The physiome of an individual's or

species In biology, a species is the basic unit of classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate s ...

physiological Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

state is the description of its functional behavior. The physiome describes the physiological dynamics of the normal intact

organism In biology, an organism () is any living system that functions as an individual entity. All organisms are composed of cells (cell theory). Organisms are classified by taxonomy into groups such as multicellular animals, plants, and ...

and is built upon information and structure (

genome In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding ge ...

proteome The proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. ...

, and

morphome Morphome is one of the omes in biology to map and classify all the morphological features of species. Morphome is different from phenome in that it is the totality of morphological variants while phenome includes non-morphological variants. See ...

). The term comes from "physio-" (nature) and "-ome" (as a whole). The concept of a physiome project was presented to the

International Union of Physiological Sciences The International Union of Physiological Sciences, abbreviated IUPS, is the global umbrella organization for physiology. IUPS aims to facilitate initiatives that strengthen the discipline of physiology. IUPS is a scientific union member of the I ...

(IUPS) by its Commission on Bioengineering in Physiology in 1993. A workshop on designing the Physiome Project was held in 1997. At its world congress in 2001, the IUPS designated the project as a major focus for the next decade. The project is led by the Physiome Commission of the IUPS. Other research initiatives related to the physiome include: *The EuroPhysiome Initiative *The NSR Physiome Project of the National Simulation Resource (NSR) at the

University of Washington The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington. Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...

, supporting the IUPS Physiome Project *The Wellcome Trust Heart Physiome Project, a collaboration between the

University of Auckland , mottoeng = By natural ability and hard work , established = 1883; years ago , endowment = NZD $293 million (31 December 2021) , budget = NZD $1.281 billion (31 December 2021) , chancellor = Cecilia Tarrant , vice_chancellor = Dawn F ...

and the

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

, part of the wider IUPS Physiome Project

References

External links

National Resource for Cell Analysis and Modeling (NRCAM)
Physiology Biophysics {{biophysics-stub

See also

References

External links