim became the administrative center of Ishimsky Uyezd. In 1921-1922 Ishim was the center of the West Siberian rebellion. In 1984, the city began a sister city relationship with Grand Forks, North Dakota in the United States. This relationship terminated in the late 1990s due to economic turmoil in Ishim. In 2017 Ishim began a sister relationship with Suroviki ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryo
An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm cell. The resulting fusion of these two cells produces a single-celled zygote that undergoes many cell divisions that produce cells known as blastomeres. The blastomeres are arranged as a solid ball that when reaching a certain size, called a morula, takes in fluid to create a cavity called a blastocoel. The structure is then termed a blastula, or a blastocyst in mammals. The mammalian blastocyst hatches before implantating into the endometrial lining of the womb. Once implanted the embryo will continue its development through the next stages of gastrulation, neurulation, and organogenesis. Gastrulation is the formation of the three germ layers that will form all of the different parts of the body. Neurulation forms the nervous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Reese Hospital
Michael Reese Hospital and Medical Center was an American hospital located in the Bronzeville neighborhood of Chicago, Illinois. Founded in 1881, Michael Reese Hospital was a major research and teaching hospital and one of the oldest and largest hospitals in Chicago, Illinois. It was located at 2929 S. Ellis Avenue on the near south side of Chicago, next to Lake Shore Drive (U.S. Route 41) which lies along Lake Michigan. The hospital closed its Internal Medicine Residency at the end of the 2007–2008 academic year and finished transferring patients to Mercy Hospital and Medical Center before the end of 2008. The 48-acre campus was then vacated by January 2009. From 2007 to its closing, Michael Reese had been owned by Envision Hospital Corporation of Scottsdale, Arizona. The hospital officially closed August 31, 2009. At one time, the hospital had a large health plan which included 300,000 patients; at the time of the hospital's closure the health plan was terminated and it only ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Google
Google LLC () is an American multinational technology company focusing on search engine technology, online advertising, cloud computing, computer software, quantum computing, e-commerce, artificial intelligence, and consumer electronics. It has been referred to as "the most powerful company in the world" and one of the world's most valuable brands due to its market dominance, data collection, and technological advantages in the area of artificial intelligence. Its parent company Alphabet is considered one of the Big Five American information technology companies, alongside Amazon, Apple, Meta, and Microsoft. Google was founded on September 4, 1998, by Larry Page and Sergey Brin while they were PhD students at Stanford University in California. Together they own about 14% of its publicly listed shares and control 56% of its stockholder voting power through super-voting stock. The company went public via an initial public offering (IPO) in 2004. In 2015, Google was reor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sergey Brin
Sergey Mikhailovich Brin (russian: link=no, Сергей Михайлович Брин; born August 21, 1973) is an American business magnate, computer scientist, and internet entrepreneur, who co-founded Google with Larry Page. Brin was the president of Google's parent company, Alphabet Inc., until stepping down from the role on December 3, 2019. He and Page remain at Alphabet as co-founders, controlling shareholders, board members, and employees. As of November 2022, Brin is the 12th-richest person in the world, with an estimated net worth of $78.0 billion. Brin immigrated to the United States with his family from the Soviet Union at the age of six. He earned his bachelor's degree at the University of Maryland, College Park, following in his father's and grandfather's footsteps by studying mathematics, as well as computer science. After graduation, he enrolled in Stanford University to acquire a PhD in computer science. There he met Page, with whom he built a web search e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diploma Tax
The diploma tax is an informal reference to the one-time payment imposed in the Soviet Union on would-be emigrants who received a higher education there. It was introduced in August 1972.Указ Президиума Верховного Совета СССР от 3 августа 1972 года «О возмещении гражданами СССР, выезжающими на постоянное жительство за границу, государственных затрат на обучение» , ''Ведомости Верховного Совета СССР'', 1972, no. 52, p. 519 The professed justification for the tax was to repay state expenses for public education, but the measure was designed to combat the brain drain caused by the growing emigration of Soviet Jews and other members of the intelligentsia to the West. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ukrainian SSR
The Ukrainian Soviet Socialist Republic ( uk, Украї́нська Радя́нська Соціалісти́чна Респу́бліка, ; russian: Украи́нская Сове́тская Социалисти́ческая Респу́блика, group=note), abbreviated as the Ukrainian SSR, UkrSSR, or UkSSR, and also known as Soviet Ukraine, was one of the constituent republics of the Soviet Union from 1922 until 1991. In the anthem of the Ukrainian SSR, it was referred to simply as ''Ukraine''. Under the Soviet one-party model, the Ukrainian SSR was governed by the Communist Party of the Soviet Union through its republican branch: the Communist Party of Ukraine. The first iterations of the Ukrainian SSR were established during the Russian Revolution, particularly after the Bolshevik Revolution. The outbreak of the Ukrainian–Soviet War in the former Russian Empire saw the Bolsheviks defeat the independent Ukrainian People's Republic, after which they fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polar Body Biopsy
Polar body biopsy is the sampling of a polar body of an oocyte. It was first applied clinically in humans in 1987 after extensive animal studies. A ''polar body'' is a small haploid cell that is formed concomitantly as an egg cell during oogenesis, but which generally does not have the ability to be fertilized. After sampling of a polar body, subsequent analysis can be used to predict viability and pregnancy chance of the oocyte, as well as the future health of a person resulting from such a pregnancy. The latter use makes it a form of preimplantation genetic screening (PGS). Compared to a blastocyst biopsy, a polar body biopsy can potentially be of lower costs, less harmful side-effects, and more sensitive in detecting abnormalities."Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies". Scott Jr, Richard T., Nathan R. Treff, John Stevens, Eric J. Forman, Kathleen H. Hong, Mandy G. Katz-Jaffe, William B. Schoolcraft. Journal of Assisted R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In-vitro Fertilization
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's ovulatory process, removing an ovum or ova (egg or eggs) from their ovaries and letting sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is transferred by catheter into the uterus, with the intention of establishing a successful pregnancy. IVF is a type of assisted reproductive technology used for infertility treatment, gestational surrogacy, and, in combination with pre-implantation genetic testing, avoiding transmission of genetic conditions. A fertilised egg from a donor may implant into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries have banned or otherwise regulate the availability of IVF treatment, giving rise to fertility tourism. Restrictio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pre-implantation Genetic Diagnosis
Preimplantation genetic diagnosis (PGD or PIGD) is the genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization. PGD is considered in a similar fashion to prenatal diagnosis. When used to screen for a specific genetic disease, its main advantage is that it avoids selective abortion, as the method makes it highly likely that the baby will be free of the disease under consideration. PGD thus is an adjunct to assisted reproductive technology, and requires in vitro fertilization (IVF) to obtain oocytes or embryos for evaluation. Embryos are generally obtained through blastomere or blastocyst biopsy. The latter technique has proved to be less deleterious for the embryo, therefore it is advisable to perform the biopsy around day 5 or 6 of development. The world's first PGD was performed by Handyside, Kontogianni and Winston at the Hammersmith Hospital in London. Female embryos were selectively transferred ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amniocentesis
Amniocentesis is a medical procedure used primarily in the prenatal diagnosis of genetic conditions. It has other uses such as in the assessment of infection and fetal lung maturity. Prenatal diagnostic testing, which includes amniocentesis, is necessary to conclusively diagnose the majority of genetic disorders, with amniocentesis being the gold-standard procedure after 15 weeks' gestation. In this procedure, a thin needle is inserted into the abdomen of the pregnant woman. The needle punctures the amnion, which is the membrane that surrounds the developing fetus. The fluid within the amnion is called amniotic fluid, and because this fluid surrounds the developing fetus, it contains fetal cells. The amniotic fluid is sampled and analyzed via methods such as karyotyping and DNA analysis technology for genetic abnormalities. An amniocentesis is typically performed in the second trimester between the 15th and 20th week of gestation. Women who choose to have this test are prima ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosomal Disorders
A chromosomal abnormality, chromosomal anomaly, chromosomal aberration, chromosomal mutation, or chromosomal disorder, is a missing, extra, or irregular portion of chromosomal DNA. These can occur in the form of numerical abnormalities, where there is an atypical number of chromosomes, or as structural abnormalities, where one or more individual chromosomes are altered. Chromosome mutation was formerly used in a strict sense to mean a change in a chromosomal segment, involving more than one gene. Chromosome anomalies usually occur when there is an error in cell division following meiosis or mitosis. Chromosome abnormalities may be detected or confirmed by comparing an individual's karyotype, or full set of chromosomes, to a typical karyotype for the species via genetic testing. Numerical abnormality An abnormal number of chromosomes is called aneuploidy, and occurs when an individual is either missing a chromosome from a pair (resulting in monosomy) or has more than two chromos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
