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Virtual Physiological Human
The Virtual Physiological Human (VPH) is a European initiative that focuses on a methodological and technological framework that, once established, will enable collaborative investigation of the human body as a single complex system. The collective framework will make it possible to share resources and observations formed by institutions and organizations, creating disparate but integrated computer models of the mechanical, physical and biochemical functions of a living human body. VPH is a framework which aims to be descriptive, integrative and predictive.STEP research road map Clapworthy ''et al.'' state that the framework should be descriptive by allowing laboratory and healthcare observations around the world "to be collected, catalogued, organized, shared and combined in any possible way." It shou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complex System
A complex system is a system composed of many components which may interact with each other. Examples of complex systems are Earth's global climate, organisms, the human brain, infrastructure such as power grid, transportation or communication systems, complex software and electronic systems, social and economic organizations (like cities), an ecosystem, a living cell, and ultimately the entire universe. Complex systems are systems whose behavior is intrinsically difficult to model due to the dependencies, competitions, relationships, or other types of interactions between their parts or between a given system and its environment. Systems that are "complex" have distinct properties that arise from these relationships, such as nonlinearity, emergence, spontaneous order, adaptation, and feedback loops, among others. Because such systems appear in a wide variety of fields, the commonalities among them have become the topic of their independent area of research. In many cases, i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiome
The physiome of an individual's or species' physiological state is the description of its functional behavior. The physiome describes the physiological dynamics of the normal intact organism and is built upon information and structure (genome, proteome, and morphome). The term comes from "physio-" (nature) and "-ome" (as a whole). The concept of a physiome project was presented to the International Union of Physiological Sciences (IUPS) by its Commission on Bioengineering in Physiology in 1993. A workshop on designing the Physiome Project was held in 1997. At its world congress in 2001, the IUPS designated the project as a major focus for the next decade. The project is led by the Physiome Commission of the IUPS. Other research initiatives related to the physiome include: *The EuroPhysiome Initiative *The NSR Physiome Project of the National Simulation Resource (NSR) at the University of Washington, supporting the IUPS Physiome Project *The Wellcome Trust Heart Physiome Project, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Informatics
Health informatics is the field of science and engineering that aims at developing methods and technologies for the acquisition, processing, and study of patient data, which can come from different sources and modalities, such as electronic health records, diagnostic test results, medical scans. The health domain provides an extremely wide variety of problems that can be tackled using computational techniques. Health informatics is a spectrum of multidisciplinary fields that includes study of the design, development and application of computational innovations to improve health care. The disciplines involved combines medicine fields with computing fields, in particular computer engineering, software engineering, information engineering, bioinformatics, bio-inspired computing, theoretical computer science, information systems, data science, information technology, autonomic computing, and behavior informatics. In academic institutions, medical informatics research focus on a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anatomical Simulation
Anatomy () is the branch of biology concerned with the study of the structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old science, having its beginnings in prehistoric times. Anatomy is inherently tied to developmental biology, embryology, comparative anatomy, evolutionary biology, and phylogeny, as these are the processes by which anatomy is generated, both over immediate and long-term timescales. Anatomy and physiology, which study the structure and function of organisms and their parts respectively, make a natural pair of related disciplines, and are often studied together. Human anatomy is one of the essential basic sciences that are applied in medicine. The discipline of anatomy is divided into macroscopic and microscopic. Macroscopic anatomy, or gross anatomy, is the examination of an animal's body parts using unaided eyesight. Gross anatomy also includes the branch o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VPHOP
The Virtual Physiological Human (VPH) is a European initiative that focuses on a methodological and technological framework that, once established, will enable collaborative investigation of the human body as a single complex system. The collective framework will make it possible to share resources and observations formed by institutions and organizations, creating disparate but integrated computer models of the mechanical, physical and biochemical functions of a living human body. VPH is a framework which aims to be descriptive, integrative and predictive.STEP research road map Clapworthy ''et al.'' state that the framework should be descriptive by allowing laboratory and healthcare observations around the world "to be collected, catalogued, organized, shared and combined in any possible way." It shou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virtual Physiological Rat
The Virtual Physiological Rat (VPR) Project is an international collaboration aimed simulating the integrated cardiovascular function of the rat and supported by the National Institute of General Medical Sciences as a National Center for Systems Biology. The project is motivated by the fact that, although there exist both a depth of knowledge of basic cardiovascular physiology and a host of physiological and genomic data from animal models of disease, there is a lack of understanding of how multiple genes and environmental factors interact to determine cardiovascular phenotype. The Virtual Physiological Rat Project is focused on developing computational tools to capture the underlying systems physiology as well as the pathophysiological perturbations associated with disease. These tools are being developed and validated based on experimental characterization of physiological function across a number of organ systems in rat strains engineered to show relevant disease phenotypes. Compu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiome
The physiome of an individual's or species' physiological state is the description of its functional behavior. The physiome describes the physiological dynamics of the normal intact organism and is built upon information and structure (genome, proteome, and morphome). The term comes from "physio-" (nature) and "-ome" (as a whole). The concept of a physiome project was presented to the International Union of Physiological Sciences (IUPS) by its Commission on Bioengineering in Physiology in 1993. A workshop on designing the Physiome Project was held in 1997. At its world congress in 2001, the IUPS designated the project as a major focus for the next decade. The project is led by the Physiome Commission of the IUPS. Other research initiatives related to the physiome include: *The EuroPhysiome Initiative *The NSR Physiome Project of the National Simulation Resource (NSR) at the University of Washington, supporting the IUPS Physiome Project *The Wellcome Trust Heart Physiome Project, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living Human Project
{{no footnotes, date=September 2016 The Living Human Project (LHP) is a project that begun in 2002 to develop a distributed repository of anatomo-functional data and simulation algorithms for the human musculoskeletal apparatus used to create the physiome of the human musculoskeletal system. In 2006 the BEL was merged with Biomed Town, an Internet community for those who have a professional interest in biomedical research. Living Human Digital Library The LHDL project was ended in January 2009, and soon after the LHDL consortium released a biomedical data management and sharing service called ''Physiome Space''. Physiome Space lets individual researchers as well as for large consortia to share with their peers large collections of biomedical data, including medical imaging and computer simulations. See also * List of omics topics in biology * Virtual Physiological Human * Physiomics * Physiome * Physiology * EuroPhysiome * Human anatomy The human body is the structure of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Anatomy
The human body is the structure of a human being. It is composed of many different types of cells that together create tissues and subsequently organ systems. They ensure homeostasis and the viability of the human body. It comprises a head, hair, neck, trunk (which includes the thorax and abdomen), arms and hands, legs and feet. The study of the human body involves anatomy, physiology, histology and embryology. The body varies anatomically in known ways. Physiology focuses on the systems and organs of the human body and their functions. Many systems and mechanisms interact in order to maintain homeostasis, with safe levels of substances such as sugar and oxygen in the blood. The body is studied by health professionals, physiologists, anatomists, and by artists to assist them in their work. Composition The human body is composed of elements including hydrogen, oxygen, carbon, calcium and phosphorus. These elements reside in trillions of cells and non-cellula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EuroPhysiome
The physiome of an individual's or species' physiological state is the description of its functional behavior. The physiome describes the physiological dynamics of the normal intact organism and is built upon information and structure (genome, proteome, and morphome). The term comes from "physio-" (nature) and "-ome" (as a whole). The concept of a physiome project was presented to the International Union of Physiological Sciences (IUPS) by its Commission on Bioengineering in Physiology in 1993. A workshop on designing the Physiome Project was held in 1997. At its world congress in 2001, the IUPS designated the project as a major focus for the next decade. The project is led by the Physiome Commission of the IUPS. Other research initiatives related to the physiome include: *The EuroPhysiome Initiative *The NSR Physiome Project of the National Simulation Resource (NSR) at the University of Washington, supporting the IUPS Physiome Project *The Wellcome Trust Heart Physiome Project, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytome
Cytomics is the study of cell biology (cytology) and biochemistry in cellular systems at the single cell level. It combines all the bioinformatic knowledge to attempt to understand the molecular architecture and functionality of the cell system (Cytome). Much of this is achieved by using molecular and microscopic techniques that allow the various components of a cell to be visualised as they interact ''in vivo''. Cytome Cytomes are the cellular systems, subsystems, and functional components of the body. The cytome is the collection of the complex and dynamic cellular processes (structure and function) underlying physiological processes. It describes the structural and functional heterogeneity of the cellular diversity of an organism. Human Cytome Project The Human Cytome Project is aimed at the study of the biological system structure and function of an organism at the cytome level.Valet G., Predictive medicine by cytomics and the challenges of a human cytome project, Business Br ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
